DE69820633D1 - Analgetische verfahren, die synthetischen katalysatoren zur dismutierung von superoxid radicalen verwenden - Google Patents
Analgetische verfahren, die synthetischen katalysatoren zur dismutierung von superoxid radicalen verwendenInfo
- Publication number
- DE69820633D1 DE69820633D1 DE69820633T DE69820633T DE69820633D1 DE 69820633 D1 DE69820633 D1 DE 69820633D1 DE 69820633 T DE69820633 T DE 69820633T DE 69820633 T DE69820633 T DE 69820633T DE 69820633 D1 DE69820633 D1 DE 69820633D1
- Authority
- DE
- Germany
- Prior art keywords
- dismuting
- analgetic
- methods
- superoxide radicals
- synthetic catalysts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003054 catalyst Substances 0.000 title abstract 2
- 230000000202 analgesic effect Effects 0.000 title 1
- 208000000114 Pain Threshold Diseases 0.000 abstract 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 238000007323 disproportionation reaction Methods 0.000 abstract 1
- 230000003028 elevating effect Effects 0.000 abstract 1
- 230000000917 hyperalgesic effect Effects 0.000 abstract 1
- 239000000014 opioid analgesic Substances 0.000 abstract 1
- 229940005483 opioid analgesics Drugs 0.000 abstract 1
- 230000037040 pain threshold Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Catalysts (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5040297P | 1997-06-20 | 1997-06-20 | |
US50402P | 1997-06-20 | ||
PCT/US1998/012231 WO1998058636A1 (en) | 1997-06-20 | 1998-06-15 | Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69820633D1 true DE69820633D1 (de) | 2004-01-29 |
DE69820633T2 DE69820633T2 (de) | 2004-09-23 |
Family
ID=21965044
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69820633T Expired - Fee Related DE69820633T2 (de) | 1997-06-20 | 1998-06-15 | Analgetische verfahren, die synthetischen katalysatoren zur dismutierung von superoxid radicalen verwenden |
Country Status (12)
Country | Link |
---|---|
US (2) | US6180620B1 (de) |
EP (1) | EP1001752B1 (de) |
JP (1) | JP2002506445A (de) |
AT (1) | ATE256467T1 (de) |
AU (1) | AU733415B2 (de) |
CA (1) | CA2294155A1 (de) |
DE (1) | DE69820633T2 (de) |
DK (1) | DK1001752T3 (de) |
ES (1) | ES2215305T3 (de) |
PT (1) | PT1001752E (de) |
WO (1) | WO1998058636A1 (de) |
ZA (1) | ZA985376B (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6127356A (en) | 1993-10-15 | 2000-10-03 | Duke University | Oxidant scavengers |
US20050171198A1 (en) * | 1997-06-20 | 2005-08-04 | Metaphore Pharmaceuticals, Inc. | SODm therapy for treatment, prevention, inhibition and reversal of inflammatory disease |
US20060270639A1 (en) * | 1997-06-20 | 2006-11-30 | Daniela Salvemini | Combinations of superoxide dismutase mimetics and nonsteroidal analgesic/anti-inflammatory drugs |
US6214817B1 (en) * | 1997-06-20 | 2001-04-10 | Monsanto Company | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity |
ATE238307T1 (de) | 1997-11-03 | 2003-05-15 | Univ Duke | Substituierte porphyrinen |
US20030032634A1 (en) * | 2001-06-01 | 2003-02-13 | Piganelli Jon D. | Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance |
WO2000043395A1 (en) | 1999-01-25 | 2000-07-27 | National Jewish Medical And Research Center | Substituted porphyrins |
ATE291446T1 (de) | 1999-05-27 | 2005-04-15 | Monsanto Co | Biomaterialien, modifiziert mit superoxid- dismutase imitatoren |
US20030069281A1 (en) * | 2000-06-14 | 2003-04-10 | Irwin Fridovich | Tetrapyrroles |
US20020072512A1 (en) * | 2000-12-08 | 2002-06-13 | Metaphore Pharmaceuticals, Inc | Method of preventing and treating HIV-mediated central nervous system damage |
EP1347773B1 (de) * | 2001-01-05 | 2010-04-14 | Metaphore Pharmaceuticals Inc. | Zusammensetzungen und verfahren zur erhöhung der zytokin-aktivität und zur behandlung der hypotension assoziiert mit der verabreichung von zytokinen |
AU2002248366B2 (en) | 2001-01-19 | 2006-10-26 | Aeolus Sciences, Inc. | Cancer therapy |
WO2002058686A2 (en) * | 2001-01-26 | 2002-08-01 | Metaphore Pharmaceuticals, Inc. | Method of treatment of neurodegenerative disorders using pentaaza-macrocyclic ligand complexes |
EP2988125B1 (de) * | 2001-03-02 | 2019-05-08 | Galera Labs, LLC | Mangan(ii) pentaazacycloalkane komplexe |
US20040137638A1 (en) * | 2002-03-04 | 2004-07-15 | Slomczynska Urszula J. | Chromatography of metal complexes |
EP1417219A4 (de) * | 2001-06-08 | 2005-05-25 | Metaphore Pharmaceuticals Inc | Bibliotheken konformationsgehinderter peptide, chirale azakronen und peptidomimetika, und verfahren zu deren herstellung |
US20040266742A1 (en) * | 2001-06-26 | 2004-12-30 | Daniela Salvemini | Combination therapy of an sodm and a corticosteroid for prevention and/or treatment of inflammatory disease |
EP1450824A4 (de) * | 2001-11-02 | 2005-09-28 | Elan Corp Plc | Pharmazeutische zusammensetzung |
DE60231246D1 (de) * | 2001-12-14 | 2009-04-02 | Alcon Inc | Superoxiddismutas-mimetika zur behandlung von augenerkrankungen |
US6933275B2 (en) * | 2002-05-01 | 2005-08-23 | The Board Of Trustees Of The Leland Stanford Junior University | Protein kinase C peptides for use in withdrawal |
CA2488500A1 (en) * | 2002-06-07 | 2003-12-18 | Duke University | Substituted porphyrins |
US20030232784A1 (en) * | 2002-06-14 | 2003-12-18 | Benedict James J. | Hyaluronic acid-associated superoxide dismutase mimics and their use in the treatment of joint pain |
US6984636B2 (en) * | 2002-08-12 | 2006-01-10 | Medical Research Council | Mitochondrially targeted antioxidants |
US8623412B2 (en) * | 2002-09-23 | 2014-01-07 | Elan Pharma International Limited | Abuse-resistant pharmaceutical compositions |
BR0317026A (pt) * | 2002-12-06 | 2005-10-25 | Alcon Inc | Mìmicos de superóxido dismutase para o tratamento de distúrbios e doenças oculares |
MXPA05005937A (es) * | 2002-12-06 | 2005-08-18 | Alcon Inc | Imitaciones de superoxido de dismutasa para el tratamiento de trastornos y enfermedades oculares. |
KR100648618B1 (ko) * | 2003-11-19 | 2006-11-23 | 주식회사 웰스킨 | 활성 산소 억제제 |
BRPI0417549A (pt) * | 2003-12-11 | 2007-03-27 | Alcon Inc | miméticos de superóxido dismutase para o tratamento de lesão de nervo óptico e retinal |
US8217166B2 (en) * | 2005-05-05 | 2012-07-10 | Galera Therapeutics, Llc | Polyethylene glycolated superoxide dismutase mimetics |
US20120301403A1 (en) | 2007-06-21 | 2012-11-29 | Galera Therapeutics, Llc | Polyethylene glycolated superoxide dismutase mimetics |
WO2006069326A2 (en) * | 2004-12-21 | 2006-06-29 | Metaphore Pharmaceuticals, Inc. | Polyethylene glycolated superoxide dismutase mimetics |
KR100724586B1 (ko) | 2005-12-09 | 2007-06-04 | 세종대학교산학협력단 | 수퍼옥사이드 디스뮤타아제 활성을 갖는 고리화합물 |
SI2056675T1 (sl) * | 2006-10-12 | 2019-08-30 | Galera Labs, Llc | Postopki za zdravljenje oralnega mukozitisa |
US8486928B2 (en) * | 2007-11-14 | 2013-07-16 | Galera Therapeutics | Super-oxide dismutase mimetics |
EP2296645B1 (de) | 2008-05-22 | 2014-11-19 | Galera Therapeutics, LLC | Antitumorale kombinationstherapie |
DK2300003T3 (da) | 2008-05-23 | 2014-05-26 | Nat Jewish Health | Forbindelser til anvendelse i behandling af skade forbundet med eksponering for en alkylerende art |
EP2760874A4 (de) | 2011-09-26 | 2015-04-08 | Galera Therapeutics Llc | Verfahren zur behandlung von erkrankungen |
UA126788C2 (uk) | 2015-08-11 | 2023-02-08 | Ґалера Лебз, Елелсі | Комплексні сполуки, що містять макроциклічне кільце пентаази, які мають пероральну біодоступність |
EP3582753A4 (de) * | 2017-02-15 | 2020-12-16 | Galera Labs, LLC | Makrocyclische pentaaza-ringkomplexe zur lokalen intestinalen verabreichung |
IL295620B2 (en) | 2017-04-13 | 2024-01-01 | Galera Labs Llc | Cancer immunotherapy combined with a macrocyclic ring pentase complex |
EP3388082A1 (de) | 2017-04-13 | 2018-10-17 | Galera Labs, LLC | Kombinationskrebsimmuntherapie mit makrocyclischem pentaaza-ringkomplex |
SG11202007317XA (en) | 2018-01-31 | 2020-08-28 | Galera Labs Llc | Combination cancer therapy with pentaaza macrocyclic ring complex and platinum-based anticancer agent |
US20230071463A1 (en) | 2020-02-13 | 2023-03-09 | Teva Pharmaceuticals International Gmbh | Solid state forms of avasopasem manganese and process for preparation thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0751496B2 (ja) | 1986-04-02 | 1995-06-05 | 武田薬品工業株式会社 | リポソ−ムの製造法 |
US4999347A (en) | 1986-08-28 | 1991-03-12 | Sorenson John R J | Analgesic method |
US5216021A (en) | 1986-08-28 | 1993-06-01 | Sorenson John R J | Analgesic method |
JPS63313581A (ja) * | 1987-06-16 | 1988-12-21 | Ube Ind Ltd | 修飾ス−パ−オキシドジスムタ−ゼ |
CA2072934C (en) | 1991-07-19 | 2007-08-28 | Karl William Aston | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
KR0145953B1 (ko) | 1991-07-19 | 1998-08-17 | 제임스 클리프튼 보올딩 | 슈퍼옥사이드의 불균화촉매로서 효과적인 질소를 포함하는 마크로사이클 릭리간드의 망간착물 |
CN1088086A (zh) * | 1992-12-14 | 1994-06-22 | 西北大学 | 一种新型的护肤保健品 |
US6204259B1 (en) | 1993-01-14 | 2001-03-20 | Monsanto Company | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
US6525041B1 (en) | 1995-06-06 | 2003-02-25 | Pharmacia Corporation | Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
IL125889A0 (en) | 1996-03-13 | 1999-04-11 | Monsanto Co | Bioconjugates of manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
-
1998
- 1998-04-09 US US09/057,831 patent/US6180620B1/en not_active Expired - Fee Related
- 1998-06-15 JP JP50459399A patent/JP2002506445A/ja not_active Ceased
- 1998-06-15 ES ES98929022T patent/ES2215305T3/es not_active Expired - Lifetime
- 1998-06-15 CA CA002294155A patent/CA2294155A1/en not_active Abandoned
- 1998-06-15 WO PCT/US1998/012231 patent/WO1998058636A1/en active IP Right Grant
- 1998-06-15 AU AU80685/98A patent/AU733415B2/en not_active Ceased
- 1998-06-15 AT AT98929022T patent/ATE256467T1/de not_active IP Right Cessation
- 1998-06-15 DK DK98929022T patent/DK1001752T3/da active
- 1998-06-15 EP EP98929022A patent/EP1001752B1/de not_active Expired - Lifetime
- 1998-06-15 DE DE69820633T patent/DE69820633T2/de not_active Expired - Fee Related
- 1998-06-15 PT PT98929022T patent/PT1001752E/pt unknown
- 1998-06-19 ZA ZA985376A patent/ZA985376B/xx unknown
-
2000
- 2000-08-09 US US09/634,152 patent/US6395725B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2215305T3 (es) | 2004-10-01 |
WO1998058636A1 (en) | 1998-12-30 |
DK1001752T3 (da) | 2004-04-19 |
EP1001752A1 (de) | 2000-05-24 |
PT1001752E (pt) | 2004-05-31 |
JP2002506445A (ja) | 2002-02-26 |
US6180620B1 (en) | 2001-01-30 |
DE69820633T2 (de) | 2004-09-23 |
EP1001752B1 (de) | 2003-12-17 |
ATE256467T1 (de) | 2004-01-15 |
CA2294155A1 (en) | 1998-12-30 |
US6395725B1 (en) | 2002-05-28 |
AU733415B2 (en) | 2001-05-17 |
ZA985376B (en) | 1999-06-21 |
AU8068598A (en) | 1999-01-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: STROHSCHAENK UND KOLLEGEN, 85521 OTTOBRUNN |
|
8339 | Ceased/non-payment of the annual fee |