ATE516366T1 - Regulierte aptamer-therapeutika - Google Patents
Regulierte aptamer-therapeutikaInfo
- Publication number
- ATE516366T1 ATE516366T1 AT03771887T AT03771887T ATE516366T1 AT E516366 T1 ATE516366 T1 AT E516366T1 AT 03771887 T AT03771887 T AT 03771887T AT 03771887 T AT03771887 T AT 03771887T AT E516366 T1 ATE516366 T1 AT E516366T1
- Authority
- AT
- Austria
- Prior art keywords
- aptamer therapeutics
- regulated aptamer
- therapeutic compositions
- presented
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1048—SELEX
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3519—Fusion with another nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39848602P | 2002-07-25 | 2002-07-25 | |
US39886302P | 2002-07-25 | 2002-07-25 | |
PCT/US2003/023402 WO2004011680A1 (en) | 2002-07-25 | 2003-07-25 | Regulated aptamer therapeutics |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE516366T1 true ATE516366T1 (de) | 2011-07-15 |
Family
ID=32475361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03771887T ATE516366T1 (de) | 2002-07-25 | 2003-07-25 | Regulierte aptamer-therapeutika |
Country Status (7)
Country | Link |
---|---|
US (2) | US20040110235A1 (de) |
EP (1) | EP1543158B1 (de) |
JP (1) | JP2005533862A (de) |
AT (1) | ATE516366T1 (de) |
AU (1) | AU2003261264B2 (de) |
CA (1) | CA2492463A1 (de) |
WO (1) | WO2004011680A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2070939B1 (de) | 2001-05-25 | 2014-04-02 | Duke University | Modulatoren von pharmakologischen Wirkstoffen |
FR2867784B1 (fr) * | 2004-03-17 | 2006-06-09 | Commissariat Energie Atomique | Aptameres selectionnes a partir de cellules vivantes tumorales et leurs applications |
CN103045601B (zh) | 2004-04-22 | 2015-04-01 | 雷加多生物科学公司 | 改良的凝血因子调节物 |
EP1742959A2 (de) * | 2004-04-26 | 2007-01-17 | Archemix Corporation | Immunoglobulin e-nukleinsäureliganden und deren verwendung als therapeutika für atopische erkrankungen |
US20090130650A1 (en) * | 2006-02-17 | 2009-05-21 | Weihong Tan | Methods for the production of highly sensitive and specific cell surface probes |
US20090117549A1 (en) * | 2006-07-18 | 2009-05-07 | Weihong Tan | Aptamer-based methods for identifying cellular biomarkers |
GB0719367D0 (en) | 2007-10-03 | 2007-11-14 | Procarta Biosystems Ltd | Transcription factor decoys, compositions and methods |
GB0906130D0 (en) * | 2008-10-03 | 2009-05-20 | Procrata Biosystems Ltd | Transcription factor decoys |
WO2010088286A1 (en) * | 2009-01-28 | 2010-08-05 | Smartcells, Inc. | Synthetic conjugates and uses thereof |
AU2010208295A1 (en) * | 2009-01-28 | 2011-08-04 | Smartcells, Inc. | Polynucleotide aptamer-based cross -linked materials and uses thereof |
JP2012526130A (ja) * | 2009-05-05 | 2012-10-25 | アルテルムネ テクフノロジエス,エルエルシー | 化学的にプログラム可能な免疫 |
GB201002413D0 (en) | 2010-02-12 | 2010-03-31 | Procarta Biosystems Ltd | Nucleic acid complexes |
US10316320B2 (en) | 2013-04-18 | 2019-06-11 | Bar Ilan University | Systems comprising non-immunogenic and nuclease resistant nucleic acid origami devices for molecular computation |
WO2014170898A1 (en) * | 2013-04-18 | 2014-10-23 | Bar-Ilan University | Non-immunogenic and nuclease resistant nucleic acid origami devices and compositions thereof |
WO2016025750A2 (en) * | 2014-08-13 | 2016-02-18 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for regulation of gene expression with, and detection of, folinic acid and folates |
EP3330379B1 (de) * | 2015-07-27 | 2021-10-27 | Posco | Aptamer gegen insulinrezeptor und pharmazeutische zusammensetzung damit |
CN107083387A (zh) * | 2016-10-17 | 2017-08-22 | 柳州立洁科技有限公司 | 一种高亲和力胰岛素核酸适体ins4及其制备方法 |
CN108613862B (zh) * | 2018-05-10 | 2020-10-27 | 北京理工大学 | 一种基于毛细管电泳的双靶同步核酸适配体筛选方法 |
KR20230131326A (ko) * | 2022-03-03 | 2023-09-13 | 주식회사 압타머사이언스 | 인슐린 수용체 특이적 압타머 및 이의 이용 |
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-
2003
- 2003-07-25 US US10/627,543 patent/US20040110235A1/en not_active Abandoned
- 2003-07-25 AT AT03771887T patent/ATE516366T1/de not_active IP Right Cessation
- 2003-07-25 AU AU2003261264A patent/AU2003261264B2/en not_active Ceased
- 2003-07-25 JP JP2004524864A patent/JP2005533862A/ja active Pending
- 2003-07-25 WO PCT/US2003/023402 patent/WO2004011680A1/en active Application Filing
- 2003-07-25 CA CA002492463A patent/CA2492463A1/en not_active Abandoned
- 2003-07-25 EP EP03771887A patent/EP1543158B1/de not_active Expired - Lifetime
-
2005
- 2005-11-30 US US11/291,610 patent/US7960102B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US7960102B2 (en) | 2011-06-14 |
US20040110235A1 (en) | 2004-06-10 |
EP1543158A1 (de) | 2005-06-22 |
AU2003261264A1 (en) | 2004-02-16 |
JP2005533862A (ja) | 2005-11-10 |
EP1543158A4 (de) | 2007-06-06 |
US20060084109A1 (en) | 2006-04-20 |
EP1543158B1 (de) | 2011-07-13 |
CA2492463A1 (en) | 2004-02-05 |
AU2003261264B2 (en) | 2008-12-11 |
WO2004011680A1 (en) | 2004-02-05 |
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