CN100566715C - 通过局部施用氟喹诺酮类治疗呼吸器官的细菌疾病 - Google Patents
通过局部施用氟喹诺酮类治疗呼吸器官的细菌疾病 Download PDFInfo
- Publication number
- CN100566715C CN100566715C CNB2004800039275A CN200480003927A CN100566715C CN 100566715 C CN100566715 C CN 100566715C CN B2004800039275 A CNB2004800039275 A CN B2004800039275A CN 200480003927 A CN200480003927 A CN 200480003927A CN 100566715 C CN100566715 C CN 100566715C
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- Prior art keywords
- ciprofloxacin
- betaine
- disease
- preparation
- infection
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 229940124307 fluoroquinolone Drugs 0.000 title description 3
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
剂量分组 | 血药浓度[mg*h/l] | C<sub>max</sub>[mg/l] | t<sub>1/2</sub>[h] |
A1 | 124 | 49.1 | 1.96 |
A2 | 304 | 76 | 13.47 |
B | 3.20 | 6.65 | 0.847 |
C | 0.497 | 0.610 | 0.758 |
剂量分组 | 0.25小时 | 0.5小时 | 1小时 | 3小时 | 5小时 |
A1 | 49.1 | 44.3 | 40.1 | 12.6 | 7.21 |
A2 | 76 | 76 | 76 | 54 | 54 |
B | 6.65 | 1.67 | 0.63 | 0.10 | 0 |
C | 0.61 | 0.35 | 0.14 | 0 | 0 |
剂量分组 | 微生物数量的降低(log-个体) |
A-0.8mg/kg环丙沙星内铵盐i.t. | -4.0 |
B-2.5mg/kg环丙沙星内铵盐i.t. | -5.8 |
C-7.5mg/kg环丙沙星内铵盐i.t. | -10 |
D-0.8mg/kg盐酸环丙沙星i.t. | -1.8 |
E-2.5mg/kg盐酸环丙沙星i.t. | -1.1 |
F-7.5mg/kg盐酸环丙沙星i.t. | -2.8 |
G-2.5mg/kg盐酸环丙沙星i.v. | -2.8 |
H-7.5mg/kg盐酸环丙沙星i.v. | -3.5 |
I-22.5mg/kg盐酸环丙沙星i.v. | -5.4 |
J-67.5mg/kg盐酸环丙沙星i.v. | -8.8 |
Claims (5)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10305318.2 | 2003-02-10 | ||
DE10305319A DE10305319A1 (de) | 2003-02-10 | 2003-02-10 | Behandlung bakteriell verursachter Lungenkrankheiten |
DE10305319.0 | 2003-02-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1747733A CN1747733A (zh) | 2006-03-15 |
CN100566715C true CN100566715C (zh) | 2009-12-09 |
Family
ID=32747666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004800039275A Expired - Fee Related CN100566715C (zh) | 2003-02-10 | 2004-01-28 | 通过局部施用氟喹诺酮类治疗呼吸器官的细菌疾病 |
Country Status (3)
Country | Link |
---|---|
CN (1) | CN100566715C (zh) |
DE (1) | DE10305319A1 (zh) |
ZA (1) | ZA200506287B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8834930B2 (en) * | 2008-05-15 | 2014-09-16 | Novartis Ag | Pulmonary delivery of a fluoroquinolone |
CN109260180A (zh) * | 2017-07-17 | 2019-01-25 | 北京盈科瑞创新药物研究有限公司 | 一种盐酸莫西沙星雾化吸入用溶液制剂及其制备方法 |
-
2003
- 2003-02-10 DE DE10305319A patent/DE10305319A1/de not_active Withdrawn
-
2004
- 2004-01-28 CN CNB2004800039275A patent/CN100566715C/zh not_active Expired - Fee Related
-
2005
- 2005-08-05 ZA ZA200506287A patent/ZA200506287B/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE10305319A1 (de) | 2004-08-26 |
ZA200506287B (en) | 2006-10-25 |
CN1747733A (zh) | 2006-03-15 |
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