JP2001524956A - 迅速溶解性の頑丈な投与形態物 - Google Patents
迅速溶解性の頑丈な投与形態物Info
- Publication number
- JP2001524956A JP2001524956A JP54409398A JP54409398A JP2001524956A JP 2001524956 A JP2001524956 A JP 2001524956A JP 54409398 A JP54409398 A JP 54409398A JP 54409398 A JP54409398 A JP 54409398A JP 2001524956 A JP2001524956 A JP 2001524956A
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- JP
- Japan
- Prior art keywords
- dosage form
- tablet
- weight
- particles
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.直接経口投与に適した硬質の、圧縮された迅速溶解投与形態物であって、活 性成分と、非直接圧縮充填剤及び滑剤を含むマトリックスとからなり、前記投与 形態物は患者の口内で迅速に溶解することにより前記活性成分を放出するととも に、U.S.Pに従って試験したときに約2%以下の脆砕性を有することを特徴 とする投与形態物。 2.前記脆砕性は約1%以下であることを特徴とする請求の範囲第1項に記載の 投与形態物。 3.少なくとも約15Nの硬度を有することを特徴とする請求の範囲第1項に記 載の投与形態物。 4.前記硬度は約20ニュートン乃至約50ニュートンの範囲にあることを特徴 とする請求の範囲第3項に記載の投与形態物。 5.前記硬度は約35ニュートンであることを特徴とする請求の範囲第4項に記 載の投与形態物。 6.前記投与形態物は約90秒以内で溶解することを特徴とする請求の範囲第1 項に記載の投与形態物。 7.前記投与形態物は約60秒以内で溶解することを特徴とする請求の範囲第6 項に記載の投与形態物。 8.前記投与形態物は約45秒以内で溶解することを特徴とする請求の範囲第7 項に記載の投与形態物。 9.少なくとも1つの粒子を更に備え、該粒子は前記活性成分及び保護材料を含 むことを特徴とする請求の範囲第1項に記載の投与形態物。 10.前記保護材料は吸着質、マイクログラニュール、マトリックス及びコーテ ィングよりなるから選ばれることを特徴とする請求の範囲第9項に記載の投与形 態物。 11.前記保護材料はコーティングであることを特徴とする請求の範囲第10項 に記載の投与形態物。 12.前記コーティングは重量で粒子の少なくとも約5%を構成することを特徴 とする請求の範囲第11項に記載の投与形態物。 13.前記コーティングは粒子の約5乃至約75重量%を構成することを特徴と する請求の範囲第11項に記載の投与形態物。 14.前記非直接圧縮充填剤は約25乃至約95重量%の量が存在することを特 徴とする請求の範囲第1項に記載の投与形態物。 15.前記非直接圧縮充填剤は約50乃至約95重量%の量が存在することを特 徴とする請求の範囲第14項に記載の投与形態物。 16.前記非直接圧縮充填剤は約60乃至約95重量%の量が存在することを特 徴とする請求の範囲第15項に記載の投与形態物。 17.前記非着説圧縮充填剤は非直接圧縮糖または非直接圧縮糖アルコールであ ることを特徴とする請求の範囲第1項に記載の投与形態物。 18.前記活性成分は系分配性成分、ビタミン、ミネラル及び食餌補給物並びに 非系分配性薬剤成分よりなる群から選ばれることを特徴とする請求の範囲第1項 に記載の投与形態物。 19.前記薬剤成分は制酸剤、鎮痛剤、抗炎症剤、解熱剤、抗生物質、殺菌剤、 弛緩剤、食欲増進剤、抗ヒスタミン剤、抗喘息剤、抗利尿剤、抗膨満剤、抗偏頭 痛剤、生物学的製剤、抗鎮痙剤、鎮静剤、抗亢進剤、抗高血圧剤、トランキライ ザ、デコンジェスタント、ベータブロッカ及びこれらの組み合わせを含むことを 特徴とする請求の範囲第18項に記載の投与形態物。 20.前記活性成分は最終投与形態物の約80重量%以下の量が提供されること を特徴とする請求の範囲第1項に記載の投与形態物。 21.前記活性成分は最終投与形態物の約60重量%以下の量が提供されること を特徴とする請求の範囲第20項に記載の投与形態物。 22.前記粒子は最終投与形態物の約75重量%以下の量が提供されることを特 徴とする請求の範囲第9項に記載の投与形態物。 23.前記粒子は最終投与形態物の約60重量%以下の量が提供されることを特 徴とする請求の範囲第22項に記載の投与形態物。 24.前記粒子は迅速放出粒子であることを特徴とする請求の範囲第9項に記載 の投与形態物。 25.前記粒子は持続放出粒子であることを特徴とする請求の範囲第9項に記載 の投与形態物。 26.前記滑剤は疎水性滑剤であることを特徴とする請求の範囲第1項に記載の 投与形態物。 27.前記疎水性滑剤は約1乃至約5重量%の量が提供されることを特徴とする 請求の範囲第26項に記載の投与形態物。 28.前記疎水性滑剤は約1乃至約2.5重量%の量が提供されることを特徴と する請求の範囲第27項に記載の投与形態物。 29.前記疎水性滑剤は約1.5乃至約2重量%の量が提供されることを特徴と する請求の範囲第28項に記載の投与形態物。 30.吸い上げ剤を更に備えることを特徴とする請求の範囲第1項に記載の投与 形態物。 31.前記吸い上げ剤は約5重量%未満の量が提供されることを特徴とする請求 の範囲第30項に記載の投与形態物。 32.直接経口投与に適した硬質の圧縮された迅速溶解タブレットであって、活 性成分及び保護材料を含む粒子を備え、該粒子はタブレットの重量に対して約0 .01乃至約75重量%の量が提供され、更に非直接圧縮充填剤、吸い上げ剤及 び疎水性滑剤を含むマトリックスを備え、前記タブレットのマトリックスはマト リックス材料の全重量に対して少なくとも約60%の迅速水溶性成分を有し、前 記タブレットは約15乃至約50ニュートンの硬度と、U.S.Pにより測定し たときに2%未満の脆砕性とを有しかつ患者の口内で約60秒未満で瞬時に溶解 することにより前記粒子を放出するとともにばらで保管することができることを 特徴とするタブレット。 33.前記圧縮充填剤は90ミクロン以下の平均粒度を有し、前記充填剤はタブ レットの約25重量%を越え約95重量%以下の量が提供され、前記吸い上げ剤 はタブレットの重量に対して約2乃至約5重量%の量が提供され、前記滑剤はタ ブレットの重量に対して約1.0乃至約2.5重量%の量が提供されることを特 徴とする請求の範囲第32項に記載のタブレット。 34.前記脆砕性は約1%以下であることを特徴とする請求の範囲第32項に記 載のタブレット。 35.前記硬度は約35ニュートンであることを特徴とする請求の範囲第32項 に記載のタブレット。 36.前記タブレットは約45秒未満で溶解することを特徴とする請求の範囲第 32項に記載のタブレット。 37.パッケージ化された経口崩壊性投与形態物の製造方法であって、 (a)活性成分と、非直接圧縮充填剤及び滑剤を含むマトリックスとの混合物 を形成する工程と、 (b)前記混合物を圧縮して前記活性成分が前記経口溶解性マトリックスに分 配されている複数の硬質の圧縮された迅速崩壊投与形態物を形成する工程とを備 え、前記投与形態物は直接経口投与に適し、前記投与形態物は少なくとも約15 ニュートンの硬度を有し、患者の口内で約60秒未満で瞬時に溶解することによ り前記活性成分を放出し、更に (c)前記タブレットをパッケージ化する前に前記タブレットをばらで保管す る工程を備えることを特徴とする方法。 38.パッケージあたり少なくとも1つのタブレットとなるように前記タブレッ トをパッケージのルーメンに入れる工程を更に備えることを特徴とする請求の範 囲第37項に記載の方法。 39.複数の前記圧縮タブレットを1つのパッケージの1つのルーメンに入れる ことを特徴とする請求の範囲第38項に記載の方法。 40.前記圧縮行程は直接圧縮により行われることを特徴とする請求の範囲第3 7項に記載の方法。 41.直接経口投与に適した複数の硬質の圧縮された迅速溶解タブレットを含む 開放自在でかつ再閉止自在のパッケージであって、活性成分及び保護材料を含む 粒子を備え、該粒子は前記タブレットの重量に対して約0.01乃至約75重量 %の量が提供され、更に非直接圧縮充填剤及び疎水性滑剤を含むタブレットマト リックスを備え、前記タブレットマトリックスはマトリックス材料の全重量に対 して少なくとも約60%の迅速水溶性成分を有し、前記タブレットは約15乃至 約50ニュートンの硬度と、U.S.Pにより測定したときに2%未満の脆砕性 とを有しかつ患者の口内で約60秒未満で瞬時に溶解することにより前記粒子を 放出するとともにばらで保管することができることを特徴とするパッケージ。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US4324297P | 1997-04-16 | 1997-04-16 | |
US60/043,242 | 1997-04-16 | ||
US09/057,884 | 1998-04-09 | ||
US09/057,884 US6024981A (en) | 1997-04-16 | 1998-04-09 | Rapidly dissolving robust dosage form |
PCT/US1998/007216 WO1998046215A1 (en) | 1997-04-16 | 1998-04-13 | Rapidly dissolving robust dosage form |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2007249399A Division JP5072513B2 (ja) | 1997-04-16 | 2007-09-26 | 迅速溶解性の頑丈な投与形態物 |
Publications (1)
Publication Number | Publication Date |
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JP2001524956A true JP2001524956A (ja) | 2001-12-04 |
Family
ID=21926209
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
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JP54409398A Withdrawn JP2001524956A (ja) | 1997-04-16 | 1998-04-13 | 迅速溶解性の頑丈な投与形態物 |
JP2007249399A Expired - Lifetime JP5072513B2 (ja) | 1997-04-16 | 2007-09-26 | 迅速溶解性の頑丈な投与形態物 |
JP2012092155A Pending JP2012162558A (ja) | 1997-04-16 | 2012-04-13 | 迅速溶解性の頑丈な投与形態物 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
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JP2007249399A Expired - Lifetime JP5072513B2 (ja) | 1997-04-16 | 2007-09-26 | 迅速溶解性の頑丈な投与形態物 |
JP2012092155A Pending JP2012162558A (ja) | 1997-04-16 | 2012-04-13 | 迅速溶解性の頑丈な投与形態物 |
Country Status (10)
Country | Link |
---|---|
US (2) | US6024981A (ja) |
EP (3) | EP0975336A4 (ja) |
JP (3) | JP2001524956A (ja) |
AU (1) | AU726336B2 (ja) |
CA (1) | CA2284663C (ja) |
DK (2) | DK2266538T3 (ja) |
ES (2) | ES2647356T3 (ja) |
HK (1) | HK1137654A1 (ja) |
PT (2) | PT2147669E (ja) |
WO (1) | WO1998046215A1 (ja) |
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JP2005533045A (ja) * | 2002-06-10 | 2005-11-04 | ビタ、シエンティフィカ、ソシエダッド、リミターダ | 経口崩壊錠およびその製造法 |
JP2005535622A (ja) * | 2002-06-21 | 2005-11-24 | バイオヴェイル ラボラトリーズ インコーポレイテッド | 迅速溶解性組成物およびそれを基にした錠剤 |
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Cited By (10)
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JP2001058944A (ja) * | 1999-06-18 | 2001-03-06 | Takeda Chem Ind Ltd | 速崩壊性固形製剤 |
JP2005526095A (ja) * | 2002-03-20 | 2005-09-02 | エラン ファーマ インターナショナル,リミティド | 脆砕性の低い急速溶解投与剤型 |
JP2010285451A (ja) * | 2002-03-20 | 2010-12-24 | Elan Pharma Internatl Ltd | 脆砕性の低い急速溶解投与剤型 |
JP2005533045A (ja) * | 2002-06-10 | 2005-11-04 | ビタ、シエンティフィカ、ソシエダッド、リミターダ | 経口崩壊錠およびその製造法 |
JP2005535622A (ja) * | 2002-06-21 | 2005-11-24 | バイオヴェイル ラボラトリーズ インコーポレイテッド | 迅速溶解性組成物およびそれを基にした錠剤 |
JP2011079864A (ja) * | 2002-06-21 | 2011-04-21 | Biovail Lab Internatl Srl | 迅速溶解性組成物およびそれを基にした錠剤 |
WO2006115285A1 (ja) * | 2005-04-21 | 2006-11-02 | Takeda Pharmaceutical Company Limited | 医薬組成物 |
JP2008280316A (ja) * | 2007-05-14 | 2008-11-20 | Taisho Pharm Ind Ltd | 経口投与用錠剤 |
JP2021524442A (ja) * | 2018-05-17 | 2021-09-13 | フェルティン ファルマ アー/エス | 医薬品活性成分に適した錠剤化チューインガム |
JP7214755B2 (ja) | 2018-05-17 | 2023-01-30 | フェルティン ファルマ アー/エス | 医薬品活性成分に適した錠剤化チューインガム |
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EP2266538B1 (en) | 2017-08-16 |
EP2147669B1 (en) | 2014-10-29 |
PT2266538T (pt) | 2017-11-20 |
JP2008001726A (ja) | 2008-01-10 |
ES2525720T3 (es) | 2014-12-29 |
ES2525720T5 (es) | 2018-04-05 |
WO1998046215A1 (en) | 1998-10-22 |
EP0975336A1 (en) | 2000-02-02 |
EP2147669A3 (en) | 2010-03-10 |
EP2266538A2 (en) | 2010-12-29 |
PT2147669E (pt) | 2014-12-22 |
JP2012162558A (ja) | 2012-08-30 |
CA2284663C (en) | 2003-06-17 |
US6024981A (en) | 2000-02-15 |
DK2266538T3 (en) | 2017-10-23 |
EP0975336A4 (en) | 2006-02-01 |
EP2147669A2 (en) | 2010-01-27 |
US6221392B1 (en) | 2001-04-24 |
CA2284663A1 (en) | 1998-10-22 |
EP2147669B2 (en) | 2018-01-17 |
JP5072513B2 (ja) | 2012-11-14 |
HK1137654A1 (en) | 2010-08-06 |
AU726336B2 (en) | 2000-11-02 |
DK2147669T3 (en) | 2014-11-17 |
AU6896998A (en) | 1998-11-11 |
EP2266538A3 (en) | 2013-02-13 |
DK2147669T4 (en) | 2018-03-12 |
ES2647356T3 (es) | 2017-12-21 |
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