JP2002526550A5 - - Google Patents
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- Publication number
- JP2002526550A5 JP2002526550A5 JP2000574548A JP2000574548A JP2002526550A5 JP 2002526550 A5 JP2002526550 A5 JP 2002526550A5 JP 2000574548 A JP2000574548 A JP 2000574548A JP 2000574548 A JP2000574548 A JP 2000574548A JP 2002526550 A5 JP2002526550 A5 JP 2002526550A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- bond
- amino acid
- acid group
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19845403A DE19845403B4 (de) | 1998-10-02 | 1998-10-02 | Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| DE19845403.1 | 1998-10-02 | ||
| PCT/EP1999/006930 WO2000020437A1 (de) | 1998-10-02 | 1999-09-18 | Mit gallensäuren verknüpfte propanolaminderivate zur behandlung von lipidstoffwechselstörungen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002526550A JP2002526550A (ja) | 2002-08-20 |
| JP2002526550A5 true JP2002526550A5 (https=) | 2006-09-07 |
| JP4598953B2 JP4598953B2 (ja) | 2010-12-15 |
Family
ID=7883185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000574548A Expired - Fee Related JP4598953B2 (ja) | 1998-10-02 | 1999-09-18 | 脂質代謝障害を治療するための胆汁酸と結合したプロパノールアミン誘導体 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6180618B1 (https=) |
| EP (1) | EP1117676B1 (https=) |
| JP (1) | JP4598953B2 (https=) |
| KR (1) | KR20010075511A (https=) |
| CN (1) | CN1227259C (https=) |
| AR (1) | AR035003A1 (https=) |
| AT (1) | ATE273991T1 (https=) |
| AU (1) | AU757366B2 (https=) |
| BR (1) | BR9915019A (https=) |
| CA (1) | CA2346085A1 (https=) |
| DE (2) | DE19845403B4 (https=) |
| DK (1) | DK1117676T3 (https=) |
| ES (1) | ES2226440T3 (https=) |
| HK (1) | HK1040717A1 (https=) |
| HU (1) | HUP0103570A3 (https=) |
| ID (1) | ID29353A (https=) |
| PL (1) | PL347106A1 (https=) |
| PT (1) | PT1117676E (https=) |
| RU (1) | RU2234512C2 (https=) |
| TR (1) | TR200100897T2 (https=) |
| WO (1) | WO2000020437A1 (https=) |
| ZA (1) | ZA200102586B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7053076B2 (en) | 2001-08-29 | 2006-05-30 | Xenoport, Inc. | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs |
| US7161008B2 (en) * | 2002-05-03 | 2007-01-09 | Sanofi - Aventis Deutschland GmbH | Optically active β-aminoketones, optically active 1,3-amino alcohols and processes for preparing them |
| GB0213669D0 (en) * | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| GB0817969D0 (en) * | 2008-10-01 | 2008-11-05 | Axcess Ltd | Pharmaceutical composition |
| ES2552657T3 (es) | 2010-05-26 | 2015-12-01 | Satiogen Pharmaceuticals, Inc. | Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias |
| US20130108573A1 (en) | 2011-10-28 | 2013-05-02 | Lumena Pharmaceuticals, Inc. | Bile Acid Recycling Inhibitors for Treatment of Hypercholemia and Cholestatic Liver Disease |
| AU2012328526B2 (en) | 2011-10-28 | 2017-05-25 | Shire Human Genetic Therapies, Inc. | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| AU2014229050A1 (en) | 2013-03-15 | 2015-10-22 | Lumena Pharmaceuticals Llc | Bile acid recycling inhibitors for treatment of Barrett's esophagus and gastroesophageal reflux disease |
| CA2907230A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
| EP3923943B1 (en) | 2019-02-12 | 2024-07-31 | Mirum Pharmaceuticals, Inc. | Genotype and dose-dependent response to an asbti in patients with bile salt export pump deficiency |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI892341L (fi) | 1988-06-10 | 1989-12-11 | Hoffmann La Roche | Propanolaminderivat. |
| GB2250634A (en) * | 1990-12-04 | 1992-06-10 | Marconi Gec Ltd | Point contact diodes |
| US5250524A (en) | 1990-12-06 | 1993-10-05 | Hoechst Aktiengesellschaft | Bile acid derivatives, process for their preparation and use of these compounds as pharmaceuticals |
| JP2616845B2 (ja) * | 1991-02-21 | 1997-06-04 | 清水化学株式会社 | システノール酸又はその胆汁酸抱合体を含有する血中コレステロール低下剤 |
| GB9203347D0 (en) * | 1992-02-17 | 1992-04-01 | Wellcome Found | Hypolipidaemic compounds |
| ATE147384T1 (de) * | 1992-02-22 | 1997-01-15 | Hoechst Ag | 4-amino-2-ureido-pyrimidin-5-carbonsäureamide, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| TW289021B (https=) * | 1993-05-08 | 1996-10-21 | Hoechst Ag | |
| EP0624593A3 (de) * | 1993-05-08 | 1995-06-07 | Hoechst Ag | Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel. |
| EP0869121B1 (de) * | 1997-04-04 | 2004-06-09 | Aventis Pharma Deutschland GmbH | Hypolipidämische Propanolaminderivate |
-
1998
- 1998-10-02 DE DE19845403A patent/DE19845403B4/de not_active Expired - Fee Related
-
1999
- 1999-09-18 DK DK99947385T patent/DK1117676T3/da active
- 1999-09-18 JP JP2000574548A patent/JP4598953B2/ja not_active Expired - Fee Related
- 1999-09-18 DE DE59910300T patent/DE59910300D1/de not_active Expired - Lifetime
- 1999-09-18 HK HK02102338.5A patent/HK1040717A1/zh unknown
- 1999-09-18 BR BR9915019-0A patent/BR9915019A/pt not_active IP Right Cessation
- 1999-09-18 ES ES99947385T patent/ES2226440T3/es not_active Expired - Lifetime
- 1999-09-18 AU AU60855/99A patent/AU757366B2/en not_active Ceased
- 1999-09-18 HU HU0103570A patent/HUP0103570A3/hu unknown
- 1999-09-18 ID IDW20010737A patent/ID29353A/id unknown
- 1999-09-18 AT AT99947385T patent/ATE273991T1/de not_active IP Right Cessation
- 1999-09-18 PL PL99347106A patent/PL347106A1/xx unknown
- 1999-09-18 PT PT99947385T patent/PT1117676E/pt unknown
- 1999-09-18 EP EP99947385A patent/EP1117676B1/de not_active Expired - Lifetime
- 1999-09-18 CN CNB998116343A patent/CN1227259C/zh not_active Expired - Fee Related
- 1999-09-18 KR KR1020017004131A patent/KR20010075511A/ko not_active Ceased
- 1999-09-18 WO PCT/EP1999/006930 patent/WO2000020437A1/de not_active Ceased
- 1999-09-18 RU RU2001111816/04A patent/RU2234512C2/ru not_active IP Right Cessation
- 1999-09-18 TR TR2001/00897T patent/TR200100897T2/xx unknown
- 1999-09-18 CA CA002346085A patent/CA2346085A1/en not_active Abandoned
- 1999-09-29 US US09/408,169 patent/US6180618B1/en not_active Expired - Lifetime
- 1999-09-30 AR ARP990104961A patent/AR035003A1/es unknown
-
2001
- 2001-03-29 ZA ZA200102586A patent/ZA200102586B/en unknown
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