JP2002516277A5 - - Google Patents
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- Publication number
- JP2002516277A5 JP2002516277A5 JP2000550480A JP2000550480A JP2002516277A5 JP 2002516277 A5 JP2002516277 A5 JP 2002516277A5 JP 2000550480 A JP2000550480 A JP 2000550480A JP 2000550480 A JP2000550480 A JP 2000550480A JP 2002516277 A5 JP2002516277 A5 JP 2002516277A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- embedded image
- group
- aryl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 7
- 125000003118 aryl group Chemical group 0.000 description 5
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 description 4
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 4
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 4
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 4
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 4
- 125000000623 heterocyclic group Chemical group 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- 125000003545 alkoxy group Chemical group 0.000 description 3
- 125000003282 alkyl amino group Chemical group 0.000 description 3
- 208000030961 allergic reaction Diseases 0.000 description 3
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 description 3
- 125000004093 cyano group Chemical group *C#N 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- 150000002367 halogens Chemical class 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- 125000003107 substituted aryl group Chemical group 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- -1 COCF 3 Chemical group 0.000 description 2
- 239000000048 adrenergic agonist Substances 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 150000005350 bicyclononyls Chemical group 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- ARUKYTASOALXFG-UHFFFAOYSA-N cycloheptylcycloheptane Chemical group C1CCCCCC1C1CCCCCC1 ARUKYTASOALXFG-UHFFFAOYSA-N 0.000 description 2
- NLUNLVTVUDIHFE-UHFFFAOYSA-N cyclooctylcyclooctane Chemical group C1CCCCCCC1C1CCCCCCC1 NLUNLVTVUDIHFE-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 2
- 0 O=C(Cc1ccc[s]1)*c(cc1)cc2c1[n]c(-c(cc1)ccc1NC(Cc1ccc[s]1)=O)n2 Chemical compound O=C(Cc1ccc[s]1)*c(cc1)cc2c1[n]c(-c(cc1)ccc1NC(Cc1ccc[s]1)=O)n2 0.000 description 1
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 230000001078 anti-cholinergic effect Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000003199 leukotriene receptor blocking agent Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8649498P | 1998-05-22 | 1998-05-22 | |
| US60/086,494 | 1998-05-22 | ||
| PCT/US1999/011490 WO1999061020A1 (en) | 1998-05-22 | 1999-05-21 | BENZIMIDAZOLE ANALOGS AS DOWN-REGULATORS OF IgE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002516277A JP2002516277A (ja) | 2002-06-04 |
| JP2002516277A5 true JP2002516277A5 (enExample) | 2006-07-20 |
Family
ID=22198947
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000550473A Withdrawn JP2002516274A (ja) | 1998-05-22 | 1999-05-21 | ＩｇＥ影響特性を有する化合物 |
| JP2000550479A Pending JP2002516276A (ja) | 1998-05-22 | 1999-05-21 | ＩｇＥのモジュレータとしてのベンゾイミダゾール誘導体 |
| JP2000550480A Pending JP2002516277A (ja) | 1998-05-22 | 1999-05-21 | ＩｇＥのダウンレギュレータとしてのベンゾイミダゾールアナログ |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000550473A Withdrawn JP2002516274A (ja) | 1998-05-22 | 1999-05-21 | ＩｇＥ影響特性を有する化合物 |
| JP2000550479A Pending JP2002516276A (ja) | 1998-05-22 | 1999-05-21 | ＩｇＥのモジュレータとしてのベンゾイミダゾール誘導体 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6271390B1 (enExample) |
| EP (3) | EP1079830A1 (enExample) |
| JP (3) | JP2002516274A (enExample) |
| KR (1) | KR100591652B1 (enExample) |
| CN (4) | CN1317965A (enExample) |
| AT (1) | ATE292465T1 (enExample) |
| AU (3) | AU754943B2 (enExample) |
| BR (3) | BR9910642A (enExample) |
| CA (3) | CA2332989A1 (enExample) |
| CZ (2) | CZ20004351A3 (enExample) |
| DE (1) | DE69924607T2 (enExample) |
| ES (1) | ES2241285T3 (enExample) |
| HU (3) | HUP0102128A3 (enExample) |
| IL (3) | IL139826A0 (enExample) |
| MX (3) | MXPA00011467A (enExample) |
| NO (3) | NO20005889L (enExample) |
| NZ (2) | NZ508416A (enExample) |
| PL (3) | PL345952A1 (enExample) |
| RU (2) | RU2236220C2 (enExample) |
| UA (2) | UA67774C2 (enExample) |
| WO (3) | WO1999061019A1 (enExample) |
| ZA (3) | ZA200007754B (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL139826A0 (en) * | 1998-05-22 | 2002-02-10 | Avanir Pharmaceuticals | BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF IgE |
| US6911462B2 (en) | 1998-05-22 | 2005-06-28 | Avanir Pharmaceuticals | Benzimidazole compounds for regulating IgE |
| US6919366B2 (en) * | 1998-05-22 | 2005-07-19 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of IgE |
| KR20010079782A (ko) | 1998-09-11 | 2001-08-22 | 에가시라 구니오 | 벤젠 유도체 및 이의 의약 용도 |
| US6270746B1 (en) * | 1999-02-17 | 2001-08-07 | David H. Katz | Assay for the identification of IgE antibody suppressors |
| ES2345921T3 (es) * | 1999-03-26 | 2010-10-06 | Euro-Celtique S.A. | Pirazoles, imidazoles, oxazoles, tiazoles y pirroles sustituidos con arilo y su uso. |
| CN1372548A (zh) | 1999-07-01 | 2002-10-02 | 味之素株式会社 | 杂环化合物及其医药用途 |
| EP1211240A4 (en) | 1999-09-01 | 2003-02-12 | Ajinomoto Kk | BISCYCLOPROPANOCARBOXYLIC ACID AMIDE COMPOUNDS AND MEDICINAL USE THEREOF |
| US6759425B2 (en) | 1999-10-21 | 2004-07-06 | Avanir Pharmaceuticals | Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
| US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| US20070208087A1 (en) | 2001-11-02 | 2007-09-06 | Sanders Virginia J | Compounds, compositions and methods for the treatment of inflammatory diseases |
| CA2441177A1 (en) * | 2001-03-12 | 2002-09-19 | Avanir Pharmaceuticals | Benzimidazole compounds for modulating ige and inhibiting cellular proliferation |
| EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
| JP4658473B2 (ja) * | 2001-07-27 | 2011-03-23 | キュリス，インコーポレイテッド | ヘッジホッグシグナル伝達経路メディエーター、それに関連した組成物及び利用 |
| BR0206161A (pt) | 2001-10-19 | 2005-02-01 | Ortho Mcneil Pharm Inc | 2-fenil benzimidazóis e imidazo-[4,5]-piridinas como inibidores de cds1/chk2 e adjuvantes para quimioterapia ou terapia por radiação no tratamento de câncer |
| US20080081788A1 (en) * | 2002-01-14 | 2008-04-03 | Lipps Binie V | Diagnosis and treatment for immunoglobulin E (IgE) implicated disorders |
| US20030157555A1 (en) * | 2002-01-14 | 2003-08-21 | Lipps Binie V. | Diagnosis and treatment for immunoglobulin E ( IgE) implicated disorders |
| TW200304820A (en) * | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
| PT1511710E (pt) | 2002-05-31 | 2014-02-26 | Proteotech Inc | Compostos, composições e métodos para o tratamento de doenças da amiloide e sinucleínopatias tais como doença de alzheimer, diabetes do tipo 2, e doença de parkinson |
| EP1388535A1 (en) | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylated arylcycloalkylamines and their use as pharmaceuticals |
| JP4459810B2 (ja) | 2002-08-14 | 2010-04-28 | マクロジェニクス，インコーポレーテッド | ＦｃγＲＩＩＢ特異的抗体とその利用法 |
| TWI276631B (en) | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
| WO2004024655A2 (en) | 2002-09-12 | 2004-03-25 | Avanir Pharmaceuticals | Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation |
| US20050239844A1 (en) * | 2002-11-02 | 2005-10-27 | Kyung-Lim Lee | Composition fo preventing secretion of immunoglobulin e-dependent histamine releasing factor |
| GB2397301A (en) * | 2003-01-14 | 2004-07-21 | Novo Pharmaceuticals Ltd De | Substituted 1,3,5-triazine derivatives |
| US7132440B2 (en) | 2003-04-17 | 2006-11-07 | Janssen Pharmaceutica, N.V. | Substituted benzimidazoles and imidazo-[4,5]-pyridines |
| CA2533990A1 (en) * | 2003-08-08 | 2005-02-17 | Avanir Pharmaceuticals | Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases |
| PL1718608T3 (pl) | 2004-02-20 | 2013-11-29 | Boehringer Ingelheim Int | Inhibitory polimerazy wirusowej |
| EP1751097B1 (en) * | 2004-05-12 | 2009-12-30 | Proteotech, Inc. | Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies |
| WO2006004791A1 (en) | 2004-06-30 | 2006-01-12 | Janssen Pharmaceutica, N.V. | Aryl-substituted benzimidazole and imidazopyridine ethers as anti-cancer agents |
| WO2006040645A1 (en) * | 2004-10-11 | 2006-04-20 | Ranbaxy Laboratories Limited | N-(3,5-dichloropyridin-4-yl)-2,4,5-alkoxy and 2,3,4-alkoxy benzamide derivatives as pde-iv (phophodiesterase type-iv) inhibitors for the treatment of inflammatory diseases such as asthma |
| ATE533485T1 (de) † | 2005-10-31 | 2011-12-15 | Merck Sharp & Dohme | Cetp-inhibitoren |
| EP1790345A1 (en) * | 2005-11-02 | 2007-05-30 | Esbatech AG | Triazin beta-secretase inhibitors |
| US7671221B2 (en) * | 2005-12-28 | 2010-03-02 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| CN101395147B (zh) * | 2005-12-28 | 2013-05-29 | 弗特克斯药品有限公司 | 作为atp-结合盒转运蛋白调节剂用于治疗囊性纤维化的1-(苯并[d][1,3]间二氧杂环戊烯-5-基)-n-(苯基)环丙烷-甲酰胺衍生物及相关化合物 |
| PT2029173T (pt) | 2006-06-26 | 2016-11-02 | Macrogenics Inc | Anticorpos específicos fc rib e seus métodos de uso |
| WO2010045633A2 (en) * | 2008-10-17 | 2010-04-22 | National Jewish Health | Measurement and analysis of leukotrienes |
| MX2011006332A (es) | 2008-12-23 | 2011-06-27 | Abbott Lab | Compuestos antivirales. |
| EP2367823A1 (en) | 2008-12-23 | 2011-09-28 | Abbott Laboratories | Anti-viral compounds |
| SG175144A1 (en) | 2009-04-15 | 2011-11-28 | Abbott Lab | Anti-viral compounds |
| US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
| PE20110679A1 (es) | 2009-06-11 | 2011-10-20 | Abbvie Bahamas Ltd | Derivados de (4-tert-butilfenil)pirrolidin-2,5-difenil como inhibidores del hcv |
| US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
| US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
| US8420655B2 (en) | 2009-12-04 | 2013-04-16 | Boehringer Ingelheim International Gmbh | Benzimidazole inhibitors of leukotriene production |
| NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
| PT2595965T (pt) | 2010-07-20 | 2016-08-22 | Vestaron Corp | Triazinas e pirimidinas inseticidas |
| US8829200B2 (en) | 2010-10-29 | 2014-09-09 | Boehringer Ingelheim International Gmbh | Benzimidazole inhibitors of leukotriene production |
| JP5789888B2 (ja) | 2010-11-01 | 2015-10-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成のベンゾイミダゾールインヒビター |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
| US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
| WO2015103490A1 (en) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Solid antiviral dosage forms |
| WO2019018562A1 (en) | 2017-07-19 | 2019-01-24 | Ideaya Biosciences, Inc. | AMIDO COMPOUND AS MODULATORS OF AHR |
| JP7611832B2 (ja) * | 2018-09-18 | 2025-01-10 | ターンズ・インコーポレイテッド | 特定の白血病を治療するための化合物 |
| CN110054558B (zh) * | 2019-05-16 | 2022-03-25 | 海门瑞一医药科技有限公司 | 一种1-三氟甲基环丙烷-1-甲酸的制备方法 |
| CN112441983B (zh) * | 2019-08-29 | 2023-09-15 | 山东福长药业有限公司 | 一种基于苯并咪唑取代的硝基苯的化合物及其制备方法 |
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-
1999
- 1999-05-21 IL IL13982699A patent/IL139826A0/xx unknown
- 1999-05-21 WO PCT/US1999/011322 patent/WO1999061019A1/en not_active Ceased
- 1999-05-21 JP JP2000550473A patent/JP2002516274A/ja not_active Withdrawn
- 1999-05-21 UA UA2000116723A patent/UA67774C2/uk unknown
- 1999-05-21 NZ NZ508416A patent/NZ508416A/en unknown
- 1999-05-21 HU HU0102128A patent/HUP0102128A3/hu unknown
- 1999-05-21 PL PL99345952A patent/PL345952A1/xx unknown
- 1999-05-21 HU HU0101894A patent/HUP0101894A3/hu unknown
- 1999-05-21 CA CA002332989A patent/CA2332989A1/en not_active Abandoned
- 1999-05-21 AU AU43120/99A patent/AU754943B2/en not_active Ceased
- 1999-05-21 WO PCT/US1999/011490 patent/WO1999061020A1/en not_active Ceased
- 1999-05-21 IL IL13982899A patent/IL139828A0/xx unknown
- 1999-05-21 PL PL99345219A patent/PL345219A1/xx unknown
- 1999-05-21 MX MXPA00011467A patent/MXPA00011467A/es unknown
- 1999-05-21 JP JP2000550479A patent/JP2002516276A/ja active Pending
- 1999-05-21 AU AU41978/99A patent/AU4197899A/en not_active Abandoned
- 1999-05-21 MX MXPA00011422A patent/MXPA00011422A/es not_active IP Right Cessation
- 1999-05-21 MX MXPA00011470A patent/MXPA00011470A/es unknown
- 1999-05-21 ES ES99924442T patent/ES2241285T3/es not_active Expired - Lifetime
- 1999-05-21 EP EP99953286A patent/EP1079830A1/en not_active Withdrawn
- 1999-05-21 EP EP99925756A patent/EP1077695A2/en not_active Withdrawn
- 1999-05-21 RU RU2000129523/15A patent/RU2236220C2/ru not_active IP Right Cessation
- 1999-05-21 PL PL99345560A patent/PL345560A1/xx not_active IP Right Cessation
- 1999-05-21 BR BR9910642-6A patent/BR9910642A/pt not_active Application Discontinuation
- 1999-05-21 CA CA002332985A patent/CA2332985A1/en not_active Abandoned
- 1999-05-21 BR BR9910641-8A patent/BR9910641A/pt not_active Application Discontinuation
- 1999-05-21 BR BR9910640-0A patent/BR9910640A/pt not_active IP Right Cessation
- 1999-05-21 AT AT99924442T patent/ATE292465T1/de not_active IP Right Cessation
- 1999-05-21 DE DE69924607T patent/DE69924607T2/de not_active Expired - Fee Related
- 1999-05-21 CZ CZ20004351A patent/CZ20004351A3/cs unknown
- 1999-05-21 NZ NZ508413A patent/NZ508413A/en unknown
- 1999-05-21 WO PCT/US1999/011363 patent/WO1999061013A2/en not_active Ceased
- 1999-05-21 JP JP2000550480A patent/JP2002516277A/ja active Pending
- 1999-05-21 US US09/316,870 patent/US6271390B1/en not_active Expired - Fee Related
- 1999-05-21 EP EP99924442A patent/EP1077700B1/en not_active Expired - Lifetime
- 1999-05-21 RU RU2000129524/15A patent/RU2236221C2/ru not_active IP Right Cessation
- 1999-05-21 CN CN99809101A patent/CN1317965A/zh active Pending
- 1999-05-21 CZ CZ20004350A patent/CZ20004350A3/cs unknown
- 1999-05-21 UA UA2000116724A patent/UA67775C2/uk unknown
- 1999-05-21 IL IL13982799A patent/IL139827A0/xx unknown
- 1999-05-21 CN CNA2005100859764A patent/CN1721411A/zh active Pending
- 1999-05-21 HU HU0102550A patent/HUP0102550A3/hu unknown
- 1999-05-21 KR KR1020007013141A patent/KR100591652B1/ko not_active Expired - Fee Related
- 1999-05-21 CA CA002332999A patent/CA2332999A1/en not_active Abandoned
- 1999-05-21 AU AU40942/99A patent/AU754562B2/en not_active Ceased
- 1999-05-21 CN CNB998091057A patent/CN1219510C/zh not_active Expired - Fee Related
- 1999-05-21 CN CN99809102A patent/CN1311675A/zh active Pending
-
2000
- 2000-02-21 ZA ZA200007754A patent/ZA200007754B/en unknown
- 2000-11-21 NO NO20005889A patent/NO20005889L/no unknown
- 2000-11-21 NO NO20005888A patent/NO20005888L/no unknown
- 2000-11-21 NO NO20005887A patent/NO20005887L/no not_active Application Discontinuation
- 2000-12-21 ZA ZA200007753A patent/ZA200007753B/xx unknown
- 2000-12-21 ZA ZA200007752A patent/ZA200007752B/en unknown
-
2001
- 2001-06-14 US US09/882,340 patent/US6451829B2/en not_active Expired - Fee Related
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