ES2226440T3 - Derivados de propanolamina enlazados biliares para el tratamiento de trastornos del metabolismo de los lipidos. - Google Patents
Derivados de propanolamina enlazados biliares para el tratamiento de trastornos del metabolismo de los lipidos.Info
- Publication number
- ES2226440T3 ES2226440T3 ES99947385T ES99947385T ES2226440T3 ES 2226440 T3 ES2226440 T3 ES 2226440T3 ES 99947385 T ES99947385 T ES 99947385T ES 99947385 T ES99947385 T ES 99947385T ES 2226440 T3 ES2226440 T3 ES 2226440T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- link
- compounds
- amino acid
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract description 14
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- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 4
- 239000000203 mixture Substances 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 16
- 238000002360 preparation method Methods 0.000 claims description 14
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 10
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 208000031226 Hyperlipidaemia Diseases 0.000 claims description 4
- 230000037356 lipid metabolism Effects 0.000 claims description 4
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- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 30
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 description 28
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| DE19845403A DE19845403B4 (de) | 1998-10-02 | 1998-10-02 | Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| DE19845403 | 1998-10-02 |
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| ES2226440T3 true ES2226440T3 (es) | 2005-03-16 |
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| ES99947385T Expired - Lifetime ES2226440T3 (es) | 1998-10-02 | 1999-09-18 | Derivados de propanolamina enlazados biliares para el tratamiento de trastornos del metabolismo de los lipidos. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6180618B1 (https=) |
| EP (1) | EP1117676B1 (https=) |
| JP (1) | JP4598953B2 (https=) |
| KR (1) | KR20010075511A (https=) |
| CN (1) | CN1227259C (https=) |
| AR (1) | AR035003A1 (https=) |
| AT (1) | ATE273991T1 (https=) |
| AU (1) | AU757366B2 (https=) |
| BR (1) | BR9915019A (https=) |
| CA (1) | CA2346085A1 (https=) |
| DE (2) | DE19845403B4 (https=) |
| DK (1) | DK1117676T3 (https=) |
| ES (1) | ES2226440T3 (https=) |
| HK (1) | HK1040717A1 (https=) |
| HU (1) | HUP0103570A3 (https=) |
| ID (1) | ID29353A (https=) |
| PL (1) | PL347106A1 (https=) |
| PT (1) | PT1117676E (https=) |
| RU (1) | RU2234512C2 (https=) |
| TR (1) | TR200100897T2 (https=) |
| WO (1) | WO2000020437A1 (https=) |
| ZA (1) | ZA200102586B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7053076B2 (en) | 2001-08-29 | 2006-05-30 | Xenoport, Inc. | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs |
| US7161008B2 (en) * | 2002-05-03 | 2007-01-09 | Sanofi - Aventis Deutschland GmbH | Optically active β-aminoketones, optically active 1,3-amino alcohols and processes for preparing them |
| GB0213669D0 (en) * | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| GB0817969D0 (en) * | 2008-10-01 | 2008-11-05 | Axcess Ltd | Pharmaceutical composition |
| ES2552657T3 (es) | 2010-05-26 | 2015-12-01 | Satiogen Pharmaceuticals, Inc. | Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias |
| US20130108573A1 (en) | 2011-10-28 | 2013-05-02 | Lumena Pharmaceuticals, Inc. | Bile Acid Recycling Inhibitors for Treatment of Hypercholemia and Cholestatic Liver Disease |
| AU2012328526B2 (en) | 2011-10-28 | 2017-05-25 | Shire Human Genetic Therapies, Inc. | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| AU2014229050A1 (en) | 2013-03-15 | 2015-10-22 | Lumena Pharmaceuticals Llc | Bile acid recycling inhibitors for treatment of Barrett's esophagus and gastroesophageal reflux disease |
| CA2907230A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
| EP3923943B1 (en) | 2019-02-12 | 2024-07-31 | Mirum Pharmaceuticals, Inc. | Genotype and dose-dependent response to an asbti in patients with bile salt export pump deficiency |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI892341L (fi) | 1988-06-10 | 1989-12-11 | Hoffmann La Roche | Propanolaminderivat. |
| GB2250634A (en) * | 1990-12-04 | 1992-06-10 | Marconi Gec Ltd | Point contact diodes |
| US5250524A (en) | 1990-12-06 | 1993-10-05 | Hoechst Aktiengesellschaft | Bile acid derivatives, process for their preparation and use of these compounds as pharmaceuticals |
| JP2616845B2 (ja) * | 1991-02-21 | 1997-06-04 | 清水化学株式会社 | システノール酸又はその胆汁酸抱合体を含有する血中コレステロール低下剤 |
| GB9203347D0 (en) * | 1992-02-17 | 1992-04-01 | Wellcome Found | Hypolipidaemic compounds |
| ATE147384T1 (de) * | 1992-02-22 | 1997-01-15 | Hoechst Ag | 4-amino-2-ureido-pyrimidin-5-carbonsäureamide, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| TW289021B (https=) * | 1993-05-08 | 1996-10-21 | Hoechst Ag | |
| EP0624593A3 (de) * | 1993-05-08 | 1995-06-07 | Hoechst Ag | Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel. |
| EP0869121B1 (de) * | 1997-04-04 | 2004-06-09 | Aventis Pharma Deutschland GmbH | Hypolipidämische Propanolaminderivate |
-
1998
- 1998-10-02 DE DE19845403A patent/DE19845403B4/de not_active Expired - Fee Related
-
1999
- 1999-09-18 DK DK99947385T patent/DK1117676T3/da active
- 1999-09-18 JP JP2000574548A patent/JP4598953B2/ja not_active Expired - Fee Related
- 1999-09-18 DE DE59910300T patent/DE59910300D1/de not_active Expired - Lifetime
- 1999-09-18 HK HK02102338.5A patent/HK1040717A1/zh unknown
- 1999-09-18 BR BR9915019-0A patent/BR9915019A/pt not_active IP Right Cessation
- 1999-09-18 ES ES99947385T patent/ES2226440T3/es not_active Expired - Lifetime
- 1999-09-18 AU AU60855/99A patent/AU757366B2/en not_active Ceased
- 1999-09-18 HU HU0103570A patent/HUP0103570A3/hu unknown
- 1999-09-18 ID IDW20010737A patent/ID29353A/id unknown
- 1999-09-18 AT AT99947385T patent/ATE273991T1/de not_active IP Right Cessation
- 1999-09-18 PL PL99347106A patent/PL347106A1/xx unknown
- 1999-09-18 PT PT99947385T patent/PT1117676E/pt unknown
- 1999-09-18 EP EP99947385A patent/EP1117676B1/de not_active Expired - Lifetime
- 1999-09-18 CN CNB998116343A patent/CN1227259C/zh not_active Expired - Fee Related
- 1999-09-18 KR KR1020017004131A patent/KR20010075511A/ko not_active Ceased
- 1999-09-18 WO PCT/EP1999/006930 patent/WO2000020437A1/de not_active Ceased
- 1999-09-18 RU RU2001111816/04A patent/RU2234512C2/ru not_active IP Right Cessation
- 1999-09-18 TR TR2001/00897T patent/TR200100897T2/xx unknown
- 1999-09-18 CA CA002346085A patent/CA2346085A1/en not_active Abandoned
- 1999-09-29 US US09/408,169 patent/US6180618B1/en not_active Expired - Lifetime
- 1999-09-30 AR ARP990104961A patent/AR035003A1/es unknown
-
2001
- 2001-03-29 ZA ZA200102586A patent/ZA200102586B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1040717A1 (zh) | 2002-06-21 |
| WO2000020437A1 (de) | 2000-04-13 |
| KR20010075511A (ko) | 2001-08-09 |
| RU2234512C2 (ru) | 2004-08-20 |
| BR9915019A (pt) | 2001-08-14 |
| CN1321166A (zh) | 2001-11-07 |
| PT1117676E (pt) | 2004-11-30 |
| DE19845403A1 (de) | 2000-04-13 |
| TR200100897T2 (tr) | 2001-10-22 |
| CN1227259C (zh) | 2005-11-16 |
| DK1117676T3 (da) | 2004-12-20 |
| DE19845403B4 (de) | 2005-02-10 |
| ATE273991T1 (de) | 2004-09-15 |
| PL347106A1 (en) | 2002-03-25 |
| JP4598953B2 (ja) | 2010-12-15 |
| AR035003A1 (es) | 2004-04-14 |
| HUP0103570A3 (en) | 2003-01-28 |
| US6180618B1 (en) | 2001-01-30 |
| JP2002526550A (ja) | 2002-08-20 |
| ID29353A (id) | 2001-08-23 |
| DE59910300D1 (de) | 2004-09-23 |
| EP1117676B1 (de) | 2004-08-18 |
| CA2346085A1 (en) | 2000-04-13 |
| EP1117676A1 (de) | 2001-07-25 |
| AU757366B2 (en) | 2003-02-20 |
| HUP0103570A2 (hu) | 2002-02-28 |
| ZA200102586B (en) | 2001-10-03 |
| AU6085599A (en) | 2000-04-26 |
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