JP2002515324A - 粒子製造方法及び装置 - Google Patents
粒子製造方法及び装置Info
- Publication number
- JP2002515324A JP2002515324A JP2000549367A JP2000549367A JP2002515324A JP 2002515324 A JP2002515324 A JP 2002515324A JP 2000549367 A JP2000549367 A JP 2000549367A JP 2000549367 A JP2000549367 A JP 2000549367A JP 2002515324 A JP2002515324 A JP 2002515324A
- Authority
- JP
- Japan
- Prior art keywords
- fluid
- solution
- vehicle
- supercritical fluid
- supercritical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002245 particle Substances 0.000 title claims abstract description 144
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 5
- 239000012530 fluid Substances 0.000 claims abstract description 315
- 239000013076 target substance Substances 0.000 claims abstract description 99
- 238000000034 method Methods 0.000 claims abstract description 77
- 239000000725 suspension Substances 0.000 claims abstract description 76
- 239000000047 product Substances 0.000 claims abstract description 49
- 238000002156 mixing Methods 0.000 claims abstract description 40
- 239000002904 solvent Substances 0.000 claims abstract description 28
- 239000002244 precipitate Substances 0.000 claims abstract description 8
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 106
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 54
- 239000001569 carbon dioxide Substances 0.000 claims description 53
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 53
- 230000015572 biosynthetic process Effects 0.000 claims description 41
- 229910052757 nitrogen Inorganic materials 0.000 claims description 27
- 239000000126 substance Substances 0.000 claims description 19
- 239000003607 modifier Substances 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 13
- 239000003814 drug Substances 0.000 claims description 9
- 238000001556 precipitation Methods 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 7
- 238000011144 upstream manufacturing Methods 0.000 claims description 7
- 238000012546 transfer Methods 0.000 claims description 4
- 229910052756 noble gas Inorganic materials 0.000 claims description 2
- 239000000243 solution Substances 0.000 description 92
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 28
- 238000000634 powder X-ray diffraction Methods 0.000 description 18
- 238000002466 solution-enhanced dispersion by supercritical fluid Methods 0.000 description 17
- 239000012296 anti-solvent Substances 0.000 description 16
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 239000000463 material Substances 0.000 description 15
- 235000001968 nicotinic acid Nutrition 0.000 description 14
- 239000011664 nicotinic acid Substances 0.000 description 14
- 229960003512 nicotinic acid Drugs 0.000 description 13
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 12
- AZUYLZMQTIKGSC-UHFFFAOYSA-N 1-[6-[4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one Chemical compound ClC=1C(=C2C=NNC2=CC=1C)C=1C(=NN(C=1C)C1CC2(CN(C2)C(C=C)=O)C1)C=1C=C2C=NN(C2=CC=1)C AZUYLZMQTIKGSC-UHFFFAOYSA-N 0.000 description 11
- 239000000843 powder Substances 0.000 description 10
- 238000000113 differential scanning calorimetry Methods 0.000 description 8
- 239000007789 gas Substances 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 7
- 239000007858 starting material Substances 0.000 description 7
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 6
- 239000006185 dispersion Substances 0.000 description 6
- 229960001680 ibuprofen Drugs 0.000 description 6
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 6
- 229960004889 salicylic acid Drugs 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- XPDWGBQVDMORPB-UHFFFAOYSA-N Fluoroform Chemical compound FC(F)F XPDWGBQVDMORPB-UHFFFAOYSA-N 0.000 description 4
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 239000011324 bead Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000010408 film Substances 0.000 description 3
- 229910052734 helium Inorganic materials 0.000 description 3
- 239000001307 helium Substances 0.000 description 3
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 239000000376 reactant Substances 0.000 description 3
- 239000013077 target material Substances 0.000 description 3
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- AFYPFACVUDMOHA-UHFFFAOYSA-N chlorotrifluoromethane Chemical compound FC(F)(F)Cl AFYPFACVUDMOHA-UHFFFAOYSA-N 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- -1 helium Chemical class 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 2
- 229960000991 ketoprofen Drugs 0.000 description 2
- 239000008206 lipophilic material Substances 0.000 description 2
- 239000001272 nitrous oxide Substances 0.000 description 2
- 230000001376 precipitating effect Effects 0.000 description 2
- 239000012047 saturated solution Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- SFZCNBIFKDRMGX-UHFFFAOYSA-N sulfur hexafluoride Chemical compound FS(F)(F)(F)(F)F SFZCNBIFKDRMGX-UHFFFAOYSA-N 0.000 description 2
- 229960000909 sulfur hexafluoride Drugs 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229910052724 xenon Inorganic materials 0.000 description 2
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 2
- 101150000715 DA18 gene Proteins 0.000 description 1
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000005465 channeling Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 239000011557 critical solution Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000003721 gunpowder Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052754 neon Inorganic materials 0.000 description 1
- GKAOGPIIYCISHV-UHFFFAOYSA-N neon atom Chemical compound [Ne] GKAOGPIIYCISHV-UHFFFAOYSA-N 0.000 description 1
- 150000002835 noble gases Chemical class 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 229950005065 oxiniacic acid Drugs 0.000 description 1
- 238000003921 particle size analysis Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000002407 reforming Methods 0.000 description 1
- 229960005018 salmeterol xinafoate Drugs 0.000 description 1
- 238000001878 scanning electron micrograph Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
- B01D11/0407—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solute
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0488—Flow sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J3/00—Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
- B01J3/008—Processes carried out under supercritical conditions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Formation And Processing Of Food Products (AREA)
- Medicinal Preparation (AREA)
- Glanulating (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9810559.6A GB9810559D0 (en) | 1998-05-15 | 1998-05-15 | Method and apparatus for particle formation |
| GB9810559.6 | 1998-05-15 | ||
| PCT/GB1999/001337 WO1999059710A1 (en) | 1998-05-15 | 1999-04-29 | Methods and apparatus for particle formation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002515324A true JP2002515324A (ja) | 2002-05-28 |
| JP2002515324A5 JP2002515324A5 (enExample) | 2005-12-22 |
Family
ID=10832197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000549367A Pending JP2002515324A (ja) | 1998-05-15 | 1999-04-29 | 粒子製造方法及び装置 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6576262B1 (enExample) |
| EP (1) | EP1077760B1 (enExample) |
| JP (1) | JP2002515324A (enExample) |
| AT (1) | ATE232754T1 (enExample) |
| AU (1) | AU751106B2 (enExample) |
| CA (1) | CA2329902C (enExample) |
| DE (1) | DE69905460T2 (enExample) |
| DK (1) | DK1077760T3 (enExample) |
| ES (1) | ES2193700T3 (enExample) |
| GB (1) | GB9810559D0 (enExample) |
| MX (1) | MXPA00011185A (enExample) |
| WO (1) | WO1999059710A1 (enExample) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004110585A1 (ja) * | 2003-06-10 | 2004-12-23 | Taisho Pharmaceutical Co., Ltd. | 放射球状晶析物およびその製造方法並びにこれを利用するドライパウダー製剤 |
| JP2006510480A (ja) * | 2002-12-20 | 2006-03-30 | グラクソ グループ リミテッド | 生成した粒子を非超臨界流体中の懸濁液として単離するための装置および方法 |
| JP2008545534A (ja) * | 2005-06-10 | 2008-12-18 | バッテル メモリアル インスティチュート | 少なくとも一つの流体を近臨界または超臨界の担体流体と混合する工程を含む、流体を混合するための機器および方法 |
| WO2013146558A1 (en) * | 2012-03-26 | 2013-10-03 | Ricoh Company, Ltd. | Method for producing particles, toner, developer, and image forming apparatus |
| JP2018094555A (ja) * | 2018-01-15 | 2018-06-21 | 株式会社リコー | 粒子の製造方法 |
| JP2019518938A (ja) * | 2016-04-29 | 2019-07-04 | ユニバーシティ オブ ヘルシンキ | 材料の物理化学特性決定のための方法およびデバイス |
| JP2020006369A (ja) * | 2019-08-07 | 2020-01-16 | 株式会社リコー | 粒子の製造方法 |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9703673D0 (en) * | 1997-02-21 | 1997-04-09 | Bradford Particle Design Ltd | Method and apparatus for the formation of particles |
| GB9810559D0 (en) * | 1998-05-15 | 1998-07-15 | Bradford Particle Design Ltd | Method and apparatus for particle formation |
| JP4874483B2 (ja) | 1999-06-09 | 2012-02-15 | ロバート イー． シーバース | 超臨界流体補助ネブライゼーション及びバブル乾燥 |
| GB9915975D0 (en) * | 1999-07-07 | 1999-09-08 | Bradford Particle Design Ltd | Method for the formation of particles |
| EP1090894A1 (de) * | 1999-10-06 | 2001-04-11 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Herstellung feinpartikulärer Explosivstoffe |
| GB9927011D0 (en) | 1999-11-16 | 2000-01-12 | Advanced Phytonics Ltd | Method for the production of particles |
| US6761909B1 (en) | 1999-12-21 | 2004-07-13 | Rxkinetix, Inc. | Particulate insulin-containing products and method of manufacture |
| US6669960B2 (en) | 1999-12-21 | 2003-12-30 | Rxkinetix, Inc. | Particulate drug-containing products and method of manufacture |
| FR2815540B1 (fr) * | 2000-10-19 | 2005-06-10 | Separex Sa | Procede de fabrication de tres fines particules constituees d'un principe insere dans une molecule hote |
| GB0027357D0 (en) * | 2000-11-09 | 2000-12-27 | Bradford Particle Design Plc | Particle formation methods and their products |
| AU2002221320B2 (en) * | 2000-12-08 | 2006-06-15 | The University Of Sydney | Synthesis of small particles |
| AUPR197000A0 (en) | 2000-12-08 | 2001-01-11 | Unisearch Limited | Synthesis of small particles |
| GB0102075D0 (en) | 2001-01-26 | 2001-03-14 | Astrazeneca Ab | Process |
| SI1363726T1 (en) * | 2001-02-26 | 2005-02-28 | Dompe S.P.A. | Apparatus and method for micron and submicron particle formation |
| US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
| US7585493B2 (en) | 2001-05-24 | 2009-09-08 | Alexza Pharmaceuticals, Inc. | Thin-film drug delivery article and method of use |
| US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
| US20030051728A1 (en) | 2001-06-05 | 2003-03-20 | Lloyd Peter M. | Method and device for delivering a physiologically active compound |
| US7090830B2 (en) | 2001-05-24 | 2006-08-15 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
| GB0117696D0 (en) * | 2001-07-20 | 2001-09-12 | Bradford Particle Design Plc | Particle information |
| GB0208742D0 (en) | 2002-04-17 | 2002-05-29 | Bradford Particle Design Ltd | Particulate materials |
| FR2830760B1 (fr) | 2001-10-12 | 2004-06-04 | Pf Medicament | Procede de preparation d'un compose d'interaction de substances actives avec un support poreux par fluide supercritique |
| KR100887429B1 (ko) | 2001-10-22 | 2009-03-09 | 돔페 파르마 에스.피.에이. | 초임계 유체 공정: 단백질 미세입자의 제조 및 그의 안정화 |
| US7574930B2 (en) * | 2002-02-15 | 2009-08-18 | Implant Sciences Corporation | Trace chemical sensing |
| CA2478327A1 (en) * | 2002-03-20 | 2003-10-02 | Advanced Inhalation Research, Inc. | Hgh (human growth hormone) formulations for pulmonary administration |
| US7008644B2 (en) * | 2002-03-20 | 2006-03-07 | Advanced Inhalation Research, Inc. | Method and apparatus for producing dry particles |
| US20050163725A1 (en) * | 2002-03-20 | 2005-07-28 | Blizzard Charles D. | Method for administration of growth hormone via pulmonary delivery |
| CA2482272C (en) * | 2002-04-12 | 2011-08-16 | Feyecon Development & Implementation B.V. | Process for small particle formation |
| US7582284B2 (en) | 2002-04-17 | 2009-09-01 | Nektar Therapeutics | Particulate materials |
| GB0216562D0 (en) * | 2002-04-25 | 2002-08-28 | Bradford Particle Design Ltd | Particulate materials |
| US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
| CA2510019A1 (en) * | 2002-12-19 | 2004-07-08 | Baxter International, Inc. | Process for preparing combination pharmaceutical formulations using supercritical fluids |
| FR2854079B1 (fr) | 2003-04-25 | 2007-11-30 | Pf Medicament | Procede de preparation de complexes moleculaires |
| WO2004098561A2 (en) * | 2003-05-08 | 2004-11-18 | Nektar Therapeutics Uk Ltd | Particulate materials |
| EP1625336B9 (en) | 2003-05-21 | 2012-03-21 | Alexza Pharmaceuticals, Inc. | Use of a layer of solid fuel, method for producing such a layer and associated heating unit |
| US7767118B2 (en) | 2003-06-03 | 2010-08-03 | Ferro Corporation | Nanoparticles from supercritical fluid antisolvent process using particle growth and agglomeration retardants |
| JP2007505136A (ja) * | 2003-09-10 | 2007-03-08 | マツプ・フアーマシユーテイカルズ・インコーポレーテツド | ジヒドロエルゴタミンを肺吸入により体循環に送達するためのエアゾール製剤 |
| US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
| AU2004322756B2 (en) | 2004-08-12 | 2011-04-14 | Alexza Pharmaceuticals, Inc. | Aerosol drug delivery device incorporating percussively activated heat packages |
| AU2006272438B2 (en) | 2005-07-15 | 2011-08-04 | Map Pharmaceuticals, Inc. | Method of particle formation |
| US20070120281A1 (en) * | 2005-11-08 | 2007-05-31 | Boris Khusid | Manufacture of fine particles and nano particles and coating thereof |
| KR20090077066A (ko) | 2006-10-06 | 2009-07-14 | 뉴사우스 이노베이션즈 피티와이 리미티드 | 입자 형성 |
| WO2008070279A2 (en) * | 2006-10-11 | 2008-06-12 | Crititech, Inc. | Method for precipitation of small medicament particles into use containers |
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- 1999-04-29 CA CA002329902A patent/CA2329902C/en not_active Expired - Lifetime
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006510480A (ja) * | 2002-12-20 | 2006-03-30 | グラクソ グループ リミテッド | 生成した粒子を非超臨界流体中の懸濁液として単離するための装置および方法 |
| WO2004110585A1 (ja) * | 2003-06-10 | 2004-12-23 | Taisho Pharmaceutical Co., Ltd. | 放射球状晶析物およびその製造方法並びにこれを利用するドライパウダー製剤 |
| JPWO2004110585A1 (ja) * | 2003-06-10 | 2006-07-20 | 大正製薬株式会社 | 放射球状晶析物およびその製造方法並びにこれを利用するドライパウダー製剤 |
| JP2008545534A (ja) * | 2005-06-10 | 2008-12-18 | バッテル メモリアル インスティチュート | 少なくとも一つの流体を近臨界または超臨界の担体流体と混合する工程を含む、流体を混合するための機器および方法 |
| WO2013146558A1 (en) * | 2012-03-26 | 2013-10-03 | Ricoh Company, Ltd. | Method for producing particles, toner, developer, and image forming apparatus |
| JP2013198880A (ja) * | 2012-03-26 | 2013-10-03 | Ricoh Co Ltd | 粒子の製造方法、トナー、現像剤、及び画像形成装置 |
| JP2019518938A (ja) * | 2016-04-29 | 2019-07-04 | ユニバーシティ オブ ヘルシンキ | 材料の物理化学特性決定のための方法およびデバイス |
| JP7096771B2 (ja) | 2016-04-29 | 2022-07-06 | ザ ソリュビィリティ カンパニー オーユー | 材料の物理化学特性決定のための方法およびデバイス |
| JP2018094555A (ja) * | 2018-01-15 | 2018-06-21 | 株式会社リコー | 粒子の製造方法 |
| JP2020006369A (ja) * | 2019-08-07 | 2020-01-16 | 株式会社リコー | 粒子の製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69905460T2 (de) | 2004-02-26 |
| DK1077760T3 (da) | 2003-06-16 |
| WO1999059710A1 (en) | 1999-11-25 |
| CA2329902C (en) | 2008-07-15 |
| DE69905460D1 (de) | 2003-03-27 |
| EP1077760A1 (en) | 2001-02-28 |
| ATE232754T1 (de) | 2003-03-15 |
| US20040071783A1 (en) | 2004-04-15 |
| GB9810559D0 (en) | 1998-07-15 |
| AU3720999A (en) | 1999-12-06 |
| US6576262B1 (en) | 2003-06-10 |
| MXPA00011185A (es) | 2003-05-19 |
| CA2329902A1 (en) | 1999-11-25 |
| ES2193700T3 (es) | 2003-11-01 |
| AU751106B2 (en) | 2002-08-08 |
| EP1077760B1 (en) | 2003-02-19 |
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