JP2002506445A - スーパーオキシドラジカルの不均化反応のための合成触媒を用いる鎮痛方法 - Google Patents
スーパーオキシドラジカルの不均化反応のための合成触媒を用いる鎮痛方法Info
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- JP2002506445A JP2002506445A JP50459399A JP50459399A JP2002506445A JP 2002506445 A JP2002506445 A JP 2002506445A JP 50459399 A JP50459399 A JP 50459399A JP 50459399 A JP50459399 A JP 50459399A JP 2002506445 A JP2002506445 A JP 2002506445A
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5040297P | 1997-06-20 | 1997-06-20 | |
| US60/050,402 | 1997-06-20 | ||
| PCT/US1998/012231 WO1998058636A1 (en) | 1997-06-20 | 1998-06-15 | Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002506445A true JP2002506445A (ja) | 2002-02-26 |
| JP2002506445A5 JP2002506445A5 (https=) | 2007-12-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50459399A Ceased JP2002506445A (ja) | 1997-06-20 | 1998-06-15 | スーパーオキシドラジカルの不均化反応のための合成触媒を用いる鎮痛方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6180620B1 (https=) |
| EP (1) | EP1001752B1 (https=) |
| JP (1) | JP2002506445A (https=) |
| AT (1) | ATE256467T1 (https=) |
| AU (1) | AU733415B2 (https=) |
| CA (1) | CA2294155A1 (https=) |
| DE (1) | DE69820633T2 (https=) |
| DK (1) | DK1001752T3 (https=) |
| ES (1) | ES2215305T3 (https=) |
| PT (1) | PT1001752E (https=) |
| WO (1) | WO1998058636A1 (https=) |
| ZA (1) | ZA985376B (https=) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007513948A (ja) * | 2003-12-11 | 2007-05-31 | アルコン，インコーポレイテッド | 視神経損傷および網膜損傷の処置のためのスーパーオキシドジスムターゼ模倣物 |
| JP2014526562A (ja) * | 2011-09-26 | 2014-10-06 | ガレラ・セラピューティクス・リミテッド・ライアビリティ・カンパニー | 疾患の治療方法 |
| JP2018525388A (ja) * | 2015-08-11 | 2018-09-06 | ガレラ・ラブス・リミテッド・ライアビリティ・カンパニーＧａｌｅｒａ Ｌａｂｓ， Ｌｌｃ | 経口バイオアベイラビリティを有するペンタアザ大環状環錯体 |
| US10610533B2 (en) | 2006-10-12 | 2020-04-07 | Galera Labs, Llc | Methods of treating oral mucositis |
| US11246950B2 (en) | 2017-04-13 | 2022-02-15 | Galera Labs, Llc | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
| US12156863B2 (en) | 2016-09-01 | 2024-12-03 | Galera Labs, Llc | Combination cancer therapy with pentaaza macrocyclic ring complex and ascorbate compound |
| US12220420B2 (en) | 2016-05-03 | 2025-02-11 | Galera Labs, Llc | Combination therapy for cancer treatment |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6127356A (en) | 1993-10-15 | 2000-10-03 | Duke University | Oxidant scavengers |
| US20060270639A1 (en) * | 1997-06-20 | 2006-11-30 | Daniela Salvemini | Combinations of superoxide dismutase mimetics and nonsteroidal analgesic/anti-inflammatory drugs |
| US6214817B1 (en) * | 1997-06-20 | 2001-04-10 | Monsanto Company | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity |
| US20050171198A1 (en) * | 1997-06-20 | 2005-08-04 | Metaphore Pharmaceuticals, Inc. | SODm therapy for treatment, prevention, inhibition and reversal of inflammatory disease |
| IL135949A0 (en) | 1997-11-03 | 2001-05-20 | Univ Duke | Substituted porphyrins |
| DK1616869T3 (da) | 1999-01-25 | 2012-05-07 | Nat Jewish Health | Substituerede porphyriner og deres terapeutiske anvendelse |
| DE60018925T2 (de) | 1999-05-27 | 2006-04-13 | Pharmacia Corp.(N.D.Ges.D.Staates Delaware) | Biomaterialien, modifiziert mit superoxid-dismutase imitatoren |
| US20030069281A1 (en) * | 2000-06-14 | 2003-04-10 | Irwin Fridovich | Tetrapyrroles |
| US20020072512A1 (en) * | 2000-12-08 | 2002-06-13 | Metaphore Pharmaceuticals, Inc | Method of preventing and treating HIV-mediated central nervous system damage |
| DE60235955D1 (de) * | 2001-01-05 | 2010-05-27 | Metaphore Pharmaceuticals Inc | Zusammensetzungen und verfahren zur erhöhung der zytokin-aktivität und zur behandlung der hypotension assoziiert mit der verabreichung von zytokinen |
| EP1392328B1 (en) | 2001-01-19 | 2009-08-12 | National Jewish Medical and Research Center | Medicament for protection in radiotherapy |
| WO2002058686A2 (en) * | 2001-01-26 | 2002-08-01 | Metaphore Pharmaceuticals, Inc. | Method of treatment of neurodegenerative disorders using pentaaza-macrocyclic ligand complexes |
| EP1405066B1 (en) * | 2001-03-02 | 2015-06-17 | Galera Therapeutics LLC | Chromatography of metal complexes |
| US20040137638A1 (en) | 2002-03-04 | 2004-07-15 | Slomczynska Urszula J. | Chromatography of metal complexes |
| AU2002312194B8 (en) * | 2001-06-01 | 2008-05-15 | Aeolus Sciences, Inc. | Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance |
| CA2449631A1 (en) * | 2001-06-08 | 2002-12-19 | Metaphore Pharmaceuticals, Inc. | Libraries of conformationally constrained peptides, chiral azacrowns, and peptidomimetics and methods of making the same |
| CA2451602A1 (en) * | 2001-06-26 | 2003-01-03 | Metaphore Pharmaceuticals, Inc. | Combination therapy of an sodm and a corticosteroid for prevention and/or treatment of inflammatory disease |
| EP1450824A4 (en) * | 2001-11-02 | 2005-09-28 | Elan Corp Plc | PHARMACEUTICAL COMPOSITION |
| SI1463563T1 (sl) * | 2001-12-14 | 2009-06-30 | Alcon Inc | Superoksidni dizmutazni mimetiki za zdravljenje očesnih motenj in bolezni |
| US6933275B2 (en) * | 2002-05-01 | 2005-08-23 | The Board Of Trustees Of The Leland Stanford Junior University | Protein kinase C peptides for use in withdrawal |
| AU2003237500A1 (en) * | 2002-06-07 | 2003-12-22 | Duke University | Substituted porphyrins |
| US20030232784A1 (en) * | 2002-06-14 | 2003-12-18 | Benedict James J. | Hyaluronic acid-associated superoxide dismutase mimics and their use in the treatment of joint pain |
| US6984636B2 (en) * | 2002-08-12 | 2006-01-10 | Medical Research Council | Mitochondrially targeted antioxidants |
| CA2499994C (en) * | 2002-09-23 | 2012-07-10 | Verion, Inc. | Abuse-resistant pharmaceutical compositions |
| US20060089343A1 (en) * | 2002-12-06 | 2006-04-27 | Alcon, Inc. | Superoxide dismutase mimics for the treatment of ocular disorders and diseases |
| MXPA05005937A (es) * | 2002-12-06 | 2005-08-18 | Alcon Inc | Imitaciones de superoxido de dismutasa para el tratamiento de trastornos y enfermedades oculares. |
| KR100648618B1 (ko) * | 2003-11-19 | 2006-11-23 | 주식회사 웰스킨 | 활성 산소 억제제 |
| WO2006069326A2 (en) * | 2004-12-21 | 2006-06-29 | Metaphore Pharmaceuticals, Inc. | Polyethylene glycolated superoxide dismutase mimetics |
| US8217166B2 (en) * | 2005-05-05 | 2012-07-10 | Galera Therapeutics, Llc | Polyethylene glycolated superoxide dismutase mimetics |
| US20120301403A1 (en) | 2007-06-21 | 2012-11-29 | Galera Therapeutics, Llc | Polyethylene glycolated superoxide dismutase mimetics |
| KR100724586B1 (ko) | 2005-12-09 | 2007-06-04 | 세종대학교산학협력단 | 수퍼옥사이드 디스뮤타아제 활성을 갖는 고리화합물 |
| US8486928B2 (en) * | 2007-11-14 | 2013-07-16 | Galera Therapeutics | Super-oxide dismutase mimetics |
| EP2296645B1 (en) | 2008-05-22 | 2014-11-19 | Galera Therapeutics, LLC | Combination antitumor therapy |
| US11382895B2 (en) | 2008-05-23 | 2022-07-12 | National Jewish Health | Methods for treating injury associated with exposure to an alkylating species |
| CN110520107A (zh) | 2017-02-15 | 2019-11-29 | 加莱拉实验室有限责任公司 | 用于局部肠递送的五氮杂大环状环配合物 |
| EP3388082A1 (en) | 2017-04-13 | 2018-10-17 | Galera Labs, LLC | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
| MX2020008028A (es) | 2018-01-31 | 2020-12-11 | Galera Labs Llc | Terapia de combinacion para cancer con complejo de anillo macrociclico de pentaaza y agente anticancer basado en platino. |
| US20230071463A1 (en) * | 2020-02-13 | 2023-03-09 | Teva Pharmaceuticals International Gmbh | Solid state forms of avasopasem manganese and process for preparation thereof |
| AU2024300676A1 (en) * | 2023-07-21 | 2026-01-29 | Board Of Regents Of The University Of Texas System | Carcinogenesis reduction with pentaaza macrocyclic ring complex |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0751496B2 (ja) | 1986-04-02 | 1995-06-05 | 武田薬品工業株式会社 | リポソ−ムの製造法 |
| US5216021A (en) | 1986-08-28 | 1993-06-01 | Sorenson John R J | Analgesic method |
| US4999347A (en) | 1986-08-28 | 1991-03-12 | Sorenson John R J | Analgesic method |
| JPS63313581A (ja) * | 1987-06-16 | 1988-12-21 | Ube Ind Ltd | 修飾ス−パ−オキシドジスムタ−ゼ |
| CA2072934C (en) | 1991-07-19 | 2007-08-28 | Karl William Aston | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| ES2113952T3 (es) | 1991-07-19 | 1998-05-16 | Monsanto Co | Complejos de manganeso con ligandos macrociclicos nitrogenados eficaces como catalizadores para dismutar superoxidos. |
| CN1088086A (zh) * | 1992-12-14 | 1994-06-22 | 西北大学 | 一种新型的护肤保健品 |
| US6204259B1 (en) | 1993-01-14 | 2001-03-20 | Monsanto Company | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| US6525041B1 (en) | 1995-06-06 | 2003-02-25 | Pharmacia Corporation | Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| BR9708179A (pt) | 1996-03-13 | 1999-07-27 | Monsanto Co | Bioconjugados de complexos de manganês ou ferro de ligantes macrociclicos contendo nitrogênio eficazes como catalizadores para desmutar superoxidos |
-
1998
- 1998-04-09 US US09/057,831 patent/US6180620B1/en not_active Expired - Fee Related
- 1998-06-15 ES ES98929022T patent/ES2215305T3/es not_active Expired - Lifetime
- 1998-06-15 EP EP98929022A patent/EP1001752B1/en not_active Expired - Lifetime
- 1998-06-15 DE DE69820633T patent/DE69820633T2/de not_active Expired - Fee Related
- 1998-06-15 JP JP50459399A patent/JP2002506445A/ja not_active Ceased
- 1998-06-15 AU AU80685/98A patent/AU733415B2/en not_active Ceased
- 1998-06-15 CA CA002294155A patent/CA2294155A1/en not_active Abandoned
- 1998-06-15 PT PT98929022T patent/PT1001752E/pt unknown
- 1998-06-15 DK DK98929022T patent/DK1001752T3/da active
- 1998-06-15 WO PCT/US1998/012231 patent/WO1998058636A1/en not_active Ceased
- 1998-06-15 AT AT98929022T patent/ATE256467T1/de not_active IP Right Cessation
- 1998-06-19 ZA ZA985376A patent/ZA985376B/xx unknown
-
2000
- 2000-08-09 US US09/634,152 patent/US6395725B1/en not_active Expired - Fee Related
Cited By (20)
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|---|---|---|---|---|
| JP2007513948A (ja) * | 2003-12-11 | 2007-05-31 | アルコン，インコーポレイテッド | 視神経損傷および網膜損傷の処置のためのスーパーオキシドジスムターゼ模倣物 |
| US10610533B2 (en) | 2006-10-12 | 2020-04-07 | Galera Labs, Llc | Methods of treating oral mucositis |
| US11612608B2 (en) | 2006-10-12 | 2023-03-28 | Galera Labs, Llc | Methods of treating oral mucositis |
| JP2023027289A (ja) * | 2011-09-26 | 2023-03-01 | ガレラ・ラブス・リミテッド・ライアビリティ・カンパニー | 疾患の治療方法 |
| JP2014526562A (ja) * | 2011-09-26 | 2014-10-06 | ガレラ・セラピューティクス・リミテッド・ライアビリティ・カンパニー | 疾患の治療方法 |
| JP2018035162A (ja) * | 2011-09-26 | 2018-03-08 | ガレラ・ラブス・リミテッド・ライアビリティ・カンパニーＧａｌｅｒａ Ｌａｂｓ， Ｌｌｃ | 疾患の治療方法 |
| JP7697688B2 (ja) | 2011-09-26 | 2025-06-24 | ガレラ・ラブス・リミテッド・ライアビリティ・カンパニー | 疾患の治療方法 |
| US10493081B2 (en) | 2011-09-26 | 2019-12-03 | Galera Labs, Llc | Methods for treatment of diseases |
| JP2020183416A (ja) * | 2011-09-26 | 2020-11-12 | ガレラ・ラブス・リミテッド・ライアビリティ・カンパニーＧａｌｅｒａ Ｌａｂｓ， Ｌｌｃ | 疾患の治療方法 |
| US11826373B2 (en) | 2011-09-26 | 2023-11-28 | Galera Labs, Llc | Methods for treatment of diseases |
| US12077549B2 (en) | 2015-08-11 | 2024-09-03 | Galera Labs, Llc | Pentaaza macrocyclic ring complexes possessing oral bioavailability |
| JP7041959B2 (ja) | 2015-08-11 | 2022-03-25 | ガレラ・ラブス・リミテッド・ライアビリティ・カンパニー | 経口バイオアベイラビリティを有するペンタアザ大環状環錯体 |
| JP2022023183A (ja) * | 2015-08-11 | 2022-02-07 | ガレラ・ラブス・リミテッド・ライアビリティ・カンパニー | 経口バイオアベイラビリティを有するペンタアザ大環状環錯体 |
| US11066433B2 (en) | 2015-08-11 | 2021-07-20 | Galera Labs, Llc | Pentaaza macrocyclic ring complexes possessing oral bioavailability |
| US10597415B2 (en) | 2015-08-11 | 2020-03-24 | Galera Labs, Llc | Pentaaza macrocyclic ring complexes possessing oral bioavailability |
| JP2018525388A (ja) * | 2015-08-11 | 2018-09-06 | ガレラ・ラブス・リミテッド・ライアビリティ・カンパニーＧａｌｅｒａ Ｌａｂｓ， Ｌｌｃ | 経口バイオアベイラビリティを有するペンタアザ大環状環錯体 |
| US12220420B2 (en) | 2016-05-03 | 2025-02-11 | Galera Labs, Llc | Combination therapy for cancer treatment |
| US12156863B2 (en) | 2016-09-01 | 2024-12-03 | Galera Labs, Llc | Combination cancer therapy with pentaaza macrocyclic ring complex and ascorbate compound |
| US11246950B2 (en) | 2017-04-13 | 2022-02-15 | Galera Labs, Llc | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
| US12551581B2 (en) | 2017-04-13 | 2026-02-17 | Galera Labs, Llc | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
Also Published As
| Publication number | Publication date |
|---|---|
| US6180620B1 (en) | 2001-01-30 |
| ATE256467T1 (de) | 2004-01-15 |
| ES2215305T3 (es) | 2004-10-01 |
| DK1001752T3 (da) | 2004-04-19 |
| DE69820633T2 (de) | 2004-09-23 |
| DE69820633D1 (de) | 2004-01-29 |
| ZA985376B (en) | 1999-06-21 |
| WO1998058636A1 (en) | 1998-12-30 |
| AU733415B2 (en) | 2001-05-17 |
| CA2294155A1 (en) | 1998-12-30 |
| AU8068598A (en) | 1999-01-04 |
| EP1001752A1 (en) | 2000-05-24 |
| EP1001752B1 (en) | 2003-12-17 |
| US6395725B1 (en) | 2002-05-28 |
| PT1001752E (pt) | 2004-05-31 |
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