RU2234512C2 - Соединенные с желчными кислотами производные пропаноламина, лекарственное средство - Google Patents

Соединенные с желчными кислотами производные пропаноламина, лекарственное средство Download PDF

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Publication number
RU2234512C2
RU2234512C2 RU2001111816/04A RU2001111816A RU2234512C2 RU 2234512 C2 RU2234512 C2 RU 2234512C2 RU 2001111816/04 A RU2001111816/04 A RU 2001111816/04A RU 2001111816 A RU2001111816 A RU 2001111816A RU 2234512 C2 RU2234512 C2 RU 2234512C2
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RU
Russia
Prior art keywords
compounds
alkyl
bond
formula
treatment
Prior art date
Application number
RU2001111816/04A
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English (en)
Russian (ru)
Other versions
RU2001111816A (ru
Inventor
Зигфрид ШТЕНГЕЛИН (DE)
Зигфрид ШТЕНГЕЛИН
Альфонс ЭНСЕН (DE)
Альфонс ЭНСЕН
Хайнер ГЛОМБИК (DE)
Хайнер Гломбик
Вернер КРАМЕР (DE)
Вернер Крамер
Ойген ФАЛЬК (DE)
Ойген Фальк
Original Assignee
Авентис Фарма Дойчланд Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Авентис Фарма Дойчланд Гмбх filed Critical Авентис Фарма Дойчланд Гмбх
Publication of RU2001111816A publication Critical patent/RU2001111816A/ru
Application granted granted Critical
Publication of RU2234512C2 publication Critical patent/RU2234512C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
RU2001111816/04A 1998-10-02 1999-09-18 Соединенные с желчными кислотами производные пропаноламина, лекарственное средство RU2234512C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19845403.1 1998-10-02
DE19845403A DE19845403B4 (de) 1998-10-02 1998-10-02 Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung

Publications (2)

Publication Number Publication Date
RU2001111816A RU2001111816A (ru) 2003-09-27
RU2234512C2 true RU2234512C2 (ru) 2004-08-20

Family

ID=7883185

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2001111816/04A RU2234512C2 (ru) 1998-10-02 1999-09-18 Соединенные с желчными кислотами производные пропаноламина, лекарственное средство

Country Status (22)

Country Link
US (1) US6180618B1 (https=)
EP (1) EP1117676B1 (https=)
JP (1) JP4598953B2 (https=)
KR (1) KR20010075511A (https=)
CN (1) CN1227259C (https=)
AR (1) AR035003A1 (https=)
AT (1) ATE273991T1 (https=)
AU (1) AU757366B2 (https=)
BR (1) BR9915019A (https=)
CA (1) CA2346085A1 (https=)
DE (2) DE19845403B4 (https=)
DK (1) DK1117676T3 (https=)
ES (1) ES2226440T3 (https=)
HK (1) HK1040717A1 (https=)
HU (1) HUP0103570A3 (https=)
ID (1) ID29353A (https=)
PL (1) PL347106A1 (https=)
PT (1) PT1117676E (https=)
RU (1) RU2234512C2 (https=)
TR (1) TR200100897T2 (https=)
WO (1) WO2000020437A1 (https=)
ZA (1) ZA200102586B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2525290C2 (ru) * 2008-10-01 2014-08-10 Эксисс Лимитед Желчные кислоты и бигуаниды как ингибиторы протеаз для сохранения целостности пептидов в пищеварительном канале

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053076B2 (en) 2001-08-29 2006-05-30 Xenoport, Inc. Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
US7161008B2 (en) * 2002-05-03 2007-01-09 Sanofi - Aventis Deutschland GmbH Optically active β-aminoketones, optically active 1,3-amino alcohols and processes for preparing them
GB0213669D0 (en) * 2002-06-14 2002-07-24 Astrazeneca Ab Chemical compounds
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
EP2575821B1 (en) 2010-05-26 2015-08-12 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
CA2852957C (en) 2011-10-28 2020-08-04 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
CN104023727B (zh) 2011-10-28 2017-04-05 鲁美纳医药公司 用于治疗小儿胆汁淤积性肝病的胆汁酸再循环抑制剂
US20140275090A1 (en) 2013-03-15 2014-09-18 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease
CN105228615A (zh) 2013-03-15 2016-01-06 鲁美纳医药公司 用于治疗巴雷特食管和胃食管返流疾病的胆汁酸再循环抑制剂
PL3923943T3 (pl) 2019-02-12 2024-12-09 Mirum Pharmaceuticals, Inc. Zależna od genotypu i dawki odpowiedź na asbti u pacjentów z niedoborem pompy eksportu soli żółciowych

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0624593A2 (de) * 1993-05-08 1994-11-17 Hoechst Aktiengesellschaft Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel
US5610151A (en) * 1993-05-08 1997-03-11 Hoechst Aktiengesellschaft Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments
EP0869121A1 (de) * 1997-04-04 1998-10-07 Hoechst Marion Roussel Deutschland GmbH Hypolipidämische Propanolaminderivate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI892341A7 (fi) 1988-06-10 1989-12-11 Hoffmann La Roche Propanoliamiinijohdannaisia
GB2250634A (en) * 1990-12-04 1992-06-10 Marconi Gec Ltd Point contact diodes
NZ240846A (en) 1990-12-06 1994-04-27 Hoechst Ag Dimeric bile acid derivatives; preparatory processes and pharmaceutical compositions
JP2616845B2 (ja) * 1991-02-21 1997-06-04 清水化学株式会社 システノール酸又はその胆汁酸抱合体を含有する血中コレステロール低下剤
GB9203347D0 (en) * 1992-02-17 1992-04-01 Wellcome Found Hypolipidaemic compounds
DK0557879T3 (da) * 1992-02-22 1997-06-16 Hoechst Ag 4-amino-2-ureido-pyrimidin-5-carboxylsyreamider, fremgangsmåde til deres fremstilling, lægemidler med indhold af disse forbindelser og deres anvendelse

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0624593A2 (de) * 1993-05-08 1994-11-17 Hoechst Aktiengesellschaft Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel
US5610151A (en) * 1993-05-08 1997-03-11 Hoechst Aktiengesellschaft Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments
EP0869121A1 (de) * 1997-04-04 1998-10-07 Hoechst Marion Roussel Deutschland GmbH Hypolipidämische Propanolaminderivate

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2525290C2 (ru) * 2008-10-01 2014-08-10 Эксисс Лимитед Желчные кислоты и бигуаниды как ингибиторы протеаз для сохранения целостности пептидов в пищеварительном канале

Also Published As

Publication number Publication date
HUP0103570A3 (en) 2003-01-28
DE19845403B4 (de) 2005-02-10
ID29353A (id) 2001-08-23
BR9915019A (pt) 2001-08-14
EP1117676B1 (de) 2004-08-18
DE59910300D1 (de) 2004-09-23
TR200100897T2 (tr) 2001-10-22
PT1117676E (pt) 2004-11-30
PL347106A1 (en) 2002-03-25
DK1117676T3 (da) 2004-12-20
CN1321166A (zh) 2001-11-07
EP1117676A1 (de) 2001-07-25
AR035003A1 (es) 2004-04-14
WO2000020437A1 (de) 2000-04-13
ZA200102586B (en) 2001-10-03
HUP0103570A2 (hu) 2002-02-28
JP4598953B2 (ja) 2010-12-15
ATE273991T1 (de) 2004-09-15
JP2002526550A (ja) 2002-08-20
HK1040717A1 (zh) 2002-06-21
AU6085599A (en) 2000-04-26
KR20010075511A (ko) 2001-08-09
AU757366B2 (en) 2003-02-20
US6180618B1 (en) 2001-01-30
ES2226440T3 (es) 2005-03-16
CN1227259C (zh) 2005-11-16
DE19845403A1 (de) 2000-04-13
CA2346085A1 (en) 2000-04-13

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20060919