JP2001518284A5 - - Google Patents
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- JP2001518284A5 JP2001518284A5 JP2000513863A JP2000513863A JP2001518284A5 JP 2001518284 A5 JP2001518284 A5 JP 2001518284A5 JP 2000513863 A JP2000513863 A JP 2000513863A JP 2000513863 A JP2000513863 A JP 2000513863A JP 2001518284 A5 JP2001518284 A5 JP 2001518284A5
- Authority
- JP
- Japan
- Prior art keywords
- reaction vessel
- adsorption matrix
- sample
- analyte
- holding device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 description 21
- 238000001179 sorption measurement Methods 0.000 description 18
- 239000011159 matrix material Substances 0.000 description 17
- 239000000523 sample Substances 0.000 description 14
- 239000011521 glass Substances 0.000 description 13
- 239000012491 analyte Substances 0.000 description 10
- 239000002245 particle Substances 0.000 description 8
- 229910004298 SiO 2 Inorganic materials 0.000 description 7
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 150000007523 nucleic acids Chemical class 0.000 description 5
- 102000039446 nucleic acids Human genes 0.000 description 5
- 108020004707 nucleic acids Proteins 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 229910018072 Al 2 O 3 Inorganic materials 0.000 description 4
- 238000010828 elution Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- -1 B 2 O 3 Inorganic materials 0.000 description 3
- 108091005804 Peptidases Proteins 0.000 description 3
- 239000004365 Protease Substances 0.000 description 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 3
- 239000012472 biological sample Substances 0.000 description 3
- 235000019419 proteases Nutrition 0.000 description 3
- 239000013578 denaturing buffer Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 238000007399 DNA isolation Methods 0.000 description 1
- 108010067770 Endopeptidase K Proteins 0.000 description 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical class NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 1
- 229910000272 alkali metal oxide Inorganic materials 0.000 description 1
- 229910000287 alkaline earth metal oxide Inorganic materials 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 239000012149 elution buffer Substances 0.000 description 1
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 1
- ZJYYHGLJYGJLLN-UHFFFAOYSA-N guanidinium thiocyanate Chemical compound SC#N.NC(N)=N ZJYYHGLJYGJLLN-UHFFFAOYSA-N 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012139 lysis buffer Substances 0.000 description 1
- 238000007885 magnetic separation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19743518.1 | 1997-10-01 | ||
| DE19743518A DE19743518A1 (de) | 1997-10-01 | 1997-10-01 | Automatisierbare universell anwendbare Probenvorbereitungsmethode |
| PCT/EP1998/006196 WO1999016781A2 (de) | 1997-10-01 | 1998-09-29 | Automatisierbare universell anwendbare probenvorbereitungsmethode |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007047875A Division JP2007175060A (ja) | 1997-10-01 | 2007-02-27 | 生体試料中の被検物単離装置 |
| JP2007280179A Division JP4659013B2 (ja) | 1997-10-01 | 2007-10-29 | 磁性色素 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001518284A JP2001518284A (ja) | 2001-10-16 |
| JP2001518284A5 true JP2001518284A5 (https=) | 2006-01-05 |
| JP4048022B2 JP4048022B2 (ja) | 2008-02-13 |
Family
ID=7844362
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000513863A Expired - Lifetime JP4048022B2 (ja) | 1997-10-01 | 1998-09-29 | 自動化可能なユニバーサル試料調製方法 |
| JP2007047875A Pending JP2007175060A (ja) | 1997-10-01 | 2007-02-27 | 生体試料中の被検物単離装置 |
| JP2007280179A Expired - Lifetime JP4659013B2 (ja) | 1997-10-01 | 2007-10-29 | 磁性色素 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007047875A Pending JP2007175060A (ja) | 1997-10-01 | 2007-02-27 | 生体試料中の被検物単離装置 |
| JP2007280179A Expired - Lifetime JP4659013B2 (ja) | 1997-10-01 | 2007-10-29 | 磁性色素 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6562568B1 (https=) |
| EP (2) | EP1019430B1 (https=) |
| JP (3) | JP4048022B2 (https=) |
| KR (1) | KR20010024366A (https=) |
| AT (1) | ATE366739T1 (https=) |
| AU (1) | AU1028299A (https=) |
| CA (1) | CA2305171C (https=) |
| DE (2) | DE19743518A1 (https=) |
| DK (1) | DK1019430T3 (https=) |
| ES (2) | ES2398713T3 (https=) |
| IL (2) | IL135299A0 (https=) |
| PT (1) | PT1019430E (https=) |
| WO (1) | WO1999016781A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8110351B2 (en) | 2002-01-16 | 2012-02-07 | Invitrogen Dynal As | Method for isolating nucleic acids and protein from a single sample |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19520398B4 (de) | 1995-06-08 | 2009-04-16 | Roche Diagnostics Gmbh | Magnetisches Pigment |
| KR100463475B1 (ko) * | 1995-06-08 | 2005-06-22 | 로셰 디아그노스틱스 게엠베하 | 자기성피그먼트 |
| BR9815569A (pt) * | 1997-12-06 | 2001-10-09 | Dna Res Instr Ltd | Método para extração de biomoléculas de material biológico |
| EP1147226B1 (en) * | 1999-01-27 | 2013-01-23 | Folim G. Halaka | Materials and methods for the purification of polyelectrolytes |
| DE19937607A1 (de) * | 1999-08-09 | 2001-02-15 | Bilatec Ges Zur Entwicklung Bi | Reagenzienkit zur Isolierung von Nukleinsäuren |
| WO2001037291A1 (en) * | 1999-11-17 | 2001-05-25 | Roche Diagnostics Gmbh | Magnetic glass particles, method for their preparation and uses thereof |
| US20030104520A1 (en) * | 2000-06-15 | 2003-06-05 | Ellington Andrew D. | Regulatable, catalytically active nucleic acids |
| US7494817B2 (en) * | 2000-09-06 | 2009-02-24 | Transnet Yx, Inc. | Methods for genotype screening using magnetic particles |
| DE10127068A1 (de) * | 2001-05-23 | 2002-11-28 | Bio Medical Apherese Systeme G | Vorrichtung und Verfahren zum Inkubieren und Wiederabtrennen von Magnetteilchen in und von flüssige biologische Dispersionen |
| DE10147439B4 (de) * | 2001-09-26 | 2014-01-30 | Qiagen Gmbh | Verfahren zur Isolierung von DNA aus biologischen Proben |
| WO2003057910A2 (en) | 2002-01-08 | 2003-07-17 | Roche Diagnostics Gmbh | Use of silica material in an amplification reaction |
| US20040234898A1 (en) * | 2002-02-06 | 2004-11-25 | Batishko Charles R. | Magnetic flowcell systems and methods |
| ATE516366T1 (de) | 2002-07-25 | 2011-07-15 | Archemix Corp | Regulierte aptamer-therapeutika |
| US9394332B2 (en) | 2002-08-29 | 2016-07-19 | Epigenomics Ag | Method for bisulfite treatment |
| DE602004009038T3 (de) | 2003-01-29 | 2015-06-25 | Roche Diagnostics Gmbh | Verbessertes Verfahren zur Behandlung durch Bisulfit |
| US7601491B2 (en) | 2003-02-06 | 2009-10-13 | Becton, Dickinson And Company | Pretreatment method for extraction of nucleic acid from biological samples and kits therefor |
| JP3644641B2 (ja) * | 2003-03-07 | 2005-05-11 | 株式会社日立ハイテクノロジーズ | 核酸回収方法 |
| WO2005054466A2 (en) † | 2003-07-25 | 2005-06-16 | Ambion, Inc. | Methods and compositions for preparing rna from a fixed sample |
| US20050042660A1 (en) * | 2003-07-31 | 2005-02-24 | Hall Gerald Edward | Devices and methods for isolating RNA |
| GB0319671D0 (en) * | 2003-08-21 | 2003-09-24 | Secr Defence | Apparatus for processing a fluid sample |
| CA2482097C (en) | 2003-10-13 | 2012-02-21 | F. Hoffmann-La Roche Ag | Methods for isolating nucleic acids |
| WO2005054502A1 (en) | 2003-12-02 | 2005-06-16 | Roche Diagnostics Gmbh | Improved method for bisulfite treatment |
| KR20060129340A (ko) * | 2003-12-30 | 2006-12-15 | 시그마-알드리치컴퍼니 | 효소 소화에 의한 핵산의 신속한 제조 |
| EP2251441B1 (en) | 2004-02-10 | 2013-05-08 | F. Hoffmann-La Roche AG | Detection of parvovirus B19 |
| US9267167B2 (en) | 2004-06-28 | 2016-02-23 | Becton, Dickinson And Company | Dissolvable films and methods including the same |
| US20060099605A1 (en) * | 2004-11-11 | 2006-05-11 | Hall Gerald E Jr | Devices and methods for isolating RNA |
| EP1632578A1 (en) | 2004-09-03 | 2006-03-08 | Roche Diagnostics GmbH | DNA decontamination method |
| EP1690938A1 (de) | 2005-02-11 | 2006-08-16 | Qiagen GmbH | Verfahren zur Isolierung von Nukleinsäuren, wobei die Nukleinsäuren bei erhöhter Temperatur an einer Matrix immobilisiert werden |
| US20060269929A1 (en) * | 2005-05-26 | 2006-11-30 | Hall Gerald E Jr | Methods and kits for DNA purification on polymeric membranes at low ionic strength |
| US20060270843A1 (en) * | 2005-05-26 | 2006-11-30 | Hall Gerald E Jr | Methods for isolation of nucleic acids |
| JP4733456B2 (ja) * | 2005-07-26 | 2011-07-27 | シスメックス株式会社 | 前処理の外部精度管理方法、核酸検出処理の外部精度管理方法、検量線作成処理の外部精度管理方法、前処理の外部精度管理コンピュータ、核酸検出処理の外部精度管理コンピュータ、検量線作成処理の外部精度管理コンピュータ、前処理装置、及び核酸検出装置 |
| GB0525231D0 (en) * | 2005-12-12 | 2006-01-18 | Genpoint As | Method |
| US7981606B2 (en) | 2005-12-21 | 2011-07-19 | Roche Molecular Systems, Inc. | Control for nucleic acid testing |
| FR2895993A1 (fr) * | 2006-01-10 | 2007-07-13 | Immunid Sarl | Composition pour la stabilisation d'echantillons biologiques et procede de stabilisation |
| ES2601391T3 (es) * | 2006-01-27 | 2017-02-15 | Becton Dickinson And Company | Inmunoensayo de flujo lateral con modalidad de detección encapsulada |
| US8895267B2 (en) * | 2006-11-03 | 2014-11-25 | Siemens Healthcare Diagnostics Inc. | Random access system and method for polymerase chain reaction testing |
| CN102776173B (zh) | 2006-12-11 | 2014-10-29 | 霍夫曼-拉罗奇有限公司 | 使用聚多卡醇和衍生物的核酸分离 |
| ATE490320T1 (de) | 2006-12-13 | 2010-12-15 | Hoffmann La Roche | Verwendung von acetalen zur isolation von nukleinsäuren |
| WO2008071384A1 (en) | 2006-12-13 | 2008-06-19 | Roche Diagnostics Gmbh | Use of tde for the isolation of nucleic acids |
| US8535888B2 (en) | 2006-12-29 | 2013-09-17 | Mayo Foundation For Medical Education And Research | Compositions and methods for detecting methicillin-resistant S. aureus |
| US7985375B2 (en) * | 2007-04-06 | 2011-07-26 | Qiagen Gaithersburg, Inc. | Sample preparation system and method for processing clinical specimens |
| US8703492B2 (en) | 2007-04-06 | 2014-04-22 | Qiagen Gaithersburg, Inc. | Open platform hybrid manual-automated sample processing system |
| DE102008010693A1 (de) * | 2008-02-22 | 2009-08-27 | Qiagen Gmbh | Neue Matrixmaterialien, Verfahren zu ihrer Herstellung und ihre Verwendung in Verfahren zur Isolierung von Biomolekülen |
| JP5572939B2 (ja) * | 2008-10-27 | 2014-08-20 | 株式会社島津製作所 | Ｄｎａの塩基配列決定法 |
| US8911663B2 (en) | 2009-03-05 | 2014-12-16 | Quebec Metal Powders, Ltd. | Insulated iron-base powder for soft magnetic applications |
| TWI407994B (zh) | 2009-10-22 | 2013-09-11 | Ind Tech Res Inst | 分離核酸的方法、試劑及套組 |
| US9953141B2 (en) | 2009-11-18 | 2018-04-24 | Becton, Dickinson And Company | Laboratory central control unit method and system |
| DE112011102524T5 (de) * | 2010-07-29 | 2013-07-11 | Roche Diagnostics Gmbh | Präparation generischer Proben |
| JP6348202B2 (ja) * | 2010-07-29 | 2018-06-27 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 一般的な試料調製 |
| US9175332B2 (en) | 2010-07-29 | 2015-11-03 | Roche Molecular Systems, Inc. | Generic PCR |
| US8609340B2 (en) | 2010-07-29 | 2013-12-17 | Roche Molecular Systems, Inc. | Control nucleic acids for multiple parameters |
| US9725754B2 (en) | 2010-07-29 | 2017-08-08 | Sean F. Boyle | Generic sample preparation |
| CA2835641C (en) * | 2011-05-11 | 2019-05-28 | Exosome Diagnostics, Inc. | Nucleic acid extraction from heterogeneous biological materials |
| EP2776152B1 (en) * | 2011-11-09 | 2018-03-28 | The Regents of The University of California | Superparamagnetic colloids with enhanced charge stability for high quality magnetically tunable photonic structures |
| EP2664914A1 (en) * | 2012-05-16 | 2013-11-20 | Koninklijke Philips N.V. | Magnetically assisted processing of a medium |
| US9399986B2 (en) | 2012-07-31 | 2016-07-26 | General Electric Company | Devices and systems for isolating biomolecules and associated methods thereof |
| AU2013334189B2 (en) | 2012-10-24 | 2018-08-02 | Genmark Diagnostics, Inc. | Integrated multiplex target analysis |
| US20140322706A1 (en) | 2012-10-24 | 2014-10-30 | Jon Faiz Kayyem | Integrated multipelx target analysis |
| JP6351702B2 (ja) | 2013-03-15 | 2018-07-04 | ジェンマーク ダイアグノスティクス， インコーポレイテッド | 変形可能流体容器を操作するためのシステム、方法、および装置 |
| USD881409S1 (en) | 2013-10-24 | 2020-04-14 | Genmark Diagnostics, Inc. | Biochip cartridge |
| US9498778B2 (en) | 2014-11-11 | 2016-11-22 | Genmark Diagnostics, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
| JP5928435B2 (ja) | 2013-11-01 | 2016-06-01 | 株式会社安川電機 | ロボットシステム、検査方法および被検査物の生産方法 |
| CN105255855A (zh) * | 2014-07-10 | 2016-01-20 | 上海艾迪康医学检验所有限公司 | 在固体表面保存核酸的方法及其保存液 |
| US10005080B2 (en) | 2014-11-11 | 2018-06-26 | Genmark Diagnostics, Inc. | Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation |
| US9598722B2 (en) | 2014-11-11 | 2017-03-21 | Genmark Diagnostics, Inc. | Cartridge for performing assays in a closed sample preparation and reaction system |
| EP3218480A1 (en) | 2014-11-14 | 2017-09-20 | Corning Incorporated | Methods and kits for post-ivt rna purification |
| EP3434372B1 (en) | 2014-11-19 | 2020-02-26 | F. Hoffmann-La Roche AG | Particle mixing |
| US10001501B2 (en) | 2015-12-31 | 2018-06-19 | Universal Diagnostics, S. L. | Systems and methods for automated, customizable sample preparation for detection of metabolites and lipids |
| EP3400308B1 (en) | 2016-01-05 | 2020-02-19 | Roche Diagnostics GmbH | Successive capture of nucleic acid by magnetic glass particles |
| US20180073011A1 (en) * | 2016-09-12 | 2018-03-15 | Roche Molecular Systems, Inc. | Methods and compositions for purifying double stranded nucleic acids |
| CN111133106A (zh) | 2017-07-12 | 2020-05-08 | 外来体诊断公司 | 用于分离和富集生物流体来源的细胞外囊泡的方法及其使用方法 |
| CN114381368B (zh) * | 2021-12-31 | 2023-10-27 | 北京理工大学 | 一种利用气液界面自动分离生物分析物的系统及方法 |
Family Cites Families (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2913419A (en) * | 1956-04-18 | 1959-11-17 | Du Pont | Chemical process and composition |
| US2885366A (en) * | 1956-06-28 | 1959-05-05 | Du Pont | Product comprising a skin of dense, hydrated amorphous silica bound upon a core of another solid material and process of making same |
| DE2313331C2 (de) * | 1973-03-17 | 1986-11-13 | Merck Patent Gmbh, 6100 Darmstadt | Eisenoxidhaltige Glimmerschuppenpigmente |
| US3945862A (en) * | 1973-06-26 | 1976-03-23 | Merck & Co., Inc. | Coated ferrous substrates comprising an amorphous magnesia-silica complex |
| US4133169A (en) * | 1974-08-30 | 1979-01-09 | Ebauches S.A. | Electronic circuit for a quartz crystal watch |
| DE2625106C2 (de) * | 1976-06-04 | 1982-03-11 | Bayer Ag, 5090 Leverkusen | Eisenoxidschwarz-Pigmente mit verbesserter Oxidationsbeständigkeit und Verfahren zu ihrer Herstellung |
| US4126437A (en) * | 1976-12-02 | 1978-11-21 | Xerox Corporation | Magnetic glass carrier materials |
| US4124735A (en) * | 1976-12-02 | 1978-11-07 | Xerox Corporation | Magnetic glass carrier materials |
| US4124385A (en) * | 1976-12-02 | 1978-11-07 | Xerox Corporation | Magnetic glass carrier materials |
| US4395271A (en) * | 1979-04-13 | 1983-07-26 | Corning Glass Works | Method for making porous magnetic glass and crystal-containing structures |
| US4297337A (en) * | 1979-04-13 | 1981-10-27 | Corning Glass Works | Solid-phase immunoassays using magnetic glass |
| JPS5676510A (en) * | 1979-11-28 | 1981-06-24 | Tdk Corp | Manufacture of magnetic recording material |
| JPS56105337A (en) * | 1980-01-28 | 1981-08-21 | Tdk Corp | Magnetic recording medium and its production |
| US4280918A (en) * | 1980-03-10 | 1981-07-28 | International Business Machines Corporation | Magnetic particle dispersions |
| US4360441A (en) * | 1981-06-25 | 1982-11-23 | Corning Glass Works | Glass-encapsulated magnetic materials and methods for making them |
| US4454234A (en) * | 1981-12-30 | 1984-06-12 | Czerlinski George H | Coated magnetizable microparticles, reversible suspensions thereof, and processes relating thereto |
| US4448884A (en) * | 1982-03-03 | 1984-05-15 | Kms Fusion, Inc. | Glass-surface microcarrier for growth of cell cultures |
| US4477492A (en) * | 1983-04-22 | 1984-10-16 | E. I. Du Pont De Nemours And Company | Process for preparing superficially porous supports for chromatography and catalysts |
| US4695392A (en) * | 1983-05-12 | 1987-09-22 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| US4554088A (en) * | 1983-05-12 | 1985-11-19 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| US4672040A (en) * | 1983-05-12 | 1987-06-09 | Advanced Magnetics, Inc. | Magnetic particles for use in separations |
| US4628037A (en) * | 1983-05-12 | 1986-12-09 | Advanced Magnetics, Inc. | Binding assays employing magnetic particles |
| US4698302A (en) * | 1983-05-12 | 1987-10-06 | Advanced Magnetics, Inc. | Enzymatic reactions using magnetic particles |
| US4695393A (en) * | 1983-05-12 | 1987-09-22 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| GB8401636D0 (en) * | 1984-01-21 | 1984-02-22 | British Petroleum Co Plc | Coating process |
| US5236623A (en) * | 1984-07-11 | 1993-08-17 | Rhone-Poulenc Chimie | Process for the production of a silica colloid |
| US4824712A (en) * | 1984-07-16 | 1989-04-25 | Ppg Industries, Inc. | Treatment of glass to reduce venting during thermal treatment and a glass article made thereby |
| US4748121A (en) * | 1984-11-30 | 1988-05-31 | Ppg Industries, Inc. | Porous glass fibers with immobilized biochemically active material |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5597531A (en) * | 1985-10-04 | 1997-01-28 | Immunivest Corporation | Resuspendable coated magnetic particles and stable magnetic particle suspensions |
| US5512332A (en) * | 1985-10-04 | 1996-04-30 | Immunivest Corporation | Process of making resuspendable coated magnetic particles |
| US5076950A (en) * | 1985-12-20 | 1991-12-31 | Syntex (U.S.A.) Inc. | Magnetic composition for particle separation |
| US5206568A (en) * | 1986-03-26 | 1993-04-27 | Beckman Instruments, Inc. | Coordinated control of stepper motors |
| US4751211A (en) * | 1986-08-07 | 1988-06-14 | Aluminum Company Of America | Composite adsorbent for removing acids from organophosphate functional fluids |
| JPS63109105A (ja) * | 1986-10-25 | 1988-05-13 | Chisso Corp | 強磁性金属微粒子の製造方法 |
| DE3639949A1 (de) * | 1986-11-22 | 1988-06-09 | Diagen Inst Molekularbio | Verfahren zur trennung von langkettigen nukleinsaeuren |
| US4699171A (en) * | 1986-12-19 | 1987-10-13 | Sundstrand Corporation | Multiple port relief valve |
| US4767670A (en) * | 1987-01-21 | 1988-08-30 | E. I. Du Pont De Nemours And Company | Chromatographic supports for separation of oligonucleotides |
| NO162946C (no) * | 1987-08-21 | 1990-03-14 | Otto Soerensen | Anordning for magnetisk separasjon av celler. |
| CH672445A5 (https=) | 1987-02-27 | 1989-11-30 | Hratch Boyadjian | |
| EP0281390B1 (en) * | 1987-03-02 | 1994-06-22 | Gen-Probe Incorporated | Polycationic supports for nucleic acid purification, separation and hybridization |
| ES2066851T3 (es) * | 1988-05-24 | 1995-03-16 | Anagen Uk Ltd | Particulas atraibles magneticamente y metodo de preparacion. |
| US5312485A (en) * | 1988-08-05 | 1994-05-17 | J. M. Huber Corporation | Precipitated encapsulated paper pigments and methods |
| US5041390A (en) * | 1988-08-11 | 1991-08-20 | Skov Per S | Method and means for allergy diagnosis |
| US5075430A (en) * | 1988-12-12 | 1991-12-24 | Bio-Rad Laboratories, Inc. | Process for the purification of DNA on diatomaceous earth |
| US5234809A (en) | 1989-03-23 | 1993-08-10 | Akzo N.V. | Process for isolating nucleic acid |
| US5352645A (en) * | 1989-04-14 | 1994-10-04 | E. I. Du Pont De Nemours And Company | Silica microspheres, method of improving attrition resistance and use |
| US5055194A (en) * | 1989-07-28 | 1991-10-08 | University Of Pennsylvania | Support for high performance liquid chromatography in a magnetically stabilized fluidized bed |
| US5279936A (en) * | 1989-12-22 | 1994-01-18 | Syntex (U.S.A.) Inc. | Method of separation employing magnetic particles and second medium |
| US5523231A (en) * | 1990-02-13 | 1996-06-04 | Amersham International Plc | Method to isolate macromolecules using magnetically attractable beads which do not specifically bind the macromolecules |
| DE69108958T2 (de) * | 1990-02-21 | 1995-12-14 | Toda Kogyo Corp | Superparamagnetische feine Teilchen aus Eisenoxid und magnetische Aufzeichnungsträger, welche diese enthalten. |
| US5316699A (en) * | 1990-03-28 | 1994-05-31 | The United States Of America As Repesented By The Secretary Of Commerce | Process for the controlled preparation of a composite of ultrafine magnetic particles homogeneously dispersed in a dielectric matrix |
| WO1991016675A1 (en) * | 1990-04-06 | 1991-10-31 | Applied Biosystems, Inc. | Automated molecular biology laboratory |
| US5763173A (en) * | 1990-06-11 | 1998-06-09 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand inhibitors to DNA polymerases |
| US5210015A (en) * | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US5217804A (en) * | 1990-11-06 | 1993-06-08 | Eastman Kodak Company | Magnetic particles |
| US5155018A (en) * | 1991-07-10 | 1992-10-13 | Hahnemann University | Process and kit for isolating and purifying RNA from biological sources |
| US5395498A (en) * | 1991-11-06 | 1995-03-07 | Gombinsky; Moshe | Method for separating biological macromolecules and means therfor |
| US5610274A (en) * | 1991-11-20 | 1997-03-11 | Cpg, Inc. | Production and use of magnetic porous inorganic materials |
| US5734020A (en) * | 1991-11-20 | 1998-03-31 | Cpg, Inc. | Production and use of magnetic porous inorganic materials |
| US5346994A (en) * | 1992-01-28 | 1994-09-13 | Piotr Chomczynski | Shelf-stable product and process for isolating RNA, DNA and proteins |
| EP0566790B1 (en) * | 1992-04-23 | 1996-08-07 | Toda Kogyo Corp. | Magnetic powder and magnetic toner |
| TW221381B (https=) * | 1992-04-28 | 1994-03-01 | Du Pont | |
| IT1256064B (it) * | 1992-07-28 | 1995-11-27 | Donegani Guido Ist | Metodo per la preparazione di geli porosi contenenti boro |
| CA2107524C (en) * | 1992-10-06 | 1999-01-19 | Hiromitsu Misawa | Iron oxide particles and process for producing the same |
| US5578238A (en) * | 1992-10-30 | 1996-11-26 | Lord Corporation | Magnetorheological materials utilizing surface-modified particles |
| AU669398B2 (en) * | 1992-11-13 | 1996-06-06 | Becton Dickinson & Company | Boron silicates aluminum silicates phosphosilicates and purification of DNA |
| US5648170A (en) * | 1993-04-27 | 1997-07-15 | Toda Kogyo Corporation | Coated granular magnetite particles and process for producing the same |
| CA2170604C (en) * | 1993-08-30 | 2007-03-13 | Vikas V. Padhye | Nucleic acid purification compositions and methods |
| US5438127A (en) * | 1993-09-27 | 1995-08-01 | Becton Dickinson And Company | DNA purification by solid phase extraction using a PCl3 modified glass fiber membrane |
| US5503816A (en) * | 1993-09-27 | 1996-04-02 | Becton Dickinson And Company | Silicate compounds for DNA purification |
| US5599627A (en) * | 1993-10-08 | 1997-02-04 | Toda Kogyo Corporation | Magnetic particles comprising magnetite core and process for producing the same |
| US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| JP4113580B2 (ja) * | 1994-02-07 | 2008-07-09 | キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング | エンドトキシンを減量又は除去する方法 |
| US5990301A (en) * | 1994-02-07 | 1999-11-23 | Qiagen Gmbh | Process for the separation and purification of nucleic acids from biological sources |
| GB9411572D0 (en) * | 1994-06-09 | 1994-08-03 | Amersham Int Plc | Magnetic bead precipitation method |
| EP0772776B1 (de) * | 1994-07-27 | 2000-03-22 | Herbert Dr. Pilgrimm | Superparamagnetische teilchen, verfahren zur herstellung und deren verwendung |
| US5705628A (en) * | 1994-09-20 | 1998-01-06 | Whitehead Institute For Biomedical Research | DNA purification and isolation using magnetic particles |
| US5660984A (en) * | 1994-12-09 | 1997-08-26 | Davis; Thomas E. | DNA isolating apparatus comprising a non-porous DNA binding, anion exchange resin and methods of use thereof |
| FR2732116B1 (fr) * | 1995-03-21 | 1997-05-09 | Bio Merieux | Procede et dispositif pour la determination qualitative et/ou quantitative d'un analyte, notamment d'une bacterie, dans un echantillon, par voie magnetique |
| US5683875A (en) * | 1995-05-04 | 1997-11-04 | Hewlett-Packard Company | Method for detecting a target nucleic acid analyte in a sample |
| IN188702B (https=) * | 1995-06-01 | 2002-10-26 | Degussa | |
| DE19520398B4 (de) * | 1995-06-08 | 2009-04-16 | Roche Diagnostics Gmbh | Magnetisches Pigment |
| DE19520964A1 (de) | 1995-06-08 | 1996-12-12 | Inst Neue Mat Gemein Gmbh | Beschichtete anorganische Pigmente, Verfahren zu deren Herstellung und deren Verwendung |
| JP2965131B2 (ja) | 1995-07-07 | 1999-10-18 | 東洋紡績株式会社 | 核酸結合用磁性担体およびそれを用いる核酸単離方法 |
| EP0852263A1 (en) | 1995-09-13 | 1998-07-08 | Wakunaga Seiyaku Kabushiki Kaisha | Method for concentrating variant nucleic acid and nucleic acid concentration test kit for effecting the method |
| US5783686A (en) | 1995-09-15 | 1998-07-21 | Beckman Instruments, Inc. | Method for purifying nucleic acids from heterogenous mixtures |
| US5904848A (en) * | 1996-02-21 | 1999-05-18 | Cpg, Inc. | Controlled pore glass-synthetic resin membrane |
| US5972721A (en) * | 1996-03-14 | 1999-10-26 | The United States Of America As Represented By The Secretary Of The Air Force | Immunomagnetic assay system for clinical diagnosis and other purposes |
| DE19622885A1 (de) * | 1996-06-07 | 1997-12-11 | Boehringer Mannheim Gmbh | Reagenzzubereitung enthaltend magnetische Partikel in Form einer Tablette |
| CZ297990B6 (cs) | 1997-01-21 | 2007-05-16 | W. R. Grace & Co.-Conn. | Cásticový adsorbent a zpusob jeho výroby |
| US6027945A (en) | 1997-01-21 | 2000-02-22 | Promega Corporation | Methods of isolating biological target materials using silica magnetic particles |
| US5990479A (en) * | 1997-11-25 | 1999-11-23 | Regents Of The University Of California | Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
| US6242235B1 (en) | 1998-06-24 | 2001-06-05 | Promega Corp. | Polymerase stabilization by polyethoxylated amine surfactants |
| JP3561235B2 (ja) * | 1998-11-30 | 2004-09-02 | ロシュ ダイアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 核酸を精製するための磁性粒子 |
| US7267964B2 (en) * | 2000-03-31 | 2007-09-11 | Merial Limited | DNA molecules encoding ligand gated ion channels from Dermacentor variabilis |
-
1997
- 1997-10-01 DE DE19743518A patent/DE19743518A1/de not_active Ceased
-
1998
- 1998-09-29 AT AT98952670T patent/ATE366739T1/de active
- 1998-09-29 DE DE59814056T patent/DE59814056D1/de not_active Expired - Lifetime
- 1998-09-29 EP EP98952670A patent/EP1019430B1/de not_active Expired - Lifetime
- 1998-09-29 EP EP07003878A patent/EP1783135B1/de not_active Expired - Lifetime
- 1998-09-29 KR KR1020007003473A patent/KR20010024366A/ko not_active Withdrawn
- 1998-09-29 JP JP2000513863A patent/JP4048022B2/ja not_active Expired - Lifetime
- 1998-09-29 PT PT98952670T patent/PT1019430E/pt unknown
- 1998-09-29 WO PCT/EP1998/006196 patent/WO1999016781A2/de not_active Ceased
- 1998-09-29 CA CA002305171A patent/CA2305171C/en not_active Expired - Lifetime
- 1998-09-29 ES ES07003878T patent/ES2398713T3/es not_active Expired - Lifetime
- 1998-09-29 AU AU10282/99A patent/AU1028299A/en not_active Abandoned
- 1998-09-29 IL IL13529998A patent/IL135299A0/xx unknown
- 1998-09-29 DK DK98952670T patent/DK1019430T3/da active
- 1998-09-29 ES ES98952670T patent/ES2290996T3/es not_active Expired - Lifetime
- 1998-09-29 US US09/509,750 patent/US6562568B1/en not_active Expired - Lifetime
-
2000
- 2000-03-27 IL IL135299A patent/IL135299A/en not_active IP Right Cessation
-
2003
- 2003-04-30 US US10/426,641 patent/US20030199078A1/en not_active Abandoned
-
2007
- 2007-02-27 JP JP2007047875A patent/JP2007175060A/ja active Pending
- 2007-10-29 JP JP2007280179A patent/JP4659013B2/ja not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8110351B2 (en) | 2002-01-16 | 2012-02-07 | Invitrogen Dynal As | Method for isolating nucleic acids and protein from a single sample |
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