JP2002506445A5 - - Google Patents

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Publication number
JP2002506445A5
JP2002506445A5 JP1999504593A JP50459399A JP2002506445A5 JP 2002506445 A5 JP2002506445 A5 JP 2002506445A5 JP 1999504593 A JP1999504593 A JP 1999504593A JP 50459399 A JP50459399 A JP 50459399A JP 2002506445 A5 JP2002506445 A5 JP 2002506445A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1999504593A
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English (en)
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JP2002506445A (ja
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Priority claimed from PCT/US1998/012231 external-priority patent/WO1998058636A1/en
Publication of JP2002506445A publication Critical patent/JP2002506445A/ja
Publication of JP2002506445A5 publication Critical patent/JP2002506445A5/ja
Ceased legal-status Critical Current

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Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
Figure 2002506445
JP50459399A 1997-06-20 1998-06-15 スーパーオキシドラジカルの不均化反応のための合成触媒を用いる鎮痛方法 Ceased JP2002506445A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5040297P 1997-06-20 1997-06-20
US60/050,402 1997-06-20
PCT/US1998/012231 WO1998058636A1 (en) 1997-06-20 1998-06-15 Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals

Publications (2)

Publication Number Publication Date
JP2002506445A JP2002506445A (ja) 2002-02-26
JP2002506445A5 true JP2002506445A5 (ja) 2007-12-06

Family

ID=21965044

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50459399A Ceased JP2002506445A (ja) 1997-06-20 1998-06-15 スーパーオキシドラジカルの不均化反応のための合成触媒を用いる鎮痛方法

Country Status (12)

Country Link
US (2) US6180620B1 (ja)
EP (1) EP1001752B1 (ja)
JP (1) JP2002506445A (ja)
AT (1) ATE256467T1 (ja)
AU (1) AU733415B2 (ja)
CA (1) CA2294155A1 (ja)
DE (1) DE69820633T2 (ja)
DK (1) DK1001752T3 (ja)
ES (1) ES2215305T3 (ja)
PT (1) PT1001752E (ja)
WO (1) WO1998058636A1 (ja)
ZA (1) ZA985376B (ja)

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US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
US6214817B1 (en) * 1997-06-20 2001-04-10 Monsanto Company Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity
US20050171198A1 (en) * 1997-06-20 2005-08-04 Metaphore Pharmaceuticals, Inc. SODm therapy for treatment, prevention, inhibition and reversal of inflammatory disease
US20060270639A1 (en) * 1997-06-20 2006-11-30 Daniela Salvemini Combinations of superoxide dismutase mimetics and nonsteroidal analgesic/anti-inflammatory drugs
CA2309154C (en) 1997-11-03 2010-02-16 Duke University Substituted porphyrins
EP1616869B1 (en) 1999-01-25 2012-04-04 National Jewish Health Substituted porphyrins and their therapeutic use
DE60018925T2 (de) 1999-05-27 2006-04-13 Pharmacia Corp.(N.D.Ges.D.Staates Delaware) Biomaterialien, modifiziert mit superoxid-dismutase imitatoren
US20030069281A1 (en) * 2000-06-14 2003-04-10 Irwin Fridovich Tetrapyrroles
US20020072512A1 (en) * 2000-12-08 2002-06-13 Metaphore Pharmaceuticals, Inc Method of preventing and treating HIV-mediated central nervous system damage
DE60235955D1 (de) * 2001-01-05 2010-05-27 Metaphore Pharmaceuticals Inc Zusammensetzungen und verfahren zur erhöhung der zytokin-aktivität und zur behandlung der hypotension assoziiert mit der verabreichung von zytokinen
CA2436245C (en) 2001-01-19 2013-04-23 National Jewish Medical And Research Center Medicament for protection in radiotherapy
AU2002236861A1 (en) * 2001-01-26 2002-08-06 Metaphore Pharmaceuticals, Inc. Method of treatment of neurodegenerative disorders using pentaaza-macrocyclic ligand complexes
US20040137638A1 (en) 2002-03-04 2004-07-15 Slomczynska Urszula J. Chromatography of metal complexes
WO2002071054A1 (en) * 2001-03-02 2002-09-12 Metaphore Pharmaceuticals, Inc. Chromatography of metal complexes
EP1439842A4 (en) * 2001-06-01 2009-09-02 Nat Jewish Med & Res Center OXIDANT CAPTAIN FOR THE TREATMENT OF DIABETES OR FOR THE USE IN THE TRANSPLANTATION OR INDUCTION OF IMMUNOTOLERANE
JP2005518334A (ja) * 2001-06-08 2005-06-23 メタファー・ファーマシューティカルズ・インコーポレイテッド コンホーメーション的に束縛されたペプチド、キラルアザクラウンおよびペプチド模倣物のライブラリーならびにその製造方法
MXPA03011795A (es) * 2001-06-26 2005-10-18 Metaphore Pharmaceuticals Inc Terapia de combinacion de una superoxido dismutasa mimetica y un corticosteroide para la prevencion y/o el tratamiento de una enfermedad inflamatoria.
US20030125347A1 (en) * 2001-11-02 2003-07-03 Elan Corporation Plc Pharmaceutical composition
CN101092432A (zh) * 2001-12-14 2007-12-26 艾尔科公司 治疗眼睛障碍和疾病的超氧化物歧化酶模拟物
US6933275B2 (en) * 2002-05-01 2005-08-23 The Board Of Trustees Of The Leland Stanford Junior University Protein kinase C peptides for use in withdrawal
US7485721B2 (en) * 2002-06-07 2009-02-03 Duke University Substituted porphyrins
US20030232784A1 (en) * 2002-06-14 2003-12-18 Benedict James J. Hyaluronic acid-associated superoxide dismutase mimics and their use in the treatment of joint pain
CA2397684A1 (en) * 2002-08-12 2004-02-12 Michael P. Murphy Mitochondrially targeted antioxidants
JP5189242B2 (ja) * 2002-09-23 2013-04-24 アルケルメス ファーマ アイルランド リミテッド 乱用抵抗性の医薬組成物
MXPA05005937A (es) * 2002-12-06 2005-08-18 Alcon Inc Imitaciones de superoxido de dismutasa para el tratamiento de trastornos y enfermedades oculares.
AU2003298917A1 (en) * 2002-12-06 2004-06-30 Alcon, Inc. Superoxide dismutase mimics for the treatment of ocular disorders and diseases
KR100648618B1 (ko) * 2003-11-19 2006-11-23 주식회사 웰스킨 활성 산소 억제제
AU2004305531B2 (en) * 2003-12-11 2009-11-26 Alcon, Inc. Superoxide dismutase mimics for the treatment of optic nerve and retinal damage
WO2006069326A2 (en) * 2004-12-21 2006-06-29 Metaphore Pharmaceuticals, Inc. Polyethylene glycolated superoxide dismutase mimetics
US20120301403A1 (en) 2007-06-21 2012-11-29 Galera Therapeutics, Llc Polyethylene glycolated superoxide dismutase mimetics
US8217166B2 (en) * 2005-05-05 2012-07-10 Galera Therapeutics, Llc Polyethylene glycolated superoxide dismutase mimetics
KR100724586B1 (ko) 2005-12-09 2007-06-04 세종대학교산학협력단 수퍼옥사이드 디스뮤타아제 활성을 갖는 고리화합물
DK2056675T3 (en) 2006-10-12 2019-04-23 Galera Labs Llc Methods for treating oral mucositis
WO2009065059A2 (en) * 2007-11-14 2009-05-22 Kereos, Inc. Super-oxide dismutase mimetics
ES2530462T3 (es) 2008-05-22 2015-03-03 Galera Therapeutics Llc Combinación terapia antitumoral
US11382895B2 (en) 2008-05-23 2022-07-12 National Jewish Health Methods for treating injury associated with exposure to an alkylating species
US9149483B2 (en) 2011-09-26 2015-10-06 Galera Labs, Llc Methods for treatment of diseases
CN108350009B (zh) 2015-08-11 2021-07-09 加莱拉实验室有限责任公司 具有口服生物利用率的五氮杂大环状环络合物
US20210361701A1 (en) * 2017-02-15 2021-11-25 Galera Labs, Llc Pentaaza macrocyclic ring complexes for local delivery
EP3388082A1 (en) 2017-04-13 2018-10-17 Galera Labs, LLC Combination cancer immunotherapy with pentaaza macrocyclic ring complex
IL269915B (en) 2017-04-13 2022-09-01 Galera Labs Llc Cancer immunotherapy combined with a macrocyclic ring pentase complex
CA3090129A1 (en) 2018-01-31 2019-08-08 Galera Labs, Llc Combination cancer therapy with pentaaza macrocyclic ring complex and platinum-based anticancer agent
EP4103573A1 (en) 2020-02-13 2022-12-21 Teva Pharmaceuticals International GmbH Solid state forms of avasopasem manganese and process for preparation thereof

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JPH0751496B2 (ja) 1986-04-02 1995-06-05 武田薬品工業株式会社 リポソ−ムの製造法
US4999347A (en) 1986-08-28 1991-03-12 Sorenson John R J Analgesic method
US5216021A (en) 1986-08-28 1993-06-01 Sorenson John R J Analgesic method
JPS63313581A (ja) * 1987-06-16 1988-12-21 Ube Ind Ltd 修飾ス−パ−オキシドジスムタ−ゼ
EP0598753B1 (en) 1991-07-19 1998-03-18 Monsanto Company Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
CA2072934C (en) 1991-07-19 2007-08-28 Karl William Aston Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
CN1088086A (zh) * 1992-12-14 1994-06-22 西北大学 一种新型的护肤保健品
US6204259B1 (en) 1993-01-14 2001-03-20 Monsanto Company Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US6525041B1 (en) 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
BR9708179A (pt) 1996-03-13 1999-07-27 Monsanto Co Bioconjugados de complexos de manganês ou ferro de ligantes macrociclicos contendo nitrogênio eficazes como catalizadores para desmutar superoxidos

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