RU2234512C2 - Соединенные с желчными кислотами производные пропаноламина, лекарственное средство - Google Patents

Соединенные с желчными кислотами производные пропаноламина, лекарственное средство Download PDF

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Publication number
RU2234512C2
RU2234512C2 RU2001111816/04A RU2001111816A RU2234512C2 RU 2234512 C2 RU2234512 C2 RU 2234512C2 RU 2001111816/04 A RU2001111816/04 A RU 2001111816/04A RU 2001111816 A RU2001111816 A RU 2001111816A RU 2234512 C2 RU2234512 C2 RU 2234512C2
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RU
Russia
Prior art keywords
compounds
alkyl
bond
formula
treatment
Prior art date
Application number
RU2001111816/04A
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English (en)
Russian (ru)
Other versions
RU2001111816A (ru
Inventor
Зигфрид ШТЕНГЕЛИН (DE)
Зигфрид ШТЕНГЕЛИН
Альфонс ЭНСЕН (DE)
Альфонс ЭНСЕН
Хайнер ГЛОМБИК (DE)
Хайнер Гломбик
Вернер КРАМЕР (DE)
Вернер Крамер
Ойген ФАЛЬК (DE)
Ойген Фальк
Original Assignee
Авентис Фарма Дойчланд Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Авентис Фарма Дойчланд Гмбх filed Critical Авентис Фарма Дойчланд Гмбх
Publication of RU2001111816A publication Critical patent/RU2001111816A/ru
Application granted granted Critical
Publication of RU2234512C2 publication Critical patent/RU2234512C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
RU2001111816/04A 1998-10-02 1999-09-18 Соединенные с желчными кислотами производные пропаноламина, лекарственное средство RU2234512C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19845403A DE19845403B4 (de) 1998-10-02 1998-10-02 Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19845403.1 1998-10-02

Publications (2)

Publication Number Publication Date
RU2001111816A RU2001111816A (ru) 2003-09-27
RU2234512C2 true RU2234512C2 (ru) 2004-08-20

Family

ID=7883185

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2001111816/04A RU2234512C2 (ru) 1998-10-02 1999-09-18 Соединенные с желчными кислотами производные пропаноламина, лекарственное средство

Country Status (22)

Country Link
US (1) US6180618B1 (https=)
EP (1) EP1117676B1 (https=)
JP (1) JP4598953B2 (https=)
KR (1) KR20010075511A (https=)
CN (1) CN1227259C (https=)
AR (1) AR035003A1 (https=)
AT (1) ATE273991T1 (https=)
AU (1) AU757366B2 (https=)
BR (1) BR9915019A (https=)
CA (1) CA2346085A1 (https=)
DE (2) DE19845403B4 (https=)
DK (1) DK1117676T3 (https=)
ES (1) ES2226440T3 (https=)
HK (1) HK1040717A1 (https=)
HU (1) HUP0103570A3 (https=)
ID (1) ID29353A (https=)
PL (1) PL347106A1 (https=)
PT (1) PT1117676E (https=)
RU (1) RU2234512C2 (https=)
TR (1) TR200100897T2 (https=)
WO (1) WO2000020437A1 (https=)
ZA (1) ZA200102586B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2525290C2 (ru) * 2008-10-01 2014-08-10 Эксисс Лимитед Желчные кислоты и бигуаниды как ингибиторы протеаз для сохранения целостности пептидов в пищеварительном канале

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053076B2 (en) 2001-08-29 2006-05-30 Xenoport, Inc. Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
US7161008B2 (en) * 2002-05-03 2007-01-09 Sanofi - Aventis Deutschland GmbH Optically active β-aminoketones, optically active 1,3-amino alcohols and processes for preparing them
GB0213669D0 (en) * 2002-06-14 2002-07-24 Astrazeneca Ab Chemical compounds
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
ES2552657T3 (es) 2010-05-26 2015-12-01 Satiogen Pharmaceuticals, Inc. Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias
US20130108573A1 (en) 2011-10-28 2013-05-02 Lumena Pharmaceuticals, Inc. Bile Acid Recycling Inhibitors for Treatment of Hypercholemia and Cholestatic Liver Disease
AU2012328526B2 (en) 2011-10-28 2017-05-25 Shire Human Genetic Therapies, Inc. Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
AU2014229050A1 (en) 2013-03-15 2015-10-22 Lumena Pharmaceuticals Llc Bile acid recycling inhibitors for treatment of Barrett's esophagus and gastroesophageal reflux disease
CA2907230A1 (en) 2013-03-15 2014-09-18 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease
EP3923943B1 (en) 2019-02-12 2024-07-31 Mirum Pharmaceuticals, Inc. Genotype and dose-dependent response to an asbti in patients with bile salt export pump deficiency

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0624593A2 (de) * 1993-05-08 1994-11-17 Hoechst Aktiengesellschaft Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel
US5610151A (en) * 1993-05-08 1997-03-11 Hoechst Aktiengesellschaft Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments
EP0869121A1 (de) * 1997-04-04 1998-10-07 Hoechst Marion Roussel Deutschland GmbH Hypolipidämische Propanolaminderivate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI892341L (fi) 1988-06-10 1989-12-11 Hoffmann La Roche Propanolaminderivat.
GB2250634A (en) * 1990-12-04 1992-06-10 Marconi Gec Ltd Point contact diodes
US5250524A (en) 1990-12-06 1993-10-05 Hoechst Aktiengesellschaft Bile acid derivatives, process for their preparation and use of these compounds as pharmaceuticals
JP2616845B2 (ja) * 1991-02-21 1997-06-04 清水化学株式会社 システノール酸又はその胆汁酸抱合体を含有する血中コレステロール低下剤
GB9203347D0 (en) * 1992-02-17 1992-04-01 Wellcome Found Hypolipidaemic compounds
ATE147384T1 (de) * 1992-02-22 1997-01-15 Hoechst Ag 4-amino-2-ureido-pyrimidin-5-carbonsäureamide, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0624593A2 (de) * 1993-05-08 1994-11-17 Hoechst Aktiengesellschaft Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel
US5610151A (en) * 1993-05-08 1997-03-11 Hoechst Aktiengesellschaft Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments
EP0869121A1 (de) * 1997-04-04 1998-10-07 Hoechst Marion Roussel Deutschland GmbH Hypolipidämische Propanolaminderivate

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2525290C2 (ru) * 2008-10-01 2014-08-10 Эксисс Лимитед Желчные кислоты и бигуаниды как ингибиторы протеаз для сохранения целостности пептидов в пищеварительном канале

Also Published As

Publication number Publication date
HK1040717A1 (zh) 2002-06-21
WO2000020437A1 (de) 2000-04-13
KR20010075511A (ko) 2001-08-09
BR9915019A (pt) 2001-08-14
CN1321166A (zh) 2001-11-07
PT1117676E (pt) 2004-11-30
DE19845403A1 (de) 2000-04-13
TR200100897T2 (tr) 2001-10-22
CN1227259C (zh) 2005-11-16
DK1117676T3 (da) 2004-12-20
DE19845403B4 (de) 2005-02-10
ATE273991T1 (de) 2004-09-15
ES2226440T3 (es) 2005-03-16
PL347106A1 (en) 2002-03-25
JP4598953B2 (ja) 2010-12-15
AR035003A1 (es) 2004-04-14
HUP0103570A3 (en) 2003-01-28
US6180618B1 (en) 2001-01-30
JP2002526550A (ja) 2002-08-20
ID29353A (id) 2001-08-23
DE59910300D1 (de) 2004-09-23
EP1117676B1 (de) 2004-08-18
CA2346085A1 (en) 2000-04-13
EP1117676A1 (de) 2001-07-25
AU757366B2 (en) 2003-02-20
HUP0103570A2 (hu) 2002-02-28
ZA200102586B (en) 2001-10-03
AU6085599A (en) 2000-04-26

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20060919