ATE217347T1 - Diagnose mittels signalverstärkung durch ein ribozym - Google Patents

Diagnose mittels signalverstärkung durch ein ribozym

Info

Publication number
ATE217347T1
ATE217347T1 AT94903451T AT94903451T ATE217347T1 AT E217347 T1 ATE217347 T1 AT E217347T1 AT 94903451 T AT94903451 T AT 94903451T AT 94903451 T AT94903451 T AT 94903451T AT E217347 T1 ATE217347 T1 AT E217347T1
Authority
AT
Austria
Prior art keywords
target
ribozyme
bound
molecule
image
Prior art date
Application number
AT94903451T
Other languages
English (en)
Inventor
Andy Shih
Jeffrey M Bockman
Shaji T George
Original Assignee
Univ Yale
Ribozyme Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale, Ribozyme Pharm Inc filed Critical Univ Yale
Application granted granted Critical
Publication of ATE217347T1 publication Critical patent/ATE217347T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3517—Marker; Tag

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Road Signs Or Road Markings (AREA)
  • Stereo-Broadcasting Methods (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Dental Preparations (AREA)
  • Amplifiers (AREA)
  • Peptides Or Proteins (AREA)
AT94903451T 1992-12-04 1993-12-03 Diagnose mittels signalverstärkung durch ein ribozym ATE217347T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98530892A 1992-12-04 1992-12-04
PCT/US1993/011775 WO1994013833A1 (en) 1992-12-04 1993-12-03 Ribozyme amplified diagnostics

Publications (1)

Publication Number Publication Date
ATE217347T1 true ATE217347T1 (de) 2002-05-15

Family

ID=25531365

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94903451T ATE217347T1 (de) 1992-12-04 1993-12-03 Diagnose mittels signalverstärkung durch ein ribozym

Country Status (8)

Country Link
US (1) US5589332A (de)
EP (2) EP1195442A3 (de)
JP (2) JP3595841B2 (de)
AT (1) ATE217347T1 (de)
AU (1) AU675482B2 (de)
DE (1) DE69331911T2 (de)
ES (1) ES2176233T3 (de)
WO (1) WO1994013833A1 (de)

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JP2004000281A (ja) 2004-01-08
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EP1195442A2 (de) 2002-04-10
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