MA32158B1 - Thiazolyldihydroindazoles - Google Patents

Thiazolyldihydroindazoles

Info

Publication number
MA32158B1
MA32158B1 MA33164A MA33164A MA32158B1 MA 32158 B1 MA32158 B1 MA 32158B1 MA 33164 A MA33164 A MA 33164A MA 33164 A MA33164 A MA 33164A MA 32158 B1 MA32158 B1 MA 32158B1
Authority
MA
Morocco
Prior art keywords
thiazolyldihydroindazoles
drug
excessive
prepare
compounds
Prior art date
Application number
MA33164A
Other languages
Arabic (ar)
English (en)
Inventor
Maria Impagnatiello
Darryl Mcconnell
Dirk Kessler
Oliver Kraemer
Siegfried Schneider
Der Veen Lars Van
Ulrike Weyer-Czernilofsky
Tobias Wunberg
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39591172&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32158(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MA32158B1 publication Critical patent/MA32158B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

La présente invention porte sur des composés de formule générale (1) dans laquelle r1 à r3 sont définis comme dans la revendication 1, qui sont appropriés pour le traitement de maladies caractérisées par une prolifération cellulaire excessive ou anormale, et sur l'utilisation de ceux-ci pour préparer un médicament ayant les propriétés mentionnées ci-dessus.
MA33164A 2008-03-13 2010-09-09 Thiazolyldihydroindazoles MA32158B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08152721 2008-03-13
PCT/EP2009/052959 WO2009112565A1 (fr) 2008-03-13 2009-03-13 Thiazolyldihydroindazoles

Publications (1)

Publication Number Publication Date
MA32158B1 true MA32158B1 (fr) 2011-03-01

Family

ID=39591172

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33164A MA32158B1 (fr) 2008-03-13 2010-09-09 Thiazolyldihydroindazoles

Country Status (21)

Country Link
US (2) US20110118208A1 (fr)
EP (1) EP2280982A1 (fr)
JP (1) JP2011513471A (fr)
KR (1) KR20100135743A (fr)
CN (1) CN102015728A (fr)
AR (1) AR070877A1 (fr)
AU (1) AU2009224659A1 (fr)
BR (1) BRPI0908583A2 (fr)
CA (1) CA2717488A1 (fr)
CL (1) CL2009000599A1 (fr)
CO (1) CO6290768A2 (fr)
EA (1) EA201001427A1 (fr)
EC (1) ECSP10010532A (fr)
IL (1) IL207776A0 (fr)
MA (1) MA32158B1 (fr)
MX (1) MX2010009837A (fr)
PE (1) PE20091617A1 (fr)
TW (1) TW200942548A (fr)
UY (1) UY31700A (fr)
WO (1) WO2009112565A1 (fr)
ZA (1) ZA201006023B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011049625A1 (fr) 2009-10-20 2011-04-28 Mansour Samadpour Procédé de criblage d'aflatoxine dans des produits
MX352661B (es) 2009-11-05 2017-12-04 Rhizen Pharmaceuticals S A Star Moduladores novedosos de benzopiran cinasa.
TW201245176A (en) 2011-01-26 2012-11-16 Boehringer Ingelheim Int New 5-alkynyl-pyridines
US8466162B2 (en) 2011-01-26 2013-06-18 Boehringer Ingelheim International Gmbh 5-alkynyl-pyridines
EP2546249A1 (fr) 2011-07-15 2013-01-16 Boehringer Ingelheim International Gmbh 5-Alkynyl-pyrimidines
CA2833935C (fr) 2011-05-04 2020-09-15 Dhanapalan Nagarathnam Nouveaux composes en tant que modulateurs de proteines kinases
EP2870157B1 (fr) 2012-07-04 2017-08-30 Rhizen Pharmaceuticals S.A. Inhibiteurs sélectifs de pi3k delta

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004048877A1 (de) * 2004-10-07 2006-04-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg PI3-Kinasen
MX2007004051A (es) * 2004-10-07 2007-05-24 Boehringer Ingelheim Int Pi3-quinasas.
UY29149A1 (es) 2004-10-07 2006-05-31 Boehringer Ingelheim Int Tiazolil-dihidro-indazoles
CN101460506A (zh) 2006-04-06 2009-06-17 贝林格尔.英格海姆国际有限公司 用作蛋白激酶抑制剂的噻唑基-二氢-吲唑衍生物
RU2008143555A (ru) * 2006-04-06 2010-06-27 Бёрингер Ингельхайм Интернациональ Гмбх (De) Тиазолилдигидроиндазолы
US20070259855A1 (en) * 2006-04-06 2007-11-08 Udo Maier Thiazolyl-dihydro-indazole
US20070238718A1 (en) * 2006-04-06 2007-10-11 Matthias Grauert Thiazolyl-dihydro-indazole

Also Published As

Publication number Publication date
TW200942548A (en) 2009-10-16
ZA201006023B (en) 2011-10-26
JP2011513471A (ja) 2011-04-28
CN102015728A (zh) 2011-04-13
IL207776A0 (en) 2010-12-30
AU2009224659A1 (en) 2009-09-17
US20110118208A1 (en) 2011-05-19
UY31700A (es) 2009-11-10
EA201001427A1 (ru) 2011-04-29
KR20100135743A (ko) 2010-12-27
WO2009112565A1 (fr) 2009-09-17
MX2010009837A (es) 2010-09-28
PE20091617A1 (es) 2009-11-12
BRPI0908583A2 (pt) 2019-09-24
EP2280982A1 (fr) 2011-02-09
CL2009000599A1 (es) 2011-01-07
CA2717488A1 (fr) 2009-09-17
ECSP10010532A (es) 2010-11-30
US8304556B2 (en) 2012-11-06
CO6290768A2 (es) 2011-06-20
US20120108567A1 (en) 2012-05-03
AR070877A1 (es) 2010-05-12

Similar Documents

Publication Publication Date Title
TN2009000551A1 (fr) Nouveaux composes chimiques
MA32158B1 (fr) Thiazolyldihydroindazoles
MA31906B1 (fr) Inhibiteurs de la replication du virus de limmunodeficience humaine
MA32506B1 (fr) Nouveaux composes
MA33302B1 (fr) 2, 4-diaminopyrimidines pour le traitement de maladies caracterisees par une proliferation cellulaire excessive ou anormale
TN2009000324A1 (fr) Composes tricycliques et leur utilisation comme modulateurs du recepteur de glucocorticoides
MA33606B1 (fr) Dérivés de pyrimidine en tant qu'inhibiteurs de protéine tyrosine kinase 2
MA31949B1 (fr) Dérivés d'aminotriazole comme agonistes d'alx
TNSN07070A1 (fr) Composes aminoheteroaryliques enantiomeriquement purs servant d'inhibiteurs de proteine-kinases
MA33155B1 (fr) Composes organiques et leurs utilisations
MA30232B1 (fr) Inhibiteurs de kinase bases sur l'hydantoine
MA33737B1 (fr) Dérivés de glycoside et utilisations de ceux-ci
MA33604B1 (fr) Composés et compositions en tant qu'inhibiteurs de protéine kinase
TN2011000454A1 (fr) Derives de benzofurannyle utilises comme inhibiteurs de glucokinase
MA31260B1 (fr) 3-imidazolyl-indoles pour le traitement de maladies proliferatives
MA31167B1 (fr) Inhibiteurs de l'activite de akt
TN2015000547A1 (fr) Composes heteroaromatiques et leur utilisation comme ligands de dopamine d1
MA31767B1 (fr) Composes organiques et leurs utilisations
MA32351B1 (fr) Derives d'aminodihydrothiazine a titre d'inhibiteurs de bace pour le traitement de la maladie d'alzheimer
MY142988A (en) Novel aminobenzophenone compounds
UA90698C2 (en) Triazole substituted aminobenzophenone compounds
MA33492B1 (fr) Inhibiteurs de bace
MA32466B1 (fr) Derives de triazole utiles pour le traitement de maladies
MA33209B1 (fr) Inhibiteurs de la replication du virus de l'hepatite c
MA33053B1 (fr) Inhibiteurs de la poly(adp-ribose) polymerase (parp)