JP2002506844A5 - - Google Patents
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- Publication number
- JP2002506844A5 JP2002506844A5 JP2000536684A JP2000536684A JP2002506844A5 JP 2002506844 A5 JP2002506844 A5 JP 2002506844A5 JP 2000536684 A JP2000536684 A JP 2000536684A JP 2000536684 A JP2000536684 A JP 2000536684A JP 2002506844 A5 JP2002506844 A5 JP 2002506844A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- group
- copper
- compound
- cis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000002466 imines Chemical class 0.000 description 13
- 239000003054 catalyst Substances 0.000 description 10
- 238000000034 method Methods 0.000 description 8
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 7
- 229910052802 copper Inorganic materials 0.000 description 7
- 239000010949 copper Substances 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 6
- SQDFHQJTAWCFIB-UHFFFAOYSA-N n-methylidenehydroxylamine Chemical compound ON=C SQDFHQJTAWCFIB-UHFFFAOYSA-N 0.000 description 5
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 description 4
- 238000005984 hydrogenation reaction Methods 0.000 description 4
- 150000002576 ketones Chemical class 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 125000001424 substituent group Chemical group 0.000 description 3
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 125000002837 carbocyclic group Chemical group 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- JGDFBJMWFLXCLJ-UHFFFAOYSA-N copper chromite Chemical compound [Cu]=O.[Cu]=O.O=[Cr]O[Cr]=O JGDFBJMWFLXCLJ-UHFFFAOYSA-N 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 description 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 125000002723 alicyclic group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- -1 cyclic imines Chemical class 0.000 description 1
- 125000000392 cycloalkenyl group Chemical group 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- NNGAQKAUYDTUQR-UHFFFAOYSA-N cyclohexanimine Chemical compound N=C1CCCCC1 NNGAQKAUYDTUQR-UHFFFAOYSA-N 0.000 description 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 description 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- CPQCSJYYDADLCZ-UHFFFAOYSA-N n-methylhydroxylamine Chemical compound CNO CPQCSJYYDADLCZ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH64598 | 1998-03-18 | ||
| CH645/98 | 1998-03-18 | ||
| PCT/EP1999/001696 WO1999047486A1 (en) | 1998-03-18 | 1999-03-16 | Process for the cis-selective catalytic hydrogenation of cyclohexylidenamines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002506844A JP2002506844A (ja) | 2002-03-05 |
| JP2002506844A5 true JP2002506844A5 (https=) | 2006-05-11 |
Family
ID=4191841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000536684A Pending JP2002506844A (ja) | 1998-03-18 | 1999-03-16 | シクロヘキシリデンアミンのｃｉｓ−選択的接触水素化方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6232501B1 (https=) |
| EP (1) | EP1064250B1 (https=) |
| JP (1) | JP2002506844A (https=) |
| CN (1) | CN1216033C (https=) |
| AR (1) | AR018164A1 (https=) |
| AU (1) | AU759530B2 (https=) |
| CA (1) | CA2323629A1 (https=) |
| DE (1) | DE69916593T2 (https=) |
| ES (1) | ES2217748T3 (https=) |
| HU (1) | HUP0101322A3 (https=) |
| IL (2) | IL138172A0 (https=) |
| PT (1) | PT1064250E (https=) |
| TR (1) | TR200002673T2 (https=) |
| TW (1) | TWI220427B (https=) |
| WO (1) | WO1999047486A1 (https=) |
| ZA (1) | ZA200004624B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6500987B1 (en) | 1998-11-27 | 2002-12-31 | Teva Pharmaceutical Industries Ltd. | Sertraline hydrochloride polymorphs |
| ATE264831T1 (de) | 1999-07-29 | 2004-05-15 | Ciba Sc Holding Ag | Verfahren zur cis-selektiven katalytischen hydrierung von cyclohexylidenaminen |
| US6495721B1 (en) | 1999-08-09 | 2002-12-17 | Teva Pharmaceutical Industries Ltd. | Sertraline hydrochloride Form II and methods for the preparation thereof |
| TWI260315B (en) | 1999-10-29 | 2006-08-21 | Ciba Sc Holding Ag | Polymorphic forms of sertraline hydrochloride |
| US7442838B2 (en) | 1999-10-29 | 2008-10-28 | Ciba Specialty Chemicals Corp. | Polymorphic forms of sertraline hydrochloride |
| EP1230211B1 (en) | 1999-11-16 | 2005-07-20 | Ciba SC Holding AG | Process for the preparation of ketimines |
| ATE295349T1 (de) * | 1999-11-16 | 2005-05-15 | Ciba Sc Holding Ag | Verfahren zur herstellung von ketiminen |
| ES2281374T3 (es) | 1999-12-21 | 2007-10-01 | Teva Pharmaceutical Industries Ltd. | Nuevos polimorfos de hidrocloruro de sertralina, procedimientos para su preparacion, composiciones que los contienen y metodos para su utilizacion. |
| CZ20023269A3 (cs) * | 2000-03-14 | 2003-09-17 | Teva Pharmaceutical Industries Ltd. | Způsob přípravy (+) -cis-sertralinu |
| US6723878B2 (en) | 2001-06-15 | 2004-04-20 | Orion Corporation Fermion | Method for preparing sertraline |
| AU2003251290A1 (en) | 2002-04-29 | 2003-11-17 | Teva Pharmaceutical Industries Ltd. | Process for preparation of polymorphic form ii of sertraline hydrochloride, pharmaceutical formulations and methods of administration thereof |
| ES2242555T1 (es) * | 2003-04-14 | 2005-11-16 | Teva Pharmaceutical Industries Limited | Hidrogenacion de intermediarios de imina de sertralina con catalizadores. |
| WO2006129324A2 (en) | 2005-06-03 | 2006-12-07 | Hetero Drugs Limited | A highly stereoselective synthesis of sertraline |
| US8354558B2 (en) * | 2007-12-21 | 2013-01-15 | Basf Se | Process for diastereoselective conversion of chiral imines |
| US8415500B2 (en) * | 2007-12-21 | 2013-04-09 | Basf Se | One-stage reductive amination |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4536518A (en) * | 1979-11-01 | 1985-08-20 | Pfizer Inc. | Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine |
| US5290806A (en) * | 1990-03-06 | 1994-03-01 | Basf Aktiengesellschaft | 4-(4-tert-butylphenyl) cyclohexylamines, and fungicides containing same |
| GB9114948D0 (en) * | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
| IL112569A (en) * | 1994-02-10 | 1999-12-22 | Wyeth John & Brother Ltd | Pharmaceutical compositions comprising cyclohexylamine derivatives certain such novel compounds and their preparation |
| HU222341B1 (hu) | 1996-12-18 | 2003-06-28 | Richter Gedeon Vegyészeti Gyár Rt. | Eljárás sertralin előállítására és az eljárásban alkalmazott intermedier |
| DE19812054A1 (de) * | 1998-03-19 | 1999-09-23 | Hoechst Schering Agrevo Gmbh | Verfahren zur Herstellung 4-substituierter cis-Cyclohexylamine |
-
1999
- 1999-03-16 ES ES99915616T patent/ES2217748T3/es not_active Expired - Lifetime
- 1999-03-16 US US09/646,211 patent/US6232501B1/en not_active Expired - Lifetime
- 1999-03-16 AR ARP990101137A patent/AR018164A1/es active IP Right Grant
- 1999-03-16 IL IL13817299A patent/IL138172A0/xx not_active IP Right Cessation
- 1999-03-16 TR TR2000/02673T patent/TR200002673T2/xx unknown
- 1999-03-16 CN CN998041378A patent/CN1216033C/zh not_active Expired - Fee Related
- 1999-03-16 HU HU0101322A patent/HUP0101322A3/hu unknown
- 1999-03-16 WO PCT/EP1999/001696 patent/WO1999047486A1/en not_active Ceased
- 1999-03-16 PT PT99915616T patent/PT1064250E/pt unknown
- 1999-03-16 DE DE69916593T patent/DE69916593T2/de not_active Expired - Lifetime
- 1999-03-16 AU AU34128/99A patent/AU759530B2/en not_active Ceased
- 1999-03-16 CA CA002323629A patent/CA2323629A1/en not_active Abandoned
- 1999-03-16 JP JP2000536684A patent/JP2002506844A/ja active Pending
- 1999-03-16 EP EP99915616A patent/EP1064250B1/en not_active Expired - Lifetime
- 1999-03-17 TW TW088104122A patent/TWI220427B/zh not_active IP Right Cessation
-
2000
- 2000-08-30 IL IL138172A patent/IL138172A/en unknown
- 2000-09-04 ZA ZA200004624A patent/ZA200004624B/xx unknown
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