JP2002513814A5 - - Google Patents

Download PDF

Info

Publication number
JP2002513814A5
JP2002513814A5 JP2000547274A JP2000547274A JP2002513814A5 JP 2002513814 A5 JP2002513814 A5 JP 2002513814A5 JP 2000547274 A JP2000547274 A JP 2000547274A JP 2000547274 A JP2000547274 A JP 2000547274A JP 2002513814 A5 JP2002513814 A5 JP 2002513814A5
Authority
JP
Japan
Prior art keywords
nucleic acid
group
solid support
formula
modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2000547274A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002513814A (ja
JP4477774B2 (ja
Filing date
Publication date
Priority claimed from US09/071,876 external-priority patent/US6048695A/en
Application filed filed Critical
Publication of JP2002513814A publication Critical patent/JP2002513814A/ja
Publication of JP2002513814A5 publication Critical patent/JP2002513814A5/ja
Application granted granted Critical
Publication of JP4477774B2 publication Critical patent/JP4477774B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2000547274A 1998-05-04 1999-05-04 化学修飾された核酸および核酸の固体支持体への結合方法 Expired - Fee Related JP4477774B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/071,876 1998-05-04
US09/071,876 US6048695A (en) 1998-05-04 1998-05-04 Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
PCT/US1999/009810 WO1999057323A1 (en) 1998-05-04 1999-05-04 Chemically modified nucleic acids and methods for coupling nucleic acids to solid support

Publications (3)

Publication Number Publication Date
JP2002513814A JP2002513814A (ja) 2002-05-14
JP2002513814A5 true JP2002513814A5 (enExample) 2005-11-17
JP4477774B2 JP4477774B2 (ja) 2010-06-09

Family

ID=22104163

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000547274A Expired - Fee Related JP4477774B2 (ja) 1998-05-04 1999-05-04 化学修飾された核酸および核酸の固体支持体への結合方法

Country Status (8)

Country Link
US (3) US6048695A (enExample)
EP (1) EP1075544B1 (enExample)
JP (1) JP4477774B2 (enExample)
AT (1) ATE535615T1 (enExample)
AU (1) AU770695B2 (enExample)
CA (1) CA2326684C (enExample)
DE (1) DE99920342T1 (enExample)
WO (1) WO1999057323A1 (enExample)

Families Citing this family (181)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6426183B1 (en) * 1995-12-21 2002-07-30 Kenneth L. Beattie Oligonucleotide microarrays: direct covalent attachment to glass
US7078224B1 (en) 1999-05-14 2006-07-18 Promega Corporation Cell concentration and lysate clearance using paramagnetic particles
AU2001263094B2 (en) * 1998-05-04 2008-07-10 Baylor College Of Medicine Compositions and methods for array-based genomic nucleic acid analysis of biological molecules
US6048695A (en) * 1998-05-04 2000-04-11 Baylor College Of Medicine Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
US6979728B2 (en) * 1998-05-04 2005-12-27 Baylor College Of Medicine Articles of manufacture and methods for array based analysis of biological molecules
US6248127B1 (en) * 1998-08-21 2001-06-19 Medtronic Ave, Inc. Thromboresistant coated medical device
JP2000157272A (ja) * 1998-12-01 2000-06-13 Hitachi Software Eng Co Ltd バイオチップ及びその製造方法
DE19957827C2 (de) * 1999-11-25 2003-06-12 Epigenomics Ag Verwendung eines Oligomer-Arrays mit PNA- und/oder DNA-Oligomeren auf einer Oberfläche
JP2001149060A (ja) * 1999-11-29 2001-06-05 Nisshinbo Ind Inc 核酸固定化基板
SE9904506D0 (sv) * 1999-12-09 1999-12-09 Karolinska Innovations Ab Method for immobilisation
AU2843201A (en) * 1999-12-21 2001-07-03 Vbc-Genomics Bioscience Research Gmbh Compound comprising a peptide moiety and an organo-silane moiety.
EP1110967A1 (en) * 1999-12-21 2001-06-27 LION Bioscience AG Compound comprising a biomolecule moiety and an organo-silane moiety
EP1111069A1 (en) * 1999-12-22 2001-06-27 BioChip Technologies GmbH Modified nucleic acids and their use
ATE356231T1 (de) * 2000-01-11 2007-03-15 Nanogen Recognomics Gmbh Biomoleküle mit multiplen anbindungsabschnitten zur bindung an eine substratoberfläche
FR2804129B1 (fr) * 2000-01-20 2002-10-18 Centre Nat Rech Scient Procedes de synthese et d'immobilisation d'acides nucleiques sur un support solide silanise
US20040014102A1 (en) * 2000-02-22 2004-01-22 Shiping Chen High density parallel printing of microarrays
CA2399189A1 (en) * 2000-02-22 2001-08-30 Genospectra, Inc. Microarray fabrication techniques and apparatus
CN1404415A (zh) 2000-02-22 2003-03-19 基因谱公司 微阵列制造技术及设备
JP3502803B2 (ja) * 2000-03-06 2004-03-02 日立ソフトウエアエンジニアリング株式会社 マイクロアレイ、マイクロアレイ作製方法及びマイクロアレイにおけるピン間スポット量誤差補正方法
CA2402525A1 (en) * 2000-03-31 2001-10-11 Genentech, Inc. Compositions and methods for detecting and quantifying gene expression
KR100352171B1 (ko) * 2000-04-14 2002-09-12 (주) 제노텍 올리고뉴클레오타이드를 지지체에 고정시키는 방법 및 그방법에 의하여 제조되는 올리고뉴클레오타이드 어레이
US20030219816A1 (en) * 2001-07-02 2003-11-27 Keith Solomon Composite microarray slides
US6890483B2 (en) 2000-07-05 2005-05-10 Cuno Incorporated Non-luminescent substrate
WO2002002585A2 (en) * 2000-07-05 2002-01-10 Cuno, Inc. Low fluorescence nylon/glass composites for microdiagnostics
CA2418105A1 (en) * 2000-08-03 2002-02-14 Massachusetts Institute Of Technology Microarrays of functional biomolecules, and uses therefor
US20020102617A1 (en) * 2000-08-03 2002-08-01 Macbeath Gavin Protein microarrays
KR100379720B1 (ko) * 2000-10-14 2003-04-11 주식회사 마크로젠 덴드리머 단일층 지지체 및 그의 제조방법
CA2426540A1 (en) * 2000-10-20 2002-07-25 Biocardia, Inc. Leukocyte expression profiling
US6861214B1 (en) 2000-10-23 2005-03-01 Beckman Coulter, Inc. Immobilization of biopolymers to aminated substrates by direct adsorption
US20020150887A1 (en) * 2000-11-09 2002-10-17 National Institute Of Advanced Industrial Science And Technology Methods and nucleic acid probes for molecular genetic analysis of polluted environments and environmental samples
US20020146684A1 (en) * 2001-04-09 2002-10-10 Meldal Morten Peter One dimensional unichemo protection (UCP) in organic synthesis
CA2446417A1 (en) * 2001-05-03 2002-11-14 Sigma Genosys, L.P. Methods for assembling protein microarrays
EP1385859A2 (en) * 2001-05-10 2004-02-04 Baylor College Of Medicine Compositions and methods for array-based genomic nucleic acid analysis of biological molecules
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
FR2826957B1 (fr) * 2001-07-09 2005-09-30 Centre Nat Rech Scient Procede de fonctionnalisation de supports solides, supports solides fonctionnalises et leurs utilisations
US10272409B2 (en) 2001-07-11 2019-04-30 Michael E. Hogan Methods and devices based upon a novel form of nucleic acid duplex on a surface
ATE424468T1 (de) * 2001-07-11 2009-03-15 Baylor College Medicine Verfahren und vorrichtungen auf grundlage einer neuen form eines nukleinsäureduplex auf einer oberfläche
DE10139283A1 (de) * 2001-08-09 2003-03-13 Epigenomics Ag Verfahren und Nukleinsäuren zur Analyse von Colon-Krebs
US20030087309A1 (en) * 2001-08-27 2003-05-08 Shiping Chen Desktop drug screening system
US20050032060A1 (en) * 2001-08-31 2005-02-10 Shishir Shah Arrays comprising pre-labeled biological molecules and methods for making and using these arrays
US9671396B2 (en) * 2001-09-05 2017-06-06 Joon Won Park Solid substrate comprising array of dendrons and methods for using the same
US7351529B2 (en) * 2001-09-27 2008-04-01 Perkinelmer Las, Inc. Methods for detecting genetic mosaicisms using arrays
CA2463725A1 (en) 2001-10-12 2003-11-06 Spectral Genomics, Inc. Compilations of nucleic acids and arrays and methods of using them
US7439346B2 (en) * 2001-10-12 2008-10-21 Perkinelmer Las Inc. Nucleic acids arrays and methods of use therefor
WO2003042697A1 (en) * 2001-11-14 2003-05-22 Genospectra, Inc. Biochemical analysis system with combinatorial chemistry applications
WO2003048727A2 (en) * 2001-12-03 2003-06-12 Invitrogen Corporation Identification of rearrangements in nucleic acid molecules
CN1610742B (zh) * 2001-12-26 2010-05-05 佳能株式会社 探针介质
KR100450191B1 (ko) * 2001-12-28 2004-10-02 삼성에스디아이 주식회사 생체물질 고정용 기판 및 이의 제조방법
AU2003220159A1 (en) * 2002-03-08 2003-09-22 Spectral Genomics, Inc. Articles of manufacture and methods for making hydrophobic derivatized arrays
US6916621B2 (en) * 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
US7226771B2 (en) 2002-04-19 2007-06-05 Diversa Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
EP1497418B1 (en) 2002-04-19 2012-10-17 Verenium Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
US7217512B2 (en) 2002-05-09 2007-05-15 Corning Incorporated Reagent and method for attaching target molecules to a surface
AU2003272548A1 (en) * 2002-09-16 2004-04-30 Plexxikon, Inc. Crystal structure of pim-1 kinase
US7129046B2 (en) * 2002-10-21 2006-10-31 Agilent Technologies, Inc. Linking to chemical array assemblies with metal layers
US7195908B2 (en) 2002-10-31 2007-03-27 Corning Incorporated Supports treated with triamine for immobilizing biomolecules
US20050048573A1 (en) * 2003-02-03 2005-03-03 Plexxikon, Inc. PDE5A crystal structure and uses
EP1627045A2 (en) * 2003-02-28 2006-02-22 Plexxikon, Inc. Pyk2 crystal structure and uses
EP2194133B1 (en) 2003-03-06 2015-12-02 BASF Enzymes LLC Amylases, nucleic acids encoding them and methods for making and using them
CA2515583C (en) 2003-03-07 2015-07-14 Diversa Corporation Hydrolases, nucleic acids encoding them and methods for making and using them
EP1613733B1 (en) 2003-04-04 2015-06-03 BASF Enzymes LLC Pectate lyases, nucleic acids encoding them and methods for making and using them
US7892745B2 (en) * 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
FR2854696A1 (fr) * 2003-05-06 2004-11-12 Commissariat Energie Atomique Support de biopuce utilisant des couches minces de materiau sol gel et procede de realisation
CN103484486B (zh) 2003-07-02 2018-04-24 维莱尼姆公司 葡聚糖酶,编码它们的核酸以及制备和使用它们的方法
US20050079548A1 (en) * 2003-07-07 2005-04-14 Plexxikon, Inc. Ligand development using PDE4B crystal structures
US7741089B2 (en) 2003-08-11 2010-06-22 Verenium Corporation Laccases, nucleic acids encoding them and methods for making and using them
WO2005028624A2 (en) * 2003-09-15 2005-03-31 Plexxikon, Inc. Molecular scaffolds for kinase ligand development
US7279280B2 (en) * 2003-09-25 2007-10-09 Mgp Biotech, Inc. Apparatus and method for detecting genetic mutations and single nucleotide polymorphisms
CA2543091C (en) * 2003-10-24 2013-09-03 John Austin Apparatus and method for dispensing fluid, semi-solid and solid samples
AU2004286845A1 (en) * 2003-10-30 2005-05-19 Tufts-New England Medical Center Prenatal diagnosis using cell-free fetal DNA in amniotic fluid
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
JP5138938B2 (ja) * 2003-12-19 2013-02-06 プレキシコン インコーポレーテッド Ret調節剤の開発のための化合物および方法
EP1720015A1 (en) * 2004-03-17 2006-11-08 Matsushita Electric Industrial Co., Ltd. Process for producing biochip, probe solution, and biochip
JP2008503446A (ja) * 2004-05-06 2008-02-07 プレキシコン,インコーポレーテッド Pde4b阻害剤及びその使用
US8911942B2 (en) * 2004-05-20 2014-12-16 Quest Diagnostics Investments Incorporated Single label comparative hybridization
AU2005264938B2 (en) 2004-06-16 2011-11-24 Verenium Corporation Compositions and methods for enzymatic decolorization of chlorophyll
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
TW200616632A (en) * 2004-06-17 2006-06-01 Plexxikon Inc Compounds modulating c-kit activity and uses therefor
CN101048407A (zh) * 2004-09-03 2007-10-03 普莱希科公司 双环杂芳基pde4b抑制剂
US7645575B2 (en) * 2004-09-08 2010-01-12 Xdx, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
US20090142854A1 (en) * 2004-11-16 2009-06-04 Robert Veronique Silanizing agents comprising a saccharide end group and uses thereof, in particular for the functionalization of solid supports
US20060160114A1 (en) * 2004-12-02 2006-07-20 Oncotech, Inc. Reagents and methods for predicting drug resistance
US20060147943A1 (en) * 2004-12-30 2006-07-06 Lewis Mark A Substrates having pendant epoxide groups for binding biomolecules and methods of making and using thereof
EP1846760B1 (en) * 2005-01-27 2010-12-15 Quest Diagnostics Investments Incorporated Rapid comparative genome hybridization
EP1869174B1 (en) 2005-03-10 2015-02-18 BASF Enzymes LLC Lyase enzymes, nucleic acids encoding them and methods for making and using them
EA018577B1 (ru) 2005-03-15 2013-09-30 Верениум Корпорейшн Целлюлазы, нуклеиновые кислоты, кодирующие их, и способы их получения и применения
WO2006102497A2 (en) * 2005-03-22 2006-09-28 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for diagnosis, monitoring and development of therapeutics for treatment of atherosclerotic disease
WO2006122295A2 (en) * 2005-05-11 2006-11-16 Expression Diagnostics, Inc. Methods of monitoring functional status of transplants using gene panels
AU2006272951A1 (en) * 2005-05-17 2007-02-01 Plexxikon, Inc. Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
MY153898A (en) * 2005-06-22 2015-04-15 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
WO2007005613A2 (en) * 2005-07-01 2007-01-11 Promega Corporation Network of buoyant particles for biomolecule purification
CN1908189A (zh) * 2005-08-02 2007-02-07 博奥生物有限公司 体外辅助鉴定肠型胃癌及其分化程度的方法与专用试剂盒
US8076074B2 (en) 2005-11-29 2011-12-13 Quest Diagnostics Investments Incorporated Balanced translocation in comparative hybridization
WO2007070381A2 (en) 2005-12-09 2007-06-21 Promega Corporation Nucleic acid purification with a binding matrix
EP2508622B1 (en) 2005-12-23 2016-09-14 Perkinelmer Las, Inc. Comparative genomic hybridization on encoded multiplex particles
US7932037B2 (en) 2007-12-05 2011-04-26 Perkinelmer Health Sciences, Inc. DNA assays using amplicon probes on encoded particles
US20090104613A1 (en) * 2005-12-23 2009-04-23 Perkinelmer Las, Inc. Methods and compositions relating to multiplexed genomic gain and loss assays
US20100009373A1 (en) * 2005-12-23 2010-01-14 Perkinelmer Health Sciences, Inc. Methods and compositions relating to multiplex genomic gain and loss assays
EP1987142A4 (en) 2006-02-02 2009-07-15 Verenium Corp ESTERASES AND ASSOCIATED NUCLEIC ACIDS AND METHODS
NZ595502A (en) 2006-02-10 2013-11-29 Verenium Corp Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them
ES2682284T3 (es) 2006-02-14 2018-09-19 Bp Corporation North America Inc. Xilanasas, ácidos nucleicos que las codifican y métodos para elaborarlas y usarlas
KR101622894B1 (ko) 2006-03-07 2016-05-19 바스프 엔자임스 엘엘씨 알돌라제, 이것을 코딩하는 핵산과 그 제조 방법 및 사용 방법
ES2416104T3 (es) 2006-03-07 2013-07-30 Cargill, Incorporated Aldolasas, ácidos nucleicos que las codifican y métodos para producir y usar las mismas
US20070232556A1 (en) * 2006-03-31 2007-10-04 Montine Thomas J Methods and compositions for the treatment of neurological diseases and disorders
AU2007309726A1 (en) * 2006-04-07 2008-05-02 Xdx, Inc. Steroid responsive nucleic acid expression and prediction of disease activity
CN106222185B (zh) 2006-08-04 2021-12-03 维莱尼姆公司 葡聚糖酶、编码它们的核酸及制备和使用它们的方法
WO2008021431A2 (en) * 2006-08-14 2008-02-21 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
EP2057274B1 (en) 2006-09-21 2013-12-11 DSM IP Assets B.V. Phospholipases, nucleic acids encoding them and methods for making and using them
US8877478B2 (en) 2006-09-21 2014-11-04 Verenium Corporation Phytases, nucleic acids encoding them and methods for making and using them
US8618248B2 (en) 2006-10-31 2013-12-31 President And Fellows Of Harvard College Phosphopeptide compositions and anti-phosphopeptide antibody compositions and methods of detecting phosphorylated peptides
EP2102367A2 (en) * 2006-11-09 2009-09-23 XDX, Inc. Methods for diagnosing and monitoring the status of systemic lupus erythematosus
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
PL3101128T3 (pl) 2006-12-21 2019-09-30 Basf Enzymes Llc Amylazy i glukoamylazy, kwasy nukleinowe kodujące te związki oraz sposoby wytwarzania tych związków oraz stosowania ich
RU2009122670A (ru) 2006-12-21 2011-01-27 Плекссикон, Инк. (Us) Соединения и способы для модуляции киназ и показания к их применению
PE20121126A1 (es) * 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
CN104212822A (zh) 2007-01-30 2014-12-17 Bp法人北美有限公司 用于处理木质纤维素的酶、编码它们的核酸及其制备和应用方法
EA019514B1 (ru) 2007-04-27 2014-04-30 Те Риджентс Оф Те Юниверсити Оф Калифорния Сенсоры coрастений, нуклеиновые кислоты, кодирующие их, способы их получения и применение
JP2010533729A (ja) 2007-07-17 2010-10-28 プレキシコン,インコーポレーテッド キナーゼ調節のための化合物と方法、及びそのための適応
US7507539B2 (en) * 2007-07-30 2009-03-24 Quest Diagnostics Investments Incorporated Substractive single label comparative hybridization
NZ601191A (en) 2007-10-03 2014-01-31 Verenium Corp Xylanases, nucleic acids encoding them and methods for making and using them
AU2008347234B2 (en) 2008-01-03 2015-05-28 Basf Enzymes Llc Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them
US20090215050A1 (en) * 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
WO2009137369A1 (en) * 2008-05-03 2009-11-12 Tufts Medical Center, Inc. Neonatal salivary genomics
US8357503B2 (en) 2008-08-29 2013-01-22 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
AU2009285644B2 (en) 2008-08-29 2015-08-20 Janssen Biotech, Inc. Markers and methods for assessing and treating ulcerative colitis and related disorders using a 20 gene panel
US8198062B2 (en) 2008-08-29 2012-06-12 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
US8153391B2 (en) 2008-08-29 2012-04-10 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
DE102008053270A1 (de) * 2008-10-27 2010-05-12 Medizinische Hochschule Hannover Vorrichtung und Verfahren zur Analyse von Zellen
WO2010054195A2 (en) 2008-11-07 2010-05-14 Centocor Ortho Biotech Inc. Markers and methods for assessing and treating lupus patients susceptible to photoprovocation
MX355507B (es) * 2009-03-09 2018-04-19 Bioatla Llc Proteinas mirac.
CA2738573C (en) * 2009-04-03 2013-02-19 F. Hoffmann-La Roche Ag Compositions of propane-1 sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide and uses thereof
HUE030948T2 (en) 2009-05-21 2017-06-28 Basf Enzymes Llc Phytases, nucleic acids and processes encoding them for their production and use
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
WO2011028533A2 (en) * 2009-08-24 2011-03-10 Perkinelmer Health Sciences, Inc. Methods for detecting dna methylation using encoded particles
US8222397B2 (en) * 2009-08-28 2012-07-17 Promega Corporation Methods of optimal purification of nucleic acids and kit for use in performing such methods
US8039613B2 (en) 2009-08-28 2011-10-18 Promega Corporation Methods of purifying a nucleic acid and formulation and kit for use in performing such methods
US20110086772A1 (en) * 2009-09-25 2011-04-14 Signature Genomics Laboratories Llc Multiplex (+/-) stranded arrays and assays for detecting chromosomal abnormalities associated with cancer and other diseases
UA109884C2 (uk) 2009-10-16 2015-10-26 Поліпептид, що має активність ферменту фосфатидилінозитол-специфічної фосфоліпази с, нуклеїнова кислота, що його кодує, та спосіб його виробництва і застосування
UA111708C2 (uk) 2009-10-16 2016-06-10 Бандж Ойлз, Інк. Спосіб рафінування олії
US20120322677A1 (en) 2009-10-19 2012-12-20 Stichting Het Nederlands Kanker Instituut Predicting benefit of anti-cancer therapy via array comparative genomic hybridization
WO2011048498A2 (en) 2009-10-19 2011-04-28 Stichting Het Nederlands Kanker Instituut Differentiation between brca2-associated tumours and sporadic tumours via array comparative genomic hybridization
US20120277112A1 (en) 2009-10-19 2012-11-01 Stichting Het Nederlands Kanker Instituut Predicting response to anti-cancer therapy via array comparative genomic hybridization
JP2013510166A (ja) 2009-11-06 2013-03-21 プレキシコン インコーポレーテッド キナーゼ調節のための化合物、方法およびその適用
NL2004275C2 (en) * 2010-02-22 2011-08-23 Univ Leiden Raman spectrometry.
US20140018251A1 (en) 2010-09-20 2014-01-16 Stichting Het Nederlands Kanker Instituut Methods for Predicting Response to Anti-Cancer Therapy in Cancer Patients
CA2811787A1 (en) 2010-10-06 2012-04-19 Bp Corporation North America Inc. Variant cbh i polypeptides
PE20141360A1 (es) 2011-02-07 2014-10-13 Plexxikon Inc Compuestos y metodos para la modulacion de quinasas e indicaciones para los mismos.
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
CA2836474A1 (en) 2011-05-17 2012-11-22 Plexxikon Inc. Kinase modulation and indications therefor
WO2013067448A2 (en) 2011-11-03 2013-05-10 Vca Antech Inc. Compositions and methods to detect various infectious organisms
US9850541B2 (en) 2011-12-19 2017-12-26 Valley Health System Methods and kits for detecting subjects at risk of having cancer
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
HUE065221T2 (hu) 2012-06-15 2024-05-28 Genesis Theranostix Korlatolt Feleloessegue Tarsasag Biomarker teszt praeeclampsia elõrejelzésére vagy korai kimutatására
US10670610B2 (en) 2012-06-15 2020-06-02 Wayne State University Biomarker test for prediction or early detection of preeclampsia and/or HELLP syndrome
WO2014028461A2 (en) 2012-08-13 2014-02-20 The Rockefeller University Treatment and diagnosis of melanoma
EP2914344B1 (en) 2012-10-31 2020-01-15 The Rockefeller University Treatment of metastatic colon cancer
US9267171B2 (en) 2013-02-28 2016-02-23 New York University DNA photolithography with cinnamate crosslinkers
ES2913205T3 (es) 2014-05-13 2022-06-01 Bioatla Inc Proteínas biológicas activas condicionalmente
CN106795557A (zh) 2014-06-02 2017-05-31 瓦利保健系统公司 用于肺癌诊断的方法和系统
US11111288B2 (en) 2014-08-28 2021-09-07 Bioatla, Inc. Conditionally active chimeric antigen receptors for modified t-cells
DK3186284T3 (da) 2014-08-28 2022-05-09 Bioatla Inc Betinget aktive kimæriske antigenreceptorer til modificerede t-celler
US10513699B2 (en) 2014-09-03 2019-12-24 Bioatla, Llc Discovering and producing conditionally active biologic proteins in the same eukaryotic cell production hosts
SG11201705988UA (en) 2015-02-24 2017-08-30 Bioatla Llc Conditionally active biological proteins
US10160755B2 (en) 2015-04-08 2018-12-25 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
FR3038734A1 (fr) * 2015-07-10 2017-01-13 Centre Nat De La Rech Scient (Cnrs) Nouveaux materiaux optiques fonctionnalises
US10829484B2 (en) 2015-07-28 2020-11-10 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US9938273B2 (en) 2015-12-07 2018-04-10 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
EP4122958A1 (en) 2016-05-13 2023-01-25 BioAtla, Inc. Anti-ror2 antibodies, antibody fragments, their immunoconjugates and uses thereof
TW201815766A (zh) 2016-09-22 2018-05-01 美商普雷辛肯公司 用於ido及tdo調節之化合物及方法以及其適應症
JP7193460B2 (ja) 2016-12-23 2022-12-20 プレキシコン インコーポレーテッド Cdk8調節およびその適応症のための化合物および方法
WO2018226846A1 (en) 2017-06-07 2018-12-13 Plexxikon Inc. Compounds and methods for kinase modulation
EP3713575A4 (en) 2017-11-21 2021-08-25 Rgenix, Inc. POLYMORPHS AND THEIR USES
WO2019136560A1 (en) 2018-01-09 2019-07-18 Mcmaster University Fluorosilinated liquid-infused surfaces with embedded biomolecules, methods of making and uses thereof
EP3594290A1 (en) 2018-07-13 2020-01-15 Haelixa GmbH Marked items and verification methods
US11884980B2 (en) 2018-11-28 2024-01-30 Bioscreening & Diagnostics Llc Method for detection of traumatic brain injury
JP7689964B2 (ja) 2019-12-13 2025-06-09 インスピルナ,インコーポレーテッド 金属塩及びその使用
EP4368613A1 (fr) 2022-11-08 2024-05-15 aeChem Life Technologies Sàrl Dérivés de dicyanomethanides de phthalazinium
US20250314664A1 (en) 2024-04-03 2025-10-09 Mars, Incorporated Compositions and methods to detect infectious organisms

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4231910A (en) * 1979-02-08 1980-11-04 Dow Corning Corporation Primer composition
CA1130228A (en) * 1980-05-21 1982-08-24 Chiang-Chang Liao Support matrix for amino-containing biologically active substances
CA1253129A (en) * 1984-02-09 1989-04-25 Thomas R. Jones Porous inorganic materials
US4957858A (en) * 1986-04-16 1990-09-18 The Salk Instute For Biological Studies Replicative RNA reporter systems
US4637687A (en) * 1984-06-14 1987-01-20 General Electric Company Cascaded, dual cell transflective liquid crystal display
US4818681A (en) * 1985-02-22 1989-04-04 Molecular Diagnostics, Inc. Fast and specific immobilization of nucleic acids to solid supports
US5641630A (en) * 1985-06-13 1997-06-24 Amgen Inc. Method and kit for performing nucleic acid hybridization assays
US4806631A (en) * 1985-09-30 1989-02-21 Miles Inc. Immobilization of nucleic acids on solvolyzed nylon supports
US5190864A (en) * 1986-04-15 1993-03-02 Northeastern University Enzyme amplification by using free enzyme to release enzyme from an immobilized enzyme material
US4937188A (en) * 1986-04-15 1990-06-26 Northeastern University Enzyme activity amplification method for increasing assay sensitivity
US4713116A (en) * 1987-01-02 1987-12-15 Ralston Purina Company Protein modified with a silanation reagent as an adhesive binder and process of producing
AU613982B2 (en) * 1987-11-27 1991-08-15 Ecc International Limited Porous inorganic material
GB8803413D0 (en) * 1988-02-15 1988-03-16 Ecc Int Ltd Biological support
US5024933A (en) * 1988-05-10 1991-06-18 Enzo Biochem, Inc. Method and kit for sample adherence to test substrate
US5071909A (en) * 1989-07-26 1991-12-10 Millipore Corporation Immobilization of proteins and peptides on insoluble supports
US5252743A (en) * 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5215882A (en) * 1989-11-30 1993-06-01 Ortho Diagnostic Systems, Inc. Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays
EP0455905B1 (en) * 1990-05-11 1998-06-17 Microprobe Corporation Dipsticks for nucleic acid hybridization assays and methods for covalently immobilizing oligonucleotides
DE4018778A1 (de) * 1990-06-12 1991-12-19 Braun Melsungen Ag Adsorptionsmaterial zur selektiven entfernung von ldl- oder/und vldl
IL102486A (en) * 1991-10-04 1997-11-20 Orgenics Ltd Method and apparatus for detection of nucleic acid sequences with a nucleic acid probe
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5412087A (en) * 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5610287A (en) * 1993-12-06 1997-03-11 Molecular Tool, Inc. Method for immobilizing nucleic acid molecules
US6015880A (en) * 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5554744A (en) * 1994-09-23 1996-09-10 Hybridon, Inc. Method for loading solid supports for nucleic acid synthesis
US5688642A (en) * 1994-12-01 1997-11-18 The United States Of America As Represented By The Secretary Of The Navy Selective attachment of nucleic acid molecules to patterned self-assembled surfaces
US5807756A (en) * 1995-01-10 1998-09-15 At Point Bio Ceramic assembly for use in biological assays
US5601982A (en) * 1995-02-07 1997-02-11 Sargent; Jeannine P. Method and apparatus for determining the sequence of polynucleotides
US5959098A (en) * 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
US5630932A (en) * 1995-09-06 1997-05-20 Molecular Imaging Corporation Tip etching system and method for etching platinum-containing wire
US5658802A (en) * 1995-09-07 1997-08-19 Microfab Technologies, Inc. Method and apparatus for making miniaturized diagnostic arrays
US5851769A (en) * 1995-09-27 1998-12-22 The Regents Of The University Of California Quantitative DNA fiber mapping
US6156502A (en) * 1995-12-21 2000-12-05 Beattie; Kenneth Loren Arbitrary sequence oligonucleotide fingerprinting
US6426183B1 (en) * 1995-12-21 2002-07-30 Kenneth L. Beattie Oligonucleotide microarrays: direct covalent attachment to glass
US5567294A (en) * 1996-01-30 1996-10-22 Board Of Governors, University Of Alberta Multiple capillary biochemical analyzer with barrier member
AU734704B2 (en) * 1996-05-30 2001-06-21 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6979728B2 (en) * 1998-05-04 2005-12-27 Baylor College Of Medicine Articles of manufacture and methods for array based analysis of biological molecules
US6048695A (en) * 1998-05-04 2000-04-11 Baylor College Of Medicine Chemically modified nucleic acids and methods for coupling nucleic acids to solid support

Similar Documents

Publication Publication Date Title
JP4477774B2 (ja) 化学修飾された核酸および核酸の固体支持体への結合方法
US5900481A (en) Bead linkers for immobilizing nucleic acids to solid supports
US6218111B1 (en) Tag reagent and assay method
US7553958B2 (en) Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
US6133436A (en) Beads bound to a solid support and to nucleic acids
JP5274852B2 (ja) 光分解性化合物と前記化合物がカップリングしたオリゴマープローブアレイ用基板、オリゴマープローブアレイおよびその製造方法
EP0937097B1 (en) Compositions and methods for immobilizing nucleic acids to solid supports
US20020028455A1 (en) Methods and reagents for assembling molecules on solid supports
JPS58180500A (ja) Dnaの化学的合成方法
EP1200628A2 (en) Attachment of oligonucleotides to solid supports through schiff base type linkages for capture and detection of nucleic acids
JP2008138005A (ja) 新規な保護基及びオリゴヌクレオチド合成のための改良方法における該新規な保護基の使用
JPS5927900A (ja) 固定化オリゴヌクレオチド
JP2008070393A (ja) 特に生物学的チップの生産のためのプローブの固定化方法
US20240209018A1 (en) Universal linker reagents for dna synthesis
Sojka et al. A novel phosphoramidite method for automated synthesis of oligonucleotides on glass supports for biosensor development
HK1020197B (en) Compositions and methods for immobilizing nucleic acids to solid supports