ATE291446T1 - Biomaterialien, modifiziert mit superoxid- dismutase imitatoren - Google Patents

Biomaterialien, modifiziert mit superoxid- dismutase imitatoren

Info

Publication number
ATE291446T1
ATE291446T1 AT00932810T AT00932810T ATE291446T1 AT E291446 T1 ATE291446 T1 AT E291446T1 AT 00932810 T AT00932810 T AT 00932810T AT 00932810 T AT00932810 T AT 00932810T AT E291446 T1 ATE291446 T1 AT E291446T1
Authority
AT
Austria
Prior art keywords
biomaterials
mimitators
modified
superoxide dismutase
biomaterials modified
Prior art date
Application number
AT00932810T
Other languages
English (en)
Inventor
Richard Ornberg
Kishore Udipi
Dennis Forster
Dennis Riley
Bruce Thurmond
Susan Henke
Kerry Brethaur
Saikat Joardar
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of ATE291446T1 publication Critical patent/ATE291446T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/20Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04Macromolecular materials
    • A61L31/042Polysaccharides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005Compounds without a metal-carbon linkage
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02Iron compounds
    • C07F15/025Iron compounds without a metal-carbon linkage
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • C08B15/05Derivatives containing elements other than carbon, hydrogen, oxygen, halogens or sulfur
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/00272-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00Polymeric products of isocyanates or isothiocyanates
    • C08G18/06Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08Processes
    • C08G18/10Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00Polymeric products of isocyanates or isothiocyanates
    • C08G18/06Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40High-molecular-weight compounds
    • C08G18/48Polyethers
    • C08G18/4854Polyethers containing oxyalkylene groups having four carbon atoms in the alkylene group
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00Polymeric products of isocyanates or isothiocyanates
    • C08G18/06Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/65Low-molecular-weight compounds having active hydrogen with high-molecular-weight compounds having active hydrogen
    • C08G18/66Compounds of groups C08G18/42, C08G18/48, or C08G18/52
    • C08G18/6666Compounds of group C08G18/48 or C08G18/52
    • C08G18/667Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38
    • C08G18/6681Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/32 or C08G18/3271 and/or polyamines of C08G18/38
    • C08G18/6685Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/32 or C08G18/3271 and/or polyamines of C08G18/38 with compounds of group C08G18/3225 or polyamines of C08G18/38
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00Polymeric products of isocyanates or isothiocyanates
    • C08G18/06Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/71Monoisocyanates or monoisothiocyanates
    • C08G18/718Monoisocyanates or monoisothiocyanates containing silicon
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00Polymeric products of isocyanates or isothiocyanates
    • C08G18/06Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/72Polyisocyanates or polyisothiocyanates
    • C08G18/73Polyisocyanates or polyisothiocyanates acyclic
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08HDERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00Macromolecular products derived from proteins
    • C08H1/06Macromolecular products derived from proteins derived from horn, hoofs, hair, skin or leather

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cosmetics (AREA)
AT00932810T 1999-05-27 2000-05-26 Biomaterialien, modifiziert mit superoxid- dismutase imitatoren ATE291446T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13629899P 1999-05-27 1999-05-27
PCT/US2000/014847 WO2000072893A2 (en) 1999-05-27 2000-05-26 Biomaterials modified with superoxide dismutase mimics

Publications (1)

Publication Number Publication Date
ATE291446T1 true ATE291446T1 (de) 2005-04-15

Family

ID=22472236

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00932810T ATE291446T1 (de) 1999-05-27 2000-05-26 Biomaterialien, modifiziert mit superoxid- dismutase imitatoren
AT05006278T ATE383364T1 (de) 1999-05-27 2000-05-26 Biomaterialien, modifiziert mit superoxid- dismutase imitatoren

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT05006278T ATE383364T1 (de) 1999-05-27 2000-05-26 Biomaterialien, modifiziert mit superoxid- dismutase imitatoren

Country Status (9)

Country Link
US (3) US7445641B1 (de)
EP (1) EP1185312B1 (de)
JP (1) JP2003500174A (de)
AT (2) ATE291446T1 (de)
AU (1) AU5048400A (de)
CA (1) CA2374472A1 (de)
DE (2) DE60037768T2 (de)
ES (1) ES2240101T3 (de)
WO (1) WO2000072893A2 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1616869T3 (da) 1999-01-25 2012-05-07 Nat Jewish Health Substituerede porphyriner og deres terapeutiske anvendelse
EP1185312B1 (de) 1999-05-27 2005-03-23 Monsanto Company Biomaterialien, modifiziert mit superoxid-dismutase imitatoren
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US20040137638A1 (en) * 2002-03-04 2004-07-15 Slomczynska Urszula J. Chromatography of metal complexes
EP1247537A1 (de) * 2001-04-04 2002-10-09 Isotis B.V. Beschichtung für medizinische Vorrichtungen
AU2002312194B8 (en) 2001-06-01 2008-05-15 Aeolus Sciences, Inc. Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance
CN1620325A (zh) 2001-12-14 2005-05-25 艾尔科公司 治疗眼睛障碍和疾病的超氧化物歧化酶模拟物
US7919075B1 (en) * 2002-03-20 2011-04-05 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices
US6835387B2 (en) * 2002-06-11 2004-12-28 Scimed Life Systems, Inc. Sustained release of superoxide dismutase mimics from implantable or insertable medical devices
US20030232784A1 (en) * 2002-06-14 2003-12-18 Benedict James J. Hyaluronic acid-associated superoxide dismutase mimics and their use in the treatment of joint pain
MXPA05005937A (es) 2002-12-06 2005-08-18 Alcon Inc Imitaciones de superoxido de dismutasa para el tratamiento de trastornos y enfermedades oculares.
US20040254629A1 (en) * 2003-04-25 2004-12-16 Brian Fernandes Methods and apparatus for treatment of aneurysmal tissue
US7053051B2 (en) 2003-10-28 2006-05-30 Medtronic, Inc. Methods of preparing crosslinked materials and bioprosthetic devices
US7299082B2 (en) 2003-10-31 2007-11-20 Abbott Diabetes Care, Inc. Method of calibrating an analyte-measurement device, and associated methods, devices and systems
ZA200603347B (en) 2003-12-11 2009-02-25 Alcon Inc Superoxide dismutase mimics for the treatment of optic nerve and retinal damage
EP1559728A1 (de) * 2004-01-28 2005-08-03 Total Petrochemicals Research Feluy Pfropfung von Übergangsmetallkomplexen auf Trägern
US8165651B2 (en) 2004-02-09 2012-04-24 Abbott Diabetes Care Inc. Analyte sensor, and associated system and method employing a catalytic agent
US7971333B2 (en) * 2006-05-30 2011-07-05 Advanced Cardiovascular Systems, Inc. Manufacturing process for polymetric stents
US9050393B2 (en) * 2005-02-08 2015-06-09 Bruce N. Saffran Medical devices and methods for modulation of physiology using device-based surface chemistry
US20070014726A1 (en) * 2005-07-18 2007-01-18 Sensors For Medicine And Science Oxidation-resistant indicator macromolecule
US7785647B2 (en) * 2005-07-25 2010-08-31 Advanced Cardiovascular Systems, Inc. Methods of providing antioxidants to a drug containing product
US8394446B2 (en) 2005-07-25 2013-03-12 Abbott Cardiovascular Systems Inc. Methods of providing antioxidants to implantable medical devices
ES2509884T3 (es) 2005-08-18 2014-10-20 Zimmer Gmbh Artículos de polietileno de peso molecular ultra-alto y métodos para formar artículos de polietileno de peso molecular ultra-alto
US7682152B2 (en) 2005-12-20 2010-03-23 Ford Christopher W Force distributing dental implant assembly
US20070141532A1 (en) * 2005-12-20 2007-06-21 Ford Christopher W Force distributing dental implant assembly
US8647654B2 (en) * 2005-12-22 2014-02-11 The Penn State Research Foundation Method and systems for forming and using nanoengineered sculptured thin films
US20070160642A1 (en) * 2006-01-12 2007-07-12 Pacetti Stephen D Implantable medical devices coated with a polymer-bound superoxide dismutase mimic
US7885698B2 (en) 2006-02-28 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing continuous calibration of implantable analyte sensors
PT2056675T (pt) 2006-10-12 2019-05-09 Galera Labs Llc Métodos de tratamento da mucosite oral
US8664290B2 (en) 2007-04-10 2014-03-04 Zimmer, Inc. Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
EP2578248B1 (de) * 2007-04-10 2021-05-19 Zimmer, Inc. Antioxidans-stabilisiertes, vernetztes Polyethylen mit ultrahohem Molekulargewicht für Medizingeräteanwendungen
US8278406B2 (en) * 2007-04-27 2012-10-02 Wisconsin Alumni Research Foundation Bioactive and biocompatible polyurethane-buthanediol-glycosaminoglycan salt copolymers
US8652212B2 (en) 2008-01-30 2014-02-18 Zimmer, Inc. Orthopedic component of low stiffness
US8011926B2 (en) 2008-05-15 2011-09-06 Ford Christopher W Polymeric dental implant assembly
EP2732817B1 (de) 2008-05-23 2016-08-24 National Jewish Health Verbindung zur Verwendung bei der Behandlung von Verletzungen aufgrund der Exposition gegenüber Phosgen oder Chlorgas
SG193220A1 (en) 2008-08-22 2013-09-30 Novomer Inc Catalysts and methods for polymer synthesis
WO2010057644A1 (en) 2008-11-20 2010-05-27 Zimmer Gmbh Polyethylene materials
US8332042B2 (en) * 2009-01-15 2012-12-11 Medtronic, Inc. Medical lead with stiffening coil
US8399535B2 (en) 2010-06-10 2013-03-19 Zimmer, Inc. Polymer [[s]] compositions including an antioxidant
EP2760874A4 (de) 2011-09-26 2015-04-08 Galera Therapeutics Llc Verfahren zur behandlung von erkrankungen
WO2014182542A1 (en) 2013-05-06 2014-11-13 Abbott Cardiovascular Systems Inc. A hollow stent filled with a therapeutic agent formulation
US9708467B2 (en) 2013-10-01 2017-07-18 Zimmer, Inc. Polymer compositions comprising one or more protected antioxidants
RU2683203C2 (ru) 2013-12-31 2019-03-26 Эбботт Дайабитиз Кэр Инк. Снабженный автономным питанием датчик аналита и использующие его устройства
CA2942565A1 (en) 2014-03-12 2015-09-17 Zimmer, Inc. Melt-stabilized ultra high molecular weight polyethylene and method of making the same
CA2969751C (en) 2014-12-03 2020-09-22 Zimmer, Inc. Antioxidant-infused ultra high molecular weight polyethylene
EA201890471A1 (ru) 2015-08-11 2018-10-31 ГАЛЕРА ЛЭБЗ, ЭлЭлСи Комплексные соединения, содержащие макроциклическое кольцо пентаазы, обладающие пероральной биодоступностью
US11246950B2 (en) 2017-04-13 2022-02-15 Galera Labs, Llc Combination cancer immunotherapy with pentaaza macrocyclic ring complex
JP2020532643A (ja) * 2017-09-01 2020-11-12 ピーエムアイディージー・エルエルシーPmidg,Llc 官能基化および架橋ポリマー
US20220080628A1 (en) * 2020-09-17 2022-03-17 Nutech Ventures Method of reinforcement for keratin materials

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US580458A (en) * 1897-04-13 Knotter mechanism fo r grain-binders
US540383A (en) * 1895-06-04 Means for lubricating bearings of steam-engines
US3506411A (en) * 1966-11-16 1970-04-14 Amp Inc Cold crimped sleeve applicator
DE3134896C2 (de) 1981-09-03 1985-03-28 W.C. Heraeus Gmbh, 6450 Hanau Kabelzuleitung für Herzschrittmacher-Elektroden
US4718908A (en) 1984-06-04 1988-01-12 Richards Medical Company High-strength, cold-forged type 316L stainless steel for orthopedic implant
JPS61135671A (ja) 1984-12-04 1986-06-23 三菱鉱業セメント株式会社 インプラント材
US4863964A (en) * 1985-07-02 1989-09-05 Biomedical Frontiers, Inc. Method for the stabilization of deferoxamine to chelate free ions in physiological fluid
US4775426A (en) * 1986-04-03 1988-10-04 Richards Medical Company Method of manufacturing surgical implants from cast stainless steel and product
US5227405A (en) * 1987-03-31 1993-07-13 Duke University Superoxide dismutase mimic
US5334371A (en) * 1988-07-20 1994-08-02 Schering Aktiengesellschaft Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI
JPH02231078A (ja) 1989-03-03 1990-09-13 Ube Ind Ltd ヒアルロン酸修飾スーパーオキシドジスムターゼ
US5252720A (en) 1989-03-06 1993-10-12 Board Of Regents, The University Of Texas System Metal complexes of water soluble texaphyrins
JP2858126B2 (ja) 1989-06-30 1999-02-17 京セラ株式会社 生体インプラント材とその製法
US5386012A (en) 1990-02-06 1995-01-31 Strid; Lars Growth factor in connection with artificial implants
US5545208A (en) 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5626863A (en) 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
EP0525210A4 (en) 1991-02-20 1993-07-28 Tdk Corporation Composite bio-implant and production method therefor
US5326568A (en) * 1991-05-03 1994-07-05 Giampapa Vincent C Method of tissue-specific delivery
CA2072934C (en) * 1991-07-19 2007-08-28 Karl William Aston Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
DE69224839T2 (de) 1991-07-19 1998-10-08 Monsanto Co Mangan-Komplexe mit Stickstoff enthaltenden makrozyklischen Liganden, wirksam als Superoxiddismutasekatalysatoren.
ZA929575B (en) 1991-12-10 1994-06-10 Dow Chemical Co Bicyclopolyazamacrocyclocarboxyclic acid complexes,their conjugates,processes for their preparation,and use as contrast agents
US5176745A (en) * 1991-12-11 1993-01-05 Milliken Research Corporation Aqueous ink composition and colorants useful therein
US5507767A (en) 1992-01-15 1996-04-16 Cook Incorporated Spiral stent
US5876452A (en) 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
US5879359A (en) 1992-08-03 1999-03-09 Fidia S.P.A. Biodegradable guide channels comprised of esters of hyaluronic acid for use in tissue repair as surgical aids
US5840319A (en) 1992-10-08 1998-11-24 Alakhov; Valery Yu Biological agent compositions
US5402834A (en) * 1992-11-25 1995-04-04 Merck & Co., Inc. Solution preparation system
US5834509A (en) 1992-12-07 1998-11-10 Eukarion, Inc. Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
US5403834A (en) 1992-12-07 1995-04-04 Eukarion, Inc. Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
US5696109A (en) * 1992-12-07 1997-12-09 Eukarion, Inc. Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
CN1088069A (zh) 1992-12-18 1994-06-22 胡耀祖 香味健美胸罩
US6204259B1 (en) 1993-01-14 2001-03-20 Monsanto Company Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US5836313A (en) 1993-02-08 1998-11-17 Massachusetts Institute Of Technology Methods for making composite hydrogels for corneal prostheses
US6294185B1 (en) 1993-03-12 2001-09-25 Auburn University Monomeric and polymeric cyclic amine and N-halamine compounds
EP0706376B2 (de) * 1993-07-19 2007-08-08 Angiotech Pharmaceuticals, Inc. Anti-angiogene mittel und verfahren zu deren verwendung
US5626861A (en) 1994-04-01 1997-05-06 Massachusetts Institute Of Technology Polymeric-hydroxyapatite bone composite
GB9407812D0 (en) * 1994-04-20 1994-06-15 Nycomed Salutar Inc Compounds
CN1152880A (zh) 1994-04-22 1997-06-25 孟山都公司 使用含氮大环配拉体的金属络合物的诊断图像分析的方法
US5525621A (en) * 1994-05-20 1996-06-11 Cytos Pharmaceuticals Llc Imidazole derivatives as protective agents in reperfusion injury and severe inflammatory responses
GB9412273D0 (en) 1994-06-18 1994-08-10 Univ Nottingham Administration means
US5749839A (en) 1994-08-18 1998-05-12 Duke University Direct mechanical bi-ventricular cardiac assist device
US5817303A (en) 1995-05-05 1998-10-06 Protein Polymer Technologies, Inc. Bonding together tissue with adhesive containing polyfunctional crosslinking agent and protein polymer
WO1996039409A1 (en) * 1995-06-05 1996-12-12 Nitromed, Inc. Nitrosylated and nitrated superoxide oxidants and reductants
US6525041B1 (en) 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
CA2178541C (en) * 1995-06-07 2009-11-24 Neal E. Fearnot Implantable medical device
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
JPH11507621A (ja) 1995-06-07 1999-07-06 モンサント カンパニー 置換ポリアザ大環状化合物の製造法
US6774278B1 (en) * 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
CA2229781A1 (en) 1995-08-17 1997-02-27 Monsanto Company Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
JP3008833B2 (ja) * 1995-10-25 2000-02-14 トヨタ自動車株式会社 車体の横滑り速度推定装置
US5665428A (en) 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
US5830539A (en) 1995-11-17 1998-11-03 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods for functionalizing and coating substrates and devices made according to the methods
US5861032A (en) 1996-01-31 1999-01-19 Surface Genesis, Inc. Medical device having a biocompatible coating and oxidation method of coupling therefor
JP2000507929A (ja) 1996-03-13 2000-06-27 モンサント カンパニー ジスムタチンスーパーオキシドの触媒として有効な窒素含有大環状化合物配位子を持つ鉄錯体
CA2249011A1 (en) * 1996-03-13 1997-09-18 Monsanto Company Bioconjugates of manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US5891862A (en) 1996-03-15 1999-04-06 Geltex Pharmaceuticals, Inc. Polyvalent polymers for the treatment of rotavirus infection
US5876433A (en) 1996-05-29 1999-03-02 Ethicon, Inc. Stent and method of varying amounts of heparin coated thereon to control treatment
US5824047A (en) 1996-10-11 1998-10-20 C. R. Bard, Inc. Vascular graft fabric
US5877263A (en) 1996-11-25 1999-03-02 Meadox Medicals, Inc. Process for preparing polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents
US5879697A (en) 1997-04-30 1999-03-09 Schneider Usa Inc Drug-releasing coatings for medical devices
US5885609A (en) 1997-05-23 1999-03-23 Northeastern University Biocompatible articles and method for making same
US6180620B1 (en) 1997-06-20 2001-01-30 G.D. Searle & Co. Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals
US5837752A (en) * 1997-07-17 1998-11-17 Massachusetts Institute Of Technology Semi-interpenetrating polymer networks
US5851227A (en) 1997-07-30 1998-12-22 Sulzer Intermedics Inc. Cardiac pacemaker cable lead
US6569688B2 (en) * 1997-08-26 2003-05-27 Technion Research & Development Foundation Ltd. Intravascular apparatus method
US6323218B1 (en) * 1998-03-11 2001-11-27 The General Hospital Corporation Agents for use in the treatment of Alzheimer's disease
WO1999065538A1 (en) * 1998-06-19 1999-12-23 Oxibio, Inc. Medical device having anti-infective and contraceptive properties
EP1185312B1 (de) 1999-05-27 2005-03-23 Monsanto Company Biomaterialien, modifiziert mit superoxid-dismutase imitatoren
US20040110722A1 (en) 1999-05-27 2004-06-10 Ornberg Richard L. Modified hyaluronic acid polymers
US20030232784A1 (en) 2002-06-14 2003-12-18 Benedict James J. Hyaluronic acid-associated superoxide dismutase mimics and their use in the treatment of joint pain

Also Published As

Publication number Publication date
EP1185312A2 (de) 2002-03-13
US20060089710A1 (en) 2006-04-27
ES2240101T3 (es) 2005-10-16
DE60037768D1 (de) 2008-02-21
EP1185312B1 (de) 2005-03-23
DE60037768T2 (de) 2009-01-15
DE60018925D1 (de) 2005-04-28
US7445641B1 (en) 2008-11-04
DE60018925T2 (de) 2006-04-13
JP2003500174A (ja) 2003-01-07
US20040116332A1 (en) 2004-06-17
WO2000072893A3 (en) 2001-08-30
WO2000072893A2 (en) 2000-12-07
US7004976B2 (en) 2006-02-28
AU5048400A (en) 2000-12-18
CA2374472A1 (en) 2000-12-07
ATE383364T1 (de) 2008-01-15

Similar Documents

Publication Publication Date Title
ATE291446T1 (de) Biomaterialien, modifiziert mit superoxid- dismutase imitatoren
DK0973819T3 (da) Ikke-antigene forgrenede polymerkonjugater
AR073856A2 (es) Polinucleotido que codifica un polipeptido con actividad de alfa-amilasa y casete de expresion que lo comprende.
TW200614971A (en) Absorbent article
AU6812694A (en) Detergent compositions comprising soil release agents
DE60134147D1 (de) Träger in partikelform zur verbesserung der oral- absorption von wikstoffen
BR9805012A (pt) ão de hiperuricemia em um mamìfero sofrendo de hiperuricema.
ES2106086T3 (es) Biomaterial a base de colageno y sus aplicaciones.
ES2189893T3 (es) Articulo absorbente que tiene integridad y captacion mejoradas.
WO2002013877A8 (en) Flushable and anaerobically degradable films and laminates
DE60010072D1 (de) Stereokomplexe hydrogele
TR199801954T2 (xx) Eprosartan dihidrat ve �retimi ve form�lasyonu i�in bir proses.
TR199903202A2 (xx) Etilen kopolimerlerinin ve terpolimerlerinin molek�l a��rl�klar�n�n azalt�lmas�n�n prosesi.
ATE533517T1 (de) Biologisch abbaubare polyphosphazene mit pyrrolidonseitengruppen
ES2181461T3 (es) Utilizacion de nuevos agentes inductores de muerte celular en sinergia con interferones.
TR200201706T1 (tr) Düşük molekül ağırlıklı yan zincirler ile olefin aşı kopolimerlerinin yapılması için radyasyon prosesi
TR199903203A3 (tr) Yüksek oranda seffaf polimerik bilesim.
AU2001281773A1 (en) Plaster cover for children
BR0109086A (pt) Polìmeros reativos
ATE286746T1 (de) Proteinhaltige hydrogele
DE50010274D1 (de) Bistabiles Schütz
EP0712934A3 (de) Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften
DE60037180D1 (de) Polymerisierbare Zusammensetzungen für die Herstellung von transparenten Polymersubstraten, transparente Polymersubstrate die so hergestellt wurden und deren Verwendung in der Optik
SE9004011L (sv) Vattenhaltiga suspensioner av vattenoloesliga, silikabaserade, oorganiska material
WO1998029566A3 (en) Novel method for testing the differentiation status in pancreatic cells of a mammal

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties