JP2002516276A5 - - Google Patents
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- JP2002516276A5 JP2002516276A5 JP2000550479A JP2000550479A JP2002516276A5 JP 2002516276 A5 JP2002516276 A5 JP 2002516276A5 JP 2000550479 A JP2000550479 A JP 2000550479A JP 2000550479 A JP2000550479 A JP 2000550479A JP 2002516276 A5 JP2002516276 A5 JP 2002516276A5
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- 150000001875 compounds Chemical class 0.000 description 11
- 125000003118 aryl group Chemical group 0.000 description 7
- 0 *[n]1c(-c2ccccc2)nc2c1C=CI1=C=C21 Chemical compound *[n]1c(-c2ccccc2)nc2c1C=CI1=C=C21 0.000 description 5
- 125000000217 alkyl group Chemical group 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- 208000030961 allergic reaction Diseases 0.000 description 3
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 description 2
- 239000000048 adrenergic agonist Substances 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 2
- 125000003107 substituted aryl group Chemical group 0.000 description 2
- TVNHJCBZMUWEPJ-UHFFFAOYSA-N C=C(C1)C(c(cc2)ccc2NC(c(ccc(Cl)c2)c2Cl)=O)=Nc2c1ccc(NC(C1=C[I]=CC=C1)=O)c2 Chemical compound C=C(C1)C(c(cc2)ccc2NC(c(ccc(Cl)c2)c2Cl)=O)=Nc2c1ccc(NC(C1=C[I]=CC=C1)=O)c2 TVNHJCBZMUWEPJ-UHFFFAOYSA-N 0.000 description 1
- RYCDIDFMOJAHTR-UHFFFAOYSA-N CC(Nc(cc1)cc2c1[nH]c(C(C=C1)C#CC=C1NC(c(c(Cl)c1)ccc1Cl)=O)n2)=O Chemical compound CC(Nc(cc1)cc2c1[nH]c(C(C=C1)C#CC=C1NC(c(c(Cl)c1)ccc1Cl)=O)n2)=O RYCDIDFMOJAHTR-UHFFFAOYSA-N 0.000 description 1
- JEJOWPBTKHBJEE-UHFFFAOYSA-N CC1(CC(CCC2)CC2C1)C(Nc(cc1)cc2c1[nH]c(-c(cc1)ccc1NC(c1ccc[s]1)=O)n2)=O Chemical compound CC1(CC(CCC2)CC2C1)C(Nc(cc1)cc2c1[nH]c(-c(cc1)ccc1NC(c1ccc[s]1)=O)n2)=O JEJOWPBTKHBJEE-UHFFFAOYSA-N 0.000 description 1
- WLBXNHHZYXMSFD-UHFFFAOYSA-N O=C(C1(CC(C2)C3)CC3CC2C1)Nc(cc1)cc2c1[nH]c(-c(cc1)ccc1NC(c1cc(Cl)cc(Cl)c1)=O)n2 Chemical compound O=C(C1(CC(C2)C3)CC3CC2C1)Nc(cc1)cc2c1[nH]c(-c(cc1)ccc1NC(c1cc(Cl)cc(Cl)c1)=O)n2 WLBXNHHZYXMSFD-UHFFFAOYSA-N 0.000 description 1
- GJZWFQXXXBULJS-UHFFFAOYSA-N O=C(C1(CC(C2)C3)CC3CC2C1)Nc1ccc2[nH]c(-c(cc3)ccc3NC(c(ccc(Cl)c3)c3Cl)=O)nc2c1 Chemical compound O=C(C1(CC(C2)C3)CC3CC2C1)Nc1ccc2[nH]c(-c(cc3)ccc3NC(c(ccc(Cl)c3)c3Cl)=O)nc2c1 GJZWFQXXXBULJS-UHFFFAOYSA-N 0.000 description 1
- ZDXVTKWMXWYRIW-UHFFFAOYSA-N O=C(C1CCCC1)Nc(cc1)ccc1-c1nc2cc(NC(c3cnccc3)=O)ccc2[nH]1 Chemical compound O=C(C1CCCC1)Nc(cc1)ccc1-c1nc2cc(NC(c3cnccc3)=O)ccc2[nH]1 ZDXVTKWMXWYRIW-UHFFFAOYSA-N 0.000 description 1
- YJUKOATYPJQLBR-UHFFFAOYSA-N O=C(c1ccc[s]1)Nc(cc1)ccc1-c1nc2cc(NC(c3cccnc3)=O)ccc2[nH]1 Chemical compound O=C(c1ccc[s]1)Nc(cc1)ccc1-c1nc2cc(NC(c3cccnc3)=O)ccc2[nH]1 YJUKOATYPJQLBR-UHFFFAOYSA-N 0.000 description 1
- ZBQQGGIKORZRQQ-UHFFFAOYSA-N O=C(c1cccnc1)Nc(cc1)cc2c1[nH]c(-c(cc1)ccc1NCc(c(Cl)ccc1)c1Cl)n2 Chemical compound O=C(c1cccnc1)Nc(cc1)cc2c1[nH]c(-c(cc1)ccc1NCc(c(Cl)ccc1)c1Cl)n2 ZBQQGGIKORZRQQ-UHFFFAOYSA-N 0.000 description 1
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 230000001078 anti-cholinergic effect Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 150000005350 bicyclononyls Chemical group 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- ARUKYTASOALXFG-UHFFFAOYSA-N cycloheptylcycloheptane Chemical group C1CCCCCC1C1CCCCCC1 ARUKYTASOALXFG-UHFFFAOYSA-N 0.000 description 1
- NLUNLVTVUDIHFE-UHFFFAOYSA-N cyclooctylcyclooctane Chemical group C1CCCCCCC1C1CCCCCCC1 NLUNLVTVUDIHFE-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000003199 leukotriene receptor blocking agent Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 description 1
- -1 polycyclic cycloaryl Chemical group 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8649498P | 1998-05-22 | 1998-05-22 | |
| US60/086,494 | 1998-05-22 | ||
| PCT/US1999/011322 WO1999061019A1 (en) | 1998-05-22 | 1999-05-21 | BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF IgE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002516276A JP2002516276A (ja) | 2002-06-04 |
| JP2002516276A5 true JP2002516276A5 (enExample) | 2006-07-20 |
Family
ID=22198947
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000550480A Pending JP2002516277A (ja) | 1998-05-22 | 1999-05-21 | ＩｇＥのダウンレギュレータとしてのベンゾイミダゾールアナログ |
| JP2000550473A Withdrawn JP2002516274A (ja) | 1998-05-22 | 1999-05-21 | ＩｇＥ影響特性を有する化合物 |
| JP2000550479A Pending JP2002516276A (ja) | 1998-05-22 | 1999-05-21 | ＩｇＥのモジュレータとしてのベンゾイミダゾール誘導体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000550480A Pending JP2002516277A (ja) | 1998-05-22 | 1999-05-21 | ＩｇＥのダウンレギュレータとしてのベンゾイミダゾールアナログ |
| JP2000550473A Withdrawn JP2002516274A (ja) | 1998-05-22 | 1999-05-21 | ＩｇＥ影響特性を有する化合物 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6271390B1 (enExample) |
| EP (3) | EP1077700B1 (enExample) |
| JP (3) | JP2002516277A (enExample) |
| KR (1) | KR100591652B1 (enExample) |
| CN (4) | CN1311675A (enExample) |
| AT (1) | ATE292465T1 (enExample) |
| AU (3) | AU754562B2 (enExample) |
| BR (3) | BR9910641A (enExample) |
| CA (3) | CA2332985A1 (enExample) |
| CZ (2) | CZ20004351A3 (enExample) |
| DE (1) | DE69924607T2 (enExample) |
| ES (1) | ES2241285T3 (enExample) |
| HU (3) | HUP0102128A3 (enExample) |
| IL (3) | IL139827A0 (enExample) |
| MX (3) | MXPA00011422A (enExample) |
| NO (3) | NO20005887L (enExample) |
| NZ (2) | NZ508413A (enExample) |
| PL (3) | PL345219A1 (enExample) |
| RU (2) | RU2236221C2 (enExample) |
| UA (2) | UA67775C2 (enExample) |
| WO (3) | WO1999061019A1 (enExample) |
| ZA (3) | ZA200007754B (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6911462B2 (en) | 1998-05-22 | 2005-06-28 | Avanir Pharmaceuticals | Benzimidazole compounds for regulating IgE |
| HUP0102128A3 (en) * | 1998-05-22 | 2002-05-28 | Avanir Pharmaceuticals San Die | Mediciaments containing benzimidazole derivatives as modulators of ige |
| US6919366B2 (en) * | 1998-05-22 | 2005-07-19 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of IgE |
| BR9913562A (pt) | 1998-09-11 | 2001-05-22 | Ajinomoto Kk | Derivados de benzeno, inibidor de ativação de ap-1 e nf-capa b, inibidor de produção de citoquina inflamatória, inibidor de produção de metaloprotease matricial ou inibidor de aparecimento de fator de adesão de célula inflamatório, e, agente antiinflamatório, anti-reumático, imunossupressor, inibidor de metástase cancerosa, remédio para arterioesclerose e agente antiviral |
| US6270746B1 (en) * | 1999-02-17 | 2001-08-07 | David H. Katz | Assay for the identification of IgE antibody suppressors |
| KR20020015308A (ko) * | 1999-03-26 | 2002-02-27 | 추후보정 | 아릴 치환된 피라졸, 이미다졸, 옥사졸, 티아졸 및 피롤,및 이의 용도 |
| JP4609691B2 (ja) * | 1999-07-01 | 2011-01-12 | 味の素株式会社 | 複素環化合物及びその医薬用途 |
| AU6866700A (en) | 1999-09-01 | 2001-03-26 | Ajinomoto Co., Inc. | Biscyclopropanecarboxylic acid amide compounds and medicinal use thereof |
| US6759425B2 (en) | 1999-10-21 | 2004-07-06 | Avanir Pharmaceuticals | Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
| US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| US20070208087A1 (en) | 2001-11-02 | 2007-09-06 | Sanders Virginia J | Compounds, compositions and methods for the treatment of inflammatory diseases |
| PT1368028E (pt) | 2001-03-12 | 2007-11-26 | Avanir Pharmaceuticals | Compostos de benzimidazole para modulação de ige e inibição da proliferação celular |
| EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
| NZ530580A (en) * | 2001-07-27 | 2007-02-23 | Curis Inc | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
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| US20030157555A1 (en) * | 2002-01-14 | 2003-08-21 | Lipps Binie V. | Diagnosis and treatment for immunoglobulin E ( IgE) implicated disorders |
| US20080081788A1 (en) * | 2002-01-14 | 2008-04-03 | Lipps Binie V | Diagnosis and treatment for immunoglobulin E (IgE) implicated disorders |
| TW200304820A (en) * | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
| SI2527315T1 (sl) | 2002-05-31 | 2014-06-30 | Proteotech Inc., | Spojine, sestavki in metode za zdravljenje amiloidnih bolezni in sinukleinopatij, kot so Alzheimerjeva bolezen, diabetes tipa 2 in Parkinsonova bolezen |
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| DK1534335T4 (en) | 2002-08-14 | 2015-10-05 | Macrogenics Inc | FCGAMMARIIB-SPECIFIC ANTIBODIES AND PROCEDURES FOR USE THEREOF |
| AU2003270426A1 (en) | 2002-09-12 | 2004-04-30 | Avanir Pharmaceuticals | PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION |
| TWI276631B (en) | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
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| KR20120091276A (ko) | 2004-02-20 | 2012-08-17 | 베링거 인겔하임 인터내셔날 게엠베하 | 바이러스 폴리머라제 억제제 |
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| CA2572218C (en) | 2004-06-30 | 2013-06-11 | Janssen Pharmaceutica, N.V. | Aryl-substituted benzimidazole and imidazopyridine ethers as anti-cancer agents |
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| EP1954287B2 (en) † | 2005-10-31 | 2016-02-24 | Merck Sharp & Dohme Corp. | Cetp inhibitors |
| EP1790345A1 (en) * | 2005-11-02 | 2007-05-30 | Esbatech AG | Triazin beta-secretase inhibitors |
| US7671221B2 (en) * | 2005-12-28 | 2010-03-02 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| CA2856037C (en) * | 2005-12-28 | 2017-03-07 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
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| CN102459165B (zh) | 2009-04-15 | 2015-09-02 | Abbvie公司 | 抗病毒化合物 |
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| JP5690839B2 (ja) * | 2009-12-04 | 2015-03-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン産生のベンゾイミダゾール阻害薬 |
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| PT2595965T (pt) | 2010-07-20 | 2016-08-22 | Vestaron Corp | Triazinas e pirimidinas inseticidas |
| WO2012058254A1 (en) | 2010-10-29 | 2012-05-03 | Boehringer Ingelheim International Gmbh | Benzimidazole inhibitors of leukotriene production |
| JP5789888B2 (ja) | 2010-11-01 | 2015-10-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成のベンゾイミダゾールインヒビター |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
| US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
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| US11548867B2 (en) | 2017-07-19 | 2023-01-10 | Idea Ya Biosciences, Inc. | Amido compounds as AhR modulators |
| EP3852745A4 (en) | 2018-09-18 | 2022-05-04 | Terns, Inc. | COMPOUNDS FOR TREATMENT OF CERTAIN LEUKEMIA |
| CN110054558B (zh) * | 2019-05-16 | 2022-03-25 | 海门瑞一医药科技有限公司 | 一种1-三氟甲基环丙烷-1-甲酸的制备方法 |
| CN112441983B (zh) * | 2019-08-29 | 2023-09-15 | 山东福长药业有限公司 | 一种基于苯并咪唑取代的硝基苯的化合物及其制备方法 |
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| EP1342199A1 (en) * | 2000-11-15 | 2003-09-10 | Manugistics Atlanta, Inc. | Promotion pricing system and method |
| US20020198794A1 (en) * | 2001-06-21 | 2002-12-26 | Williams Edward P. | Inventory management system for determining suggested part stocking levels for a vehicle dealer |
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1999
- 1999-05-21 HU HU0102128A patent/HUP0102128A3/hu unknown
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- 1999-05-21 CA CA002332985A patent/CA2332985A1/en not_active Abandoned
- 1999-05-21 CN CN99809102A patent/CN1311675A/zh active Pending
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- 1999-05-21 EP EP99924442A patent/EP1077700B1/en not_active Expired - Lifetime
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- 1999-05-21 EP EP99925756A patent/EP1077695A2/en not_active Withdrawn
- 1999-05-21 BR BR9910641-8A patent/BR9910641A/pt not_active Application Discontinuation
- 1999-05-21 CZ CZ20004351A patent/CZ20004351A3/cs unknown
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- 1999-05-21 BR BR9910640-0A patent/BR9910640A/pt not_active IP Right Cessation
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- 1999-05-21 CN CNB998091057A patent/CN1219510C/zh not_active Expired - Fee Related
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- 1999-05-21 WO PCT/US1999/011322 patent/WO1999061019A1/en not_active Ceased
- 1999-05-21 BR BR9910642-6A patent/BR9910642A/pt not_active Application Discontinuation
- 1999-05-21 CN CN99809101A patent/CN1317965A/zh active Pending
- 1999-05-21 PL PL99345560A patent/PL345560A1/xx not_active IP Right Cessation
- 1999-05-21 WO PCT/US1999/011490 patent/WO1999061020A1/en not_active Ceased
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- 1999-05-21 JP JP2000550473A patent/JP2002516274A/ja not_active Withdrawn
- 1999-05-21 JP JP2000550479A patent/JP2002516276A/ja active Pending
- 1999-05-21 US US09/316,870 patent/US6271390B1/en not_active Expired - Fee Related
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- 1999-05-21 CN CNA2005100859764A patent/CN1721411A/zh active Pending
- 1999-05-21 RU RU2000129524/15A patent/RU2236221C2/ru not_active IP Right Cessation
- 1999-05-21 ES ES99924442T patent/ES2241285T3/es not_active Expired - Lifetime
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- 1999-05-21 WO PCT/US1999/011363 patent/WO1999061013A2/en not_active Ceased
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- 1999-05-21 HU HU0101894A patent/HUP0101894A3/hu unknown
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2000
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2001
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