JP2002527459A5 - - Google Patents

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Publication number
JP2002527459A5
JP2002527459A5 JP2000576801A JP2000576801A JP2002527459A5 JP 2002527459 A5 JP2002527459 A5 JP 2002527459A5 JP 2000576801 A JP2000576801 A JP 2000576801A JP 2000576801 A JP2000576801 A JP 2000576801A JP 2002527459 A5 JP2002527459 A5 JP 2002527459A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000576801A
Other languages
Japanese (ja)
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JP2002527459A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1999/024546 external-priority patent/WO2000023023A1/en
Publication of JP2002527459A publication Critical patent/JP2002527459A/ja
Publication of JP2002527459A5 publication Critical patent/JP2002527459A5/ja
Pending legal-status Critical Current

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JP2000576801A 1998-10-20 1999-10-20 粘膜表面を水和する方法 Pending JP2002527459A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10499998P 1998-10-20 1998-10-20
US60/104,999 1998-10-20
PCT/US1999/024546 WO2000023023A1 (en) 1998-10-20 1999-10-20 Methods of hydrating mucosal surfaces

Publications (2)

Publication Number Publication Date
JP2002527459A JP2002527459A (ja) 2002-08-27
JP2002527459A5 true JP2002527459A5 (enExample) 2005-12-22

Family

ID=22303527

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000576801A Pending JP2002527459A (ja) 1998-10-20 1999-10-20 粘膜表面を水和する方法

Country Status (8)

Country Link
US (2) US6264975B1 (enExample)
EP (1) EP1143896B1 (enExample)
JP (1) JP2002527459A (enExample)
AT (1) ATE347880T1 (enExample)
AU (1) AU757139B2 (enExample)
CA (1) CA2346656A1 (enExample)
DE (1) DE69934435T2 (enExample)
WO (1) WO2000023023A1 (enExample)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6264975B1 (en) * 1998-10-20 2001-07-24 The University Of North Carolina At Chapel Hill Methods of hydrating mucosal surfaces
WO2000075365A2 (en) * 1999-06-08 2000-12-14 University Of Iowa Research Foundation Compounds and methods to enhance raav transduction
JP2004513870A (ja) 1999-07-19 2004-05-13 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル ナトリウムチャネルブロッカーの結合物及びその使用法
US7241447B1 (en) * 1999-10-07 2007-07-10 University Of Iowa Research Foundation Adeno-associated virus vectors and uses thereof
DE60218884T2 (de) * 2001-11-02 2007-12-20 Ngk Insulators, Ltd., Nagoya Zusammensetzungen für lösungen für sonden, reaktionsfähiger chip bei dem diese verwendet werden, sowie herstellungsverfahren
CN1612739A (zh) * 2001-11-06 2005-05-04 印斯拜尔药品股份有限公司 治疗或预防炎性疾病的方法
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US7179481B2 (en) * 2002-09-19 2007-02-20 Kimberly-Clark Worldwide, Inc. Vaginal health products
EP1567862A4 (en) * 2002-11-22 2007-04-18 Univ Carnegie Mellon COMPOSITIONS AND METHODS FOR REVERSIBLE INFLAMMATION OF BIOMOLECULES
US7098189B2 (en) * 2002-12-16 2006-08-29 Kimberly-Clark Worldwide, Inc. Wound and skin care compositions
US7056889B2 (en) 2002-12-16 2006-06-06 Kimberly-Clark, Worldwide, Inc. Compounds that bind P2Y2 or P2Y1 receptors
GB0303506D0 (en) * 2003-02-14 2003-03-19 Novartis Ag Organic compounds
US7638138B2 (en) 2003-02-21 2009-12-29 Translational Research, Ltd. Compositions for nasal administration of pharmaceuticals
MXPA05010379A (es) 2003-03-27 2006-05-31 Bioactis Ltd Aparato para administrar una medicina en polvo en la cavidad intranasal.
AU2004227915A1 (en) * 2003-03-31 2004-10-21 John F. Engelhardt Pharmico-gene theraphy of epithelial sodium channel associated disoders
US20050090505A1 (en) * 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
PT1663235E (pt) 2003-08-18 2013-10-29 Parion Sciences Inc Novos bloqueadores dos canais do sódio de pirazinoílguanidina protegida
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
JP4991037B2 (ja) * 2004-04-01 2012-08-01 カーディオム ファーマ コーポレイション イオンチャネル調節化合物を含む薬物結合体
WO2005097087A2 (en) * 2004-04-01 2005-10-20 Cardiome Pharma Corp. Merged ion channel modulating compounds and uses thereof
US7705036B2 (en) 2004-04-01 2010-04-27 Cardiome Pharma Corp. Deuterated aminocyclohexyl ether compounds and processes for preparing same
CA2561819A1 (en) 2004-04-01 2005-12-01 Cardiome Pharma Corp. Prodrugs of ion channel modulating compounds and uses thereof
US7485666B2 (en) * 2004-06-17 2009-02-03 Kimberly-Clark Worldwide, Inc. Vaginal health products
US8673360B2 (en) 2004-08-10 2014-03-18 Shin Nippon Biomedical Laboratories, Ltd. Compositions that enable rapid-acting and highly absorptive intranasal administration
KR20070059063A (ko) * 2004-08-18 2007-06-11 마이클 알 존슨. 지방족 아미드 및 에스테르 피라지노일구아니딘 나트륨채널 차단제
US7115561B2 (en) * 2004-09-22 2006-10-03 Patterson James A Medicament composition and method of administration
JP5159314B2 (ja) 2004-11-18 2013-03-06 カーディオム ファーマ コーポレイション アミノシクロヘキシルエーテル化合物の合成方法
WO2006082588A2 (en) * 2005-02-07 2006-08-10 Pharmalight Inc. Method and device for ophthalmic administration of active pharmaceutical ingredients
BRPI0612138B8 (pt) 2005-06-15 2021-05-25 Cardiome Pharma Corp compostos éter aminocicloexílicos e método para fazer os mesmos
JP2009535034A (ja) * 2006-04-28 2009-10-01 ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン 哺乳動物細胞のパルボウイルス形質導入を調節若しくはウイルス感染を変えるための方法および化合物、ウイルス受容体若しくは共受容体の同定方法
BRPI0716884A2 (pt) * 2006-09-07 2013-10-15 Parion Sciences Inc Método de intensificação de hidratação mucosal e clearance mucosal através de tratamento com bloqueadores do canal de sódio e osmolitos
JP2010502739A (ja) * 2006-09-07 2010-01-28 パリオン・サイエンシィズ・インコーポレーテッド ナトリウムチャネル阻害剤及び浸透圧調節物質を用いた処置による粘膜水和及び粘液クリアランスの改善
JP5415769B2 (ja) 2006-12-26 2014-02-12 株式会社新日本科学 経鼻投与用製剤
FI119513B (fi) * 2007-03-07 2008-12-15 Dextech Medical Ab Muokatut hydroksipolymeerikonjugaatit, joilla on tappava vaikutus tuumorisoluihin
EP2211956A4 (en) * 2007-10-10 2014-07-09 Parion Sciences Inc DISPOSAL OF OSMOLYTES WITH A NOSE CANNULA
KR101654549B1 (ko) 2008-02-26 2016-09-07 패리온 사이언스 인코퍼레이티드 다중방향족 나트륨 채널 차단제
US20110118207A1 (en) * 2008-04-07 2011-05-19 Dextech Medical Ab Modified hydroxypolymer conjugates with bone seeking and tumor killing moieties
US9101539B2 (en) 2009-05-15 2015-08-11 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetics
GB2472327B (en) 2009-07-31 2013-03-13 Shin Nippon Biomedical Lab Ltd Intranasal granisetron and nasal applicator
CA2819635A1 (en) 2010-12-01 2012-06-07 Spinal Modulation, Inc. Directed delivery of agents to neural anatomy
US8945605B2 (en) 2011-06-07 2015-02-03 Parion Sciences, Inc. Aerosol delivery systems, compositions and methods
US8778383B2 (en) 2011-06-07 2014-07-15 Parion Sciences, Inc. Methods of treatment
BR112013032771B1 (pt) 2011-06-27 2021-01-12 Parion Sciences, Inc. dipeptídio quimicamente e metabolicamente estável possuindo potente atividade bloqueadora de canais de sódio
AR086745A1 (es) * 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
WO2013162771A1 (en) * 2012-04-23 2013-10-31 Massachusetts Institute Of Technology Lectin conjugates for mucin hydration
DK2855435T3 (en) 2012-05-29 2018-07-16 Parion Sciences Inc DENDRIMER-LIKE AMINOAMIDES WITH SODIUM CHANNEL BLOCKING ACTIVITY FOR THE TREATMENT OF DRY EYES AND OTHER MILK DISEASES
ES2674665T3 (es) 2012-12-17 2018-07-03 Parion Sciences, Inc. Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida
US9029382B2 (en) 2012-12-17 2015-05-12 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds
BR112015014349A2 (pt) 2012-12-17 2017-07-11 Parion Sciences Inc derivados de cloro-pirazina carboxamida úteis para o tratamento de doenças favorecidas por hidratação mucosa insuficiente
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
EP3137084B1 (en) * 2014-05-02 2019-12-25 The Board of Trustees of the Leland Stanford Junior University Benzyl amiloride for the treatment of psoriasis
WO2016130498A1 (en) 2015-02-10 2016-08-18 Massachusetts Institute Of Technology Isolated mucins and different microoorganisms, and methods of use
US11702672B2 (en) 2016-02-08 2023-07-18 University Of Iowa Research Foundation Methods to produce chimeric adeno-associated virus/bocavirus parvovirus
EP3426787A1 (en) 2016-03-07 2019-01-16 University of Iowa Research Foundation Aav-mediated expression using a synthetic promoter and enhancer
WO2017205739A1 (en) 2016-05-26 2017-11-30 University Of Iowa Research Foundation cis AND trans REQUIREMENTS FOR TERMINAL RESOLUTION OF HUMAN BOCAVIRUS 1
US11142775B2 (en) 2017-01-13 2021-10-12 University Of Iowa Research Foundation Bocaparvovirus small noncoding RNA and uses thereof
WO2018212846A1 (en) * 2017-05-19 2018-11-22 Ocugen, Inc. Ophthalmic compositions and methods of use
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
US20220047686A1 (en) * 2020-08-14 2022-02-17 Mayo Foundation For Medical Education And Research Methods for treating infectious diseases

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE639386A (enExample) 1962-10-30
JPS6034925B2 (ja) 1979-07-31 1985-08-12 帝人株式会社 持続性鼻腔用製剤およびその製造法
US4389393A (en) 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US4501729A (en) * 1982-12-13 1985-02-26 Research Corporation Aerosolized amiloride treatment of retained pulmonary secretions
JPS6032714A (ja) 1983-08-01 1985-02-19 Teijin Ltd 鼻腔粘膜に適用するための安定化された粉末状薬学的組成物
US4950591A (en) * 1987-08-14 1990-08-21 Cherksey Bruce D Membrane Na+ channel protein and related therapeutic compounds
US4894376A (en) 1988-02-26 1990-01-16 Trustees Of The University Of Pennsylvania Methods of treating diseases characterized by hyperexcitability of neurons
ZA893104B (en) * 1988-04-28 1989-12-27 Schering Corp Novel benzopyrido piperidine,piperidylidene and piperazine compounds,compositions,methods of manufacture and methods of use
US5707644A (en) 1989-11-04 1998-01-13 Danbiosyst Uk Limited Small particle compositions for intranasal drug delivery
GB2237510B (en) * 1989-11-04 1993-09-15 Danbiosyst Uk Small particle drug compositions for nasal administration
EP0689438B1 (en) * 1993-03-26 2003-06-04 Franciscus Wilhelmus Henricus Maria Merkus Pharmaceutical compositions for intranasal administration of apomorphine
GB9310412D0 (en) * 1993-05-20 1993-07-07 Danbiosyst Uk Nasal nicotine system
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US5656256A (en) * 1994-12-14 1997-08-12 The University Of North Carolina At Chapel Hill Methods of treating lung disease by an aerosol containing benzamil or phenamil
GB9506382D0 (en) * 1995-03-29 1995-05-17 Boots Co Plc Pharmaceutical compositions
US5635160A (en) 1995-06-07 1997-06-03 The University Of North Carolina At Chapel Hill Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions
US5789391A (en) 1996-07-03 1998-08-04 Inspire Pharmaceuticals, Inc. Method of treating sinusitis with uridine triphosphates and related compounds
AU714913B2 (en) * 1996-09-27 2000-01-13 Nastech Pharmaceutical Company, Inc. Intranasal formulations for promoting sleep and method of using the same
US6264975B1 (en) * 1998-10-20 2001-07-24 The University Of North Carolina At Chapel Hill Methods of hydrating mucosal surfaces

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