JP2002501066A - Ｇａｂａ受容体に対するリガンドとしてのトリアゾロ−ピリダジン誘導体 - Google Patents

Ｇａｂａ受容体に対するリガンドとしてのトリアゾロ−ピリダジン誘導体

Info

Publication number
JP2002501066A
JP2002501066A JP2000528565A JP2000528565A JP2002501066A JP 2002501066 A JP2002501066 A JP 2002501066A JP 2000528565 A JP2000528565 A JP 2000528565A JP 2000528565 A JP2000528565 A JP 2000528565A JP 2002501066 A JP2002501066 A JP 2002501066A
Authority
JP
Japan
Prior art keywords
methyl
triazolo
pyridazine
ylmethoxy
triazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2000528565A
Other languages
English (en)
Japanese (ja)
Inventor
カーリング，ウイリアム・ロバート
カストロ・ピネイロ，ホセ・ルイス
コリンズ，イアン・ジエイムズ
ギブリン，アレクサンダー・リチヤード
ハリソン，テイモシー
マデイン，アンドリユー
ムーア，ケビン・ウイリアム
ラツセル，マイケル・ジヨフリイ・ニール
スコツト，ゲイル
ストリート，レスリー・ジヨージフ
Original Assignee
メルク シャープ エンド ドーム リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9801233.9A external-priority patent/GB9801233D0/en
Priority claimed from GBGB9821517.1A external-priority patent/GB9821517D0/en
Application filed by メルク シャープ エンド ドーム リミテッド filed Critical メルク シャープ エンド ドーム リミテッド
Publication of JP2002501066A publication Critical patent/JP2002501066A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2000528565A 1998-01-21 1999-01-13 Ｇａｂａ受容体に対するリガンドとしてのトリアゾロ−ピリダジン誘導体 Withdrawn JP2002501066A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9801233.9A GB9801233D0 (en) 1998-01-21 1998-01-21 Therapeutic agents
GB9821517.1 1998-10-02
GB9801233.9 1998-10-02
GBGB9821517.1A GB9821517D0 (en) 1998-10-02 1998-10-02 Therapeutic agents
PCT/GB1999/000103 WO1999037644A1 (en) 1998-01-21 1999-01-13 Triazolo-pyridazine derivatives as ligands for gaba receptors

Publications (1)

Publication Number Publication Date
JP2002501066A true JP2002501066A (ja) 2002-01-15

Family

ID=26312988

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000528565A Withdrawn JP2002501066A (ja) 1998-01-21 1999-01-13 Ｇａｂａ受容体に対するリガンドとしてのトリアゾロ−ピリダジン誘導体

Country Status (24)

Country Link
US (2) US6579875B1 (US06828322-20041207-C00025.png)
EP (1) EP1049696A1 (US06828322-20041207-C00025.png)
JP (1) JP2002501066A (US06828322-20041207-C00025.png)
KR (1) KR20010034257A (US06828322-20041207-C00025.png)
CN (1) CN1110498C (US06828322-20041207-C00025.png)
AU (1) AU748737B2 (US06828322-20041207-C00025.png)
BG (1) BG104671A (US06828322-20041207-C00025.png)
BR (1) BR9906905A (US06828322-20041207-C00025.png)
CA (1) CA2315763A1 (US06828322-20041207-C00025.png)
CZ (1) CZ290883B6 (US06828322-20041207-C00025.png)
EA (1) EA002755B1 (US06828322-20041207-C00025.png)
EE (1) EE200000430A (US06828322-20041207-C00025.png)
GE (1) GEP20032868B (US06828322-20041207-C00025.png)
HR (1) HRP20000492A2 (US06828322-20041207-C00025.png)
HU (1) HUP0100575A3 (US06828322-20041207-C00025.png)
IL (1) IL136442A0 (US06828322-20041207-C00025.png)
IS (1) IS5540A (US06828322-20041207-C00025.png)
MX (1) MXPA00007135A (US06828322-20041207-C00025.png)
NO (1) NO315516B1 (US06828322-20041207-C00025.png)
NZ (1) NZ504870A (US06828322-20041207-C00025.png)
PL (1) PL341652A1 (US06828322-20041207-C00025.png)
SK (1) SK10922000A3 (US06828322-20041207-C00025.png)
WO (1) WO1999037644A1 (US06828322-20041207-C00025.png)
YU (1) YU43800A (US06828322-20041207-C00025.png)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011178787A (ja) * 2003-12-19 2011-09-15 Ube Industries Ltd ４−置換又は非置換テトラヒドロピラン−４−カルボン酸化合物又はそのエステル化合物の製法
JP2012531419A (ja) * 2009-06-23 2012-12-10 コンサート ファーマシューティカルズ インコーポレイテッド Ｇａｂａ−ａ受容体修飾物質としての重水素修飾されたトリアゾロピリダジン誘導体

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2315763A1 (en) * 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9929685D0 (en) 1999-12-15 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB0017543D0 (en) 2000-07-17 2000-09-06 Merck Sharp & Dohme Therapeutic agents
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
CA2625210A1 (en) * 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
EA015754B1 (ru) * 2005-12-21 2011-12-30 Янссен Фармацевтика, Н.В. Триазолопиридазины в качестве модуляторов тирозинкиназы
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
EP2026813A2 (en) 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
US7998971B2 (en) 2006-09-08 2011-08-16 Braincells Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2123619A1 (de) 2008-05-20 2009-11-25 Bayer Schering Pharma AG Neue [F-18]-Markierte L-Glutaminsäure-und L-Glutaminderivate (II), ihre Verwendung sowie Verfahren zu ihrer Herstellung
PT2328414E (pt) * 2008-08-29 2014-03-17 Concert Pharmaceuticals Inc Derivados de triazol-piridazina substituídos
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
AU2010276537B2 (en) 2009-07-27 2015-04-16 Gilead Sciences, Inc. Fused heterocyclic compounds as ion channel modulators
US9089531B2 (en) 2010-09-28 2015-07-28 The Regents Of The University Of California GABA agonists in the treatment of disorders associated with metabolic syndrome and GABA combinations in treatment or prophylaxis of type I diabetes
TWI510480B (zh) 2011-05-10 2015-12-01 Gilead Sciences Inc 充當離子通道調節劑之稠合雜環化合物
NO3175985T3 (US06828322-20041207-C00025.png) 2011-07-01 2018-04-28
TW201837023A (zh) 2011-07-01 2018-10-16 美商基利科學股份有限公司 作為離子通道調節劑之稠合雜環化合物
GB201321745D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
WO2017151617A1 (en) 2016-02-29 2017-09-08 Dana-Farber Cancer Institute, Inc. Stapled intracellular-targeting antimicrobial peptides to treat infection
CN107344936B (zh) * 2016-05-06 2022-06-03 上海赛默罗生物科技有限公司 三唑哒嗪类衍生物、其制备方法、药物组合物和用途
JP7305614B2 (ja) 2017-07-19 2023-07-10 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 抗生物質耐性細菌感染症の処置のための安定化抗菌ペプチド

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CA1080712A (en) * 1976-09-22 1980-07-01 Jay D. Albright Hypotensive agents
US4230705A (en) * 1976-09-22 1980-10-28 American Cyanamid Company 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating anxiety
US4112095A (en) 1976-10-07 1978-09-05 American Cyanamid Company 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents
PH12424A (en) 1976-10-26 1979-02-15 American Cyanamid Co Method of treating anxiety in mammals
US4260755A (en) 1979-10-31 1981-04-07 American Cyanamid Company Novel 6-phenyl and substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines
US4260756A (en) * 1979-11-15 1981-04-07 American Cyanamid Company 6- And 8-heteroaryl-1,2,4-triazolo[4,3-b]pyridazines
FI81350C (fi) 1982-01-18 1990-10-10 Lepetit Spa Analogfoerfarande foer framstaellning av nya, farmakologiskt aktiva 6-substituerade s-triatsolo/3,4-a/ ftalazinderivat.
IT1194310B (it) 1983-07-12 1988-09-14 Lepetit Spa Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
US4654343A (en) * 1985-10-31 1987-03-31 American Cyanamid Company N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas
SK9399A3 (en) * 1996-07-25 2000-04-10 Merck Sharp & Dohme Substituted triazolo-pyridazine derivatives as ligands for gaba receptors
CA2315763A1 (en) * 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011178787A (ja) * 2003-12-19 2011-09-15 Ube Industries Ltd ４−置換又は非置換テトラヒドロピラン−４−カルボン酸化合物又はそのエステル化合物の製法
JP2013189445A (ja) * 2003-12-19 2013-09-26 Ube Industries Ltd ４−置換又は非置換テトラヒドロピラン−４−カルボン酸化合物又はそのエステル化合物の製法
JP2012531419A (ja) * 2009-06-23 2012-12-10 コンサート ファーマシューティカルズ インコーポレイテッド Ｇａｂａ−ａ受容体修飾物質としての重水素修飾されたトリアゾロピリダジン誘導体

Also Published As

Publication number Publication date
CZ290883B6 (cs) 2002-11-13
US6579875B1 (en) 2003-06-17
CN1110498C (zh) 2003-06-04
NZ504870A (en) 2002-11-26
CN1288465A (zh) 2001-03-21
EA002755B1 (ru) 2002-08-29
EA200000783A1 (ru) 2000-12-25
HRP20000492A2 (en) 2000-12-31
EE200000430A (et) 2001-12-17
PL341652A1 (en) 2001-04-23
EP1049696A1 (en) 2000-11-08
IS5540A (is) 2000-06-16
WO1999037644A1 (en) 1999-07-29
HUP0100575A2 (hu) 2001-09-28
CZ20002691A3 (cs) 2000-12-13
BR9906905A (pt) 2000-10-10
US20040063714A1 (en) 2004-04-01
NO315516B1 (no) 2003-09-15
HUP0100575A3 (en) 2003-03-28
KR20010034257A (ko) 2001-04-25
US6828322B2 (en) 2004-12-07
CA2315763A1 (en) 1999-07-29
IL136442A0 (en) 2001-06-14
AU748737B2 (en) 2002-06-13
NO20003730L (no) 2000-09-20
NO20003730D0 (no) 2000-07-20
GEP20032868B (en) 2003-01-27
YU43800A (sh) 2002-12-10
MXPA00007135A (es) 2002-11-07
AU2065799A (en) 1999-08-09
SK10922000A3 (sk) 2001-03-12
BG104671A (en) 2001-05-31

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Effective date: 20060404