JP2002520382A - インテグリン阻害剤としてのジアシルヒドラジン誘導体 - Google Patents
インテグリン阻害剤としてのジアシルヒドラジン誘導体Info
- Publication number
- JP2002520382A JP2002520382A JP2000560082A JP2000560082A JP2002520382A JP 2002520382 A JP2002520382 A JP 2002520382A JP 2000560082 A JP2000560082 A JP 2000560082A JP 2000560082 A JP2000560082 A JP 2000560082A JP 2002520382 A JP2002520382 A JP 2002520382A
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- JP
- Japan
- Prior art keywords
- formula
- compound
- acid
- salts
- het
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 4
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 4
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19831710A DE19831710A1 (de) | 1998-07-15 | 1998-07-15 | Diacylhydrazinderivate |
| DE19831710.7 | 1998-07-15 | ||
| PCT/EP1999/004673 WO2000003973A1 (de) | 1998-07-15 | 1999-07-06 | Diacylhydrazinderivate als integrin-inhibitoren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002520382A true JP2002520382A (ja) | 2002-07-09 |
| JP2002520382A5 JP2002520382A5 (enExample) | 2006-08-31 |
Family
ID=7874107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000560082A Pending JP2002520382A (ja) | 1998-07-15 | 1999-07-06 | インテグリン阻害剤としてのジアシルヒドラジン誘導体 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6326403B1 (enExample) |
| EP (1) | EP1097127B1 (enExample) |
| JP (1) | JP2002520382A (enExample) |
| KR (1) | KR20010079520A (enExample) |
| CN (1) | CN1309633A (enExample) |
| AR (1) | AR019777A1 (enExample) |
| AT (1) | ATE234276T1 (enExample) |
| AU (1) | AU753333B2 (enExample) |
| BR (1) | BR9912072A (enExample) |
| CA (1) | CA2337305A1 (enExample) |
| DE (2) | DE19831710A1 (enExample) |
| DK (1) | DK1097127T3 (enExample) |
| ES (1) | ES2194486T3 (enExample) |
| HU (1) | HUP0102602A3 (enExample) |
| ID (1) | ID27168A (enExample) |
| NO (1) | NO20010203L (enExample) |
| PL (1) | PL345398A1 (enExample) |
| PT (1) | PT1097127E (enExample) |
| SK (1) | SK412001A3 (enExample) |
| TW (1) | TW448145B (enExample) |
| WO (1) | WO2000003973A1 (enExample) |
| ZA (1) | ZA200101267B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000072881A1 (en) * | 1999-06-01 | 2000-12-07 | Biogen, Inc. | A blocking monoclonal antibody to vla-1 and its use for the treatment of inflammatory disorders |
| UY26664A1 (es) * | 2000-04-14 | 2001-11-30 | Abbott Lab | Hidrazidas y alcoxiamidas inhibidoras de la angiogénesis. |
| US20020002152A1 (en) | 2000-04-14 | 2002-01-03 | Craig Richard A. | Hydrazide and alkoxyamide angiogenesis inhibitors |
| DE10040105A1 (de) | 2000-08-17 | 2002-02-28 | Merck Patent Gmbh | Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften |
| DE10040103A1 (de) | 2000-08-17 | 2002-02-28 | Merck Patent Gmbh | Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften II |
| DZ3415A1 (fr) * | 2000-08-31 | 2002-03-07 | Chiron Corp | Guanidinobenzamides comme mc4-r agonistes. |
| DK1385823T3 (da) | 2001-04-09 | 2007-03-26 | Novartis Vaccines & Diagnostic | Guanidinoforbindelser som melanocortin-4-receptor- (MC4-R) -agonister |
| US7358054B2 (en) | 2001-04-13 | 2008-04-15 | Biogen Idec Ma Inc. | Antibodies to VLA-1 |
| AU2003245325A1 (en) | 2002-05-23 | 2003-12-12 | Chiron Corporation | Substituted quinazolinone compounds |
| US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| US7304161B2 (en) * | 2003-02-10 | 2007-12-04 | Intrexon Corporation | Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex |
| US7456315B2 (en) * | 2003-02-28 | 2008-11-25 | Intrexon Corporation | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
| CA2523015A1 (en) | 2003-05-23 | 2004-12-29 | Chiron Corporation | Guanidino-substituted quinazolinone compounds as mc4-r agonists |
| DE10325049A1 (de) * | 2003-06-02 | 2004-12-23 | Merck Patent Gmbh | Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften III |
| MXPA06005736A (es) | 2003-11-19 | 2006-12-14 | Chiron Corp | Compuestos de quinazolinona con bioacumulacion reducida. |
| EP1765362B1 (en) | 2004-06-04 | 2012-03-28 | The Scripps Research Institute | Compositions and methods for treatment of neovascular diseases |
| JP4745175B2 (ja) * | 2005-12-28 | 2011-08-10 | 本田技研工業株式会社 | 自動二輪車 |
| BRPI0712607A8 (pt) * | 2006-05-25 | 2019-06-04 | Biogen Idec Inc | métodos de tratamento de acidente vascular cerebral |
| US8076517B2 (en) | 2007-05-29 | 2011-12-13 | Intrexon Corporation | Chiral diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
| ES2732243T3 (es) | 2012-02-16 | 2019-11-21 | Santarus Inc | Composiciones farmacéuticas de anticuerpos ANTI-VLA1 (CD49A) |
| RU2637946C2 (ru) | 2013-03-15 | 2017-12-08 | Интрексон Корпорейшн | Борсодержащие диацилгидразины |
| RU2016146826A (ru) | 2014-05-30 | 2018-07-04 | Пфайзер Инк. | Производные карбонитрилов как селективные модуляторы андрогенового рецептора |
| CN104027805B (zh) * | 2014-06-18 | 2017-02-15 | 北京大学 | 抑制整合素α5的物质在制备预防内皮细胞激活和/或动脉粥样硬化的产品中的新用途 |
| WO2016044390A1 (en) | 2014-09-17 | 2016-03-24 | Intrexon Corporation | Boron-containing diacylhydrazine compounds |
| BR112020006901A2 (pt) | 2017-11-01 | 2020-10-13 | Arrowhead Pharmaceuticals, Inc. | ligantes de integrina e usos dos mesmos |
| EP4319765A1 (en) | 2021-04-08 | 2024-02-14 | Arrowhead Pharmaceuticals, Inc. | Rnai agents for inhibiting expression of receptor for advanced glycation end-products, compositions thereof, and methods of use |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5051405A (en) * | 1989-10-10 | 1991-09-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Anti-thrombotic peptides and pseudopeptides |
| WO1992013552A1 (en) * | 1991-02-05 | 1992-08-20 | Smithkline Beecham Corporation | Anti-aggregatory peptides containing an aromatic ester or amide |
| US5530028A (en) * | 1992-11-23 | 1996-06-25 | Rohm And Haas Company | Insecticidal N'-substituted-N,N'-diacylhydrazines |
| EP0677043A1 (en) * | 1992-12-29 | 1995-10-18 | Smithkline Beecham Corporation | Platelet aggregation inhibiting compounds |
| ES2186720T3 (es) | 1994-05-27 | 2003-05-16 | Merck & Co Inc | Composiciones para inhibir la reabsorcion osea mediada por osteoclastos. |
| US5482962A (en) * | 1994-07-22 | 1996-01-09 | Rohm And Haas Company | Insecticidal N,N'-disubstituted-N-N'-diacylhydrazines |
| WO1997026250A1 (en) * | 1996-01-16 | 1997-07-24 | Merck & Co., Inc. | Integrin receptor antagonists |
-
1998
- 1998-07-15 DE DE19831710A patent/DE19831710A1/de not_active Withdrawn
-
1999
- 1999-07-06 DE DE59904547T patent/DE59904547D1/de not_active Expired - Fee Related
- 1999-07-06 JP JP2000560082A patent/JP2002520382A/ja active Pending
- 1999-07-06 KR KR1020017000359A patent/KR20010079520A/ko not_active Withdrawn
- 1999-07-06 PT PT99934576T patent/PT1097127E/pt unknown
- 1999-07-06 SK SK41-2001A patent/SK412001A3/sk unknown
- 1999-07-06 WO PCT/EP1999/004673 patent/WO2000003973A1/de not_active Ceased
- 1999-07-06 AU AU50313/99A patent/AU753333B2/en not_active Ceased
- 1999-07-06 ID IDW20010206A patent/ID27168A/id unknown
- 1999-07-06 US US09/743,605 patent/US6326403B1/en not_active Expired - Fee Related
- 1999-07-06 PL PL99345398A patent/PL345398A1/xx unknown
- 1999-07-06 CA CA002337305A patent/CA2337305A1/en not_active Abandoned
- 1999-07-06 ES ES99934576T patent/ES2194486T3/es not_active Expired - Lifetime
- 1999-07-06 EP EP99934576A patent/EP1097127B1/de not_active Expired - Lifetime
- 1999-07-06 AT AT99934576T patent/ATE234276T1/de not_active IP Right Cessation
- 1999-07-06 HU HU0102602A patent/HUP0102602A3/hu unknown
- 1999-07-06 DK DK99934576T patent/DK1097127T3/da active
- 1999-07-06 CN CN99808610A patent/CN1309633A/zh active Pending
- 1999-07-06 BR BR9912072-0A patent/BR9912072A/pt not_active IP Right Cessation
- 1999-07-13 TW TW088111860A patent/TW448145B/zh active
- 1999-07-14 AR ARP990103436A patent/AR019777A1/es not_active Application Discontinuation
-
2001
- 2001-01-12 NO NO20010203A patent/NO20010203L/no not_active Application Discontinuation
- 2001-02-14 ZA ZA200101267A patent/ZA200101267B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200101267B (en) | 2002-10-04 |
| HUP0102602A2 (hu) | 2002-01-28 |
| AU753333B2 (en) | 2002-10-17 |
| SK412001A3 (en) | 2001-08-06 |
| BR9912072A (pt) | 2001-09-25 |
| CN1309633A (zh) | 2001-08-22 |
| AR019777A1 (es) | 2002-03-13 |
| US6326403B1 (en) | 2001-12-04 |
| EP1097127B1 (de) | 2003-03-12 |
| PL345398A1 (en) | 2001-12-17 |
| NO20010203D0 (no) | 2001-01-12 |
| CA2337305A1 (en) | 2000-01-27 |
| KR20010079520A (ko) | 2001-08-22 |
| PT1097127E (pt) | 2003-07-31 |
| NO20010203L (no) | 2001-01-12 |
| HUP0102602A3 (en) | 2002-02-28 |
| ES2194486T3 (es) | 2003-11-16 |
| WO2000003973A1 (de) | 2000-01-27 |
| DK1097127T3 (da) | 2003-06-10 |
| AU5031399A (en) | 2000-02-07 |
| ID27168A (id) | 2001-03-08 |
| DE19831710A1 (de) | 2000-01-20 |
| DE59904547D1 (de) | 2003-04-17 |
| EP1097127A1 (de) | 2001-05-09 |
| TW448145B (en) | 2001-08-01 |
| ATE234276T1 (de) | 2003-03-15 |
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