ES2215305T3 - Metodos analgesicos usando los catalizadores sinteticos para la dismutacion de los radicales superoxido. - Google Patents
Metodos analgesicos usando los catalizadores sinteticos para la dismutacion de los radicales superoxido.Info
- Publication number
- ES2215305T3 ES2215305T3 ES98929022T ES98929022T ES2215305T3 ES 2215305 T3 ES2215305 T3 ES 2215305T3 ES 98929022 T ES98929022 T ES 98929022T ES 98929022 T ES98929022 T ES 98929022T ES 2215305 T3 ES2215305 T3 ES 2215305T3
- Authority
- ES
- Spain
- Prior art keywords
- heterocycle
- cycloalkyl
- attached
- independently
- carbon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5040297P | 1997-06-20 | 1997-06-20 | |
| US50402P | 1997-06-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2215305T3 true ES2215305T3 (es) | 2004-10-01 |
Family
ID=21965044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98929022T Expired - Lifetime ES2215305T3 (es) | 1997-06-20 | 1998-06-15 | Metodos analgesicos usando los catalizadores sinteticos para la dismutacion de los radicales superoxido. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6180620B1 (https=) |
| EP (1) | EP1001752B1 (https=) |
| JP (1) | JP2002506445A (https=) |
| AT (1) | ATE256467T1 (https=) |
| AU (1) | AU733415B2 (https=) |
| CA (1) | CA2294155A1 (https=) |
| DE (1) | DE69820633T2 (https=) |
| DK (1) | DK1001752T3 (https=) |
| ES (1) | ES2215305T3 (https=) |
| PT (1) | PT1001752E (https=) |
| WO (1) | WO1998058636A1 (https=) |
| ZA (1) | ZA985376B (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6127356A (en) | 1993-10-15 | 2000-10-03 | Duke University | Oxidant scavengers |
| US20050171198A1 (en) * | 1997-06-20 | 2005-08-04 | Metaphore Pharmaceuticals, Inc. | SODm therapy for treatment, prevention, inhibition and reversal of inflammatory disease |
| US6214817B1 (en) * | 1997-06-20 | 2001-04-10 | Monsanto Company | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity |
| US20060270639A1 (en) * | 1997-06-20 | 2006-11-30 | Daniela Salvemini | Combinations of superoxide dismutase mimetics and nonsteroidal analgesic/anti-inflammatory drugs |
| WO1999023097A1 (en) | 1997-11-03 | 1999-05-14 | Duke University | Substituted porphyrins |
| ATE312103T1 (de) | 1999-01-25 | 2005-12-15 | Nat Jewish Med & Res Center | Substituierte porphyrine und deren therapeutische verwendungen |
| AU5048400A (en) * | 1999-05-27 | 2000-12-18 | Monsanto Company | Biomaterials modified with superoxide dismutase mimics |
| US20030069281A1 (en) * | 2000-06-14 | 2003-04-10 | Irwin Fridovich | Tetrapyrroles |
| US20020072512A1 (en) * | 2000-12-08 | 2002-06-13 | Metaphore Pharmaceuticals, Inc | Method of preventing and treating HIV-mediated central nervous system damage |
| JP4331939B2 (ja) * | 2001-01-05 | 2009-09-16 | メタファー・ファーマシューティカルズ・インコーポレイテッド | サイトカイン活性を増強させ、そしてサイトカインの投与に伴う低血圧を治療するための組成物および方法 |
| DE60233317D1 (de) | 2001-01-19 | 2009-09-24 | Nat Jewish Med & Res Center | Medikament zum schutz in der radiotherapie |
| EP1353655A2 (en) * | 2001-01-26 | 2003-10-22 | Metaphore Pharmaceuticals Inc. | Method of treatment of neurodegenerative disorders using pentaaza-macrocyclic ligand complexes |
| CA2439971A1 (en) * | 2001-03-02 | 2002-09-12 | Metaphore Pharmaceuticals, Inc. | Chromatography of metal complexes |
| US20040137638A1 (en) | 2002-03-04 | 2004-07-15 | Slomczynska Urszula J. | Chromatography of metal complexes |
| EP1439842A4 (en) * | 2001-06-01 | 2009-09-02 | Nat Jewish Med & Res Center | OXIDANT CAPTAIN FOR THE TREATMENT OF DIABETES OR FOR THE USE IN THE TRANSPLANTATION OR INDUCTION OF IMMUNOTOLERANE |
| US20040236519A1 (en) * | 2001-06-08 | 2004-11-25 | Marshall Garland R. | Libraries of confomationally constrained peptides, chiral azacrowns, and peptidomimetics and methods of making the same |
| CA2451602A1 (en) * | 2001-06-26 | 2003-01-03 | Metaphore Pharmaceuticals, Inc. | Combination therapy of an sodm and a corticosteroid for prevention and/or treatment of inflammatory disease |
| EP1450824A4 (en) * | 2001-11-02 | 2005-09-28 | Elan Corp Plc | PHARMACEUTICAL COMPOSITION |
| WO2003051458A1 (en) * | 2001-12-14 | 2003-06-26 | Alcon, Inc. | Superoxide dismutase mimics for the treatment of ocular disorders and diseases |
| US6933275B2 (en) * | 2002-05-01 | 2005-08-23 | The Board Of Trustees Of The Leland Stanford Junior University | Protein kinase C peptides for use in withdrawal |
| US7485721B2 (en) * | 2002-06-07 | 2009-02-03 | Duke University | Substituted porphyrins |
| US20030232784A1 (en) * | 2002-06-14 | 2003-12-18 | Benedict James J. | Hyaluronic acid-associated superoxide dismutase mimics and their use in the treatment of joint pain |
| CA2397684A1 (en) * | 2002-08-12 | 2004-02-12 | Michael P. Murphy | Mitochondrially targeted antioxidants |
| EP1551402A4 (en) * | 2002-09-23 | 2009-05-27 | Verion Inc | PHARMACEUTICAL COMPOSITIONS NOT INDUCING ABUSE |
| MXPA05005937A (es) * | 2002-12-06 | 2005-08-18 | Alcon Inc | Imitaciones de superoxido de dismutasa para el tratamiento de trastornos y enfermedades oculares. |
| CN1717234A (zh) * | 2002-12-06 | 2006-01-04 | 爱尔康公司 | 用于治疗眼紊乱和疾病的超氧化物岐化酶模拟物 |
| KR100648618B1 (ko) * | 2003-11-19 | 2006-11-23 | 주식회사 웰스킨 | 활성 산소 억제제 |
| MXPA06006187A (es) * | 2003-12-11 | 2006-08-25 | Alcon Inc | Imitadores de super oxido dismutasa para el tratamiento de dano retinal y de nervio optico. |
| US8217166B2 (en) * | 2005-05-05 | 2012-07-10 | Galera Therapeutics, Llc | Polyethylene glycolated superoxide dismutase mimetics |
| US20120301403A1 (en) | 2007-06-21 | 2012-11-29 | Galera Therapeutics, Llc | Polyethylene glycolated superoxide dismutase mimetics |
| WO2006069326A2 (en) * | 2004-12-21 | 2006-06-29 | Metaphore Pharmaceuticals, Inc. | Polyethylene glycolated superoxide dismutase mimetics |
| KR100724586B1 (ko) | 2005-12-09 | 2007-06-04 | 세종대학교산학협력단 | 수퍼옥사이드 디스뮤타아제 활성을 갖는 고리화합물 |
| ES2725023T3 (es) | 2006-10-12 | 2019-09-18 | Galera Labs Llc | Métodos para el tratamiento de la mucositis oral |
| US8486928B2 (en) | 2007-11-14 | 2013-07-16 | Galera Therapeutics | Super-oxide dismutase mimetics |
| EP2296645B1 (en) | 2008-05-22 | 2014-11-19 | Galera Therapeutics, LLC | Combination antitumor therapy |
| CN102105146A (zh) | 2008-05-23 | 2011-06-22 | 国立犹太保健医院 | 用于治疗与暴露于烷化物质有关的损伤的方法 |
| EP2760874A4 (en) * | 2011-09-26 | 2015-04-08 | Galera Therapeutics Llc | METHOD FOR THE TREATMENT OF ILLNESSES |
| RS60558B1 (sr) | 2015-08-11 | 2020-08-31 | Galera Labs Llc | Pentaaza makrociklični prstenasti kompleksi koji poseduju oralnu bioraspoloživost |
| KR20180132939A (ko) | 2016-05-03 | 2018-12-12 | 갈레라 랩스, 엘엘씨 | 암 치료를 위한 조합 요법 |
| JP7166634B2 (ja) | 2016-09-01 | 2022-11-08 | ガレラ・ラブス・リミテッド・ライアビリティ・カンパニー | ペンタアザ大環状環複合体およびアスコルビン酸化合物による組み合わせ癌療法 |
| CA3053779A1 (en) * | 2017-02-15 | 2018-08-23 | Galera Labs, Llc | Pentaaza macrocyclic ring complexes for local intestinal delivery |
| EP3388082A1 (en) | 2017-04-13 | 2018-10-17 | Galera Labs, LLC | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
| IL295620B2 (en) | 2017-04-13 | 2024-01-01 | Galera Labs Llc | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
| CA3090129A1 (en) | 2018-01-31 | 2019-08-08 | Galera Labs, Llc | Combination cancer therapy with pentaaza macrocyclic ring complex and platinum-based anticancer agent |
| US20230071463A1 (en) * | 2020-02-13 | 2023-03-09 | Teva Pharmaceuticals International Gmbh | Solid state forms of avasopasem manganese and process for preparation thereof |
| AU2024300676A1 (en) * | 2023-07-21 | 2026-01-29 | Board Of Regents Of The University Of Texas System | Carcinogenesis reduction with pentaaza macrocyclic ring complex |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0751496B2 (ja) | 1986-04-02 | 1995-06-05 | 武田薬品工業株式会社 | リポソ−ムの製造法 |
| US5216021A (en) | 1986-08-28 | 1993-06-01 | Sorenson John R J | Analgesic method |
| US4999347A (en) | 1986-08-28 | 1991-03-12 | Sorenson John R J | Analgesic method |
| JPS63313581A (ja) * | 1987-06-16 | 1988-12-21 | Ube Ind Ltd | 修飾ス−パ−オキシドジスムタ−ゼ |
| CA2072934C (en) | 1991-07-19 | 2007-08-28 | Karl William Aston | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| EP0598753B1 (en) | 1991-07-19 | 1998-03-18 | Monsanto Company | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| CN1088086A (zh) * | 1992-12-14 | 1994-06-22 | 西北大学 | 一种新型的护肤保健品 |
| US6204259B1 (en) | 1993-01-14 | 2001-03-20 | Monsanto Company | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| US6525041B1 (en) | 1995-06-06 | 2003-02-25 | Pharmacia Corporation | Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| KR19990087784A (ko) | 1996-03-13 | 1999-12-27 | 죤 에이치. 뷰센 | 초과산화물을 불균등화하기 위한 촉매로서 효과적인 질소함유거대고리 리간드의 망간 또는 철착물의 바이오콘쥬게이트 |
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1998
- 1998-04-09 US US09/057,831 patent/US6180620B1/en not_active Expired - Fee Related
- 1998-06-15 DE DE69820633T patent/DE69820633T2/de not_active Expired - Fee Related
- 1998-06-15 EP EP98929022A patent/EP1001752B1/en not_active Expired - Lifetime
- 1998-06-15 PT PT98929022T patent/PT1001752E/pt unknown
- 1998-06-15 CA CA002294155A patent/CA2294155A1/en not_active Abandoned
- 1998-06-15 AU AU80685/98A patent/AU733415B2/en not_active Ceased
- 1998-06-15 AT AT98929022T patent/ATE256467T1/de not_active IP Right Cessation
- 1998-06-15 ES ES98929022T patent/ES2215305T3/es not_active Expired - Lifetime
- 1998-06-15 JP JP50459399A patent/JP2002506445A/ja not_active Ceased
- 1998-06-15 WO PCT/US1998/012231 patent/WO1998058636A1/en not_active Ceased
- 1998-06-15 DK DK98929022T patent/DK1001752T3/da active
- 1998-06-19 ZA ZA985376A patent/ZA985376B/xx unknown
-
2000
- 2000-08-09 US US09/634,152 patent/US6395725B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PT1001752E (pt) | 2004-05-31 |
| DE69820633D1 (de) | 2004-01-29 |
| AU8068598A (en) | 1999-01-04 |
| ATE256467T1 (de) | 2004-01-15 |
| ZA985376B (en) | 1999-06-21 |
| AU733415B2 (en) | 2001-05-17 |
| JP2002506445A (ja) | 2002-02-26 |
| WO1998058636A1 (en) | 1998-12-30 |
| CA2294155A1 (en) | 1998-12-30 |
| EP1001752A1 (en) | 2000-05-24 |
| EP1001752B1 (en) | 2003-12-17 |
| US6395725B1 (en) | 2002-05-28 |
| US6180620B1 (en) | 2001-01-30 |
| DK1001752T3 (da) | 2004-04-19 |
| DE69820633T2 (de) | 2004-09-23 |
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