JP2002527459A - 粘膜表面を水和する方法 - Google Patents
粘膜表面を水和する方法Info
- Publication number
- JP2002527459A JP2002527459A JP2000576801A JP2000576801A JP2002527459A JP 2002527459 A JP2002527459 A JP 2002527459A JP 2000576801 A JP2000576801 A JP 2000576801A JP 2000576801 A JP2000576801 A JP 2000576801A JP 2002527459 A JP2002527459 A JP 2002527459A
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- group
- phenyl
- carrier moiety
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims abstract description 72
- 150000001875 compounds Chemical class 0.000 claims abstract description 48
- -1 phenamyl Chemical compound 0.000 claims abstract description 36
- 239000003195 sodium channel blocking agent Substances 0.000 claims abstract description 36
- 229940125794 sodium channel blocker Drugs 0.000 claims abstract description 34
- 150000003839 salts Chemical class 0.000 claims abstract description 23
- 239000000018 receptor agonist Substances 0.000 claims abstract description 17
- 229940044601 receptor agonist Drugs 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- BGGCAGOTBOAZPU-UHFFFAOYSA-N n-(diaminomethylidene)pyrazine-2-carboxamide;sodium Chemical compound [Na].NC(N)=NC(=O)C1=CN=CC=N1 BGGCAGOTBOAZPU-UHFFFAOYSA-N 0.000 claims abstract description 16
- 230000028327 secretion Effects 0.000 claims abstract description 11
- 230000009103 reabsorption Effects 0.000 claims abstract description 10
- 230000000887 hydrating effect Effects 0.000 claims abstract description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims abstract description 8
- 102000009027 Albumins Human genes 0.000 claims abstract description 7
- 108010088751 Albumins Proteins 0.000 claims abstract description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 134
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 56
- 229910052739 hydrogen Inorganic materials 0.000 claims description 48
- 239000001257 hydrogen Substances 0.000 claims description 46
- 125000004432 carbon atom Chemical group C* 0.000 claims description 39
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 32
- 239000000203 mixture Substances 0.000 claims description 31
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 15
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 15
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- 125000005059 halophenyl group Chemical group 0.000 claims description 12
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- 125000005843 halogen group Chemical group 0.000 claims description 11
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- 125000004799 bromophenyl group Chemical group 0.000 claims description 10
- 125000000068 chlorophenyl group Chemical group 0.000 claims description 10
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 10
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- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims description 4
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- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims description 4
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- 125000003884 phenylalkyl group Chemical group 0.000 claims description 3
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
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- 150000004676 glycans Chemical class 0.000 claims 3
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- 229910052760 oxygen Inorganic materials 0.000 claims 2
- VDRMSHBDXWSTNR-UHFFFAOYSA-N [Na].NC(=N)N Chemical compound [Na].NC(=N)N VDRMSHBDXWSTNR-UHFFFAOYSA-N 0.000 claims 1
- XSDQTOBWRPYKKA-UHFFFAOYSA-N amiloride Chemical compound NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N XSDQTOBWRPYKKA-UHFFFAOYSA-N 0.000 abstract description 12
- KXDROGADUISDGY-UHFFFAOYSA-N Benzamil hydrochloride Chemical compound C=1C=CC=CC=1CN=C(N)NC(=O)C1=NC(Cl)=C(N)N=C1N KXDROGADUISDGY-UHFFFAOYSA-N 0.000 abstract description 9
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- A61P11/02—Nasal agents, e.g. decongestants
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Otolaryngology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10499998P | 1998-10-20 | 1998-10-20 | |
| US60/104,999 | 1998-10-20 | ||
| PCT/US1999/024546 WO2000023023A1 (en) | 1998-10-20 | 1999-10-20 | Methods of hydrating mucosal surfaces |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002527459A true JP2002527459A (ja) | 2002-08-27 |
| JP2002527459A5 JP2002527459A5 (enExample) | 2005-12-22 |
Family
ID=22303527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000576801A Pending JP2002527459A (ja) | 1998-10-20 | 1999-10-20 | 粘膜表面を水和する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6264975B1 (enExample) |
| EP (1) | EP1143896B1 (enExample) |
| JP (1) | JP2002527459A (enExample) |
| AT (1) | ATE347880T1 (enExample) |
| AU (1) | AU757139B2 (enExample) |
| CA (1) | CA2346656A1 (enExample) |
| DE (1) | DE69934435T2 (enExample) |
| WO (1) | WO2000023023A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008179653A (ja) * | 2004-04-01 | 2008-08-07 | Cardiome Pharma Corp | Ｐｅｇ化イオンチャネル調節化合物 |
| WO2010131486A1 (en) * | 2009-05-15 | 2010-11-18 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical compositions with improved pharmacokinetics |
Families Citing this family (58)
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| GB0303506D0 (en) * | 2003-02-14 | 2003-03-19 | Novartis Ag | Organic compounds |
| US7638138B2 (en) | 2003-02-21 | 2009-12-29 | Translational Research, Ltd. | Compositions for nasal administration of pharmaceuticals |
| MXPA05010379A (es) | 2003-03-27 | 2006-05-31 | Bioactis Ltd | Aparato para administrar una medicina en polvo en la cavidad intranasal. |
| AU2004227915A1 (en) * | 2003-03-31 | 2004-10-21 | John F. Engelhardt | Pharmico-gene theraphy of epithelial sodium channel associated disoders |
| US20050090505A1 (en) * | 2003-08-18 | 2005-04-28 | Johnson Michael R. | Methods of reducing risk of infection from pathogens |
| PT1663235E (pt) | 2003-08-18 | 2013-10-29 | Parion Sciences Inc | Novos bloqueadores dos canais do sódio de pirazinoílguanidina protegida |
| US20090253714A1 (en) * | 2003-08-20 | 2009-10-08 | Johnson Michael R | Methods of reducing risk of infection from pathogens |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| WO2005097087A2 (en) * | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
| US7705036B2 (en) | 2004-04-01 | 2010-04-27 | Cardiome Pharma Corp. | Deuterated aminocyclohexyl ether compounds and processes for preparing same |
| CA2561819A1 (en) | 2004-04-01 | 2005-12-01 | Cardiome Pharma Corp. | Prodrugs of ion channel modulating compounds and uses thereof |
| US7485666B2 (en) * | 2004-06-17 | 2009-02-03 | Kimberly-Clark Worldwide, Inc. | Vaginal health products |
| US8673360B2 (en) | 2004-08-10 | 2014-03-18 | Shin Nippon Biomedical Laboratories, Ltd. | Compositions that enable rapid-acting and highly absorptive intranasal administration |
| KR20070059063A (ko) * | 2004-08-18 | 2007-06-11 | 마이클 알 존슨. | 지방족 아미드 및 에스테르 피라지노일구아니딘 나트륨채널 차단제 |
| US7115561B2 (en) * | 2004-09-22 | 2006-10-03 | Patterson James A | Medicament composition and method of administration |
| JP5159314B2 (ja) | 2004-11-18 | 2013-03-06 | カーディオム ファーマ コーポレイション | アミノシクロヘキシルエーテル化合物の合成方法 |
| WO2006082588A2 (en) * | 2005-02-07 | 2006-08-10 | Pharmalight Inc. | Method and device for ophthalmic administration of active pharmaceutical ingredients |
| BRPI0612138B8 (pt) | 2005-06-15 | 2021-05-25 | Cardiome Pharma Corp | compostos éter aminocicloexílicos e método para fazer os mesmos |
| JP2009535034A (ja) * | 2006-04-28 | 2009-10-01 | ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン | 哺乳動物細胞のパルボウイルス形質導入を調節若しくはウイルス感染を変えるための方法および化合物、ウイルス受容体若しくは共受容体の同定方法 |
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| WO2016130498A1 (en) | 2015-02-10 | 2016-08-18 | Massachusetts Institute Of Technology | Isolated mucins and different microoorganisms, and methods of use |
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- 1999-10-20 US US09/421,705 patent/US6264975B1/en not_active Expired - Fee Related
- 1999-10-20 AT AT99970585T patent/ATE347880T1/de not_active IP Right Cessation
- 1999-10-20 WO PCT/US1999/024546 patent/WO2000023023A1/en not_active Ceased
- 1999-10-20 DE DE69934435T patent/DE69934435T2/de not_active Expired - Lifetime
- 1999-10-20 JP JP2000576801A patent/JP2002527459A/ja active Pending
- 1999-10-20 EP EP99970585A patent/EP1143896B1/en not_active Expired - Lifetime
- 1999-10-20 CA CA002346656A patent/CA2346656A1/en not_active Abandoned
- 1999-10-20 AU AU12141/00A patent/AU757139B2/en not_active Ceased
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2001
- 2001-02-20 US US09/789,256 patent/US7056524B2/en not_active Expired - Fee Related
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008179653A (ja) * | 2004-04-01 | 2008-08-07 | Cardiome Pharma Corp | Ｐｅｇ化イオンチャネル調節化合物 |
| WO2010131486A1 (en) * | 2009-05-15 | 2010-11-18 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical compositions with improved pharmacokinetics |
| JP2012526726A (ja) * | 2009-05-15 | 2012-11-01 | 株式会社新日本科学 | 薬物動態が改善された鼻腔内用薬学的組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1143896A4 (en) | 2004-11-24 |
| EP1143896A1 (en) | 2001-10-17 |
| WO2000023023A1 (en) | 2000-04-27 |
| CA2346656A1 (en) | 2000-04-27 |
| ATE347880T1 (de) | 2007-01-15 |
| US6264975B1 (en) | 2001-07-24 |
| US20010034349A1 (en) | 2001-10-25 |
| AU1214100A (en) | 2000-05-08 |
| DE69934435D1 (de) | 2007-01-25 |
| US7056524B2 (en) | 2006-06-06 |
| EP1143896B1 (en) | 2006-12-13 |
| DE69934435T2 (de) | 2007-09-27 |
| AU757139B2 (en) | 2003-02-06 |
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