WO2003045942A3 - Chemokine receptor antagonists and methods of use thereof - Google Patents

Chemokine receptor antagonists and methods of use thereof Download PDF

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Publication number
WO2003045942A3
WO2003045942A3 PCT/US2002/036953 US0236953W WO03045942A3 WO 2003045942 A3 WO2003045942 A3 WO 2003045942A3 US 0236953 W US0236953 W US 0236953W WO 03045942 A3 WO03045942 A3 WO 03045942A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
receptor antagonists
chemokine receptor
activation
treating
Prior art date
Application number
PCT/US2002/036953
Other languages
French (fr)
Other versions
WO2003045942A2 (en
Inventor
Jay R Luly
Yoshisuke Nakasato
Etsuo Ohshima
Geraldine C B Harriman
Kenneth G Carson
Shomir Ghosh
Amy M Elder
Karen M Mattia
Original Assignee
Millennium Pharm Inc
Kyowa Hakko Kogyo Kk
Jay R Luly
Yoshisuke Nakasato
Etsuo Ohshima
Geraldine C B Harriman
Kenneth G Carson
Shomir Ghosh
Amy M Elder
Karen M Mattia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/148,823 external-priority patent/US6613905B1/en
Priority claimed from US09/235,102 external-priority patent/US6329385B1/en
Priority claimed from US09/362,837 external-priority patent/US6509346B2/en
Priority claimed from US09/989,086 external-priority patent/US20020169155A1/en
Priority to HU0500079A priority Critical patent/HU228314B1/en
Priority to KR1020047007728A priority patent/KR100919346B1/en
Priority to AU2002352772A priority patent/AU2002352772B2/en
Priority to IL16166902A priority patent/IL161669A0/en
Priority to DE60209937T priority patent/DE60209937T4/en
Priority to DK02789725T priority patent/DK1448566T5/en
Priority to JP2003547392A priority patent/JP4889920B2/en
Priority to SI200230327T priority patent/SI1448566T1/en
Priority to NZ532827A priority patent/NZ532827A/en
Priority to MXPA04004826A priority patent/MXPA04004826A/en
Priority to BR0213633-3A priority patent/BR0213633A/en
Priority to CN02827426.1A priority patent/CN1585772B/en
Application filed by Millennium Pharm Inc, Kyowa Hakko Kogyo Kk, Jay R Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C B Harriman, Kenneth G Carson, Shomir Ghosh, Amy M Elder, Karen M Mattia filed Critical Millennium Pharm Inc
Priority to EP02789725A priority patent/EP1448566B3/en
Priority to CA2467672A priority patent/CA2467672C/en
Priority to US10/487,168 priority patent/US7271176B2/en
Priority to DE60209937A priority patent/DE60209937D1/en
Priority to EA200400692A priority patent/EA008060B1/en
Publication of WO2003045942A2 publication Critical patent/WO2003045942A2/en
Publication of WO2003045942A3 publication Critical patent/WO2003045942A3/en
Priority to IL161669A priority patent/IL161669A/en
Priority to NO20042500A priority patent/NO328166B1/en
Priority to HK04106595A priority patent/HK1063789A1/en
Priority to US11/595,653 priority patent/US7541365B2/en
Priority to IL181191A priority patent/IL181191A/en
Priority to US12/436,271 priority patent/US8058287B2/en
Priority to US13/245,436 priority patent/US8653096B2/en
Priority to US14/105,750 priority patent/US20140371207A1/en
Priority to US14/643,773 priority patent/US9663537B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof.
PCT/US2002/036953 1998-09-04 2002-11-13 Chemokine receptor antagonists and methods of use thereof WO2003045942A2 (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
DE60209937A DE60209937D1 (en) 2001-11-21 2002-11-13 CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF THEIR APPLICATION
EA200400692A EA008060B1 (en) 1998-09-04 2002-11-13 Chemokine receptor antagonists and methods of use thereof
CA2467672A CA2467672C (en) 2001-11-21 2002-11-13 Chemokine receptor antagonists and methods of use therefor
CN02827426.1A CN1585772B (en) 2001-11-21 2002-11-13 Chemokine receptor antagonists and methods of use thereof
US10/487,168 US7271176B2 (en) 1998-09-04 2002-11-13 Chemokine receptor antagonists and methods of use thereof
AU2002352772A AU2002352772B2 (en) 2001-11-21 2002-11-13 Chemokine receptor antagonists and methods of use thereof
IL16166902A IL161669A0 (en) 2001-11-21 2002-11-13 Chemokine receptor antagonists and methods of use thereof
DE60209937T DE60209937T4 (en) 2001-11-21 2002-11-13 Chemokine receptor antagonists and methods of use
DK02789725T DK1448566T5 (en) 2001-11-21 2002-11-13 Chemokine Receptor Antagonists and Methods for Using Them
JP2003547392A JP4889920B2 (en) 2001-11-21 2002-11-13 Chemokine receptor antagonist and method of use thereof
SI200230327T SI1448566T1 (en) 2001-11-21 2002-11-13 Chemokine receptor antagonists and methods of use thereof
NZ532827A NZ532827A (en) 2001-11-21 2002-11-13 Chemokine receptor antagonists and methods of use thereof
MXPA04004826A MXPA04004826A (en) 1998-09-04 2002-11-13 Chemokine receptor antagonists and methods of use thereof.
BR0213633-3A BR0213633A (en) 2001-11-21 2002-11-13 Method and compound for treating a disease associated with aberrant leukocyte recruitment and / or activation
KR1020047007728A KR100919346B1 (en) 2001-11-21 2002-11-13 Chemokine receptor antagonists and methods of use thereof
HU0500079A HU228314B1 (en) 1998-09-04 2002-11-13 Chemokine receptor antagonists, their use and pharmaceutical compositions containing them
EP02789725A EP1448566B3 (en) 2001-11-21 2002-11-13 Chemokine receptor antagonists and methods of use thereof
IL161669A IL161669A (en) 2001-11-21 2004-04-29 Chemokine receptor antagonists and methods of use thereof
NO20042500A NO328166B1 (en) 2001-11-21 2004-06-15 Chemokine receptor antagonists, pharmaceutical compositions containing them, such compounds for use in therapy and the use of such compounds for the manufacture of medicaments for the treatment of disease
HK04106595A HK1063789A1 (en) 2001-11-21 2004-09-02 Chemokine receptor antagonists and methods of use thereof
US11/595,653 US7541365B2 (en) 2001-11-21 2006-11-10 Chemokine receptor antagonists and methods of use therefor
IL181191A IL181191A (en) 2001-11-21 2007-02-06 Pyrrolidine derivatives, pharmaceutical compositions comprising them and uses thereof for the manufacture of a medicament for treating a disease associated with aberrant leukocyte recruitment, activation or recruitment and activation
US12/436,271 US8058287B2 (en) 2001-11-21 2009-05-06 Chemokine receptor antagonists and methods of use therefor
US13/245,436 US8653096B2 (en) 2001-11-21 2011-09-26 Chemokine receptor antagonists and methods of use thereof
US14/105,750 US20140371207A1 (en) 2001-11-21 2013-12-13 Chemokine receptor antagonists and methods of use thereof
US14/643,773 US9663537B2 (en) 2001-11-21 2015-03-10 Chemokine receptor antagonists and methods of use

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US09/148,823 US6613905B1 (en) 1998-01-21 1998-09-04 Chemokine receptor antagonists and methods of use therefor
US09/235,102 US6329385B1 (en) 1998-01-21 1999-01-21 Chemokine receptor antagonists and methods of use therefor
US09/362,837 US6509346B2 (en) 1998-01-21 1999-07-28 Chemokine receptor antagonists and methods of use therefor
US62788600A 2000-07-28 2000-07-28
US09/989,086 US20020169155A1 (en) 1998-09-04 2001-11-21 Chemokine receptor anagonists and methods of use therefor
US09/989,086 2001-11-21

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/989,086 Continuation-In-Part US20020169155A1 (en) 1998-09-04 2001-11-21 Chemokine receptor anagonists and methods of use therefor

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10/487,168 A-371-Of-International US7271176B2 (en) 1998-09-04 2002-11-13 Chemokine receptor antagonists and methods of use thereof
US10487168 A-371-Of-International 2002-11-13
US11/595,653 Continuation US7541365B2 (en) 2001-11-21 2006-11-10 Chemokine receptor antagonists and methods of use therefor

Publications (2)

Publication Number Publication Date
WO2003045942A2 WO2003045942A2 (en) 2003-06-05
WO2003045942A3 true WO2003045942A3 (en) 2003-09-12

Family

ID=46204639

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/036953 WO2003045942A2 (en) 1998-09-04 2002-11-13 Chemokine receptor antagonists and methods of use thereof

Country Status (4)

Country Link
EA (1) EA008060B1 (en)
HU (1) HU228314B1 (en)
MX (1) MXPA04004826A (en)
WO (1) WO2003045942A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9334283B2 (en) 2002-11-13 2016-05-10 Millennium Pharmaceuticals, Inc. CCR1 antagonists and methods of use thereof

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
CN1964979B (en) 2004-04-09 2011-07-27 中外制药株式会社 Novel water-soluble prodrug
CN101119725B (en) * 2004-12-17 2013-04-17 千禧药品公司 Solid forms of a chemokine receptor antagonist and methods of use thereof
EP1954133A4 (en) * 2005-11-30 2010-11-24 Glaxosmithkline Llc Pyrrolidineanilines
JP2007297306A (en) * 2006-04-28 2007-11-15 Kaneka Corp Method for producing optically active 3-(1-pyrrolidinyl)pyrrolidine
PT2229356E (en) 2007-12-03 2012-01-20 Novartis Ag 1,2-disubstituted-4-benzylamino-pyrrolidine derivatives as cetp inhibitors useful for the treatment of diseases such as hyperli pidemia or arteriosclerosis
WO2009104557A1 (en) * 2008-02-21 2009-08-27 株式会社カネカ Process for production of n-(3-pyrrolidinyl)glycine derivative
US9145383B2 (en) 2012-08-10 2015-09-29 Hallstar Innovations Corp. Compositions, apparatus, systems, and methods for resolving electronic excited states
US9867800B2 (en) 2012-08-10 2018-01-16 Hallstar Innovations Corp. Method of quenching singlet and triplet excited states of pigments, such as porphyrin compounds, particularly protoporphyrin IX, with conjugated fused tricyclic compounds have electron withdrawing groups, to reduce generation of reactive oxygen species, particularly singlet oxygen

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996031469A1 (en) * 1995-04-07 1996-10-10 Novo Nordisk A/S N-substituted azaheterocyclic carboxylic acids and esters thereof
WO1999037651A1 (en) * 1998-01-21 1999-07-29 Millenium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
WO2001009138A2 (en) * 1999-07-28 2001-02-08 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996031469A1 (en) * 1995-04-07 1996-10-10 Novo Nordisk A/S N-substituted azaheterocyclic carboxylic acids and esters thereof
WO1999037651A1 (en) * 1998-01-21 1999-07-29 Millenium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
WO2001009138A2 (en) * 1999-07-28 2001-02-08 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9334283B2 (en) 2002-11-13 2016-05-10 Millennium Pharmaceuticals, Inc. CCR1 antagonists and methods of use thereof

Also Published As

Publication number Publication date
WO2003045942A2 (en) 2003-06-05
EA200400692A1 (en) 2004-12-30
HUP0500079A2 (en) 2005-04-28
EA008060B1 (en) 2007-02-27
HUP0500079A3 (en) 2009-03-30
HU228314B1 (en) 2013-03-28
MXPA04004826A (en) 2004-08-11

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