JP2001520548A - 付属フィルタを有するカニューレ - Google Patents
付属フィルタを有するカニューレInfo
- Publication number
- JP2001520548A JP2001520548A JP54424498A JP54424498A JP2001520548A JP 2001520548 A JP2001520548 A JP 2001520548A JP 54424498 A JP54424498 A JP 54424498A JP 54424498 A JP54424498 A JP 54424498A JP 2001520548 A JP2001520548 A JP 2001520548A
- Authority
- JP
- Japan
- Prior art keywords
- cannula
- mesh
- attached
- filter
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
- A61F2/011—Instruments for their placement or removal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
- A61F2002/018—Filters implantable into blood vessels made from tubes or sheets of material, e.g. by etching or laser-cutting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0004—Rounded shapes, e.g. with rounded corners
- A61F2230/0006—Rounded shapes, e.g. with rounded corners circular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0067—Three-dimensional shapes conical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having an inflatable pocket filled with fluid, e.g. liquid or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/12—Blood circulatory system
- A61M2210/127—Aorta
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
- External Artificial Organs (AREA)
- Prostheses (AREA)
- Electrotherapy Devices (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.外表面と、大動脈に入るようにされた遠位端と、バイパス−酸素付加マシー ンからの血液を受容するようにされた近位端と、該近位端から該遠位端まで長さ 方向に延びる管腔とを有するカニューレと、 収縮状態と半径方向への拡張状態との間で拡張可能な、該カニューレに取り付 けられた拡張フレームと、 該拡張フレームに周部に沿って連続して取り付けられた第1の縁を有するメッ シュと、 該メッシュの該第1の縁に周部に沿って連続して取り付けられたエラストマー ストリップであって、使用中は大動脈の内腔に対して密閉するようにされた従順 な縁を提供するストリップと、 を備えた、付属フィルタを有する大動脈カニューレ。 2.前記拡張フレームは、チャンバーを囲む管状バルーンを備えた膨張シールで あることを特徴とする、請求項1記載のカニューレ。 3.前記拡張フレームは複数のアームを備えた傘であることを特徴とする、請求 項1記載のカニューレ。 4.前記アームは遠位端で前記カニューレの前記遠位端に旋回状に接続され、該 アームは前記メッシュの前記第1の縁に取り付けられた近位領域を有し、使用中 は、該アームが該カニューレから離れる方向に旋回されると該アームの該近位領 域は半径方向に外向きに拡張することを特徴とする、請求項3記載のカニューレ 。 5.前記カニューレは、近位端にバイパス−酸素付加マシーンに取り付けるため の形状とされた取付具を含むほぼ円筒形の部材であることを特徴とする、請求項 1記載のカニューレ。 6.前記メッシュは前記カニューレの前記外表面に接触する第2の縁をさらに備 え、該カニューレの前記管腔は該メッシュを通って延びることを特徴とする、請 求項1記載のカニューレ。 7.前記メッシュは連続しており、前記カニューレの前記管腔は該メッシュの遠 位先端より近位側で終了することを特徴とする、請求項1記載のカニューレ。 8.前記エラストマーストリップはシリコーンであることを特徴とする、請求項 3記載のカニューレ。 9.前記カニューレの前記遠位端を通って送られる血液を分散するために該カニ ューレの該遠位端に取り付けられたフロー拡散器をさらに備えたことを特徴とす る、請求項1記載のカニューレ。 10.収縮状態にあるとき前記メッシュおよび拡張フレームの輪郭を最小限にす るために該メッシュおよび拡張フレームを周部に沿って囲むスリーブをさらに備 え、該スリーブは巻き上がるように動作可能であり、これにより該メッシュおよ び拡張フレームを解放して半径方向への拡張状態へと展開させることを特徴とす る、請求項1記載のカニューレ。 11.前記カニューレの前記遠位端内のセグメントは変形可能であり、収縮状態 にあるとき前記メッシュおよび拡張フレームの輪郭を最小限にするために該拡張 フレームの一部を周部に沿って受容するように半径方向に収縮し、使用中は、該 メッシュおよび拡張フレームは拡張状態に展開され、該カニューレの該変形可能 セグメントは、バイパス中に全管腔血液量が送られるように半径方向に拡張する ことを特徴とする、請求項1記載のカニューレ。 12.外表面と、動脈に入るようにされた遠位端と、バイパス−酸素付加マシー ンからの血液を受容するようにされた近位端と、該近位端から該遠位端まで長さ 方向に延びる管腔とを有するカニューレと、 収縮状態と半径方向への拡張状態との間を拡張可能な、該カニューレに取り付 けられた拡張フレームと、 該拡張フレームに周部に沿って連続して取り付けられた第1の縁を有するメッ シュと、 収縮状態にあるとき該メッシュおよび拡張フレームの輪郭を最小限にするため に該メッシュおよび拡張フレームを周部に沿って囲むスリーブであって、巻き上 がるように動作可能であり、これにより該メッシュおよび拡張フレームを解放し て半径方向への拡張状態へと展開させる、スリーブと、 を備えたことを特徴とする、付属フィルタを有する動脈カニューレ。 13.前記拡張フレームは、チャンバーを囲む管状バルーンを備えた膨張シール であることを特徴とする、請求項12記載のカニューレ。 14.前記拡張フレームは複数のアームを備えた傘であることを特徴とする、請 求項12記載のカニューレ。 15.前記アームは遠位端で前記カニューレの前記遠位端に旋回状に接続され、 該アームは前記メッシュの前記第1の縁に取り付けられた近位領域を有し、使用 中は、該アームが該カニューレから離れる方向に旋回されるとき該アームの該近 位領域は半径方向に外向きに拡張することを特徴とする、請求項14記載のカニ ューレ。 16.前記カニューレは、近位端にバイパス−酸素付加マシーンに取り付けるた めの形状とされた取付具を含むほぼ円筒形の部材であることを特徴とする、請求 項12記載のカニューレ。 17.前記メッシュは前記カニューレの前記外表面に接触する第2の縁をさらに 備え、該カニューレの前記管腔は該メッシュを通って延びることを特徴とする、 請求項12記載のカニューレ。 18.前記メッシュは連続しており、前記カニューレの前記管腔は該メッシュの 遠位先端より近位側で終了することを特徴とする、請求項12記載のカニューレ 。 19.前記メッシュの前記第1の縁に周部に沿って連続して取り付けられた可撓 性を有するスカートをさらに備え、該スカートは使用中は大動脈の内腔に対して 密閉するようにされることを特徴とする、請求項14記載のカニューレ。 20.前記カニューレの前記遠位端を通って送られる血液を分散するために該カ ニューレの該遠位端に取り付けられたフロー拡散器をさらに備えたことを特徴と する、請求項12記載のカニューレ。 21.前記カニューレの前記遠位端内のセグメントは変形可能であり、収縮状態 にあるとき前記メッシュおよび拡張フレームの輪郭を最小限にするために該拡張 フレームの一部を周部に沿って受容するように半径方向に収縮し、使用中は、該 メッシュおよび拡張フレームは拡張状態に展開され、該カニューレの該変形可能 セグメントは、バイパス中に全管腔血液量が送られるように半径方向に拡張する ことを特徴とする、請求項12記載のカニューレ。 22.外表面と、動脈に入るようにされた遠位端と、バイパス−酸素付加マシー ンからの血液を受容するようにされた近位端と、該近位端から該遠位端まで長さ 方向に延びる管腔とを有するカニューレと、 収縮状態と半径方向への拡張状態との間を拡張可能な、該カニューレに取り付 けられた拡張フレームと、 該拡張フレームに周部に沿って連続して取り付けられた第1の縁を有するメッ シュとを備え、 該カニューレの該遠位端内のセグメントは変形可能であり、収縮状態にあると き該メッシュおよび拡張フレームの輪郭を最小限にするために該拡張フレームの 一部を周部に沿って受容するように半径方向に収縮し、使用中は、該メッシュお よび拡張フレームは拡張状態に展開され、該カニューレの該変形可能セグメント はバイパス中に全管腔血液量が送られるように半径方向に拡張することを特徴と する、付属フィルタを有する動脈カニューレ。 23.前記拡張フレームは、チャンバーを囲む管状バルーンを備えた膨張シール であることを特徴とする、請求項22記載のカニューレ。 24.前記拡張フレームは複数のアームを備えた傘であることを特徴とする、請 求項22記載のカニューレ。 25.前記アームは遠位端で前記カニューレの前記遠位端に旋回状に接続され、 該アームは前記メッシュの前記第1の縁に取り付けられた近位領域を有し、使用 中は、該アームが該カニューレから離れる方向に旋回されるとき該アームの該近 位領域は半径方向に外向きに拡張することを特徴とする、請求項24記載のカニ ューレ。 26.前記カニューレは、近位端にバイパス−酸素付加マシーンに取り付けるた めの形状とされた取付具を含むほぼ円筒形の部材であることを特徴とする、請求 項22記載のカニューレ。 27.前記メッシュは前記カニューレの前記外表面に接触する第2の縁をさらに 備え、該カニューレの前記管腔は該メッシュを通って延びることを特徴とする、 請求項22記載のカニューレ。 28.前記メッシュは連続しており、また前記カニューレの前記管腔は該メッシ ュの遠位先端より近位側で終了することを特徴とする、請求項22記載のカニュ ーレ。 29.前記メッシュの前記第1の縁に周部に沿って連続して取り付けられた可撓 性を有するスカートをさらに備え、該スカートは使用中は大動脈の内腔に対して 密閉するようにされることを特徴とする、請求項24記載のカニューレ。 30.前記カニューレの前記遠位端を通って送られる血液を分散するために該カ ニューレの該遠位端に取り付けられたフロー拡散器をさらに備えたことを特徴と する、請求項22記載のカニューレ。 31.収縮状態にあるとき前記メッシュおよび拡張フレームの輪郭を最小限にす るため該メッシュおよび拡張フレームを周部に沿って囲むスリーブをさらに備え 、該スリーブは巻き上がるように動作可能であり、これにより該メッシュおよび 拡張フレームを解放して半径方向への拡張状態へと展開させることを特徴とする 、請求項22記載のカニューレ。 32.前記フロー拡散器は前記カニューレ管腔の内部に位置することを特徴とす る、請求項9記載の動脈カニューレ。 33.前駆フロー拡散器は円錐形であることを特徴とする、請求項9記載の動脈 カニューレ。 34.前駆フロー拡散器は螺旋状であることを特徴とする、請求項9記載の動脈 カニューレ。 35.前駆フロー拡散器は、構造支持体によって前記カニューレ管腔より外部に 取り付けられることを特徴とする、請求項9記載の動脈カニューレ。 36.前駆フロー拡散器はシャフトによって前記フィルタメッシュに接続される 、請求項9記載の動脈カニューレ。 37.前記メッシュの第2の縁より遠位側に取り付けられたフィルタスリーブを さらに備えたことを特徴とする、請求項10記載の動脈カニューレ。 38.前記フィルタスリーブは、少なくとも1本の巻き上げ制御ラインおよび1 本の展開制御ラインに取り付けられることを特徴とする、請求項37記載の動脈 カニューレ。 39.前記制御ラインは制御管腔に入ることを特徴とする、請求項38記載の動 脈カニューレ。 40.前記フィルタスリーブは円形の断面を有することを特徴とする、請求項3 7記載の動脈カニューレ。 41.前記フィルタスリーブは千分の3から14インチの厚さを有することを特 徴とする、請求項37記載の動脈カニューレ。 42.前記展開および巻き上げ制御ラインに取り付けられたプーリをさらに備え たことを特徴とする、請求項38記載の動脈カニューレ。 43.前記フロー拡散器は前記カニューレ管腔の内部に位置することを特徴とす る、請求項20記載の動脈カニューレ。 44.前記フロー拡散器は円錐形であることを特徴とする、請求項20記載の動 脈カニューレ。 45.前駆フロー拡散器は螺旋状であることを特徴とする、請求項20記載の動 脈カニューレ。 46.前駆フロー拡散器は、構造支持体によって前記カニューレ管腔より外部に 取り付けられることを特徴とする、請求項20記載の動脈カニューレ。 47.前駆フロー拡散器はシャフトによって前記フィルタメッシュに接続される ことを特徴とする、請求項20記載の動脈カニューレ。 48.前記フィルタスリーブは、前記メッシュの第2の縁より遠位側で前記カニ ューレに取り付けられることを特徴とする、請求項12記載の動脈カニューレ。 49.前記フィルタスリーブは、少なくとも1本の巻き上げ制御ラインおよび1 本の展開制御ラインに取り付けられることを特徴とする、請求項48記載の動脈 カニューレ。 50.前記制御ラインは制御管腔に入ることを特徴とする、請求項49記載の動 脈カニューレ。 51.前記フィルタスリーブは円形の断面を有することを特徴とする、請求項4 8記載の動脈カニューレ。 52.前記フィルタスリーブは千分の3から14インチの厚さを有することを特 徴とする、請求項48記載の動脈カニューレ。 53.前記展開および巻き上げ制御ラインに取り付けられたプーリをさらに備え たことを特徴とする、請求項49記載の動脈カニューレ。 54.前記フロー拡散器は前記カニューレ管腔の内部に位置することを特徴とす る、請求項30記載の動脈カニューレ。 55.前記フロー拡散器は円錐形であることを特徴とする、請求項30記載の動 脈カニューレ。 56.前駆フロー拡散器は螺旋状であることを特徴とする、請求項30記載の動 脈カニューレ。 57.前駆フロー拡散器は、構造支持体によって前記カニューレ管腔より外部に 取り付けられることを特徴とする、請求項30記載の動脈カニューレ。 58.前駆フロー拡散器はシャフトによって前記フィルタメッシュに接続される ことを特徴とする、請求項30記載の動脈カニューレ。 59.前記メッシュの第2の縁より遠位側に取り付けられるフィルタスリーブを さらに備えたことを特徴とする、請求項31記載の動脈カニューレ。 60.前記フィルタスリーブは、少なくとも1本の巻き上げ制御ラインおよび1 本の展開制御ラインに取り付けられることを特徴とする、請求項59記載の動脈 カニューレ。 61.前記制御ラインは制御管腔に入ることを特徴とする、請求項60記載の動 脈カニューレ。 62.前記フィルタスリーブは円形の断面を有することを特徴とする、請求項5 9記載の動脈カニューレ。 63.前記フィルタスリーブは千分の3から14インチの厚さを有することを特 徴とする、請求項59記載の動脈カニューレ。 64.前記展開および巻き上げラインに取り付けられたプーリをさらに備えたこ とを特徴とする、請求項60記載の動脈カニューレ。 65.外表面と、動脈に入るようにされた遠位端と、バイパス−酸素付加マシー ンからの血液を受容するようにされた近位端と、該近位端から該遠位端まで長さ 方向に延びる管腔とを有するカニューレであって、軸方向に変形可能な弾性材料 により形成されるカニューレと、 収縮状態と半径方向への拡張状態との間を拡張可能な、該カニューレに取り付 けられた拡張フレームと、 該拡張フレームに周部に沿って連続して取り付けられた第1の縁を有するメッ シュと、 を備えたことを特徴とする、付属フィルタを有する動脈カニューレ。 66.前記カニューレ管腔内に挿入されたスタイレットをさらに備えたことを特 徴とする、請求項65記載の動脈カニューレ。 67.外表面と、大動脈に入るようにされた遠位端と、バイパス−酸素付加マシ ーンからの血液を受容するようにされた近位端と、該近位端から該遠位端まで長 さ方向に延びる管腔とを有するカニューレと、 収縮状態と半径方向への拡張状態との間を拡張可能な、該カニューレに取り付 けられた拡張フレームと、 近位開口部を規定する、該拡張フレームに周部に沿って連続して取り付けられ る近位縁と、遠位開口部を規定する遠位縁とを有するスリーブであって、使用中 は、粒状物質が該近位開口部に入り該スリーブによって保留されるため該スリー ブを横方向に通過するのが防止されるスリーブと、 を備えたことを特徴とする、付属フィルタを有する大動脈カニューレ。 68.前記スリーブはメッシュ材料であることを特徴とする、請求項67記載の カニューレ。 69.前記スリーブは非多孔質材料であることを特徴とする、請求項67記載の カニューレ。 70.前記スリーブは、血液の横方向の通過を可能にする穴を有する非多孔質材 料であることを特徴とする、請求項67記載のカニューレ。 71.前記拡張フレームは、チャンバー囲む管状バルーンを備えた膨張シールで あることを特徴とする、請求項67記載のカニューレ。 72.前記拡張フレームは可撓性リングであることを特徴とする、請求項67記 載のカニューレ。 73.前記拡張フレームは、前記リングを前記カニューレの前記遠位端に接続す る複数の支柱を含むことを特徴とする、請求項72記載のカニューレ。
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US08/842,727 US5989281A (en) | 1995-11-07 | 1997-04-16 | Cannula with associated filter and methods of use during cardiac surgery |
US08/842,727 | 1997-04-16 | ||
PCT/US1998/007558 WO1998046297A1 (en) | 1997-04-16 | 1998-04-15 | Cannula with associated filter and methods of use during cardiac surgery |
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Cited By (9)
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JP2007222658A (ja) * | 1997-05-08 | 2007-09-06 | Boston Scientific Corp | ガイドワイヤフィルタ装置 |
WO2007001033A1 (ja) * | 2005-06-29 | 2007-01-04 | Kaneka Corporation | カテーテル |
JP2007007021A (ja) * | 2005-06-29 | 2007-01-18 | Kaneka Corp | カテーテル |
JP2007202614A (ja) * | 2006-01-31 | 2007-08-16 | Kaneka Corp | カテーテル |
WO2009150920A1 (ja) * | 2008-06-09 | 2009-12-17 | 株式会社パイオラックスメディカルデバイス | 管状器官の治療具 |
JPWO2009150920A1 (ja) * | 2008-06-09 | 2011-11-10 | 株式会社パイオラックスメディカルデバイス | 管状器官の治療具 |
JP2020062567A (ja) * | 2015-01-23 | 2020-04-23 | コンテゴ メディカル エルエルシー | 一体型塞栓フィルタを有する介入デバイス及び関連方法 |
JP2022524985A (ja) * | 2019-03-04 | 2022-05-11 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 脳血管系を保護するためのシステム及び方法 |
JP7230230B2 (ja) | 2019-03-04 | 2023-02-28 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 脳血管系を保護するためのシステム及び方法 |
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US8840636B2 (en) | 2014-09-23 |
CA2286787A1 (en) | 1998-10-22 |
US6086605A (en) | 2000-07-11 |
US20080125808A1 (en) | 2008-05-29 |
US5989281A (en) | 1999-11-23 |
US8025674B2 (en) | 2011-09-27 |
EP0975384A4 (en) | 2005-04-06 |
DE69841869D1 (de) | 2010-10-14 |
US6423086B1 (en) | 2002-07-23 |
US7011672B2 (en) | 2006-03-14 |
US20040162576A1 (en) | 2004-08-19 |
EP0975384B1 (en) | 2010-09-01 |
JP4712009B2 (ja) | 2011-06-29 |
US6136016A (en) | 2000-10-24 |
EP0975384A1 (en) | 2000-02-02 |
US20120016408A1 (en) | 2012-01-19 |
AU7119298A (en) | 1998-11-11 |
JP2011015989A (ja) | 2011-01-27 |
JP4150429B2 (ja) | 2008-09-17 |
JP2007325948A (ja) | 2007-12-20 |
US7344551B2 (en) | 2008-03-18 |
US6235045B1 (en) | 2001-05-22 |
US20020062134A1 (en) | 2002-05-23 |
WO1998046297A1 (en) | 1998-10-22 |
US6117154A (en) | 2000-09-12 |
ATE479465T1 (de) | 2010-09-15 |
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