JP2002520323A5 - - Google Patents

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Publication number
JP2002520323A5
JP2002520323A5 JP2000559101A JP2000559101A JP2002520323A5 JP 2002520323 A5 JP2002520323 A5 JP 2002520323A5 JP 2000559101 A JP2000559101 A JP 2000559101A JP 2000559101 A JP2000559101 A JP 2000559101A JP 2002520323 A5 JP2002520323 A5 JP 2002520323A5
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JP
Japan
Prior art keywords
methylene
phenylenebis
composition
aminomethyl
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2000559101A
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English (en)
Japanese (ja)
Other versions
JP4637353B2 (ja
JP2002520323A (ja
Filing date
Publication date
Priority claimed from US09/111,895 external-priority patent/US6506770B1/en
Application filed filed Critical
Publication of JP2002520323A publication Critical patent/JP2002520323A/ja
Publication of JP2002520323A5 publication Critical patent/JP2002520323A5/ja
Application granted granted Critical
Publication of JP4637353B2 publication Critical patent/JP4637353B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2000559101A 1998-07-08 1999-07-08 抗ウイルス性大環状化合物 Expired - Lifetime JP4637353B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/111,895 1998-07-08
US09/111,895 US6506770B1 (en) 1996-06-06 1998-07-08 Antiviral compounds
PCT/CA1999/000619 WO2000002870A1 (en) 1998-07-08 1999-07-08 Antiviral macrocyclic compounds

Publications (3)

Publication Number Publication Date
JP2002520323A JP2002520323A (ja) 2002-07-09
JP2002520323A5 true JP2002520323A5 (enExample) 2005-09-15
JP4637353B2 JP4637353B2 (ja) 2011-02-23

Family

ID=22341015

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000559101A Expired - Lifetime JP4637353B2 (ja) 1998-07-08 1999-07-08 抗ウイルス性大環状化合物

Country Status (17)

Country Link
US (6) US6506770B1 (enExample)
EP (1) EP1095031B1 (enExample)
JP (1) JP4637353B2 (enExample)
KR (1) KR100778134B1 (enExample)
CN (2) CN100339080C (enExample)
AP (1) AP1436A (enExample)
AU (1) AU767359B2 (enExample)
BR (1) BR9912524A (enExample)
CA (1) CA2336634C (enExample)
HU (1) HUP0102930A3 (enExample)
IL (1) IL140605A0 (enExample)
MX (1) MXPA01000137A (enExample)
NO (1) NO20010047L (enExample)
NZ (1) NZ509699A (enExample)
PL (1) PL345516A1 (enExample)
TR (1) TR200100030T2 (enExample)
WO (1) WO2000002870A1 (enExample)

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US7169750B2 (en) * 2001-07-31 2007-01-30 Anormed, Inc. Methods to mobilize progenitor/stem cells
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US7501526B2 (en) 2005-01-20 2009-03-10 Taigen Biotechnology Synthesis of polyamine compounds
US7825088B2 (en) * 2005-04-25 2010-11-02 The Cbr Institute For Biomedical Research, Inc. Methods for the treatment of multiple myeloma
US8569280B2 (en) * 2005-04-25 2013-10-29 Immune Disease Institute Methods for the treatment of multiple myeloma
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BRPI0715393A2 (pt) * 2006-08-07 2013-06-25 Genzyme Corp terapia de combinaÇço
US20090274687A1 (en) * 2008-05-02 2009-11-05 University Of Miami Attenuation of hypoxia induced cardiovascular disorders
JP2012516354A (ja) * 2009-01-30 2012-07-19 ジェンザイム・コーポレーション 乳癌を治療するための方法及び組成物
CA2760292A1 (en) * 2009-05-01 2010-11-04 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
WO2012037034A1 (en) 2010-09-14 2012-03-22 Glycomimetics, Inc. E-selectin antagonists
GB201017345D0 (en) 2010-10-14 2010-11-24 Proximagen Ltd Receptor antagonists
WO2012061662A1 (en) * 2010-11-03 2012-05-10 Glycomimetics, Inc. Glycomimetic-peptidomimetic inhibitors of e-selectins and cxcr4 chemokine receptors
EP2709991B1 (en) 2011-05-16 2020-09-02 Genzyme Corporation Use of cxcr4 antagonists for treating WHIM syndrome, myelokathexis, neutropenia and lymphocytopenia
CN103159690B (zh) * 2011-12-14 2015-03-25 朱靖华 对称大环胺化合物的结晶形式
WO2013096926A1 (en) 2011-12-22 2013-06-27 Glycomimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use
PT2928476T (pt) 2012-12-07 2018-05-10 Glycomimetics Inc Compostos, composições e métodos que utilizam antagonistas de e-selectina para mobilização de células hematopoiéticas
CN103058998B (zh) * 2013-01-16 2016-04-13 山东鲁北药业有限公司 一种amd3465的制备工艺
WO2016089872A1 (en) 2014-12-03 2016-06-09 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
PL3277284T3 (pl) 2015-04-02 2021-03-08 Proximagen, Llc Nowe terapie nowotworu
WO2017011517A1 (en) 2015-07-16 2017-01-19 Emory University Bis-amines, compositions, and uses related to cxcr4 inhibition
CA3000844A1 (en) * 2015-10-19 2017-04-27 Ramot At Tel-Aviv University Ltd. Methods and compositions for treating neurodegenerative diseases
US10953003B2 (en) 2015-12-14 2021-03-23 X4 Pharmaceuticals, Inc. Methods for treating cancer
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ES2935834T3 (es) 2015-12-22 2023-03-10 X4 Pharmaceuticals Inc Métodos para tratar enfermedad de inmunodeficiencia
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
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US11433048B2 (en) 2016-06-16 2022-09-06 Centre National De La Recherche Scientifique CXCR4 receptor-binding compounds useful for increasing interferon level
CN109562106B (zh) 2016-06-21 2023-03-21 X4 制药有限公司 Cxcr4抑制剂及其用途
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US11072625B2 (en) 2016-10-07 2021-07-27 Glycomimetics, Inc. Highly potent multimeric e-selectin antagonists
CA3054605A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
CN111542597A (zh) 2017-10-31 2020-08-14 美真达治疗公司 用于扩增造血干细胞和祖细胞的组合物和方法
JP2021503008A (ja) 2017-10-31 2021-02-04 マジェンタ セラピューティクス インコーポレイテッドMagenta Therapeutics, Inc. 造血幹細胞および前駆細胞移植療法のための組成物および方法
US11712446B2 (en) 2017-11-30 2023-08-01 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
US10058573B1 (en) 2017-12-06 2018-08-28 Magenta Therapeutics, Inc. Dosing regimens for the mobilization of hematopoietic stem cells
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US11260079B2 (en) 2017-12-06 2022-03-01 Magenta Therapeutics, Inc. Dosing regimens for the mobilization of hematopoietic stem and progenitor cells
BR112020013198A2 (pt) 2017-12-29 2020-12-01 Glycomimetics, Inc. inibidores heterobifuncionais de e-selectina e galectina-3
CN109988153B (zh) * 2017-12-29 2021-11-19 深圳夏浠湾医药科技有限公司 一种川芎嗪衍生物及其制备方法和应用
US20200338132A1 (en) 2018-01-03 2020-10-29 Magenta Therapeutics Inc. Compositions and methods for the expansion of hematopoietic stem and progenitor cells and treatment of inherited metabolic disorders
KR20200128025A (ko) 2018-03-05 2020-11-11 글리코미메틱스, 인크. 급성 골수성 백혈병 및 관련 병태의 치료 방법
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GB9105489D0 (en) 1991-03-15 1991-05-01 Johnson Matthey Plc Improvements in chemical compounds
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US6506770B1 (en) 1996-06-06 2003-01-14 Anormed, Inc. Antiviral compounds
WO2000009152A1 (en) 1998-08-14 2000-02-24 The University Of British Columbia Therapeutic chemokine receptor antagonists
WO1999047158A2 (en) 1998-03-13 1999-09-23 The University Of British Columbia Therapeutic chemokine receptor antagonists
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