JP2011513471A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011513471A5 JP2011513471A5 JP2010550206A JP2010550206A JP2011513471A5 JP 2011513471 A5 JP2011513471 A5 JP 2011513471A5 JP 2010550206 A JP2010550206 A JP 2010550206A JP 2010550206 A JP2010550206 A JP 2010550206A JP 2011513471 A5 JP2011513471 A5 JP 2011513471A5
- Authority
- JP
- Japan
- Prior art keywords
- membered
- group
- noh
- different
- nhc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000003710 aryl alkyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 5
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 5
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 5
- 125000004404 heteroalkyl group Chemical group 0.000 claims 5
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 5
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000004438 haloalkoxy group Chemical group 0.000 claims 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000000824 cytostatic agent Substances 0.000 claims 1
- 230000001085 cytostatic effect Effects 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08152721 | 2008-03-13 | ||
| PCT/EP2009/052959 WO2009112565A1 (en) | 2008-03-13 | 2009-03-13 | Thiazolyl-dihydro-indazoles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011513471A JP2011513471A (ja) | 2011-04-28 |
| JP2011513471A5 true JP2011513471A5 (https=) | 2012-05-10 |
Family
ID=39591172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010550206A Pending JP2011513471A (ja) | 2008-03-13 | 2009-03-13 | チアゾリル−ジヒドロ−インダゾール |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20110118208A1 (https=) |
| EP (1) | EP2280982A1 (https=) |
| JP (1) | JP2011513471A (https=) |
| KR (1) | KR20100135743A (https=) |
| CN (1) | CN102015728A (https=) |
| AR (1) | AR070877A1 (https=) |
| AU (1) | AU2009224659A1 (https=) |
| BR (1) | BRPI0908583A2 (https=) |
| CA (1) | CA2717488A1 (https=) |
| CL (1) | CL2009000599A1 (https=) |
| CO (1) | CO6290768A2 (https=) |
| EA (1) | EA201001427A1 (https=) |
| EC (1) | ECSP10010532A (https=) |
| IL (1) | IL207776A0 (https=) |
| MA (1) | MA32158B1 (https=) |
| MX (1) | MX2010009837A (https=) |
| PE (1) | PE20091617A1 (https=) |
| TW (1) | TW200942548A (https=) |
| UY (1) | UY31700A (https=) |
| WO (1) | WO2009112565A1 (https=) |
| ZA (1) | ZA201006023B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011049625A1 (en) | 2009-10-20 | 2011-04-28 | Mansour Samadpour | Method for aflatoxin screening of products |
| NZ599830A (en) | 2009-11-05 | 2014-08-29 | Rhizen Pharmaceuticals Sa | Novel kinase modulators |
| US8466162B2 (en) | 2011-01-26 | 2013-06-18 | Boehringer Ingelheim International Gmbh | 5-alkynyl-pyridines |
| TW201245176A (en) | 2011-01-26 | 2012-11-16 | Boehringer Ingelheim Int | New 5-alkynyl-pyridines |
| EP2546249A1 (en) | 2011-07-15 | 2013-01-16 | Boehringer Ingelheim International Gmbh | 5-Alkynyl-pyridines |
| PH12013502240B1 (en) | 2011-05-04 | 2018-06-27 | Rhizen Pharmaceuticals Sa | Novel compounds as modulators of protein kinase |
| RS56494B1 (sr) | 2012-07-04 | 2018-01-31 | Rhizen Pharmaceuticals S A | Selektivni inhibitori pi3k delta |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2343303A1 (de) * | 2004-10-07 | 2011-07-13 | Boehringer Ingelheim International GmbH | PI3-Kinase Inhibitoren |
| UY29149A1 (es) * | 2004-10-07 | 2006-05-31 | Boehringer Ingelheim Int | Tiazolil-dihidro-indazoles |
| DE102004048877A1 (de) * | 2004-10-07 | 2006-04-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | PI3-Kinasen |
| CA2646536A1 (en) * | 2006-04-06 | 2007-10-11 | Boehringer Ingelheim International Gmbh | Thiazolyl dihydro-indazoles |
| US20070259855A1 (en) * | 2006-04-06 | 2007-11-08 | Udo Maier | Thiazolyl-dihydro-indazole |
| CN101460506A (zh) | 2006-04-06 | 2009-06-17 | 贝林格尔.英格海姆国际有限公司 | 用作蛋白激酶抑制剂的噻唑基-二氢-吲唑衍生物 |
| US20070238718A1 (en) * | 2006-04-06 | 2007-10-11 | Matthias Grauert | Thiazolyl-dihydro-indazole |
-
2009
- 2009-03-11 UY UY0001031700A patent/UY31700A/es not_active Application Discontinuation
- 2009-03-11 PE PE2009000361A patent/PE20091617A1/es not_active Application Discontinuation
- 2009-03-12 AR ARP090100892A patent/AR070877A1/es unknown
- 2009-03-12 CL CL2009000599A patent/CL2009000599A1/es unknown
- 2009-03-12 TW TW098108096A patent/TW200942548A/zh unknown
- 2009-03-13 KR KR1020107020481A patent/KR20100135743A/ko not_active Withdrawn
- 2009-03-13 CA CA2717488A patent/CA2717488A1/en not_active Abandoned
- 2009-03-13 WO PCT/EP2009/052959 patent/WO2009112565A1/en not_active Ceased
- 2009-03-13 JP JP2010550206A patent/JP2011513471A/ja active Pending
- 2009-03-13 EP EP09719604A patent/EP2280982A1/en not_active Ceased
- 2009-03-13 EA EA201001427A patent/EA201001427A1/ru unknown
- 2009-03-13 AU AU2009224659A patent/AU2009224659A1/en not_active Abandoned
- 2009-03-13 MX MX2010009837A patent/MX2010009837A/es not_active Application Discontinuation
- 2009-03-13 US US12/921,588 patent/US20110118208A1/en not_active Abandoned
- 2009-03-13 BR BRPI0908583A patent/BRPI0908583A2/pt not_active IP Right Cessation
- 2009-03-13 CN CN2009801164824A patent/CN102015728A/zh active Pending
-
2010
- 2010-08-24 IL IL207776A patent/IL207776A0/en unknown
- 2010-08-24 ZA ZA2010/06023A patent/ZA201006023B/en unknown
- 2010-09-01 CO CO10108096A patent/CO6290768A2/es not_active Application Discontinuation
- 2010-09-09 MA MA33164A patent/MA32158B1/fr unknown
- 2010-10-08 EC EC2010010532A patent/ECSP10010532A/es unknown
-
2012
- 2012-01-11 US US13/347,797 patent/US8304556B2/en active Active