CN1216033C - 亚环己基胺的顺式选择性催化氢化方法 - Google Patents

亚环己基胺的顺式选择性催化氢化方法 Download PDF

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Publication number
CN1216033C
CN1216033C CN998041378A CN99804137A CN1216033C CN 1216033 C CN1216033 C CN 1216033C CN 998041378 A CN998041378 A CN 998041378A CN 99804137 A CN99804137 A CN 99804137A CN 1216033 C CN1216033 C CN 1216033C
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CN
China
Prior art keywords
copper
compound
hydrogenation
cis
catalyst
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN998041378A
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English (en)
Chinese (zh)
Other versions
CN1293653A (zh
Inventor
H·斯坦纳
M·本兹
H·－P·雅勒特
M·托门
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
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Ciba Spezialitaetenchemie Holding AG
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Publication date
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Publication of CN1293653A publication Critical patent/CN1293653A/zh
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Publication of CN1216033C publication Critical patent/CN1216033C/zh
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/52—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of imines or imino-ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN998041378A 1998-03-18 1999-03-16 亚环己基胺的顺式选择性催化氢化方法 Expired - Fee Related CN1216033C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH64598 1998-03-18
CH645/1998 1998-03-18

Publications (2)

Publication Number Publication Date
CN1293653A CN1293653A (zh) 2001-05-02
CN1216033C true CN1216033C (zh) 2005-08-24

Family

ID=4191841

Family Applications (1)

Application Number Title Priority Date Filing Date
CN998041378A Expired - Fee Related CN1216033C (zh) 1998-03-18 1999-03-16 亚环己基胺的顺式选择性催化氢化方法

Country Status (16)

Country Link
US (1) US6232501B1 (https=)
EP (1) EP1064250B1 (https=)
JP (1) JP2002506844A (https=)
CN (1) CN1216033C (https=)
AR (1) AR018164A1 (https=)
AU (1) AU759530B2 (https=)
CA (1) CA2323629A1 (https=)
DE (1) DE69916593T2 (https=)
ES (1) ES2217748T3 (https=)
HU (1) HUP0101322A3 (https=)
IL (2) IL138172A0 (https=)
PT (1) PT1064250E (https=)
TR (1) TR200002673T2 (https=)
TW (1) TWI220427B (https=)
WO (1) WO1999047486A1 (https=)
ZA (1) ZA200004624B (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6500987B1 (en) 1998-11-27 2002-12-31 Teva Pharmaceutical Industries Ltd. Sertraline hydrochloride polymorphs
ATE264831T1 (de) 1999-07-29 2004-05-15 Ciba Sc Holding Ag Verfahren zur cis-selektiven katalytischen hydrierung von cyclohexylidenaminen
US6495721B1 (en) 1999-08-09 2002-12-17 Teva Pharmaceutical Industries Ltd. Sertraline hydrochloride Form II and methods for the preparation thereof
TWI260315B (en) 1999-10-29 2006-08-21 Ciba Sc Holding Ag Polymorphic forms of sertraline hydrochloride
US7442838B2 (en) 1999-10-29 2008-10-28 Ciba Specialty Chemicals Corp. Polymorphic forms of sertraline hydrochloride
EP1230211B1 (en) 1999-11-16 2005-07-20 Ciba SC Holding AG Process for the preparation of ketimines
ATE295349T1 (de) * 1999-11-16 2005-05-15 Ciba Sc Holding Ag Verfahren zur herstellung von ketiminen
ES2281374T3 (es) 1999-12-21 2007-10-01 Teva Pharmaceutical Industries Ltd. Nuevos polimorfos de hidrocloruro de sertralina, procedimientos para su preparacion, composiciones que los contienen y metodos para su utilizacion.
CZ20023269A3 (cs) * 2000-03-14 2003-09-17 Teva Pharmaceutical Industries Ltd. Způsob přípravy (+) -cis-sertralinu
US6723878B2 (en) 2001-06-15 2004-04-20 Orion Corporation Fermion Method for preparing sertraline
AU2003251290A1 (en) 2002-04-29 2003-11-17 Teva Pharmaceutical Industries Ltd. Process for preparation of polymorphic form ii of sertraline hydrochloride, pharmaceutical formulations and methods of administration thereof
ES2242555T1 (es) * 2003-04-14 2005-11-16 Teva Pharmaceutical Industries Limited Hidrogenacion de intermediarios de imina de sertralina con catalizadores.
WO2006129324A2 (en) 2005-06-03 2006-12-07 Hetero Drugs Limited A highly stereoselective synthesis of sertraline
US8354558B2 (en) * 2007-12-21 2013-01-15 Basf Se Process for diastereoselective conversion of chiral imines
US8415500B2 (en) * 2007-12-21 2013-04-09 Basf Se One-stage reductive amination

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US5290806A (en) * 1990-03-06 1994-03-01 Basf Aktiengesellschaft 4-(4-tert-butylphenyl) cyclohexylamines, and fungicides containing same
GB9114948D0 (en) * 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
IL112569A (en) * 1994-02-10 1999-12-22 Wyeth John & Brother Ltd Pharmaceutical compositions comprising cyclohexylamine derivatives certain such novel compounds and their preparation
HU222341B1 (hu) 1996-12-18 2003-06-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás sertralin előállítására és az eljárásban alkalmazott intermedier
DE19812054A1 (de) * 1998-03-19 1999-09-23 Hoechst Schering Agrevo Gmbh Verfahren zur Herstellung 4-substituierter cis-Cyclohexylamine

Also Published As

Publication number Publication date
IL138172A (en) 2007-09-20
ES2217748T3 (es) 2004-11-01
DE69916593D1 (de) 2004-05-27
EP1064250A1 (en) 2001-01-03
WO1999047486A1 (en) 1999-09-23
HUP0101322A2 (hu) 2002-05-29
CA2323629A1 (en) 1999-09-23
US6232501B1 (en) 2001-05-15
DE69916593T2 (de) 2005-05-25
TR200002673T2 (tr) 2000-11-21
AU3412899A (en) 1999-10-11
AR018164A1 (es) 2001-10-31
EP1064250B1 (en) 2004-04-21
IL138172A0 (en) 2001-10-31
AU759530B2 (en) 2003-04-17
TWI220427B (en) 2004-08-21
ZA200004624B (en) 2001-11-29
HUP0101322A3 (en) 2002-06-28
JP2002506844A (ja) 2002-03-05
PT1064250E (pt) 2004-09-30
CN1293653A (zh) 2001-05-02

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Granted publication date: 20050824