JP2002527459A - 粘膜表面を水和する方法 - Google Patents
粘膜表面を水和する方法Info
- Publication number
- JP2002527459A JP2002527459A JP2000576801A JP2000576801A JP2002527459A JP 2002527459 A JP2002527459 A JP 2002527459A JP 2000576801 A JP2000576801 A JP 2000576801A JP 2000576801 A JP2000576801 A JP 2000576801A JP 2002527459 A JP2002527459 A JP 2002527459A
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- group
- phenyl
- carrier moiety
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims abstract description 72
- 150000001875 compounds Chemical class 0.000 claims abstract description 48
- -1 phenamyl Chemical compound 0.000 claims abstract description 36
- 239000003195 sodium channel blocking agent Substances 0.000 claims abstract description 36
- 229940125794 sodium channel blocker Drugs 0.000 claims abstract description 34
- 150000003839 salts Chemical class 0.000 claims abstract description 23
- 239000000018 receptor agonist Substances 0.000 claims abstract description 17
- 229940044601 receptor agonist Drugs 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- BGGCAGOTBOAZPU-UHFFFAOYSA-N n-(diaminomethylidene)pyrazine-2-carboxamide;sodium Chemical compound [Na].NC(N)=NC(=O)C1=CN=CC=N1 BGGCAGOTBOAZPU-UHFFFAOYSA-N 0.000 claims abstract description 16
- 230000028327 secretion Effects 0.000 claims abstract description 11
- 230000009103 reabsorption Effects 0.000 claims abstract description 10
- 230000000887 hydrating effect Effects 0.000 claims abstract description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims abstract description 8
- 102000009027 Albumins Human genes 0.000 claims abstract description 7
- 108010088751 Albumins Proteins 0.000 claims abstract description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 134
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 56
- 229910052739 hydrogen Inorganic materials 0.000 claims description 48
- 239000001257 hydrogen Substances 0.000 claims description 46
- 125000004432 carbon atom Chemical group C* 0.000 claims description 39
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 32
- 239000000203 mixture Substances 0.000 claims description 31
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 15
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 15
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- 125000005059 halophenyl group Chemical group 0.000 claims description 12
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- 125000005843 halogen group Chemical group 0.000 claims description 11
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- 125000004799 bromophenyl group Chemical group 0.000 claims description 10
- 125000000068 chlorophenyl group Chemical group 0.000 claims description 10
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 10
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- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims description 4
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- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims description 4
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- 125000003884 phenylalkyl group Chemical group 0.000 claims description 3
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
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- 150000004676 glycans Chemical class 0.000 claims 3
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- 229910052760 oxygen Inorganic materials 0.000 claims 2
- VDRMSHBDXWSTNR-UHFFFAOYSA-N [Na].NC(=N)N Chemical compound [Na].NC(=N)N VDRMSHBDXWSTNR-UHFFFAOYSA-N 0.000 claims 1
- XSDQTOBWRPYKKA-UHFFFAOYSA-N amiloride Chemical compound NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N XSDQTOBWRPYKKA-UHFFFAOYSA-N 0.000 abstract description 12
- KXDROGADUISDGY-UHFFFAOYSA-N Benzamil hydrochloride Chemical compound C=1C=CC=CC=1CN=C(N)NC(=O)C1=NC(Cl)=C(N)N=C1N KXDROGADUISDGY-UHFFFAOYSA-N 0.000 abstract description 9
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- A61P11/02—Nasal agents, e.g. decongestants
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10499998P | 1998-10-20 | 1998-10-20 | |
| US60/104,999 | 1998-10-20 | ||
| PCT/US1999/024546 WO2000023023A1 (en) | 1998-10-20 | 1999-10-20 | Methods of hydrating mucosal surfaces |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002527459A true JP2002527459A (ja) | 2002-08-27 |
| JP2002527459A5 JP2002527459A5 (enExample) | 2005-12-22 |
Family
ID=22303527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000576801A Pending JP2002527459A (ja) | 1998-10-20 | 1999-10-20 | 粘膜表面を水和する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6264975B1 (enExample) |
| EP (1) | EP1143896B1 (enExample) |
| JP (1) | JP2002527459A (enExample) |
| AT (1) | ATE347880T1 (enExample) |
| AU (1) | AU757139B2 (enExample) |
| CA (1) | CA2346656A1 (enExample) |
| DE (1) | DE69934435T2 (enExample) |
| WO (1) | WO2000023023A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008179653A (ja) * | 2004-04-01 | 2008-08-07 | Cardiome Pharma Corp | Ｐｅｇ化イオンチャネル調節化合物 |
| WO2010131486A1 (en) * | 2009-05-15 | 2010-11-18 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical compositions with improved pharmacokinetics |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6264975B1 (en) * | 1998-10-20 | 2001-07-24 | The University Of North Carolina At Chapel Hill | Methods of hydrating mucosal surfaces |
| JP4969002B2 (ja) * | 1999-06-08 | 2012-07-04 | ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン | ｒＡＡＶ形質導入を増加するための化合物および方法 |
| ATE390414T1 (de) * | 1999-07-19 | 2008-04-15 | Univ North Carolina | Arzneimittelwirkstoffe mit zwei kovalent verknüpften wirkstoffgruppen (natriumkanalblocker/p2y2 rezeptor agonist) zur behandlung von schleimhäuten |
| US7241447B1 (en) * | 1999-10-07 | 2007-07-10 | University Of Iowa Research Foundation | Adeno-associated virus vectors and uses thereof |
| WO2003038089A1 (fr) * | 2001-11-02 | 2003-05-08 | Ngk Insulators, Ltd. | Compositions de solution de sonde, puce reactive faisant appel auxdites compositions et son procede de production |
| MXPA04004215A (es) * | 2001-11-06 | 2004-07-08 | Inspire Pharmaceuticals Inc | Metodo para el tratamiento o la prevencion de enfermedades inflamatorias. |
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US7179481B2 (en) * | 2002-09-19 | 2007-02-20 | Kimberly-Clark Worldwide, Inc. | Vaginal health products |
| AU2003291151A1 (en) * | 2002-11-22 | 2004-06-18 | Carnegie Mellon University | Compositions and methods for the reversible capture of biomolecules |
| US7056889B2 (en) | 2002-12-16 | 2006-06-06 | Kimberly-Clark, Worldwide, Inc. | Compounds that bind P2Y2 or P2Y1 receptors |
| US7098189B2 (en) * | 2002-12-16 | 2006-08-29 | Kimberly-Clark Worldwide, Inc. | Wound and skin care compositions |
| GB0303506D0 (en) * | 2003-02-14 | 2003-03-19 | Novartis Ag | Organic compounds |
| US7638138B2 (en) | 2003-02-21 | 2009-12-29 | Translational Research, Ltd. | Compositions for nasal administration of pharmaceuticals |
| USRE45404E1 (en) | 2003-03-27 | 2015-03-03 | Shin Nippon Biomedical Laboratories, Ltd. | Powder medicine applicator for nasal cavity |
| WO2004089423A2 (en) * | 2003-03-31 | 2004-10-21 | University Of Iowa Research Foundation | Pharmico-gene theraphy of epithelial sodium channel associated disoders |
| US20050090505A1 (en) * | 2003-08-18 | 2005-04-28 | Johnson Michael R. | Methods of reducing risk of infection from pathogens |
| AU2004266704B2 (en) | 2003-08-18 | 2012-02-23 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| US20090253714A1 (en) * | 2003-08-20 | 2009-10-08 | Johnson Michael R | Methods of reducing risk of infection from pathogens |
| WO2005097087A2 (en) * | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
| US7705036B2 (en) | 2004-04-01 | 2010-04-27 | Cardiome Pharma Corp. | Deuterated aminocyclohexyl ether compounds and processes for preparing same |
| CA2561819A1 (en) | 2004-04-01 | 2005-12-01 | Cardiome Pharma Corp. | Prodrugs of ion channel modulating compounds and uses thereof |
| US7485666B2 (en) * | 2004-06-17 | 2009-02-03 | Kimberly-Clark Worldwide, Inc. | Vaginal health products |
| WO2006016530A1 (ja) | 2004-08-10 | 2006-02-16 | Translational Research, Ltd. | 速効性でかつ高い吸収性を可能とする経鼻投与用組成物 |
| CA2575670A1 (en) * | 2004-08-18 | 2006-03-02 | Michael R. Johnson | Aliphatic amide & ester pyrazinoylguanidine sodium channel blockers |
| US7115561B2 (en) * | 2004-09-22 | 2006-10-03 | Patterson James A | Medicament composition and method of administration |
| US8692002B2 (en) | 2004-11-18 | 2014-04-08 | Cardiome Pharma Corp. | Synthetic process for aminocyclohexyl ether compounds |
| US20080233053A1 (en) * | 2005-02-07 | 2008-09-25 | Pharmalight Inc. | Method and Device for Ophthalmic Administration of Active Pharmaceutical Ingredients |
| JP5159616B2 (ja) | 2005-06-15 | 2013-03-06 | カーディオム ファーマ コーポレイション | アミノシクロヘキシルエーテル化合物の調製のための合成プロセス |
| EP2019964A2 (en) * | 2006-04-28 | 2009-02-04 | University of Iowa Research Foundation | Methods and compounds to modulate parvovirus transduction of mammalian cells or to alter virus infection. method to identify a viral receptor or co-receptor |
| WO2008031048A2 (en) * | 2006-09-07 | 2008-03-13 | Parion Sciences, Inc. | Enhanced mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes |
| AU2007294547A1 (en) * | 2006-09-07 | 2008-03-13 | Parion Sciences, Inc. | Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes |
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| US20120310140A1 (en) | 2010-12-01 | 2012-12-06 | Spinal Modulation, Inc. | Directed delivery of agents to neural anatomy |
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| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
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| ES2674665T3 (es) | 2012-12-17 | 2018-07-03 | Parion Sciences, Inc. | Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida |
| RU2671976C2 (ru) | 2012-12-17 | 2018-11-08 | Пэрион Сайенсиз, Инк. | Соединения 3,5-диамино-6-хлор-n-(n-(4-фенилбутил)карбамимидоил)пиразин-2-карбоксамида |
| HUE032891T2 (hu) | 2012-12-17 | 2017-11-28 | Parion Sciences Inc | Klórpirazin-karboxamid-származékok nem kielégítõ nyálkahártya-hidratáció által elõsegített megbetegedések kezelésére |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
| EP3137084B1 (en) * | 2014-05-02 | 2019-12-25 | The Board of Trustees of the Leland Stanford Junior University | Benzyl amiloride for the treatment of psoriasis |
| US9675667B2 (en) | 2015-02-10 | 2017-06-13 | Massachusetts Institute Of Technology | Isolated mucins and different microorganisms, and methods of use |
| WO2017139381A1 (en) | 2016-02-08 | 2017-08-17 | University Of Iowa Research Foundation | Methods to produce chimeric adeno-associated virus/bocavirus parvovirus |
| WO2017155973A1 (en) | 2016-03-07 | 2017-09-14 | University Of Iowa Research Foundation | Aav-mediated expression using a synthetic promoter and enhancer |
| US12173305B2 (en) | 2016-05-26 | 2024-12-24 | University Of Iowa Research Foundation | cis and trans requirements for terminal resolution of human bocavirus 1 |
| US11142775B2 (en) | 2017-01-13 | 2021-10-12 | University Of Iowa Research Foundation | Bocaparvovirus small noncoding RNA and uses thereof |
| CN110996904A (zh) * | 2017-05-19 | 2020-04-10 | 奥古根有限公司 | 眼用组合物及使用方法 |
| US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
| EP4585274A3 (en) | 2020-04-13 | 2025-09-17 | Mayo Foundation for Medical Education and Research | Electroporation devices and methods |
| US20220047686A1 (en) * | 2020-08-14 | 2022-02-17 | Mayo Foundation For Medical Education And Research | Methods for treating infectious diseases |
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| WO1996030364A1 (en) * | 1995-03-29 | 1996-10-03 | Knoll Aktiengesellschaft | Pharmaceutical compositions |
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| US5656256A (en) * | 1994-12-14 | 1997-08-12 | The University Of North Carolina At Chapel Hill | Methods of treating lung disease by an aerosol containing benzamil or phenamil |
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| US5707644A (en) | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| US5635160A (en) * | 1995-06-07 | 1997-06-03 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions |
| US6264975B1 (en) * | 1998-10-20 | 2001-07-24 | The University Of North Carolina At Chapel Hill | Methods of hydrating mucosal surfaces |
-
1999
- 1999-10-20 US US09/421,705 patent/US6264975B1/en not_active Expired - Fee Related
- 1999-10-20 JP JP2000576801A patent/JP2002527459A/ja active Pending
- 1999-10-20 WO PCT/US1999/024546 patent/WO2000023023A1/en not_active Ceased
- 1999-10-20 AU AU12141/00A patent/AU757139B2/en not_active Ceased
- 1999-10-20 AT AT99970585T patent/ATE347880T1/de not_active IP Right Cessation
- 1999-10-20 EP EP99970585A patent/EP1143896B1/en not_active Expired - Lifetime
- 1999-10-20 DE DE69934435T patent/DE69934435T2/de not_active Expired - Lifetime
- 1999-10-20 CA CA002346656A patent/CA2346656A1/en not_active Abandoned
-
2001
- 2001-02-20 US US09/789,256 patent/US7056524B2/en not_active Expired - Fee Related
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| US4501729A (en) * | 1982-12-13 | 1985-02-26 | Research Corporation | Aerosolized amiloride treatment of retained pulmonary secretions |
| US4950591A (en) * | 1987-08-14 | 1990-08-21 | Cherksey Bruce D | Membrane Na+ channel protein and related therapeutic compounds |
| JPH03504012A (ja) * | 1988-04-28 | 1991-09-05 | シェリング・コーポレーション | 新規なベンゾピリド‐ピペリジン、ピペリジリデンおよびピペラジン化合物、組成物、製造法および利用法 |
| JPH05501408A (ja) * | 1989-11-04 | 1993-03-18 | ダンバイオシスト ユーケー リミテッド | 微粒子薬物組成物 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008179653A (ja) * | 2004-04-01 | 2008-08-07 | Cardiome Pharma Corp | Ｐｅｇ化イオンチャネル調節化合物 |
| WO2010131486A1 (en) * | 2009-05-15 | 2010-11-18 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical compositions with improved pharmacokinetics |
| JP2012526726A (ja) * | 2009-05-15 | 2012-11-01 | 株式会社新日本科学 | 薬物動態が改善された鼻腔内用薬学的組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1143896A4 (en) | 2004-11-24 |
| AU1214100A (en) | 2000-05-08 |
| ATE347880T1 (de) | 2007-01-15 |
| US6264975B1 (en) | 2001-07-24 |
| DE69934435T2 (de) | 2007-09-27 |
| DE69934435D1 (de) | 2007-01-25 |
| CA2346656A1 (en) | 2000-04-27 |
| EP1143896A1 (en) | 2001-10-17 |
| EP1143896B1 (en) | 2006-12-13 |
| WO2000023023A1 (en) | 2000-04-27 |
| AU757139B2 (en) | 2003-02-06 |
| US7056524B2 (en) | 2006-06-06 |
| US20010034349A1 (en) | 2001-10-25 |
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