JP2002300887A5 - - Google Patents

Info

Publication number

JP2002300887A5

JP2002300887A5 JP2001162806A JP2001162806A JP2002300887A5 JP 2002300887 A5 JP2002300887 A5 JP 2002300887A5 JP 2001162806 A JP2001162806 A JP 2001162806A JP 2001162806 A JP2001162806 A JP 2001162806A JP 2002300887 A5 JP2002300887 A5 JP 2002300887A5

Authority

JP

Japan

Prior art keywords

activity

glutamine synthetase

protein

seq

dna

Prior art date

2001-05-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108090000623 proteins and genes Proteins 0.000 description 14
• 230000000694 effects Effects 0.000 description 13
• 102000005396 glutamine synthetase Human genes 0.000 description 13
• 108020002326 glutamine synthetase Proteins 0.000 description 13
• 241000894006 Bacteria Species 0.000 description 8
• 102000004169 proteins and genes Human genes 0.000 description 8
• 239000002773 nucleotide Substances 0.000 description 7
• 125000003729 nucleotide group Chemical group 0.000 description 7
• 150000001413 amino acids Chemical group 0.000 description 5
• 101000950981 Bacillus subtilis (strain 168) Catabolic NAD-specific glutamate dehydrogenase RocG Proteins 0.000 description 4
• 102000016901 Glutamate dehydrogenase Human genes 0.000 description 4
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 4
• 229930182816 L-glutamine Natural products 0.000 description 4
• 230000001580 bacterial effect Effects 0.000 description 4
• 230000006154 adenylylation Effects 0.000 description 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
• 125000001572 5'-adenylyl group Chemical group C=12N=C([H])N=C(N([H])[H])C=1N=C([H])N2[C@@]1([H])[C@@](O[H])([H])[C@@](O[H])([H])[C@](C(OP(=O)(O[H])[*])([H])[H])([H])O1 0.000 description 2
• 108090000992 Transferases Proteins 0.000 description 2
• 102000004357 Transferases Human genes 0.000 description 2
• 238000007792 addition Methods 0.000 description 2
• 125000000539 amino acid group Chemical group 0.000 description 2
• 230000033228 biological regulation Effects 0.000 description 2
• 238000012217 deletion Methods 0.000 description 2
• 230000037430 deletion Effects 0.000 description 2
• 238000003780 insertion Methods 0.000 description 2
• 230000037431 insertion Effects 0.000 description 2
• 230000003834 intracellular effect Effects 0.000 description 2
• 230000001105 regulatory effect Effects 0.000 description 2
• 239000000523 sample Substances 0.000 description 2
• 238000006467 substitution reaction Methods 0.000 description 2
• 108010039224 Amidophosphoribosyltransferase Proteins 0.000 description 1
• 241000186254 coryneform bacterium Species 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• 230000002074 deregulated effect Effects 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 230000004952 protein activity Effects 0.000 description 1
• -1 substitution Chemical compound 0.000 description 1