JP2002505271A5 - - Google Patents
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- Publication number
- JP2002505271A5 JP2002505271A5 JP2000534187A JP2000534187A JP2002505271A5 JP 2002505271 A5 JP2002505271 A5 JP 2002505271A5 JP 2000534187 A JP2000534187 A JP 2000534187A JP 2000534187 A JP2000534187 A JP 2000534187A JP 2002505271 A5 JP2002505271 A5 JP 2002505271A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- weight
- component
- composition according
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000000203 mixture Substances 0.000 claims 17
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 6
- 108010036949 Cyclosporine Proteins 0.000 claims 6
- 229960001265 ciclosporin Drugs 0.000 claims 6
- 229930182912 cyclosporin Natural products 0.000 claims 5
- 239000004094 surface-active agent Substances 0.000 claims 5
- 239000003120 macrolide antibiotic agent Substances 0.000 claims 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 2
- 229930105110 Cyclosporin A Natural products 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims 2
- 239000004530 micro-emulsion Substances 0.000 claims 2
- 229960001295 tocopherol Drugs 0.000 claims 2
- 239000011732 tocopherol Substances 0.000 claims 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 1
- 229940099371 diacetylated monoglycerides Drugs 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 claims 1
- -1 medium chain fatty acid triglycerides Chemical class 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 150000003138 primary alcohols Chemical class 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 235000010384 tocopherol Nutrition 0.000 claims 1
- 229930003799 tocopherol Natural products 0.000 claims 1
- 239000001069 triethyl citrate Substances 0.000 claims 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 1
- 235000013769 triethyl citrate Nutrition 0.000 claims 1
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 1
- 239000008158 vegetable oil Substances 0.000 claims 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9804742.6A GB9804742D0 (en) | 1998-03-06 | 1998-03-06 | Organic compounds |
| GB9804742.6 | 1998-03-06 | ||
| GB9805104.8 | 1998-03-10 | ||
| GBGB9805104.8A GB9805104D0 (en) | 1998-03-10 | 1998-03-10 | Organic compounds |
| GB9805199.8 | 1998-03-11 | ||
| GBGB9805199.8A GB9805199D0 (en) | 1998-03-11 | 1998-03-11 | Organic compounds |
| PCT/EP1999/001415 WO1999044584A1 (en) | 1998-03-06 | 1999-03-04 | Emulsion preconcentrates containing cyclosporin or a macrolide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004062679A Division JP2004189753A (ja) | 1998-03-06 | 2004-03-05 | サイクロスポリン類またはマクロライド含有エマルジョン前濃縮物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002505271A JP2002505271A (ja) | 2002-02-19 |
| JP2002505271A5 true JP2002505271A5 (https=) | 2005-11-04 |
Family
ID=27269231
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000534187A Withdrawn JP2002505271A (ja) | 1998-03-06 | 1999-03-04 | サイクロスポリン類またはマクロライド含有エマルジョン前濃縮物 |
| JP2004062679A Pending JP2004189753A (ja) | 1998-03-06 | 2004-03-05 | サイクロスポリン類またはマクロライド含有エマルジョン前濃縮物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004062679A Pending JP2004189753A (ja) | 1998-03-06 | 2004-03-05 | サイクロスポリン類またはマクロライド含有エマルジョン前濃縮物 |
Country Status (29)
| Country | Link |
|---|---|
| EP (2) | EP1354582A3 (https=) |
| JP (2) | JP2002505271A (https=) |
| KR (1) | KR100443306B1 (https=) |
| CN (1) | CN1195495C (https=) |
| AR (1) | AR015729A1 (https=) |
| AT (1) | ATE277599T1 (https=) |
| AU (1) | AU749217B2 (https=) |
| BE (3) | BE1012400A5 (https=) |
| BR (1) | BR9908597A (https=) |
| CA (1) | CA2322845C (https=) |
| CO (1) | CO4930289A1 (https=) |
| CZ (1) | CZ301967B6 (https=) |
| DE (2) | DE19983012T1 (https=) |
| ES (1) | ES2228014T3 (https=) |
| FR (4) | FR2775596B1 (https=) |
| GB (1) | GB2350791B (https=) |
| HU (1) | HUP0101080A3 (https=) |
| ID (1) | ID25908A (https=) |
| IL (2) | IL138248A0 (https=) |
| IT (1) | IT1313550B1 (https=) |
| MY (1) | MY129274A (https=) |
| NO (1) | NO331800B1 (https=) |
| NZ (1) | NZ506644A (https=) |
| PE (1) | PE20000324A1 (https=) |
| PT (1) | PT1059913E (https=) |
| SK (1) | SK285139B6 (https=) |
| TR (1) | TR200002586T2 (https=) |
| TW (3) | TWI248368B (https=) |
| WO (1) | WO1999044584A1 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5858401A (en) | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
| CN1236813C (zh) * | 1998-12-11 | 2006-01-18 | 药品处理公司 | 水难溶性药物的自乳化组合物 |
| EP1154759B1 (en) * | 1998-12-30 | 2008-08-13 | Dexcel Ltd. | Dispersible concentrate for the delivery of cyclosporin |
| US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
| AU2127400A (en) * | 1999-11-02 | 2001-05-14 | Cipla Limited | A pharmaceutical composition for the administration of water-insoluble pharmaceutically active substances and process for preparation thereof |
| AU1043201A (en) * | 1999-11-02 | 2001-05-14 | Cipla Limited | Cyclosporin formulation |
| GB2362573A (en) * | 2000-05-25 | 2001-11-28 | Cipla Ltd | Cyclosporin formulation |
| GB0008785D0 (en) * | 2000-04-10 | 2000-05-31 | Novartis Ag | Organic compounds |
| DE10024451A1 (de) * | 2000-05-18 | 2001-11-29 | Asta Medica Ag | Pharmazeutische Darreichungsform für Peptide, Verfahren zu deren Herstellung und Verwendung |
| WO2003002095A1 (fr) * | 2001-06-28 | 2003-01-09 | Chugai Seiyaku Kabushiki Kaisha | Preparation d'une micro-emulsion de type huile-eau |
| US6960563B2 (en) | 2001-08-31 | 2005-11-01 | Morton Grove Pharmaceuticals, Inc. | Spontaneous emulsions containing cyclosporine |
| GB2391471B (en) * | 2002-08-02 | 2005-05-04 | Satishchandra Punambhai Patel | Pharmaceutical compositions |
| KR20040047056A (ko) * | 2002-11-29 | 2004-06-05 | 한미약품 주식회사 | 비페닐디메틸디카복실레이트의 경구용 마이크로에멀젼조성물 |
| US8802116B2 (en) | 2003-02-27 | 2014-08-12 | Novasel Australia Pty. Ltd. | Poloxamer emulsion preparations |
| KR20040084240A (ko) * | 2003-03-27 | 2004-10-06 | (주) 코스메디 | 고형지질나노입자, 이를 함유하는 활성성분 전달용약학조성물 및 이의 제조방법 |
| US20050118344A1 (en) | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
| CA2578854A1 (en) * | 2004-10-29 | 2006-05-11 | Novartis Ag | Spontaneously dispersible pharmaceutical compositions |
| MX2007011250A (es) * | 2005-03-21 | 2007-11-14 | Ivax Pharmaceuticals Sro | Inhibidor de la cristalizacion y su uso en capsulas de gelatina. |
| CN101032620B (zh) * | 2007-03-08 | 2010-05-19 | 上海凯昭医药科技有限公司 | 一种环孢素自乳化制剂及其制备方法 |
| US20090130198A1 (en) * | 2007-11-21 | 2009-05-21 | Innopharmax Inc. | Pharmaceutical composition with enhanced bioavailability |
| WO2009117151A2 (en) | 2008-03-20 | 2009-09-24 | Virun, Inc. | Compositions containing non-polar compounds |
| MX2010010050A (es) | 2008-03-20 | 2011-03-15 | Virun Inc Star | Emulsiones que incluyen un derivado de polietilen glicol de tocoferol. |
| US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
| JP5567909B2 (ja) * | 2010-06-17 | 2014-08-06 | 東洋カプセル株式会社 | タクロリムス含有カプセル剤 |
| WO2011162802A1 (en) | 2010-06-21 | 2011-12-29 | Virun, Inc. | Compositions containing non-polar compounds |
| US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
| JO3337B1 (ar) | 2010-12-13 | 2019-03-13 | Debiopharm Sa | تركيبات صيدلية تشمل أليسبوريفير |
| JP5717034B2 (ja) * | 2012-08-27 | 2015-05-13 | 丸和バイオケミカル株式会社 | マクロライド系化合物を含有する土壌線虫防除用薬剤 |
| WO2014106048A2 (en) | 2012-12-31 | 2014-07-03 | Jrx Biotechnology, Inc. | Liquid topical pharmaceutical nano-emulsion formulations |
| KR101458466B1 (ko) * | 2013-06-24 | 2014-11-07 | 한국화학연구원 | 면역억제제가 봉입된 마이셀을 함유하는 경구제 |
| WO2016033549A2 (en) | 2014-08-28 | 2016-03-03 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
| US9498485B2 (en) | 2014-08-28 | 2016-11-22 | Lipocine Inc. | Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters |
| US20160361322A1 (en) | 2015-06-15 | 2016-12-15 | Lipocine Inc. | Composition and method for oral delivery of androgen prodrugs |
| KR20180053318A (ko) | 2015-09-17 | 2018-05-21 | 제이알엑스 바이오테크놀로지, 인코포레이티드 | 피부 수화 또는 보습을 향상시키기 위한 접근법 |
| US11559530B2 (en) | 2016-11-28 | 2023-01-24 | Lipocine Inc. | Oral testosterone undecanoate therapy |
| AU2019308326B2 (en) | 2018-07-20 | 2025-07-31 | Lipocine Inc. | Liver disease |
| EP3886813B1 (en) * | 2018-11-26 | 2023-03-22 | Hepion Pharmaceuticals, Inc. | Pharmaceutical formulations of cyclosporine analogs |
| WO2024014959A2 (en) * | 2022-07-15 | 2024-01-18 | Seranovo Holding B.V. | Micelle-generating formulations with improved hydrophobicity |
| WO2024014958A2 (en) * | 2022-07-15 | 2024-01-18 | Seranovo Holding B.V. | Lides formulation platform |
| CN117797093A (zh) * | 2024-02-29 | 2024-04-02 | 中国农业科学院农业环境与可持续发展研究所 | 一种以大环内酯类药物为活性成分的兽用口服纳米液体制剂 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639724A (en) * | 1984-07-24 | 1997-06-17 | Sandoz Ltd. | Cyclosporin galenic forms |
| GB8903804D0 (en) * | 1989-02-20 | 1989-04-05 | Sandoz Ltd | Improvements in or relating to organic compounds |
| JP2632010B2 (ja) * | 1988-01-29 | 1997-07-16 | 三共株式会社 | シクロスポリン製剤 |
| GB2222770B (en) * | 1988-09-16 | 1992-07-29 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporins |
| GB9113872D0 (en) * | 1991-06-27 | 1991-08-14 | Sandoz Ag | Improvements in or relating to organic compounds |
| EP1142568A1 (en) * | 1992-09-25 | 2001-10-10 | Novartis AG | Pharmaceutical compositions containing cyclosporins |
| GB2278780B (en) * | 1993-05-27 | 1998-10-14 | Sandoz Ltd | Macrolide formulations |
| DE4322826A1 (de) * | 1993-07-08 | 1995-01-12 | Galenik Labor Freiburg Gmbh | Pharmazeutisches Präparat |
| WO1995022343A1 (en) * | 1994-02-17 | 1995-08-24 | Shiseido Company, Ltd. | Cyclosporin-containing emulsion composition |
| JP3131112B2 (ja) * | 1994-02-17 | 2001-01-31 | 株式会社資生堂 | シクロスポリン含有乳化組成物 |
| ATE299017T1 (de) * | 1994-10-26 | 2005-07-15 | Novartis Pharma Gmbh | Arzneimittel |
| PE52896A1 (es) * | 1994-10-26 | 1996-12-12 | Novartis Ag | Composicion farmaceutica |
| HU215966B (hu) * | 1994-11-21 | 1999-07-28 | BIOGAL Gyógyszergyár Rt. | Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum |
| KR970064620A (ko) * | 1996-03-05 | 1997-10-13 | 임성기 | 사이클로스포린-함유 외용약제 조성물 |
| KR980008239A (ko) * | 1996-07-26 | 1998-04-30 | 김충환 | 사이클로스포린-함유 약학적 조성물 |
| US6063762A (en) * | 1997-12-05 | 2000-05-16 | Chong Kun Dang Corp. | Cyclosporin-containing microemulsion preconcentrate composition |
| WO1999029316A1 (en) * | 1997-12-10 | 1999-06-17 | Severson, Mary, L. | Pharmaceutical compositions containing an omega-3 fatty acid oil |
-
1998
- 1998-10-16 ID IDW20001708A patent/ID25908A/id unknown
-
1999
- 1999-03-04 SK SK1319-2000A patent/SK285139B6/sk not_active IP Right Cessation
- 1999-03-04 PE PE1999000178A patent/PE20000324A1/es not_active Application Discontinuation
- 1999-03-04 KR KR10-2000-7009861A patent/KR100443306B1/ko not_active Expired - Fee Related
- 1999-03-04 NZ NZ506644A patent/NZ506644A/xx not_active IP Right Cessation
- 1999-03-04 EP EP03013016A patent/EP1354582A3/en not_active Withdrawn
- 1999-03-04 CA CA002322845A patent/CA2322845C/en not_active Expired - Fee Related
- 1999-03-04 EP EP99908952A patent/EP1059913B1/en not_active Revoked
- 1999-03-04 AR ARP990100910A patent/AR015729A1/es not_active Application Discontinuation
- 1999-03-04 DE DE19983012T patent/DE19983012T1/de not_active Withdrawn
- 1999-03-04 FR FR9902748A patent/FR2775596B1/fr not_active Expired - Fee Related
- 1999-03-04 CZ CZ20003222A patent/CZ301967B6/cs not_active IP Right Cessation
- 1999-03-04 TR TR2000/02586T patent/TR200002586T2/xx unknown
- 1999-03-04 HU HU0101080A patent/HUP0101080A3/hu unknown
- 1999-03-04 DE DE69920668T patent/DE69920668T2/de not_active Expired - Lifetime
- 1999-03-04 IL IL13824899A patent/IL138248A0/xx active IP Right Grant
- 1999-03-04 AU AU28361/99A patent/AU749217B2/en not_active Ceased
- 1999-03-04 WO PCT/EP1999/001415 patent/WO1999044584A1/en not_active Ceased
- 1999-03-04 PT PT99908952T patent/PT1059913E/pt unknown
- 1999-03-04 BR BR9908597-6A patent/BR9908597A/pt not_active IP Right Cessation
- 1999-03-04 CN CNB99803746XA patent/CN1195495C/zh not_active Expired - Fee Related
- 1999-03-04 GB GB0021495A patent/GB2350791B/en not_active Expired - Fee Related
- 1999-03-04 BE BE9900153A patent/BE1012400A5/fr not_active IP Right Cessation
- 1999-03-04 AT AT99908952T patent/ATE277599T1/de active
- 1999-03-04 ES ES99908952T patent/ES2228014T3/es not_active Expired - Lifetime
- 1999-03-04 JP JP2000534187A patent/JP2002505271A/ja not_active Withdrawn
- 1999-03-05 CO CO99013726A patent/CO4930289A1/es unknown
- 1999-03-05 IT IT1999MI000452A patent/IT1313550B1/it active
- 1999-03-05 MY MYPI99000807A patent/MY129274A/en unknown
- 1999-05-21 TW TW093120909A patent/TWI248368B/zh not_active IP Right Cessation
- 1999-05-21 TW TW088107417A patent/TWI236912B/zh not_active IP Right Cessation
- 1999-05-21 TW TW094129536A patent/TWI257870B/zh not_active IP Right Cessation
- 1999-11-09 BE BE9900732A patent/BE1013423A5/fr not_active IP Right Cessation
-
2000
- 2000-08-18 BE BE2000/0520A patent/BE1013648A5/fr not_active IP Right Cessation
- 2000-08-29 NO NO20004299A patent/NO331800B1/no not_active IP Right Cessation
- 2000-09-05 IL IL138248A patent/IL138248A/en not_active IP Right Cessation
- 2000-10-25 FR FR0013782A patent/FR2800277B1/fr not_active Expired - Fee Related
-
2004
- 2004-03-05 JP JP2004062679A patent/JP2004189753A/ja active Pending
- 2004-03-26 FR FR0403163A patent/FR2853546B1/fr not_active Expired - Fee Related
-
2006
- 2006-01-05 FR FR0600097A patent/FR2881956A1/fr not_active Withdrawn
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