ATE347880T1 - Methoden zum befeuchten der nasenschleimhaut - Google Patents
Methoden zum befeuchten der nasenschleimhautInfo
- Publication number
- ATE347880T1 ATE347880T1 AT99970585T AT99970585T ATE347880T1 AT E347880 T1 ATE347880 T1 AT E347880T1 AT 99970585 T AT99970585 T AT 99970585T AT 99970585 T AT99970585 T AT 99970585T AT E347880 T1 ATE347880 T1 AT E347880T1
- Authority
- AT
- Austria
- Prior art keywords
- channel blocker
- sodium channel
- nasal airway
- subject
- reabsorption
- Prior art date
Links
- 230000003020 moisturizing effect Effects 0.000 title 1
- 210000002850 nasal mucosa Anatomy 0.000 title 1
- 229940125794 sodium channel blocker Drugs 0.000 abstract 4
- 239000003195 sodium channel blocking agent Substances 0.000 abstract 4
- BGGCAGOTBOAZPU-UHFFFAOYSA-N n-(diaminomethylidene)pyrazine-2-carboxamide;sodium Chemical compound [Na].NC(N)=NC(=O)C1=CN=CC=N1 BGGCAGOTBOAZPU-UHFFFAOYSA-N 0.000 abstract 2
- 230000009103 reabsorption Effects 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- KXDROGADUISDGY-UHFFFAOYSA-N Benzamil hydrochloride Chemical compound C=1C=CC=CC=1CN=C(N)NC(=O)C1=NC(Cl)=C(N)N=C1N KXDROGADUISDGY-UHFFFAOYSA-N 0.000 abstract 1
- 108091006146 Channels Proteins 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- NIOHELZQFBGCEO-UHFFFAOYSA-N Phenylamil Chemical compound N=1C(Cl)=C(N)N=C(N)C=1C(=O)N=C(N)NC1=CC=CC=C1 NIOHELZQFBGCEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- XSDQTOBWRPYKKA-UHFFFAOYSA-N amiloride Chemical compound NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N XSDQTOBWRPYKKA-UHFFFAOYSA-N 0.000 abstract 1
- 229960002576 amiloride Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000887 hydrating effect Effects 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Otolaryngology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10499998P | 1998-10-20 | 1998-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE347880T1 true ATE347880T1 (de) | 2007-01-15 |
Family
ID=22303527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99970585T ATE347880T1 (de) | 1998-10-20 | 1999-10-20 | Methoden zum befeuchten der nasenschleimhaut |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6264975B1 (enExample) |
| EP (1) | EP1143896B1 (enExample) |
| JP (1) | JP2002527459A (enExample) |
| AT (1) | ATE347880T1 (enExample) |
| AU (1) | AU757139B2 (enExample) |
| CA (1) | CA2346656A1 (enExample) |
| DE (1) | DE69934435T2 (enExample) |
| WO (1) | WO2000023023A1 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6264975B1 (en) * | 1998-10-20 | 2001-07-24 | The University Of North Carolina At Chapel Hill | Methods of hydrating mucosal surfaces |
| WO2000075365A2 (en) * | 1999-06-08 | 2000-12-14 | University Of Iowa Research Foundation | Compounds and methods to enhance raav transduction |
| JP2004513870A (ja) | 1999-07-19 | 2004-05-13 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | ナトリウムチャネルブロッカーの結合物及びその使用法 |
| US7241447B1 (en) * | 1999-10-07 | 2007-07-10 | University Of Iowa Research Foundation | Adeno-associated virus vectors and uses thereof |
| DE60218884T2 (de) * | 2001-11-02 | 2007-12-20 | Ngk Insulators, Ltd., Nagoya | Zusammensetzungen für lösungen für sonden, reaktionsfähiger chip bei dem diese verwendet werden, sowie herstellungsverfahren |
| CN1612739A (zh) * | 2001-11-06 | 2005-05-04 | 印斯拜尔药品股份有限公司 | 治疗或预防炎性疾病的方法 |
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US7179481B2 (en) * | 2002-09-19 | 2007-02-20 | Kimberly-Clark Worldwide, Inc. | Vaginal health products |
| EP1567862A4 (en) * | 2002-11-22 | 2007-04-18 | Univ Carnegie Mellon | COMPOSITIONS AND METHODS FOR REVERSIBLE INFLAMMATION OF BIOMOLECULES |
| US7098189B2 (en) * | 2002-12-16 | 2006-08-29 | Kimberly-Clark Worldwide, Inc. | Wound and skin care compositions |
| US7056889B2 (en) | 2002-12-16 | 2006-06-06 | Kimberly-Clark, Worldwide, Inc. | Compounds that bind P2Y2 or P2Y1 receptors |
| GB0303506D0 (en) * | 2003-02-14 | 2003-03-19 | Novartis Ag | Organic compounds |
| US7638138B2 (en) | 2003-02-21 | 2009-12-29 | Translational Research, Ltd. | Compositions for nasal administration of pharmaceuticals |
| MXPA05010379A (es) | 2003-03-27 | 2006-05-31 | Bioactis Ltd | Aparato para administrar una medicina en polvo en la cavidad intranasal. |
| AU2004227915A1 (en) * | 2003-03-31 | 2004-10-21 | John F. Engelhardt | Pharmico-gene theraphy of epithelial sodium channel associated disoders |
| US20050090505A1 (en) * | 2003-08-18 | 2005-04-28 | Johnson Michael R. | Methods of reducing risk of infection from pathogens |
| PT1663235E (pt) | 2003-08-18 | 2013-10-29 | Parion Sciences Inc | Novos bloqueadores dos canais do sódio de pirazinoílguanidina protegida |
| US20090253714A1 (en) * | 2003-08-20 | 2009-10-08 | Johnson Michael R | Methods of reducing risk of infection from pathogens |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| JP4991037B2 (ja) * | 2004-04-01 | 2012-08-01 | カーディオム ファーマ コーポレイション | イオンチャネル調節化合物を含む薬物結合体 |
| WO2005097087A2 (en) * | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
| US7705036B2 (en) | 2004-04-01 | 2010-04-27 | Cardiome Pharma Corp. | Deuterated aminocyclohexyl ether compounds and processes for preparing same |
| CA2561819A1 (en) | 2004-04-01 | 2005-12-01 | Cardiome Pharma Corp. | Prodrugs of ion channel modulating compounds and uses thereof |
| US7485666B2 (en) * | 2004-06-17 | 2009-02-03 | Kimberly-Clark Worldwide, Inc. | Vaginal health products |
| US8673360B2 (en) | 2004-08-10 | 2014-03-18 | Shin Nippon Biomedical Laboratories, Ltd. | Compositions that enable rapid-acting and highly absorptive intranasal administration |
| KR20070059063A (ko) * | 2004-08-18 | 2007-06-11 | 마이클 알 존슨. | 지방족 아미드 및 에스테르 피라지노일구아니딘 나트륨채널 차단제 |
| US7115561B2 (en) * | 2004-09-22 | 2006-10-03 | Patterson James A | Medicament composition and method of administration |
| JP5159314B2 (ja) | 2004-11-18 | 2013-03-06 | カーディオム ファーマ コーポレイション | アミノシクロヘキシルエーテル化合物の合成方法 |
| WO2006082588A2 (en) * | 2005-02-07 | 2006-08-10 | Pharmalight Inc. | Method and device for ophthalmic administration of active pharmaceutical ingredients |
| BRPI0612138B8 (pt) | 2005-06-15 | 2021-05-25 | Cardiome Pharma Corp | compostos éter aminocicloexílicos e método para fazer os mesmos |
| JP2009535034A (ja) * | 2006-04-28 | 2009-10-01 | ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン | 哺乳動物細胞のパルボウイルス形質導入を調節若しくはウイルス感染を変えるための方法および化合物、ウイルス受容体若しくは共受容体の同定方法 |
| BRPI0716884A2 (pt) * | 2006-09-07 | 2013-10-15 | Parion Sciences Inc | Método de intensificação de hidratação mucosal e clearance mucosal através de tratamento com bloqueadores do canal de sódio e osmolitos |
| JP2010502739A (ja) * | 2006-09-07 | 2010-01-28 | パリオン・サイエンシィズ・インコーポレーテッド | ナトリウムチャネル阻害剤及び浸透圧調節物質を用いた処置による粘膜水和及び粘液クリアランスの改善 |
| JP5415769B2 (ja) | 2006-12-26 | 2014-02-12 | 株式会社新日本科学 | 経鼻投与用製剤 |
| FI119513B (fi) * | 2007-03-07 | 2008-12-15 | Dextech Medical Ab | Muokatut hydroksipolymeerikonjugaatit, joilla on tappava vaikutus tuumorisoluihin |
| EP2211956A4 (en) * | 2007-10-10 | 2014-07-09 | Parion Sciences Inc | DISPOSAL OF OSMOLYTES WITH A NOSE CANNULA |
| KR101654549B1 (ko) | 2008-02-26 | 2016-09-07 | 패리온 사이언스 인코퍼레이티드 | 다중방향족 나트륨 채널 차단제 |
| US20110118207A1 (en) * | 2008-04-07 | 2011-05-19 | Dextech Medical Ab | Modified hydroxypolymer conjugates with bone seeking and tumor killing moieties |
| US9101539B2 (en) | 2009-05-15 | 2015-08-11 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical compositions with improved pharmacokinetics |
| GB2472327B (en) | 2009-07-31 | 2013-03-13 | Shin Nippon Biomedical Lab Ltd | Intranasal granisetron and nasal applicator |
| CA2819635A1 (en) | 2010-12-01 | 2012-06-07 | Spinal Modulation, Inc. | Directed delivery of agents to neural anatomy |
| US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
| US8778383B2 (en) | 2011-06-07 | 2014-07-15 | Parion Sciences, Inc. | Methods of treatment |
| BR112013032771B1 (pt) | 2011-06-27 | 2021-01-12 | Parion Sciences, Inc. | dipeptídio quimicamente e metabolicamente estável possuindo potente atividade bloqueadora de canais de sódio |
| AR086745A1 (es) * | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| WO2013162771A1 (en) * | 2012-04-23 | 2013-10-31 | Massachusetts Institute Of Technology | Lectin conjugates for mucin hydration |
| DK2855435T3 (en) | 2012-05-29 | 2018-07-16 | Parion Sciences Inc | DENDRIMER-LIKE AMINOAMIDES WITH SODIUM CHANNEL BLOCKING ACTIVITY FOR THE TREATMENT OF DRY EYES AND OTHER MILK DISEASES |
| ES2674665T3 (es) | 2012-12-17 | 2018-07-03 | Parion Sciences, Inc. | Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida |
| US9029382B2 (en) | 2012-12-17 | 2015-05-12 | Parion Sciences, Inc. | 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds |
| BR112015014349A2 (pt) | 2012-12-17 | 2017-07-11 | Parion Sciences Inc | derivados de cloro-pirazina carboxamida úteis para o tratamento de doenças favorecidas por hidratação mucosa insuficiente |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
| EP3137084B1 (en) * | 2014-05-02 | 2019-12-25 | The Board of Trustees of the Leland Stanford Junior University | Benzyl amiloride for the treatment of psoriasis |
| WO2016130498A1 (en) | 2015-02-10 | 2016-08-18 | Massachusetts Institute Of Technology | Isolated mucins and different microoorganisms, and methods of use |
| US11702672B2 (en) | 2016-02-08 | 2023-07-18 | University Of Iowa Research Foundation | Methods to produce chimeric adeno-associated virus/bocavirus parvovirus |
| EP3426787A1 (en) | 2016-03-07 | 2019-01-16 | University of Iowa Research Foundation | Aav-mediated expression using a synthetic promoter and enhancer |
| WO2017205739A1 (en) | 2016-05-26 | 2017-11-30 | University Of Iowa Research Foundation | cis AND trans REQUIREMENTS FOR TERMINAL RESOLUTION OF HUMAN BOCAVIRUS 1 |
| US11142775B2 (en) | 2017-01-13 | 2021-10-12 | University Of Iowa Research Foundation | Bocaparvovirus small noncoding RNA and uses thereof |
| WO2018212846A1 (en) * | 2017-05-19 | 2018-11-22 | Ocugen, Inc. | Ophthalmic compositions and methods of use |
| US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
| US20220047686A1 (en) * | 2020-08-14 | 2022-02-17 | Mayo Foundation For Medical Education And Research | Methods for treating infectious diseases |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE639386A (enExample) | 1962-10-30 | |||
| JPS6034925B2 (ja) | 1979-07-31 | 1985-08-12 | 帝人株式会社 | 持続性鼻腔用製剤およびその製造法 |
| US4389393A (en) | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| US4501729A (en) * | 1982-12-13 | 1985-02-26 | Research Corporation | Aerosolized amiloride treatment of retained pulmonary secretions |
| JPS6032714A (ja) | 1983-08-01 | 1985-02-19 | Teijin Ltd | 鼻腔粘膜に適用するための安定化された粉末状薬学的組成物 |
| US4950591A (en) * | 1987-08-14 | 1990-08-21 | Cherksey Bruce D | Membrane Na+ channel protein and related therapeutic compounds |
| US4894376A (en) | 1988-02-26 | 1990-01-16 | Trustees Of The University Of Pennsylvania | Methods of treating diseases characterized by hyperexcitability of neurons |
| ZA893104B (en) * | 1988-04-28 | 1989-12-27 | Schering Corp | Novel benzopyrido piperidine,piperidylidene and piperazine compounds,compositions,methods of manufacture and methods of use |
| US5707644A (en) | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| GB2237510B (en) * | 1989-11-04 | 1993-09-15 | Danbiosyst Uk | Small particle drug compositions for nasal administration |
| EP0689438B1 (en) * | 1993-03-26 | 2003-06-04 | Franciscus Wilhelmus Henricus Maria Merkus | Pharmaceutical compositions for intranasal administration of apomorphine |
| GB9310412D0 (en) * | 1993-05-20 | 1993-07-07 | Danbiosyst Uk | Nasal nicotine system |
| US5543417A (en) * | 1994-10-21 | 1996-08-06 | Merck & Co., Inc. | Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents |
| US5656256A (en) * | 1994-12-14 | 1997-08-12 | The University Of North Carolina At Chapel Hill | Methods of treating lung disease by an aerosol containing benzamil or phenamil |
| GB9506382D0 (en) * | 1995-03-29 | 1995-05-17 | Boots Co Plc | Pharmaceutical compositions |
| US5635160A (en) | 1995-06-07 | 1997-06-03 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions |
| US5789391A (en) | 1996-07-03 | 1998-08-04 | Inspire Pharmaceuticals, Inc. | Method of treating sinusitis with uridine triphosphates and related compounds |
| AU714913B2 (en) * | 1996-09-27 | 2000-01-13 | Nastech Pharmaceutical Company, Inc. | Intranasal formulations for promoting sleep and method of using the same |
| US6264975B1 (en) * | 1998-10-20 | 2001-07-24 | The University Of North Carolina At Chapel Hill | Methods of hydrating mucosal surfaces |
-
1999
- 1999-10-20 US US09/421,705 patent/US6264975B1/en not_active Expired - Fee Related
- 1999-10-20 AT AT99970585T patent/ATE347880T1/de not_active IP Right Cessation
- 1999-10-20 WO PCT/US1999/024546 patent/WO2000023023A1/en not_active Ceased
- 1999-10-20 DE DE69934435T patent/DE69934435T2/de not_active Expired - Lifetime
- 1999-10-20 JP JP2000576801A patent/JP2002527459A/ja active Pending
- 1999-10-20 EP EP99970585A patent/EP1143896B1/en not_active Expired - Lifetime
- 1999-10-20 CA CA002346656A patent/CA2346656A1/en not_active Abandoned
- 1999-10-20 AU AU12141/00A patent/AU757139B2/en not_active Ceased
-
2001
- 2001-02-20 US US09/789,256 patent/US7056524B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1143896A4 (en) | 2004-11-24 |
| JP2002527459A (ja) | 2002-08-27 |
| EP1143896A1 (en) | 2001-10-17 |
| WO2000023023A1 (en) | 2000-04-27 |
| CA2346656A1 (en) | 2000-04-27 |
| US6264975B1 (en) | 2001-07-24 |
| US20010034349A1 (en) | 2001-10-25 |
| AU1214100A (en) | 2000-05-08 |
| DE69934435D1 (de) | 2007-01-25 |
| US7056524B2 (en) | 2006-06-06 |
| EP1143896B1 (en) | 2006-12-13 |
| DE69934435T2 (de) | 2007-09-27 |
| AU757139B2 (en) | 2003-02-06 |
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