DE69916593D1 - Verfahren zur cis-selektiven katalytischen hydrierung von cyclohexylidenaminen - Google Patents

Verfahren zur cis-selektiven katalytischen hydrierung von cyclohexylidenaminen

Info

Publication number
DE69916593D1
DE69916593D1 DE69916593T DE69916593T DE69916593D1 DE 69916593 D1 DE69916593 D1 DE 69916593D1 DE 69916593 T DE69916593 T DE 69916593T DE 69916593 T DE69916593 T DE 69916593T DE 69916593 D1 DE69916593 D1 DE 69916593D1
Authority
DE
Germany
Prior art keywords
cyclohexylidenamines
selective catalytic
catalytic hydration
cis
cis selective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69916593T
Other languages
English (en)
Other versions
DE69916593T2 (de
Inventor
Heinz Steiner
Markus Benz
Hans-Peter Jalett
Marc Thommen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Ciba Spezialitaetenchemie Holding AG
Ciba SC Holding AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Spezialitaetenchemie Holding AG, Ciba SC Holding AG filed Critical Ciba Spezialitaetenchemie Holding AG
Application granted granted Critical
Publication of DE69916593D1 publication Critical patent/DE69916593D1/de
Publication of DE69916593T2 publication Critical patent/DE69916593T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/52—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of imines or imino-ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
DE69916593T 1998-03-18 1999-03-16 Verfahren zur cis-selektiven katalytischen hydrierung von cyclohexylidenaminen Expired - Lifetime DE69916593T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH64598 1998-03-18
CH64598 1998-03-18
PCT/EP1999/001696 WO1999047486A1 (en) 1998-03-18 1999-03-16 Process for the cis-selective catalytic hydrogenation of cyclohexylidenamines

Publications (2)

Publication Number Publication Date
DE69916593D1 true DE69916593D1 (de) 2004-05-27
DE69916593T2 DE69916593T2 (de) 2005-05-25

Family

ID=4191841

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69916593T Expired - Lifetime DE69916593T2 (de) 1998-03-18 1999-03-16 Verfahren zur cis-selektiven katalytischen hydrierung von cyclohexylidenaminen

Country Status (16)

Country Link
US (1) US6232501B1 (de)
EP (1) EP1064250B1 (de)
JP (1) JP2002506844A (de)
CN (1) CN1216033C (de)
AR (1) AR018164A1 (de)
AU (1) AU759530B2 (de)
CA (1) CA2323629A1 (de)
DE (1) DE69916593T2 (de)
ES (1) ES2217748T3 (de)
HU (1) HUP0101322A3 (de)
IL (2) IL138172A0 (de)
PT (1) PT1064250E (de)
TR (1) TR200002673T2 (de)
TW (1) TWI220427B (de)
WO (1) WO1999047486A1 (de)
ZA (1) ZA200004624B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6500987B1 (en) 1998-11-27 2002-12-31 Teva Pharmaceutical Industries Ltd. Sertraline hydrochloride polymorphs
AU6275900A (en) * 1999-07-29 2001-02-19 Ciba Specialty Chemicals Holding Inc. Process for the cis-selective catalytic hydrogenation of cyclohexylidenamines
US6495721B1 (en) 1999-08-09 2002-12-17 Teva Pharmaceutical Industries Ltd. Sertraline hydrochloride Form II and methods for the preparation thereof
TWI260315B (en) 1999-10-29 2006-08-21 Ciba Sc Holding Ag Polymorphic forms of sertraline hydrochloride
US7442838B2 (en) 1999-10-29 2008-10-28 Ciba Specialty Chemicals Corp. Polymorphic forms of sertraline hydrochloride
PT1230211E (pt) 1999-11-16 2005-10-31 Ciba Sc Holding Ag Processo para a preparacao de cetiminas
IL149527A0 (en) * 1999-11-16 2002-11-10 Ciba Sc Holding Ag Process for the preparation of ketimines
US6452054B2 (en) 1999-12-21 2002-09-17 Teva Pharmaceutical Industries Ltd. Sertraline hydrochloride polymorphs, processes for preparing them, compositions containing them and methods of using them
KR20070002101A (ko) 2000-03-14 2007-01-04 테바 파마슈티컬 인더스트리즈 리미티드 (+)-시스-세르트랄린의 신규한 제조 방법
US6723878B2 (en) 2001-06-15 2004-04-20 Orion Corporation Fermion Method for preparing sertraline
WO2003093217A1 (en) 2002-04-29 2003-11-13 Teva Pharmaceutical Industries Ltd. Process for preparation of polymorphic form ii of sertraline hydrochloride, pharmaceutical formulations and methods of administration thereof
DE04750154T1 (de) * 2003-04-14 2005-12-29 Teva Pharmaceutical Industries Ltd. Katalytische hydrierung von iminzwischenprodukten von sertralin
US20070260090A1 (en) 2005-06-03 2007-11-08 Hetero Drugs Limited Highly Steroselective Synthesis of Sertraline
WO2009080511A1 (de) * 2007-12-21 2009-07-02 Basf Se Verfahren zur diastereoselektiven umsetzung von chiralen iminen
EP2234959B1 (de) * 2007-12-21 2014-10-08 Basf Se Einstufige reduktive aminierung

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4536518A (en) 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US5290806A (en) * 1990-03-06 1994-03-01 Basf Aktiengesellschaft 4-(4-tert-butylphenyl) cyclohexylamines, and fungicides containing same
GB9114948D0 (en) * 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
IL112569A (en) * 1994-02-10 1999-12-22 Wyeth John & Brother Ltd Pharmaceutical compositions comprising cyclohexylamine derivatives certain such novel compounds and their preparation
HU222341B1 (hu) 1996-12-18 2003-06-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás sertralin előállítására és az eljárásban alkalmazott intermedier
DE19812054A1 (de) * 1998-03-19 1999-09-23 Hoechst Schering Agrevo Gmbh Verfahren zur Herstellung 4-substituierter cis-Cyclohexylamine

Also Published As

Publication number Publication date
CN1216033C (zh) 2005-08-24
AR018164A1 (es) 2001-10-31
IL138172A (en) 2007-09-20
AU759530B2 (en) 2003-04-17
ES2217748T3 (es) 2004-11-01
WO1999047486A1 (en) 1999-09-23
DE69916593T2 (de) 2005-05-25
US6232501B1 (en) 2001-05-15
JP2002506844A (ja) 2002-03-05
TR200002673T2 (tr) 2000-11-21
IL138172A0 (en) 2001-10-31
TWI220427B (en) 2004-08-21
PT1064250E (pt) 2004-09-30
ZA200004624B (en) 2001-11-29
HUP0101322A3 (en) 2002-06-28
CA2323629A1 (en) 1999-09-23
EP1064250B1 (de) 2004-04-21
CN1293653A (zh) 2001-05-02
HUP0101322A2 (hu) 2002-05-29
EP1064250A1 (de) 2001-01-03
AU3412899A (en) 1999-10-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: CIBA HOLDING INC., BASEL, CH

8327 Change in the person/name/address of the patent owner

Owner name: TEVA PHARMACEUTICAL INDUSTRIES LTD., PETAH TIQ, IL