EA200400444A1 - Композиции для лечения простуды - Google Patents
Композиции для лечения простудыInfo
- Publication number
- EA200400444A1 EA200400444A1 EA200400444A EA200400444A EA200400444A1 EA 200400444 A1 EA200400444 A1 EA 200400444A1 EA 200400444 A EA200400444 A EA 200400444A EA 200400444 A EA200400444 A EA 200400444A EA 200400444 A1 EA200400444 A1 EA 200400444A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compositions
- salt
- combination
- treatment
- local
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 abstract 2
- YGWFCQYETHJKNX-UHFFFAOYSA-N 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1h-imidazol-3-ium;chloride Chemical compound [Cl-].CC1=CC(C(C)(C)C)=CC(C)=C1CC1=NCC[NH2+]1 YGWFCQYETHJKNX-UHFFFAOYSA-N 0.000 abstract 1
- 208000036071 Rhinorrhea Diseases 0.000 abstract 1
- 206010039101 Rhinorrhoea Diseases 0.000 abstract 1
- 230000001078 anti-cholinergic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- OEXHQOGQTVQTAT-JRNQLAHRSA-N ipratropium Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 OEXHQOGQTVQTAT-JRNQLAHRSA-N 0.000 abstract 1
- 229960001888 ipratropium Drugs 0.000 abstract 1
- 210000002850 nasal mucosa Anatomy 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
- 239000005526 vasoconstrictor agent Substances 0.000 abstract 1
- 229960001095 xylometazoline hydrochloride Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Polyurethanes Or Polyureas (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
Abstract
Описаны новые стабильные композиции, содержащие комбинацию сосудосуживающего средства местного действия и антихолинергического средства местного действия. Предпочтительно, композиция содержит ипратропиум или его соль в комбинации с ксилометазолина гидрохлоридом или его солью. После местного введения таких композиций в слизистую носа существенно снижаются симптомы ринореи у лиц, страдающих простудой.Отчет о международном поиске был опубликован 2004.06.10.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200101356 | 2001-09-18 | ||
PCT/IB2002/003828 WO2003024433A2 (en) | 2001-09-18 | 2002-09-18 | Compositions for treatment of common cold, comprising ipratropium and xylometazoline |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200400444A1 true EA200400444A1 (ru) | 2005-02-24 |
EA008165B1 EA008165B1 (ru) | 2007-04-27 |
Family
ID=8160714
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200400444A EA008165B1 (ru) | 2001-09-18 | 2002-09-18 | Композиции для лечения простуды |
Country Status (21)
Country | Link |
---|---|
US (2) | US7652030B2 (ru) |
EP (2) | EP1446119B1 (ru) |
JP (1) | JP4500045B2 (ru) |
KR (1) | KR100810872B1 (ru) |
CN (1) | CN1290502C (ru) |
AT (1) | ATE318601T1 (ru) |
BR (1) | BRPI0212586B8 (ru) |
CA (1) | CA2460140C (ru) |
DE (1) | DE60209511T2 (ru) |
DK (1) | DK1446119T3 (ru) |
EA (1) | EA008165B1 (ru) |
ES (1) | ES2259098T3 (ru) |
HK (1) | HK1067984A1 (ru) |
HU (1) | HU226527B1 (ru) |
MX (1) | MXPA04002500A (ru) |
NO (1) | NO334441B1 (ru) |
NZ (1) | NZ531792A (ru) |
PL (1) | PL208686B1 (ru) |
PT (1) | PT1446119E (ru) |
SI (1) | SI1446119T1 (ru) |
WO (1) | WO2003024433A2 (ru) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030055026A1 (en) | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
EP1446119B1 (en) * | 2001-09-18 | 2006-03-01 | Nycomed Danmark ApS | Compositions comprising ipatropium and xylometazoline for treatment of the common cold |
TWI359675B (en) * | 2003-07-10 | 2012-03-11 | Dey L P | Bronchodilating β-agonist compositions |
CN1913882A (zh) * | 2004-02-06 | 2007-02-14 | Meda制药有限及两合公司 | 用抗胆碱能药单独或联合抗组胺药、磷酸二酯酶4抑制剂或皮质类固醇来治疗鼻炎 |
WO2005084330A2 (en) * | 2004-03-02 | 2005-09-15 | Synergia Pharma, Inc. | Compositions and methods for treating nasal congestion |
DE102004049008A1 (de) * | 2004-10-05 | 2006-04-06 | Merck Patent Gmbh | Neue Verwendung für α-Sympathomimetika mit 2-Imidazolinstruktur |
MX2007007836A (es) * | 2004-12-27 | 2007-08-20 | Eisai R&D Man Co Ltd | Metodo para estabilizar un farmaco anti-demencia. |
DE102006023770A1 (de) * | 2006-05-20 | 2007-11-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Treibgasfreie Aerosolformulierung für die Inhalation |
EP2077132A1 (en) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device, storage device and method for dispensing a formulation |
US20090270472A1 (en) * | 2008-04-25 | 2009-10-29 | Kenneth Gould | Method to use oxymetazoline to interrupt the development of the common cold syndrome |
EP2662472B1 (de) | 2009-03-31 | 2019-02-27 | Boehringer Ingelheim International Gmbh | Verfahren zur Beschichtung einer Oberfläche eines Bauteils |
US9265910B2 (en) | 2009-05-18 | 2016-02-23 | Boehringer Ingelheim International Gmbh | Adapter, inhalation device, and nebulizer |
UA107097C2 (en) | 2009-11-25 | 2014-11-25 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Dispenser |
WO2011064163A1 (en) | 2009-11-25 | 2011-06-03 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
JP5874724B2 (ja) | 2010-06-24 | 2016-03-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ネブライザ |
EP2694220B1 (de) | 2011-04-01 | 2020-05-06 | Boehringer Ingelheim International GmbH | Medizinisches gerät mit behälter |
US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
WO2013152894A1 (de) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Zerstäuber mit kodiermitteln |
WO2014158118A1 (en) * | 2013-03-29 | 2014-10-02 | Santa Farma İlaç Sanayi̇ A.Ş. | Suspension composition containing ipratropium and oxymetazoline |
EP2978407B1 (en) * | 2013-03-29 | 2020-05-06 | Santa Farma Ilaç Sanayi A.S. | Aqueous solution composition containing ipratropium and oxymetazoline |
JP6643231B2 (ja) | 2013-08-09 | 2020-02-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ネブライザ |
EP2835146B1 (en) | 2013-08-09 | 2020-09-30 | Boehringer Ingelheim International GmbH | Nebulizer |
WO2015054359A1 (en) * | 2013-10-08 | 2015-04-16 | Ebadi Mark A | Methods and compositions for symptomatic reflief of the common cold |
HUE055604T2 (hu) | 2014-05-07 | 2021-12-28 | Boehringer Ingelheim Int | Porlasztó |
DK3139983T3 (da) | 2014-05-07 | 2023-09-11 | Boehringer Ingelheim Int | Beholder og indikatoranordning, samt forstøver |
JP6580070B2 (ja) | 2014-05-07 | 2019-09-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 容器、ネブライザ、及び使用 |
EP3236933B1 (en) * | 2014-12-24 | 2018-11-14 | JADRAN - GALENSKI LABORATORIJ d.d. | A nasal composition containing sea water as stability-improving excipient |
MX2015016549A (es) * | 2015-12-02 | 2017-06-01 | Cortés Borrego Pablo | Combinacion de oximetazolina e ipratropio en aplicacion topica nasal para el tratamiento de la tos. |
US20220031739A1 (en) * | 2020-07-31 | 2022-02-03 | Eye Therapies Llc | Anti-viral compositions and methods of use thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2137981T3 (es) | 1991-11-19 | 2000-01-01 | Univ Virginia | Tratamiento combinado por agentes antimediaticos y antiviricos de resfriados comunes. |
IL101056A (en) * | 1992-02-24 | 1997-03-18 | Res & Dev Co Ltd | Composition for nasal treatment |
GB9218834D0 (en) | 1992-09-05 | 1992-10-21 | Procter & Gamble | Nasal spray products |
AU680227B2 (en) | 1992-12-09 | 1997-07-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | Stabilized medicinal aerosol solution formulations |
EP0780127A1 (en) | 1995-12-19 | 1997-06-25 | The Procter & Gamble Company | A nasal spray containing a steroid and a antihistamine |
DE19653969A1 (de) * | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole |
IL131492A0 (en) | 1997-04-30 | 2001-01-28 | Warner Lambert Co | Topical nasal antiinflammatory compositions |
AU741364B2 (en) * | 1998-01-30 | 2001-11-29 | Novartis Consumer Health S.A. | Nasal solutions |
PL193695B1 (pl) | 1998-06-18 | 2007-03-30 | Boehringer Ingelheim Pharma | Preparat farmaceutyczny do napędzanych propelentem inhalatorów zawierający połączenie dwóch lub więcej substancji aktywnych oraz jego zastosowanie |
CA2376121C (en) * | 1999-06-22 | 2008-06-10 | Boehringer Ingelheim International Gmbh | Stable xylometazoline and oxymetazoline solution |
EP1446119B1 (en) * | 2001-09-18 | 2006-03-01 | Nycomed Danmark ApS | Compositions comprising ipatropium and xylometazoline for treatment of the common cold |
-
2002
- 2002-09-18 EP EP02765268A patent/EP1446119B1/en not_active Expired - Lifetime
- 2002-09-18 KR KR1020047003882A patent/KR100810872B1/ko active IP Right Grant
- 2002-09-18 DK DK02765268T patent/DK1446119T3/da active
- 2002-09-18 SI SI200230311T patent/SI1446119T1/sl unknown
- 2002-09-18 MX MXPA04002500A patent/MXPA04002500A/es active IP Right Grant
- 2002-09-18 AT AT02765268T patent/ATE318601T1/de active
- 2002-09-18 PT PT02765268T patent/PT1446119E/pt unknown
- 2002-09-18 JP JP2003528530A patent/JP4500045B2/ja not_active Expired - Lifetime
- 2002-09-18 EP EP06075452A patent/EP1661570A3/en not_active Withdrawn
- 2002-09-18 BR BRPI0212586A patent/BRPI0212586B8/pt not_active IP Right Cessation
- 2002-09-18 US US10/489,655 patent/US7652030B2/en not_active Expired - Lifetime
- 2002-09-18 CN CNB028182871A patent/CN1290502C/zh not_active Expired - Lifetime
- 2002-09-18 NZ NZ531792A patent/NZ531792A/en not_active IP Right Cessation
- 2002-09-18 WO PCT/IB2002/003828 patent/WO2003024433A2/en active IP Right Grant
- 2002-09-18 PL PL370536A patent/PL208686B1/pl unknown
- 2002-09-18 EA EA200400444A patent/EA008165B1/ru unknown
- 2002-09-18 HU HU0402075A patent/HU226527B1/hu unknown
- 2002-09-18 DE DE60209511T patent/DE60209511T2/de not_active Expired - Lifetime
- 2002-09-18 CA CA002460140A patent/CA2460140C/en not_active Expired - Lifetime
- 2002-09-18 ES ES02765268T patent/ES2259098T3/es not_active Expired - Lifetime
-
2004
- 2004-03-12 NO NO20041070A patent/NO334441B1/no not_active IP Right Cessation
-
2005
- 2005-02-07 HK HK05101053A patent/HK1067984A1/xx not_active IP Right Cessation
-
2009
- 2009-12-11 US US12/654,145 patent/US8450339B2/en not_active Expired - Lifetime
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PD4A | Registration of transfer of a eurasian patent in accordance with the succession in title | ||
QB4A | Registration of a licence in a contracting state |