ATE291446T1 - Biomaterialien, modifiziert mit superoxid- dismutase imitatoren - Google Patents
Biomaterialien, modifiziert mit superoxid- dismutase imitatorenInfo
- Publication number
- ATE291446T1 ATE291446T1 AT00932810T AT00932810T ATE291446T1 AT E291446 T1 ATE291446 T1 AT E291446T1 AT 00932810 T AT00932810 T AT 00932810T AT 00932810 T AT00932810 T AT 00932810T AT E291446 T1 ATE291446 T1 AT E291446T1
- Authority
- AT
- Austria
- Prior art keywords
- biomaterials
- mimitators
- modified
- superoxide dismutase
- biomaterials modified
- Prior art date
Links
- 239000012620 biological material Substances 0.000 title abstract 4
- 102000019197 Superoxide Dismutase Human genes 0.000 title 1
- 108010012715 Superoxide dismutase Proteins 0.000 title 1
- 239000003054 catalyst Substances 0.000 abstract 2
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 abstract 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 238000007334 copolymerization reaction Methods 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 238000007323 disproportionation reaction Methods 0.000 abstract 1
- 230000028709 inflammatory response Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
- C08B15/05—Derivatives containing elements other than carbon, hydrogen, oxygen, halogens or sulfur
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/08—Processes
- C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/48—Polyethers
- C08G18/4854—Polyethers containing oxyalkylene groups having four carbon atoms in the alkylene group
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/65—Low-molecular-weight compounds having active hydrogen with high-molecular-weight compounds having active hydrogen
- C08G18/66—Compounds of groups C08G18/42, C08G18/48, or C08G18/52
- C08G18/6666—Compounds of group C08G18/48 or C08G18/52
- C08G18/667—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38
- C08G18/6681—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/32 or C08G18/3271 and/or polyamines of C08G18/38
- C08G18/6685—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/32 or C08G18/3271 and/or polyamines of C08G18/38 with compounds of group C08G18/3225 or polyamines of C08G18/38
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
- C08G18/71—Monoisocyanates or monoisothiocyanates
- C08G18/718—Monoisocyanates or monoisothiocyanates containing silicon
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
- C08G18/72—Polyisocyanates or polyisothiocyanates
- C08G18/73—Polyisocyanates or polyisothiocyanates acyclic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H1/00—Macromolecular products derived from proteins
- C08H1/06—Macromolecular products derived from proteins derived from horn, hoofs, hair, skin or leather
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Catalysts (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13629899P | 1999-05-27 | 1999-05-27 | |
PCT/US2000/014847 WO2000072893A2 (en) | 1999-05-27 | 2000-05-26 | Biomaterials modified with superoxide dismutase mimics |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE291446T1 true ATE291446T1 (de) | 2005-04-15 |
Family
ID=22472236
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00932810T ATE291446T1 (de) | 1999-05-27 | 2000-05-26 | Biomaterialien, modifiziert mit superoxid- dismutase imitatoren |
AT05006278T ATE383364T1 (de) | 1999-05-27 | 2000-05-26 | Biomaterialien, modifiziert mit superoxid- dismutase imitatoren |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05006278T ATE383364T1 (de) | 1999-05-27 | 2000-05-26 | Biomaterialien, modifiziert mit superoxid- dismutase imitatoren |
Country Status (9)
Country | Link |
---|---|
US (3) | US7445641B1 (de) |
EP (1) | EP1185312B1 (de) |
JP (1) | JP2003500174A (de) |
AT (2) | ATE291446T1 (de) |
AU (1) | AU5048400A (de) |
CA (1) | CA2374472A1 (de) |
DE (2) | DE60037768T2 (de) |
ES (1) | ES2240101T3 (de) |
WO (1) | WO2000072893A2 (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1616869T3 (da) | 1999-01-25 | 2012-05-07 | Nat Jewish Health | Substituerede porphyriner og deres terapeutiske anvendelse |
EP1185312B1 (de) | 1999-05-27 | 2005-03-23 | Monsanto Company | Biomaterialien, modifiziert mit superoxid-dismutase imitatoren |
US9522217B2 (en) | 2000-03-15 | 2016-12-20 | Orbusneich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
US8088060B2 (en) | 2000-03-15 | 2012-01-03 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
US20040137638A1 (en) * | 2002-03-04 | 2004-07-15 | Slomczynska Urszula J. | Chromatography of metal complexes |
EP1247537A1 (de) * | 2001-04-04 | 2002-10-09 | Isotis B.V. | Beschichtung für medizinische Vorrichtungen |
AU2002312194B8 (en) | 2001-06-01 | 2008-05-15 | Aeolus Sciences, Inc. | Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance |
CN1620325A (zh) | 2001-12-14 | 2005-05-25 | 艾尔科公司 | 治疗眼睛障碍和疾病的超氧化物歧化酶模拟物 |
US7919075B1 (en) * | 2002-03-20 | 2011-04-05 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices |
US6835387B2 (en) * | 2002-06-11 | 2004-12-28 | Scimed Life Systems, Inc. | Sustained release of superoxide dismutase mimics from implantable or insertable medical devices |
US20030232784A1 (en) * | 2002-06-14 | 2003-12-18 | Benedict James J. | Hyaluronic acid-associated superoxide dismutase mimics and their use in the treatment of joint pain |
MXPA05005937A (es) | 2002-12-06 | 2005-08-18 | Alcon Inc | Imitaciones de superoxido de dismutasa para el tratamiento de trastornos y enfermedades oculares. |
US20040254629A1 (en) * | 2003-04-25 | 2004-12-16 | Brian Fernandes | Methods and apparatus for treatment of aneurysmal tissue |
US7053051B2 (en) | 2003-10-28 | 2006-05-30 | Medtronic, Inc. | Methods of preparing crosslinked materials and bioprosthetic devices |
US7299082B2 (en) | 2003-10-31 | 2007-11-20 | Abbott Diabetes Care, Inc. | Method of calibrating an analyte-measurement device, and associated methods, devices and systems |
ZA200603347B (en) | 2003-12-11 | 2009-02-25 | Alcon Inc | Superoxide dismutase mimics for the treatment of optic nerve and retinal damage |
EP1559728A1 (de) * | 2004-01-28 | 2005-08-03 | Total Petrochemicals Research Feluy | Pfropfung von Übergangsmetallkomplexen auf Trägern |
US8165651B2 (en) | 2004-02-09 | 2012-04-24 | Abbott Diabetes Care Inc. | Analyte sensor, and associated system and method employing a catalytic agent |
US7971333B2 (en) * | 2006-05-30 | 2011-07-05 | Advanced Cardiovascular Systems, Inc. | Manufacturing process for polymetric stents |
US9050393B2 (en) * | 2005-02-08 | 2015-06-09 | Bruce N. Saffran | Medical devices and methods for modulation of physiology using device-based surface chemistry |
US20070014726A1 (en) * | 2005-07-18 | 2007-01-18 | Sensors For Medicine And Science | Oxidation-resistant indicator macromolecule |
US7785647B2 (en) * | 2005-07-25 | 2010-08-31 | Advanced Cardiovascular Systems, Inc. | Methods of providing antioxidants to a drug containing product |
US8394446B2 (en) | 2005-07-25 | 2013-03-12 | Abbott Cardiovascular Systems Inc. | Methods of providing antioxidants to implantable medical devices |
ES2509884T3 (es) | 2005-08-18 | 2014-10-20 | Zimmer Gmbh | Artículos de polietileno de peso molecular ultra-alto y métodos para formar artículos de polietileno de peso molecular ultra-alto |
US7682152B2 (en) | 2005-12-20 | 2010-03-23 | Ford Christopher W | Force distributing dental implant assembly |
US20070141532A1 (en) * | 2005-12-20 | 2007-06-21 | Ford Christopher W | Force distributing dental implant assembly |
US8647654B2 (en) * | 2005-12-22 | 2014-02-11 | The Penn State Research Foundation | Method and systems for forming and using nanoengineered sculptured thin films |
US20070160642A1 (en) * | 2006-01-12 | 2007-07-12 | Pacetti Stephen D | Implantable medical devices coated with a polymer-bound superoxide dismutase mimic |
US7885698B2 (en) | 2006-02-28 | 2011-02-08 | Abbott Diabetes Care Inc. | Method and system for providing continuous calibration of implantable analyte sensors |
PT2056675T (pt) | 2006-10-12 | 2019-05-09 | Galera Labs Llc | Métodos de tratamento da mucosite oral |
US8664290B2 (en) | 2007-04-10 | 2014-03-04 | Zimmer, Inc. | Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications |
EP2578248B1 (de) * | 2007-04-10 | 2021-05-19 | Zimmer, Inc. | Antioxidans-stabilisiertes, vernetztes Polyethylen mit ultrahohem Molekulargewicht für Medizingeräteanwendungen |
US8278406B2 (en) * | 2007-04-27 | 2012-10-02 | Wisconsin Alumni Research Foundation | Bioactive and biocompatible polyurethane-buthanediol-glycosaminoglycan salt copolymers |
US8652212B2 (en) | 2008-01-30 | 2014-02-18 | Zimmer, Inc. | Orthopedic component of low stiffness |
US8011926B2 (en) | 2008-05-15 | 2011-09-06 | Ford Christopher W | Polymeric dental implant assembly |
EP2732817B1 (de) | 2008-05-23 | 2016-08-24 | National Jewish Health | Verbindung zur Verwendung bei der Behandlung von Verletzungen aufgrund der Exposition gegenüber Phosgen oder Chlorgas |
SG193220A1 (en) | 2008-08-22 | 2013-09-30 | Novomer Inc | Catalysts and methods for polymer synthesis |
WO2010057644A1 (en) | 2008-11-20 | 2010-05-27 | Zimmer Gmbh | Polyethylene materials |
US8332042B2 (en) * | 2009-01-15 | 2012-12-11 | Medtronic, Inc. | Medical lead with stiffening coil |
US8399535B2 (en) | 2010-06-10 | 2013-03-19 | Zimmer, Inc. | Polymer [[s]] compositions including an antioxidant |
EP2760874A4 (de) | 2011-09-26 | 2015-04-08 | Galera Therapeutics Llc | Verfahren zur behandlung von erkrankungen |
WO2014182542A1 (en) | 2013-05-06 | 2014-11-13 | Abbott Cardiovascular Systems Inc. | A hollow stent filled with a therapeutic agent formulation |
US9708467B2 (en) | 2013-10-01 | 2017-07-18 | Zimmer, Inc. | Polymer compositions comprising one or more protected antioxidants |
RU2683203C2 (ru) | 2013-12-31 | 2019-03-26 | Эбботт Дайабитиз Кэр Инк. | Снабженный автономным питанием датчик аналита и использующие его устройства |
CA2942565A1 (en) | 2014-03-12 | 2015-09-17 | Zimmer, Inc. | Melt-stabilized ultra high molecular weight polyethylene and method of making the same |
CA2969751C (en) | 2014-12-03 | 2020-09-22 | Zimmer, Inc. | Antioxidant-infused ultra high molecular weight polyethylene |
EA201890471A1 (ru) | 2015-08-11 | 2018-10-31 | ГАЛЕРА ЛЭБЗ, ЭлЭлСи | Комплексные соединения, содержащие макроциклическое кольцо пентаазы, обладающие пероральной биодоступностью |
US11246950B2 (en) | 2017-04-13 | 2022-02-15 | Galera Labs, Llc | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
JP2020532643A (ja) * | 2017-09-01 | 2020-11-12 | ピーエムアイディージー・エルエルシーPmidg,Llc | 官能基化および架橋ポリマー |
US20220080628A1 (en) * | 2020-09-17 | 2022-03-17 | Nutech Ventures | Method of reinforcement for keratin materials |
Family Cites Families (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US580458A (en) * | 1897-04-13 | Knotter mechanism fo r grain-binders | ||
US540383A (en) * | 1895-06-04 | Means for lubricating bearings of steam-engines | ||
US3506411A (en) * | 1966-11-16 | 1970-04-14 | Amp Inc | Cold crimped sleeve applicator |
DE3134896C2 (de) | 1981-09-03 | 1985-03-28 | W.C. Heraeus Gmbh, 6450 Hanau | Kabelzuleitung für Herzschrittmacher-Elektroden |
US4718908A (en) | 1984-06-04 | 1988-01-12 | Richards Medical Company | High-strength, cold-forged type 316L stainless steel for orthopedic implant |
JPS61135671A (ja) | 1984-12-04 | 1986-06-23 | 三菱鉱業セメント株式会社 | インプラント材 |
US4863964A (en) * | 1985-07-02 | 1989-09-05 | Biomedical Frontiers, Inc. | Method for the stabilization of deferoxamine to chelate free ions in physiological fluid |
US4775426A (en) * | 1986-04-03 | 1988-10-04 | Richards Medical Company | Method of manufacturing surgical implants from cast stainless steel and product |
US5227405A (en) * | 1987-03-31 | 1993-07-13 | Duke University | Superoxide dismutase mimic |
US5334371A (en) * | 1988-07-20 | 1994-08-02 | Schering Aktiengesellschaft | Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI |
JPH02231078A (ja) | 1989-03-03 | 1990-09-13 | Ube Ind Ltd | ヒアルロン酸修飾スーパーオキシドジスムターゼ |
US5252720A (en) | 1989-03-06 | 1993-10-12 | Board Of Regents, The University Of Texas System | Metal complexes of water soluble texaphyrins |
JP2858126B2 (ja) | 1989-06-30 | 1999-02-17 | 京セラ株式会社 | 生体インプラント材とその製法 |
US5386012A (en) | 1990-02-06 | 1995-01-31 | Strid; Lars | Growth factor in connection with artificial implants |
US5545208A (en) | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
US5626863A (en) | 1992-02-28 | 1997-05-06 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
EP0525210A4 (en) | 1991-02-20 | 1993-07-28 | Tdk Corporation | Composite bio-implant and production method therefor |
US5326568A (en) * | 1991-05-03 | 1994-07-05 | Giampapa Vincent C | Method of tissue-specific delivery |
CA2072934C (en) * | 1991-07-19 | 2007-08-28 | Karl William Aston | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
DE69224839T2 (de) | 1991-07-19 | 1998-10-08 | Monsanto Co | Mangan-Komplexe mit Stickstoff enthaltenden makrozyklischen Liganden, wirksam als Superoxiddismutasekatalysatoren. |
ZA929575B (en) | 1991-12-10 | 1994-06-10 | Dow Chemical Co | Bicyclopolyazamacrocyclocarboxyclic acid complexes,their conjugates,processes for their preparation,and use as contrast agents |
US5176745A (en) * | 1991-12-11 | 1993-01-05 | Milliken Research Corporation | Aqueous ink composition and colorants useful therein |
US5507767A (en) | 1992-01-15 | 1996-04-16 | Cook Incorporated | Spiral stent |
US5876452A (en) | 1992-02-14 | 1999-03-02 | Board Of Regents, University Of Texas System | Biodegradable implant |
US5879359A (en) | 1992-08-03 | 1999-03-09 | Fidia S.P.A. | Biodegradable guide channels comprised of esters of hyaluronic acid for use in tissue repair as surgical aids |
US5840319A (en) | 1992-10-08 | 1998-11-24 | Alakhov; Valery Yu | Biological agent compositions |
US5402834A (en) * | 1992-11-25 | 1995-04-04 | Merck & Co., Inc. | Solution preparation system |
US5834509A (en) | 1992-12-07 | 1998-11-10 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
US5403834A (en) | 1992-12-07 | 1995-04-04 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
US5696109A (en) * | 1992-12-07 | 1997-12-09 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
CN1088069A (zh) | 1992-12-18 | 1994-06-22 | 胡耀祖 | 香味健美胸罩 |
US6204259B1 (en) | 1993-01-14 | 2001-03-20 | Monsanto Company | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
US5836313A (en) | 1993-02-08 | 1998-11-17 | Massachusetts Institute Of Technology | Methods for making composite hydrogels for corneal prostheses |
US6294185B1 (en) | 1993-03-12 | 2001-09-25 | Auburn University | Monomeric and polymeric cyclic amine and N-halamine compounds |
EP0706376B2 (de) * | 1993-07-19 | 2007-08-08 | Angiotech Pharmaceuticals, Inc. | Anti-angiogene mittel und verfahren zu deren verwendung |
US5626861A (en) | 1994-04-01 | 1997-05-06 | Massachusetts Institute Of Technology | Polymeric-hydroxyapatite bone composite |
GB9407812D0 (en) * | 1994-04-20 | 1994-06-15 | Nycomed Salutar Inc | Compounds |
CN1152880A (zh) | 1994-04-22 | 1997-06-25 | 孟山都公司 | 使用含氮大环配拉体的金属络合物的诊断图像分析的方法 |
US5525621A (en) * | 1994-05-20 | 1996-06-11 | Cytos Pharmaceuticals Llc | Imidazole derivatives as protective agents in reperfusion injury and severe inflammatory responses |
GB9412273D0 (en) | 1994-06-18 | 1994-08-10 | Univ Nottingham | Administration means |
US5749839A (en) | 1994-08-18 | 1998-05-12 | Duke University | Direct mechanical bi-ventricular cardiac assist device |
US5817303A (en) | 1995-05-05 | 1998-10-06 | Protein Polymer Technologies, Inc. | Bonding together tissue with adhesive containing polyfunctional crosslinking agent and protein polymer |
WO1996039409A1 (en) * | 1995-06-05 | 1996-12-12 | Nitromed, Inc. | Nitrosylated and nitrated superoxide oxidants and reductants |
US6525041B1 (en) | 1995-06-06 | 2003-02-25 | Pharmacia Corporation | Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
CA2178541C (en) * | 1995-06-07 | 2009-11-24 | Neal E. Fearnot | Implantable medical device |
US5609629A (en) | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
JPH11507621A (ja) | 1995-06-07 | 1999-07-06 | モンサント カンパニー | 置換ポリアザ大環状化合物の製造法 |
US6774278B1 (en) * | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
CA2229781A1 (en) | 1995-08-17 | 1997-02-27 | Monsanto Company | Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands |
JP3008833B2 (ja) * | 1995-10-25 | 2000-02-14 | トヨタ自動車株式会社 | 車体の横滑り速度推定装置 |
US5665428A (en) | 1995-10-25 | 1997-09-09 | Macromed, Inc. | Preparation of peptide containing biodegradable microspheres by melt process |
US5830539A (en) | 1995-11-17 | 1998-11-03 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Methods for functionalizing and coating substrates and devices made according to the methods |
US5861032A (en) | 1996-01-31 | 1999-01-19 | Surface Genesis, Inc. | Medical device having a biocompatible coating and oxidation method of coupling therefor |
JP2000507929A (ja) | 1996-03-13 | 2000-06-27 | モンサント カンパニー | ジスムタチンスーパーオキシドの触媒として有効な窒素含有大環状化合物配位子を持つ鉄錯体 |
CA2249011A1 (en) * | 1996-03-13 | 1997-09-18 | Monsanto Company | Bioconjugates of manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
US5891862A (en) | 1996-03-15 | 1999-04-06 | Geltex Pharmaceuticals, Inc. | Polyvalent polymers for the treatment of rotavirus infection |
US5876433A (en) | 1996-05-29 | 1999-03-02 | Ethicon, Inc. | Stent and method of varying amounts of heparin coated thereon to control treatment |
US5824047A (en) | 1996-10-11 | 1998-10-20 | C. R. Bard, Inc. | Vascular graft fabric |
US5877263A (en) | 1996-11-25 | 1999-03-02 | Meadox Medicals, Inc. | Process for preparing polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents |
US5879697A (en) | 1997-04-30 | 1999-03-09 | Schneider Usa Inc | Drug-releasing coatings for medical devices |
US5885609A (en) | 1997-05-23 | 1999-03-23 | Northeastern University | Biocompatible articles and method for making same |
US6180620B1 (en) | 1997-06-20 | 2001-01-30 | G.D. Searle & Co. | Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals |
US5837752A (en) * | 1997-07-17 | 1998-11-17 | Massachusetts Institute Of Technology | Semi-interpenetrating polymer networks |
US5851227A (en) | 1997-07-30 | 1998-12-22 | Sulzer Intermedics Inc. | Cardiac pacemaker cable lead |
US6569688B2 (en) * | 1997-08-26 | 2003-05-27 | Technion Research & Development Foundation Ltd. | Intravascular apparatus method |
US6323218B1 (en) * | 1998-03-11 | 2001-11-27 | The General Hospital Corporation | Agents for use in the treatment of Alzheimer's disease |
WO1999065538A1 (en) * | 1998-06-19 | 1999-12-23 | Oxibio, Inc. | Medical device having anti-infective and contraceptive properties |
EP1185312B1 (de) | 1999-05-27 | 2005-03-23 | Monsanto Company | Biomaterialien, modifiziert mit superoxid-dismutase imitatoren |
US20040110722A1 (en) | 1999-05-27 | 2004-06-10 | Ornberg Richard L. | Modified hyaluronic acid polymers |
US20030232784A1 (en) | 2002-06-14 | 2003-12-18 | Benedict James J. | Hyaluronic acid-associated superoxide dismutase mimics and their use in the treatment of joint pain |
-
2000
- 2000-05-26 EP EP00932810A patent/EP1185312B1/de not_active Expired - Lifetime
- 2000-05-26 ES ES00932810T patent/ES2240101T3/es not_active Expired - Lifetime
- 2000-05-26 JP JP2000620999A patent/JP2003500174A/ja active Pending
- 2000-05-26 CA CA002374472A patent/CA2374472A1/en not_active Abandoned
- 2000-05-26 AU AU50484/00A patent/AU5048400A/en not_active Abandoned
- 2000-05-26 DE DE60037768T patent/DE60037768T2/de not_active Expired - Lifetime
- 2000-05-26 AT AT00932810T patent/ATE291446T1/de not_active IP Right Cessation
- 2000-05-26 AT AT05006278T patent/ATE383364T1/de not_active IP Right Cessation
- 2000-05-26 US US09/580,007 patent/US7445641B1/en not_active Expired - Fee Related
- 2000-05-26 DE DE60018925T patent/DE60018925T2/de not_active Expired - Lifetime
- 2000-05-26 WO PCT/US2000/014847 patent/WO2000072893A2/en active IP Right Grant
-
2003
- 2003-11-05 US US10/702,407 patent/US7004976B2/en not_active Expired - Fee Related
-
2005
- 2005-09-15 US US11/227,318 patent/US20060089710A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1185312A2 (de) | 2002-03-13 |
US20060089710A1 (en) | 2006-04-27 |
ES2240101T3 (es) | 2005-10-16 |
DE60037768D1 (de) | 2008-02-21 |
EP1185312B1 (de) | 2005-03-23 |
DE60037768T2 (de) | 2009-01-15 |
DE60018925D1 (de) | 2005-04-28 |
US7445641B1 (en) | 2008-11-04 |
DE60018925T2 (de) | 2006-04-13 |
JP2003500174A (ja) | 2003-01-07 |
US20040116332A1 (en) | 2004-06-17 |
WO2000072893A3 (en) | 2001-08-30 |
WO2000072893A2 (en) | 2000-12-07 |
US7004976B2 (en) | 2006-02-28 |
AU5048400A (en) | 2000-12-18 |
CA2374472A1 (en) | 2000-12-07 |
ATE383364T1 (de) | 2008-01-15 |
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