JP2002506445A5 - - Google Patents

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Publication number
JP2002506445A5
JP2002506445A5 JP1999504593A JP50459399A JP2002506445A5 JP 2002506445 A5 JP2002506445 A5 JP 2002506445A5 JP 1999504593 A JP1999504593 A JP 1999504593A JP 50459399 A JP50459399 A JP 50459399A JP 2002506445 A5 JP2002506445 A5 JP 2002506445A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1999504593A
Other languages
English (en)
Japanese (ja)
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JP2002506445A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1998/012231 external-priority patent/WO1998058636A1/en
Publication of JP2002506445A publication Critical patent/JP2002506445A/ja
Publication of JP2002506445A5 publication Critical patent/JP2002506445A5/ja
Ceased legal-status Critical Current

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JP50459399A 1997-06-20 1998-06-15 スーパーオキシドラジカルの不均化反応のための合成触媒を用いる鎮痛方法 Ceased JP2002506445A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5040297P 1997-06-20 1997-06-20
US60/050,402 1997-06-20
PCT/US1998/012231 WO1998058636A1 (en) 1997-06-20 1998-06-15 Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals

Publications (2)

Publication Number Publication Date
JP2002506445A JP2002506445A (ja) 2002-02-26
JP2002506445A5 true JP2002506445A5 (https=) 2007-12-06

Family

ID=21965044

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50459399A Ceased JP2002506445A (ja) 1997-06-20 1998-06-15 スーパーオキシドラジカルの不均化反応のための合成触媒を用いる鎮痛方法

Country Status (12)

Country Link
US (2) US6180620B1 (https=)
EP (1) EP1001752B1 (https=)
JP (1) JP2002506445A (https=)
AT (1) ATE256467T1 (https=)
AU (1) AU733415B2 (https=)
CA (1) CA2294155A1 (https=)
DE (1) DE69820633T2 (https=)
DK (1) DK1001752T3 (https=)
ES (1) ES2215305T3 (https=)
PT (1) PT1001752E (https=)
WO (1) WO1998058636A1 (https=)
ZA (1) ZA985376B (https=)

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US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
US20060270639A1 (en) * 1997-06-20 2006-11-30 Daniela Salvemini Combinations of superoxide dismutase mimetics and nonsteroidal analgesic/anti-inflammatory drugs
US6214817B1 (en) * 1997-06-20 2001-04-10 Monsanto Company Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity
US20050171198A1 (en) * 1997-06-20 2005-08-04 Metaphore Pharmaceuticals, Inc. SODm therapy for treatment, prevention, inhibition and reversal of inflammatory disease
IL135949A0 (en) 1997-11-03 2001-05-20 Univ Duke Substituted porphyrins
DK1616869T3 (da) 1999-01-25 2012-05-07 Nat Jewish Health Substituerede porphyriner og deres terapeutiske anvendelse
DE60018925T2 (de) 1999-05-27 2006-04-13 Pharmacia Corp.(N.D.Ges.D.Staates Delaware) Biomaterialien, modifiziert mit superoxid-dismutase imitatoren
US20030069281A1 (en) * 2000-06-14 2003-04-10 Irwin Fridovich Tetrapyrroles
US20020072512A1 (en) * 2000-12-08 2002-06-13 Metaphore Pharmaceuticals, Inc Method of preventing and treating HIV-mediated central nervous system damage
DE60235955D1 (de) * 2001-01-05 2010-05-27 Metaphore Pharmaceuticals Inc Zusammensetzungen und verfahren zur erhöhung der zytokin-aktivität und zur behandlung der hypotension assoziiert mit der verabreichung von zytokinen
EP1392328B1 (en) 2001-01-19 2009-08-12 National Jewish Medical and Research Center Medicament for protection in radiotherapy
WO2002058686A2 (en) * 2001-01-26 2002-08-01 Metaphore Pharmaceuticals, Inc. Method of treatment of neurodegenerative disorders using pentaaza-macrocyclic ligand complexes
EP1405066B1 (en) * 2001-03-02 2015-06-17 Galera Therapeutics LLC Chromatography of metal complexes
US20040137638A1 (en) 2002-03-04 2004-07-15 Slomczynska Urszula J. Chromatography of metal complexes
AU2002312194B8 (en) * 2001-06-01 2008-05-15 Aeolus Sciences, Inc. Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance
CA2449631A1 (en) * 2001-06-08 2002-12-19 Metaphore Pharmaceuticals, Inc. Libraries of conformationally constrained peptides, chiral azacrowns, and peptidomimetics and methods of making the same
CA2451602A1 (en) * 2001-06-26 2003-01-03 Metaphore Pharmaceuticals, Inc. Combination therapy of an sodm and a corticosteroid for prevention and/or treatment of inflammatory disease
EP1450824A4 (en) * 2001-11-02 2005-09-28 Elan Corp Plc PHARMACEUTICAL COMPOSITION
SI1463563T1 (sl) * 2001-12-14 2009-06-30 Alcon Inc Superoksidni dizmutazni mimetiki za zdravljenje očesnih motenj in bolezni
US6933275B2 (en) * 2002-05-01 2005-08-23 The Board Of Trustees Of The Leland Stanford Junior University Protein kinase C peptides for use in withdrawal
AU2003237500A1 (en) * 2002-06-07 2003-12-22 Duke University Substituted porphyrins
US20030232784A1 (en) * 2002-06-14 2003-12-18 Benedict James J. Hyaluronic acid-associated superoxide dismutase mimics and their use in the treatment of joint pain
US6984636B2 (en) * 2002-08-12 2006-01-10 Medical Research Council Mitochondrially targeted antioxidants
CA2499994C (en) * 2002-09-23 2012-07-10 Verion, Inc. Abuse-resistant pharmaceutical compositions
US20060089343A1 (en) * 2002-12-06 2006-04-27 Alcon, Inc. Superoxide dismutase mimics for the treatment of ocular disorders and diseases
MXPA05005937A (es) * 2002-12-06 2005-08-18 Alcon Inc Imitaciones de superoxido de dismutasa para el tratamiento de trastornos y enfermedades oculares.
KR100648618B1 (ko) * 2003-11-19 2006-11-23 주식회사 웰스킨 활성 산소 억제제
US20070060557A1 (en) * 2003-12-11 2007-03-15 Klimko Peter G Superoxide dismutase mimics for the treatment of optic nerve and retinal damage
WO2006069326A2 (en) * 2004-12-21 2006-06-29 Metaphore Pharmaceuticals, Inc. Polyethylene glycolated superoxide dismutase mimetics
US8217166B2 (en) * 2005-05-05 2012-07-10 Galera Therapeutics, Llc Polyethylene glycolated superoxide dismutase mimetics
US20120301403A1 (en) 2007-06-21 2012-11-29 Galera Therapeutics, Llc Polyethylene glycolated superoxide dismutase mimetics
KR100724586B1 (ko) 2005-12-09 2007-06-04 세종대학교산학협력단 수퍼옥사이드 디스뮤타아제 활성을 갖는 고리화합물
US9855279B2 (en) 2006-10-12 2018-01-02 Galera Labs, Llc Methods of treating oral mucositis
US8486928B2 (en) * 2007-11-14 2013-07-16 Galera Therapeutics Super-oxide dismutase mimetics
EP2296645B1 (en) 2008-05-22 2014-11-19 Galera Therapeutics, LLC Combination antitumor therapy
US11382895B2 (en) 2008-05-23 2022-07-12 National Jewish Health Methods for treating injury associated with exposure to an alkylating species
JP6267638B2 (ja) 2011-09-26 2018-01-24 ガレラ・ラブス・リミテッド・ライアビリティ・カンパニーGalera Labs, Llc 疾患の治療方法
IL297735B2 (en) 2015-08-11 2024-08-01 Galera Labs Llc Macrocyclic ring pentase complexes with oral bioavailability
KR20230075528A (ko) 2016-05-03 2023-05-31 갈레라 랩스, 엘엘씨 암 치료를 위한 조합 요법
EP3506907B1 (en) 2016-09-01 2023-06-07 Galera Labs, LLC Combination cancer therapy with a pentaaza macrocyclic ring complex and an ascorbate compound
CN110520107A (zh) 2017-02-15 2019-11-29 加莱拉实验室有限责任公司 用于局部肠递送的五氮杂大环状环配合物
EP3388082A1 (en) 2017-04-13 2018-10-17 Galera Labs, LLC Combination cancer immunotherapy with pentaaza macrocyclic ring complex
IL295620B2 (en) 2017-04-13 2024-01-01 Galera Labs Llc Combination cancer immunotherapy with pentaaza macrocyclic ring complex
MX2020008028A (es) 2018-01-31 2020-12-11 Galera Labs Llc Terapia de combinacion para cancer con complejo de anillo macrociclico de pentaaza y agente anticancer basado en platino.
US20230071463A1 (en) * 2020-02-13 2023-03-09 Teva Pharmaceuticals International Gmbh Solid state forms of avasopasem manganese and process for preparation thereof
AU2024300676A1 (en) * 2023-07-21 2026-01-29 Board Of Regents Of The University Of Texas System Carcinogenesis reduction with pentaaza macrocyclic ring complex

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JPH0751496B2 (ja) 1986-04-02 1995-06-05 武田薬品工業株式会社 リポソ−ムの製造法
US5216021A (en) 1986-08-28 1993-06-01 Sorenson John R J Analgesic method
US4999347A (en) 1986-08-28 1991-03-12 Sorenson John R J Analgesic method
JPS63313581A (ja) * 1987-06-16 1988-12-21 Ube Ind Ltd 修飾ス−パ−オキシドジスムタ−ゼ
CA2072934C (en) 1991-07-19 2007-08-28 Karl William Aston Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
ES2113952T3 (es) 1991-07-19 1998-05-16 Monsanto Co Complejos de manganeso con ligandos macrociclicos nitrogenados eficaces como catalizadores para dismutar superoxidos.
CN1088086A (zh) * 1992-12-14 1994-06-22 西北大学 一种新型的护肤保健品
US6204259B1 (en) 1993-01-14 2001-03-20 Monsanto Company Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US6525041B1 (en) 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
BR9708179A (pt) 1996-03-13 1999-07-27 Monsanto Co Bioconjugados de complexos de manganês ou ferro de ligantes macrociclicos contendo nitrogênio eficazes como catalizadores para desmutar superoxidos

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