KR20010075511A - 지질대사 장애 치료용으로 사용되는, 담즙산과 결합된프로판올아민 유도체 - Google Patents

지질대사 장애 치료용으로 사용되는, 담즙산과 결합된프로판올아민 유도체 Download PDF

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Publication number
KR20010075511A
KR20010075511A KR1020017004131A KR20017004131A KR20010075511A KR 20010075511 A KR20010075511 A KR 20010075511A KR 1020017004131 A KR1020017004131 A KR 1020017004131A KR 20017004131 A KR20017004131 A KR 20017004131A KR 20010075511 A KR20010075511 A KR 20010075511A
Authority
KR
South Korea
Prior art keywords
compound
alkyl
acid
medicament
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020017004131A
Other languages
English (en)
Korean (ko)
Inventor
슈텐겔린지그프리트
엔젠알폰스
글롬비크하이너
크라머베르너
팔크오이겐
Original Assignee
로버트 흐라이탁, 미쉘 베스트
아벤티스 파마 도이칠란트 게엠베하
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 로버트 흐라이탁, 미쉘 베스트, 아벤티스 파마 도이칠란트 게엠베하 filed Critical 로버트 흐라이탁, 미쉘 베스트
Publication of KR20010075511A publication Critical patent/KR20010075511A/ko
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
KR1020017004131A 1998-10-02 1999-09-18 지질대사 장애 치료용으로 사용되는, 담즙산과 결합된프로판올아민 유도체 Ceased KR20010075511A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19845403A DE19845403B4 (de) 1998-10-02 1998-10-02 Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19845403.1 1998-10-02
PCT/EP1999/006930 WO2000020437A1 (de) 1998-10-02 1999-09-18 Mit gallensäuren verknüpfte propanolaminderivate zur behandlung von lipidstoffwechselstörungen

Publications (1)

Publication Number Publication Date
KR20010075511A true KR20010075511A (ko) 2001-08-09

Family

ID=7883185

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017004131A Ceased KR20010075511A (ko) 1998-10-02 1999-09-18 지질대사 장애 치료용으로 사용되는, 담즙산과 결합된프로판올아민 유도체

Country Status (22)

Country Link
US (1) US6180618B1 (https=)
EP (1) EP1117676B1 (https=)
JP (1) JP4598953B2 (https=)
KR (1) KR20010075511A (https=)
CN (1) CN1227259C (https=)
AR (1) AR035003A1 (https=)
AT (1) ATE273991T1 (https=)
AU (1) AU757366B2 (https=)
BR (1) BR9915019A (https=)
CA (1) CA2346085A1 (https=)
DE (2) DE19845403B4 (https=)
DK (1) DK1117676T3 (https=)
ES (1) ES2226440T3 (https=)
HK (1) HK1040717A1 (https=)
HU (1) HUP0103570A3 (https=)
ID (1) ID29353A (https=)
PL (1) PL347106A1 (https=)
PT (1) PT1117676E (https=)
RU (1) RU2234512C2 (https=)
TR (1) TR200100897T2 (https=)
WO (1) WO2000020437A1 (https=)
ZA (1) ZA200102586B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053076B2 (en) 2001-08-29 2006-05-30 Xenoport, Inc. Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
US7161008B2 (en) * 2002-05-03 2007-01-09 Sanofi - Aventis Deutschland GmbH Optically active β-aminoketones, optically active 1,3-amino alcohols and processes for preparing them
GB0213669D0 (en) * 2002-06-14 2002-07-24 Astrazeneca Ab Chemical compounds
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
GB0817969D0 (en) * 2008-10-01 2008-11-05 Axcess Ltd Pharmaceutical composition
ES2552657T3 (es) 2010-05-26 2015-12-01 Satiogen Pharmaceuticals, Inc. Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias
US20130108573A1 (en) 2011-10-28 2013-05-02 Lumena Pharmaceuticals, Inc. Bile Acid Recycling Inhibitors for Treatment of Hypercholemia and Cholestatic Liver Disease
AU2012328526B2 (en) 2011-10-28 2017-05-25 Shire Human Genetic Therapies, Inc. Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
AU2014229050A1 (en) 2013-03-15 2015-10-22 Lumena Pharmaceuticals Llc Bile acid recycling inhibitors for treatment of Barrett's esophagus and gastroesophageal reflux disease
CA2907230A1 (en) 2013-03-15 2014-09-18 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease
EP3923943B1 (en) 2019-02-12 2024-07-31 Mirum Pharmaceuticals, Inc. Genotype and dose-dependent response to an asbti in patients with bile salt export pump deficiency

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI892341L (fi) 1988-06-10 1989-12-11 Hoffmann La Roche Propanolaminderivat.
GB2250634A (en) * 1990-12-04 1992-06-10 Marconi Gec Ltd Point contact diodes
US5250524A (en) 1990-12-06 1993-10-05 Hoechst Aktiengesellschaft Bile acid derivatives, process for their preparation and use of these compounds as pharmaceuticals
JP2616845B2 (ja) * 1991-02-21 1997-06-04 清水化学株式会社 システノール酸又はその胆汁酸抱合体を含有する血中コレステロール低下剤
GB9203347D0 (en) * 1992-02-17 1992-04-01 Wellcome Found Hypolipidaemic compounds
ATE147384T1 (de) * 1992-02-22 1997-01-15 Hoechst Ag 4-amino-2-ureido-pyrimidin-5-carbonsäureamide, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
TW289021B (https=) * 1993-05-08 1996-10-21 Hoechst Ag
EP0624593A3 (de) * 1993-05-08 1995-06-07 Hoechst Ag Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel.
EP0869121B1 (de) * 1997-04-04 2004-06-09 Aventis Pharma Deutschland GmbH Hypolipidämische Propanolaminderivate

Also Published As

Publication number Publication date
HK1040717A1 (zh) 2002-06-21
WO2000020437A1 (de) 2000-04-13
RU2234512C2 (ru) 2004-08-20
BR9915019A (pt) 2001-08-14
CN1321166A (zh) 2001-11-07
PT1117676E (pt) 2004-11-30
DE19845403A1 (de) 2000-04-13
TR200100897T2 (tr) 2001-10-22
CN1227259C (zh) 2005-11-16
DK1117676T3 (da) 2004-12-20
DE19845403B4 (de) 2005-02-10
ATE273991T1 (de) 2004-09-15
ES2226440T3 (es) 2005-03-16
PL347106A1 (en) 2002-03-25
JP4598953B2 (ja) 2010-12-15
AR035003A1 (es) 2004-04-14
HUP0103570A3 (en) 2003-01-28
US6180618B1 (en) 2001-01-30
JP2002526550A (ja) 2002-08-20
ID29353A (id) 2001-08-23
DE59910300D1 (de) 2004-09-23
EP1117676B1 (de) 2004-08-18
CA2346085A1 (en) 2000-04-13
EP1117676A1 (de) 2001-07-25
AU757366B2 (en) 2003-02-20
HUP0103570A2 (hu) 2002-02-28
ZA200102586B (en) 2001-10-03
AU6085599A (en) 2000-04-26

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Patent event date: 20010330

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