JP2001513648A - 非侵入性の出生前診断 - Google Patents
非侵入性の出生前診断Info
- Publication number
- JP2001513648A JP2001513648A JP53829098A JP53829098A JP2001513648A JP 2001513648 A JP2001513648 A JP 2001513648A JP 53829098 A JP53829098 A JP 53829098A JP 53829098 A JP53829098 A JP 53829098A JP 2001513648 A JP2001513648 A JP 2001513648A
- Authority
- JP
- Japan
- Prior art keywords
- fetal
- plasma
- dna
- serum
- maternal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6879—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for sex determination
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Eye Examination Apparatus (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Apparatus For Radiation Diagnosis (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.サンプル中の胎児起源の核酸の存在を検出することからなる、妊婦からの 母親の血清または血漿サンプルに実施される検出方法。 2.検出できるように胎児核酸を増幅することを含む、請求項1記載の方法。 3.ポリメラーゼチェインリアクションにより胎児核酸を増幅する、請求項2 記載の方法。 4.少なくとも一つの胎児配列特有のオリゴヌクレオチドプライマーを増幅に おいて使用する、請求項2または3記載の方法。 5.胎児核酸が配列特異的プローブの手段により検出される、請求項1ないし 4の何れか1項記載の方法。 6.Y染色体からの胎児核酸配列の存在を検出する、請求項1ないし5の何れ か1項記載の方法。 7.Y染色体配列がDYS14座由来である、請求項6記載の方法。 8.Y染色体配列がSRY遺伝子由来である、請求項6記載の方法。 9.父系遺伝の非Y染色体の胎児核酸の存在を検出する、請求項1ないし5の 何れか1項記載の方法。 10.非Y配列がRhD遺伝子等の血液群抗原遺伝子である、請求項9記載の方法 。 11.非Y配列がRhD遺伝子等の、胎児において疾患表現型提供する遺伝子であ る、請求項9記載の方法。 12.RhD陰性母親において胎児のRhD遺伝子型決定をするための、請求項10また は11記載の方法。 13.胎児の性別を決定するための、請求項6ないし8の何れか1項記載の方法 。 14.母親の血清または血漿中の胎児核酸配列の濃度を測定することを含む、請 求項6ないし12の何れか1項記載の方法。 15.母親の血清または血漿中の胎児核酸配列の濃度の測定を定量性PCRにより 行う、請求項14記載の方法。 16.母親の血清または血漿中の胎児DNAレベルが正常よりも高いかまたは低い 場合の、母親または胎児の状態を検出するための、請求項14または15記載の方法 。 17.妊娠の特定の段階における母親血清または血漿中の胎児DNA濃度の変動の パ ターンが正常とは異なる、請求項14ないし16の何れか1項記載の方法。 18.子癇前症の検出のための、請求項16または17記載のの方法。 19.胎児の染色体異数性の検出のための、請求項16または17記載のの方法。 20.サンプルを胎児DNA富裕化工程に供することなく、サンプルが全DNAの部分 濃度において少なくとも約0.14%の胎児DNAを含む、請求項1ないし19の何れか 1項記載の方法。 21.胎児DNAの部分濃度が少なくとも約0.39%である、請求項20記載の方法。 22.以下の工程: (i)母親の血液サンプルを提供し; (ii)サンプルを細胞画分と非細胞画分とに分離し; (iii)請求項1ないし21の何れか1項記載の方法に従い非細胞画分中の胎児起 源の核酸の存在を検出し;そして (iv)胎児核酸の存在および/または量および/または配列に基づいて診断を提 供すること からなる、出生前診断を実施する方法。 23.工程(iii)において使用される非細胞画分が血漿画分である、請求項22 記載の方法。 24.母親サンプルにおいて凝血を許容しそしてその結果の血清を工程(iii) において使用するさらなる工程を実施する、請求項22記載の方法。 25.血液サンプルから有核細胞および無核細胞を全てあるいは実質全て除去し 、そして残った流体を母親または胎児の症状または特徴の胎児核酸指標に関して の試験に供することを含む、母親血液サンプルに対する出生前診断の実施方法。 26.血液サンプルの非細胞画分を得て、そして該画分に核酸分析を実施するこ とからなる、母親血液サンプルに対する出生前診断の実施方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9704444.0A GB9704444D0 (en) | 1997-03-04 | 1997-03-04 | Non-invasive prenatal diagnosis |
GB9704444.0 | 1997-03-04 | ||
PCT/GB1998/000690 WO1998039474A1 (en) | 1997-03-04 | 1998-03-04 | Non-invasive prenatal diagnosis |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2001513648A true JP2001513648A (ja) | 2001-09-04 |
JP4245666B2 JP4245666B2 (ja) | 2009-03-25 |
Family
ID=10808662
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53829098A Expired - Lifetime JP4245666B2 (ja) | 1997-03-04 | 1998-03-04 | 非侵入性の出生前診断 |
Country Status (13)
Country | Link |
---|---|
US (1) | US6258540B1 (ja) |
EP (1) | EP0994963B2 (ja) |
JP (1) | JP4245666B2 (ja) |
AT (1) | ATE240409T1 (ja) |
AU (1) | AU727919B2 (ja) |
CA (1) | CA2282793C (ja) |
DE (1) | DE69814639T3 (ja) |
DK (1) | DK0994963T4 (ja) |
ES (1) | ES2198700T5 (ja) |
GB (1) | GB9704444D0 (ja) |
HK (1) | HK1026720A1 (ja) |
PT (1) | PT994963E (ja) |
WO (1) | WO1998039474A1 (ja) |
Cited By (6)
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---|---|---|---|---|
JP2008543277A (ja) * | 2005-05-11 | 2008-12-04 | ジェネティック テクノロジーズ リミテッド | 胎児細胞を富化する方法 |
KR101256206B1 (ko) * | 2012-03-02 | 2013-04-19 | 의료법인 제일의료재단 | 태아의 성별 결정을 위한 분석방법 및 장치 |
JP2013121359A (ja) * | 2003-10-16 | 2013-06-20 | Sequenom Inc | 胎児遺伝形質の非侵襲的検出 |
JP2014507134A (ja) * | 2011-01-05 | 2014-03-27 | ザ・チャイニーズ・ユニバーシティー・オブ・ホンコン | 胎児の性染色体遺伝子型の非侵襲的出生前同定 |
JP2015142588A (ja) * | 2007-07-23 | 2015-08-06 | ザ チャイニーズ ユニバーシティー オブ ホンコン | ゲノム配列決定を使用する胎児染色体異数性の診断 |
US9216007B2 (en) | 2009-07-30 | 2015-12-22 | Samsung Medison Co., Ltd. | Setting a sagittal view in an ultrasound system |
Families Citing this family (299)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6136311A (en) * | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
US7767422B2 (en) * | 1998-09-22 | 2010-08-03 | Oncomedx, Inc. | Detection of 5T4 RNA in plasma and serum |
ATE364721T1 (de) * | 1999-06-28 | 2007-07-15 | Source Precision Medicine Inc | Verfahren zum charakterisieren von biologischen bedingungen, die kalibrierte genexpressionsprofile verwenden |
US6586177B1 (en) * | 1999-09-08 | 2003-07-01 | Exact Sciences Corporation | Methods for disease detection |
US6919174B1 (en) * | 1999-12-07 | 2005-07-19 | Exact Sciences Corporation | Methods for disease detection |
GB0009784D0 (en) | 2000-04-20 | 2000-06-07 | Simeg Limited | Methods for clinical diagnosis |
GB0016742D0 (en) * | 2000-07-10 | 2000-08-30 | Simeg Limited | Diagnostic method |
US7083924B2 (en) | 2000-07-10 | 2006-08-01 | Btg International Limited | Diagnostic method for the identification of foetal DNA in a material sample |
EP1354060B1 (en) * | 2000-08-28 | 2011-02-09 | Oncomedx, Inc. | 5t4 rna in plasma and serum as a marker for neoplastic disease |
US6664056B2 (en) | 2000-10-17 | 2003-12-16 | The Chinese University Of Hong Kong | Non-invasive prenatal monitoring |
US20090226915A1 (en) * | 2001-01-24 | 2009-09-10 | Health Discovery Corporation | Methods for Screening, Predicting and Monitoring Prostate Cancer |
CA2753372C (en) * | 2001-06-14 | 2018-08-07 | The Regents Of The University Of California | Mutations in the bcr-abl tyrosine kinase associated with resistance to sti-571 |
US6927028B2 (en) * | 2001-08-31 | 2005-08-09 | Chinese University Of Hong Kong | Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA |
JP2005514956A (ja) * | 2002-01-18 | 2005-05-26 | ジェンザイム・コーポレーション | 胎児dnaの検出および対立遺伝子の定量化のための方法 |
WO2003071252A2 (en) | 2002-02-15 | 2003-08-28 | Exact Sciences Corporation | Methods for analysis of molecular events |
US6977162B2 (en) * | 2002-03-01 | 2005-12-20 | Ravgen, Inc. | Rapid analysis of variations in a genome |
JP2006523082A (ja) | 2002-03-01 | 2006-10-12 | ラブジェン, インコーポレイテッド | ゲノム内の変異の迅速分析 |
US7442506B2 (en) * | 2002-05-08 | 2008-10-28 | Ravgen, Inc. | Methods for detection of genetic disorders |
US20070178478A1 (en) * | 2002-05-08 | 2007-08-02 | Dhallan Ravinder S | Methods for detection of genetic disorders |
US7727720B2 (en) * | 2002-05-08 | 2010-06-01 | Ravgen, Inc. | Methods for detection of genetic disorders |
WO2004029221A2 (en) | 2002-09-27 | 2004-04-08 | The General Hospital Corporation | Microfluidic device for cell separation and uses thereof |
US10966421B2 (en) | 2002-10-16 | 2021-04-06 | Streck, Inc. | Method and device for collecting and preserving cells for analysis |
DE10254601A1 (de) * | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
CA2508348C (en) * | 2002-12-06 | 2016-07-12 | Millennium Pharmaceuticals, Inc. | Methods for the identification, assessment, and treatment of patients with proteasome inhibition therapy |
JP4624977B2 (ja) * | 2003-01-17 | 2011-02-02 | ザ チャイニーズ ユニバーシティ オブ ホンコン | 妊娠障害診断マーカーとしての血中mRNA |
AU2004270220B2 (en) * | 2003-09-05 | 2009-03-05 | The Chinese University Of Hong Kong | Method for non-invasive prenatal diagnosis |
WO2005043121A2 (en) * | 2003-10-31 | 2005-05-12 | Vitatex, Inc. | Blood test prototypes and methods for the detection of circulating tumor and endothelial cells |
US7252946B2 (en) * | 2004-01-27 | 2007-08-07 | Zoragen, Inc. | Nucleic acid detection |
US8518228B2 (en) | 2011-05-20 | 2013-08-27 | The University Of British Columbia | Systems and methods for enhanced SCODA |
US10337054B2 (en) | 2004-02-02 | 2019-07-02 | Quantum-Si Incorporated | Enrichment of nucleic acid targets |
US9186685B2 (en) | 2012-01-13 | 2015-11-17 | The University Of British Columbia | Multiple arm apparatus and methods for separation of particles |
US8529744B2 (en) | 2004-02-02 | 2013-09-10 | Boreal Genomics Corp. | Enrichment of nucleic acid targets |
CA2552262C (en) | 2004-02-02 | 2016-04-19 | The University Of British Columbia | Scodaphoresis and methods and apparatus for moving and concentrating particles |
US20080026950A1 (en) * | 2004-02-24 | 2008-01-31 | Mitsubishi Rayon Co., Ltd. | Gene Relating to Estimation of Postoperative Prognosis for Breast Cancer |
US20080241827A1 (en) * | 2004-05-10 | 2008-10-02 | Exact Sciences Corporation | Methods For Detecting A Mutant Nucleic Acid |
US7709194B2 (en) | 2004-06-04 | 2010-05-04 | The Chinese University Of Hong Kong | Marker for prenatal diagnosis and monitoring |
WO2006026654A2 (en) | 2004-08-27 | 2006-03-09 | Exact Sciences Corporation | Method for detecting a recombinant event |
US8024128B2 (en) * | 2004-09-07 | 2011-09-20 | Gene Security Network, Inc. | System and method for improving clinical decisions by aggregating, validating and analysing genetic and phenotypic data |
US9109256B2 (en) | 2004-10-27 | 2015-08-18 | Esoterix Genetic Laboratories, Llc | Method for monitoring disease progression or recurrence |
US11105808B2 (en) | 2004-11-12 | 2021-08-31 | Health Discovery Corporation | Methods for screening, predicting and monitoring prostate cancer |
JP5006802B2 (ja) * | 2005-02-18 | 2012-08-22 | チルドレンズ メディカル センター コーポレイション | 上皮由来の癌診断および予後診断のためのバイオマーカーとしてのCyr61 |
BRPI0608679A2 (pt) * | 2005-04-01 | 2010-12-07 | Medvet Science Pty Ltd | métodos para detectar células neoplásicas não viáveis em um indivìduo, para avaliar e/ou monitorar uma condição neoplásica e a efetividade de um regime de tratamento terapêutico de neoplasma em um indivìduo e para tratar uma condição neoplásica e um cáncer metastásico em um indivìduo, kit diagnóstico para uma amostra biológica, uso de uma molécula interativa, composição farmacêutica, e, agente |
US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
US20070026418A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US9777314B2 (en) | 2005-04-21 | 2017-10-03 | Esoterix Genetic Laboratories, Llc | Analysis of heterogeneous nucleic acid samples |
EP2477029A1 (en) * | 2005-06-02 | 2012-07-18 | Fluidigm Corporation | Analysis using microfluidic partitioning devices |
US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
US20070178501A1 (en) * | 2005-12-06 | 2007-08-02 | Matthew Rabinowitz | System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology |
US10083273B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US8532930B2 (en) | 2005-11-26 | 2013-09-10 | Natera, Inc. | Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals |
US8515679B2 (en) * | 2005-12-06 | 2013-08-20 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
US20070027636A1 (en) * | 2005-07-29 | 2007-02-01 | Matthew Rabinowitz | System and method for using genetic, phentoypic and clinical data to make predictions for clinical or lifestyle decisions |
US10081839B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc | System and method for cleaning noisy genetic data and determining chromosome copy number |
PT2385143T (pt) | 2006-02-02 | 2016-10-18 | Univ Leland Stanford Junior | Rastreio genético fetal não-invasivo por análise digital |
US8609338B2 (en) * | 2006-02-28 | 2013-12-17 | University Of Louisville Research Foundation, Inc. | Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms |
DK2351858T3 (da) * | 2006-02-28 | 2015-04-07 | Univ Louisville Res Found | Påvisning af føtale kromosomabnormiteter ved anvendelse af tandem-enkeltnukleotid-polymorfismer |
US7754428B2 (en) | 2006-05-03 | 2010-07-13 | The Chinese University Of Hong Kong | Fetal methylation markers |
US7901884B2 (en) | 2006-05-03 | 2011-03-08 | The Chinese University Of Hong Kong | Markers for prenatal diagnosis and monitoring |
US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
EP2029779A4 (en) * | 2006-06-14 | 2010-01-20 | Living Microsystems Inc | HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS |
US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
EP2589668A1 (en) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
EP2048501B1 (en) * | 2006-08-03 | 2016-03-09 | The University of Tokyo | Antibody specific to intact human autotaxin, method of screening the same and method and reagent for examining malignant lymphoma by assaying autotaxin |
GB0616045D0 (en) * | 2006-08-11 | 2006-09-20 | Univ Bristol | Blood cell separation |
TWI335354B (en) | 2006-09-27 | 2011-01-01 | Univ Hong Kong Chinese | Methods for the detection of the degree of the methylation of a target dna and kits |
US7902345B2 (en) | 2006-12-05 | 2011-03-08 | Sequenom, Inc. | Detection and quantification of biomolecules using mass spectrometry |
PL2140269T3 (pl) * | 2007-03-27 | 2014-07-31 | Immunovia Ab | Podpis białkowy/znaczniki do wykrywania gruczolakoraka |
US20100113286A1 (en) * | 2007-05-05 | 2010-05-06 | Gilles Andre Lajoie | Methods for detection of preeclampsia |
US20100297067A1 (en) * | 2007-05-14 | 2010-11-25 | The Johns Hopkins University | Methylation markers for prostate cancer and methods of use |
US20100112590A1 (en) | 2007-07-23 | 2010-05-06 | The Chinese University Of Hong Kong | Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment |
US9404150B2 (en) | 2007-08-29 | 2016-08-02 | Sequenom, Inc. | Methods and compositions for universal size-specific PCR |
EP3358354B1 (en) | 2008-01-18 | 2020-07-15 | President and Fellows of Harvard College | Methods of detecting signatures of disease or conditions in bodily fluids |
US8475641B2 (en) | 2008-02-01 | 2013-07-02 | The University Of British Columbia | Methods and apparatus for particle introduction and recovery |
CN101999003A (zh) * | 2008-02-12 | 2011-03-30 | 诺瓦蒂斯公司 | 分离无细胞凋亡或胎儿核酸的方法 |
US20110033862A1 (en) * | 2008-02-19 | 2011-02-10 | Gene Security Network, Inc. | Methods for cell genotyping |
WO2009114579A2 (en) * | 2008-03-11 | 2009-09-17 | Urobiogics Llc | Reducing/oxidizing activity of maternal urine as indicator of fetal gender related characteristics |
CA2717320A1 (en) * | 2008-03-11 | 2009-09-17 | Sequenom, Inc. | Nucleic acid-based tests for prenatal gender determination |
US10996218B2 (en) | 2008-03-11 | 2021-05-04 | Ournextbaby Llc | Methods for chemotaxis / redox driven separation of X and Y chromosome bearing sperm and their insemination in gender specific menstrual cycles |
US20110092763A1 (en) * | 2008-05-27 | 2011-04-21 | Gene Security Network, Inc. | Methods for Embryo Characterization and Comparison |
CA2731991C (en) * | 2008-08-04 | 2021-06-08 | Gene Security Network, Inc. | Methods for allele calling and ploidy calling |
US8476013B2 (en) | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
EP3770255A1 (en) | 2008-09-16 | 2021-01-27 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
US8962247B2 (en) | 2008-09-16 | 2015-02-24 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses |
PT2562268T (pt) | 2008-09-20 | 2017-03-29 | Univ Leland Stanford Junior | Diagnóstico não invasivo de aneuploidia fetal por sequenciação |
US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
SG195652A1 (en) | 2008-11-07 | 2013-12-30 | Sequenta Inc | Methods of monitoring conditions by sequence analysis |
US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
US20100167271A1 (en) * | 2008-12-30 | 2010-07-01 | Streck, Inc. | Method for screening blood using a preservative that may be in a substantially solid state form |
HUE029424T2 (en) | 2009-01-15 | 2017-02-28 | Adaptive Biotechnologies Corp | Adaptive immunity profiling and a method for producing monoclonal antibodies |
US11634747B2 (en) | 2009-01-21 | 2023-04-25 | Streck Llc | Preservation of fetal nucleic acids in maternal plasma |
DE202010018561U1 (de) | 2009-01-21 | 2017-08-28 | Streck Inc. | Blutsammelröhrchen |
WO2010091253A1 (en) | 2009-02-06 | 2010-08-12 | Women & Infants' Hospital Of Rhode Island | Compositions, formulations and methods of treating preeclampsia-type disorders of pregnancy |
DK3290530T3 (da) | 2009-02-18 | 2020-12-07 | Streck Inc | Konservering af cellefrie nukleinsyrer |
WO2010107946A2 (en) * | 2009-03-18 | 2010-09-23 | Sequenom, Inc. | Use of thermostable endonucleases for generating reporter molecules |
EP2421955A4 (en) | 2009-04-21 | 2012-10-10 | Genetic Technologies Ltd | METHODS OF OBTAINING F TAL GENETIC MATERIAL |
WO2010121381A1 (en) | 2009-04-21 | 2010-10-28 | The University Of British Columbia | System and methods for detection of particles |
WO2010123626A1 (en) | 2009-04-24 | 2010-10-28 | University Of Southern California | Cd133 polymorphisms and expression predict clinical outcome in patients with cancer |
JP2012531202A (ja) | 2009-06-25 | 2012-12-10 | フレッド ハチンソン キャンサー リサーチ センター | 適応免疫を測定する方法 |
US8825412B2 (en) | 2010-05-18 | 2014-09-02 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US20110070590A1 (en) | 2009-09-22 | 2011-03-24 | Jan Rohozinski | Primers and Methods for Determining RhD Zygosity |
WO2011041485A1 (en) | 2009-09-30 | 2011-04-07 | Gene Security Network, Inc. | Methods for non-invasive prenatal ploidy calling |
HRP20230134T1 (hr) | 2009-11-05 | 2023-03-31 | The Chinese University Of Hong Kong | Analiza genoma fetusa iz biološkog uzorka majke |
CN102712954A (zh) | 2009-11-06 | 2012-10-03 | 小利兰·斯坦福大学托管委员会 | 器官移植患者移植排斥的非侵入性诊断 |
WO2011057184A1 (en) * | 2009-11-09 | 2011-05-12 | Streck, Inc. | Stabilization of rna in and extracting from intact cells within a blood sample |
EP2504448B1 (en) * | 2009-11-25 | 2016-10-19 | Bio-Rad Laboratories, Inc. | Methods and compositions for detecting genetic material |
GB0921873D0 (en) * | 2009-12-15 | 2010-01-27 | Cytosystems Ltd | Assay |
US20120288861A1 (en) | 2009-12-21 | 2012-11-15 | Heinz-Josef Lenz | Germline polymorphisms in the sparc gene associated with clinical outcome in gastric cancer |
US9926593B2 (en) | 2009-12-22 | 2018-03-27 | Sequenom, Inc. | Processes and kits for identifying aneuploidy |
CA2817990A1 (en) | 2009-12-23 | 2011-06-30 | Genetic Technologies Limited | Methods of enriching and detecting fetal nucleic acids |
WO2011085334A1 (en) | 2010-01-11 | 2011-07-14 | University Of Southern California | Cd44 polymorphisms predict clinical outcome in patients with gastric cancer |
EP2513341B1 (en) | 2010-01-19 | 2017-04-12 | Verinata Health, Inc | Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing |
US20120010085A1 (en) | 2010-01-19 | 2012-01-12 | Rava Richard P | Methods for determining fraction of fetal nucleic acids in maternal samples |
US10388403B2 (en) | 2010-01-19 | 2019-08-20 | Verinata Health, Inc. | Analyzing copy number variation in the detection of cancer |
US9260745B2 (en) | 2010-01-19 | 2016-02-16 | Verinata Health, Inc. | Detecting and classifying copy number variation |
ES2704701T3 (es) | 2010-01-19 | 2019-03-19 | Verinata Health Inc | Nuevo protocolo de preparación de bibliotecas de secuenciación |
US9323888B2 (en) | 2010-01-19 | 2016-04-26 | Verinata Health, Inc. | Detecting and classifying copy number variation |
US20120100548A1 (en) | 2010-10-26 | 2012-04-26 | Verinata Health, Inc. | Method for determining copy number variations |
EP2526415B1 (en) | 2010-01-19 | 2017-05-03 | Verinata Health, Inc | Partition defined detection methods |
US20110312503A1 (en) | 2010-01-23 | 2011-12-22 | Artemis Health, Inc. | Methods of fetal abnormality detection |
KR101533469B1 (ko) * | 2010-02-03 | 2015-07-02 | 연세대학교 산학협력단 | Ras의 Thr-144번과 Thr-148번의 인산화의 감지를 통한 암 진단 방법, 항암제 스크리닝 및 약효테스트 방법 |
US8774488B2 (en) | 2010-03-11 | 2014-07-08 | Cellscape Corporation | Method and device for identification of nucleated red blood cells from a maternal blood sample |
US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
WO2012012694A2 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Methods of detecting autoimmune or immune-related diseases or conditions |
BR112013001752A2 (pt) | 2010-07-23 | 2016-05-31 | Harvard College | método de detectar doenças ou condições usando células fagocídicas |
BR112013001754A2 (pt) | 2010-07-23 | 2016-05-31 | Harvard College | método para detectar marcas de doença ou condições em fluídos corpóreos |
EP2596353A4 (en) | 2010-07-23 | 2014-01-15 | Harvard College | METHOD FOR DETECTING PRENATAL OR PREGNANT DISEASES OR SUFFERING |
US10533223B2 (en) | 2010-08-06 | 2020-01-14 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
US20120034603A1 (en) | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
US10167508B2 (en) | 2010-08-06 | 2019-01-01 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities |
AU2011285534B2 (en) * | 2010-08-06 | 2015-12-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Biomarkers for prostate cancer and methods for their detection |
US11031095B2 (en) | 2010-08-06 | 2021-06-08 | Ariosa Diagnostics, Inc. | Assay systems for determination of fetal copy number variation |
US8700338B2 (en) | 2011-01-25 | 2014-04-15 | Ariosa Diagnosis, Inc. | Risk calculation for evaluation of fetal aneuploidy |
US11203786B2 (en) | 2010-08-06 | 2021-12-21 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
US20130261003A1 (en) | 2010-08-06 | 2013-10-03 | Ariosa Diagnostics, In. | Ligation-based detection of genetic variants |
US20130040375A1 (en) | 2011-08-08 | 2013-02-14 | Tandem Diagnotics, Inc. | Assay systems for genetic analysis |
US20140342940A1 (en) | 2011-01-25 | 2014-11-20 | Ariosa Diagnostics, Inc. | Detection of Target Nucleic Acids using Hybridization |
CN103228796B (zh) | 2010-08-11 | 2016-06-01 | 赛路拉公司 | 基因分型dna |
EP2619573B1 (en) * | 2010-09-16 | 2017-06-14 | Urobiologics LLC | Use of female mammal's urine for determination of fetal gender related characteristics |
CN103534591B (zh) | 2010-10-26 | 2016-04-06 | 利兰·斯坦福青年大学托管委员会 | 通过测序分析进行的非侵入性胎儿遗传筛选 |
CL2010001419A1 (es) * | 2010-12-10 | 2011-04-25 | Aquainnovo S A | Metodo para detectar el sexo de forma prenatal en el plasma de madre, mediante el uso de la reaccion de polimerasa en cadena (pcr) humano en tiempo real. |
ES2770342T3 (es) | 2010-12-22 | 2020-07-01 | Natera Inc | Procedimientos para pruebas prenatales no invasivas de paternidad |
US10131947B2 (en) | 2011-01-25 | 2018-11-20 | Ariosa Diagnostics, Inc. | Noninvasive detection of fetal aneuploidy in egg donor pregnancies |
US8756020B2 (en) | 2011-01-25 | 2014-06-17 | Ariosa Diagnostics, Inc. | Enhanced risk probabilities using biomolecule estimations |
US9994897B2 (en) | 2013-03-08 | 2018-06-12 | Ariosa Diagnostics, Inc. | Non-invasive fetal sex determination |
US11270781B2 (en) | 2011-01-25 | 2022-03-08 | Ariosa Diagnostics, Inc. | Statistical analysis for non-invasive sex chromosome aneuploidy determination |
EP3483285B1 (en) | 2011-02-09 | 2021-07-14 | Bio-Rad Laboratories, Inc. | Analysis of nucleic acids |
WO2012108920A1 (en) | 2011-02-09 | 2012-08-16 | Natera, Inc | Methods for non-invasive prenatal ploidy calling |
CA3160848A1 (en) | 2011-02-24 | 2013-03-28 | The Chinese University Of Hong Kong | Molecular testing of multiple pregnancies |
JP5976694B2 (ja) * | 2011-03-11 | 2016-08-24 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 慢性閉塞性肺疾患(copd)のマーカーとしてのnnmt |
CA2826811A1 (en) * | 2011-03-11 | 2012-09-20 | F. Hoffmann-La Roche Ag | Apex1 as marker for chronic obstructive pulmonary disease (copd) |
CA2832468C (en) | 2011-04-12 | 2023-10-31 | Verinata Health, Inc. | Resolving genome fractions using polymorphism counts |
US9411937B2 (en) | 2011-04-15 | 2016-08-09 | Verinata Health, Inc. | Detecting and classifying copy number variation |
WO2012145399A2 (en) * | 2011-04-20 | 2012-10-26 | Traxxsson, Llc | Methods of diagnosing cancer in a patient |
WO2012145382A2 (en) * | 2011-04-20 | 2012-10-26 | Traxxsson, Llc | Measurement of pka for cancer characterization |
CA2834218C (en) | 2011-04-29 | 2021-02-16 | Sequenom, Inc. | Quantification of a minority nucleic acid species using inhibitory oligonucleotides |
WO2012151391A2 (en) | 2011-05-04 | 2012-11-08 | Streck, Inc. | Inactivated virus compositions and methods of preparing such compositions |
WO2012177792A2 (en) | 2011-06-24 | 2012-12-27 | Sequenom, Inc. | Methods and processes for non-invasive assessment of a genetic variation |
SG191757A1 (en) | 2011-06-29 | 2013-08-30 | Bgi Health Service Co Ltd | Noninvasive detection of fetal genetic abnormality |
US20130018700A1 (en) * | 2011-07-14 | 2013-01-17 | International Business Machines Corporation | Optimizing product portfolios under customer choice |
EP2732053B1 (en) | 2011-07-14 | 2017-10-25 | Progenity, Inc. | Systems, apparatus and methods for biochemical analysis |
CN103842504A (zh) * | 2011-07-26 | 2014-06-04 | 独立行政法人产业技术综合研究所 | 上皮性卵巢癌标志物检测用抗体和上皮性卵巢癌判定方法 |
US8712697B2 (en) | 2011-09-07 | 2014-04-29 | Ariosa Diagnostics, Inc. | Determination of copy number variations using binomial probability calculations |
US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
US20140363832A1 (en) * | 2011-09-15 | 2014-12-11 | National University Corporation Nagoya University | Molecular marker for the early detection of malignant pleural mesothelioma and the methods of its expression analysis using blood and pleural effusion samples |
US10196681B2 (en) | 2011-10-06 | 2019-02-05 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US9984198B2 (en) | 2011-10-06 | 2018-05-29 | Sequenom, Inc. | Reducing sequence read count error in assessment of complex genetic variations |
US9367663B2 (en) | 2011-10-06 | 2016-06-14 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
CA2850785C (en) | 2011-10-06 | 2022-12-13 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US10424394B2 (en) | 2011-10-06 | 2019-09-24 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US8688388B2 (en) | 2011-10-11 | 2014-04-01 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
WO2013057568A1 (en) | 2011-10-18 | 2013-04-25 | Multiplicom Nv | Fetal chromosomal aneuploidy diagnosis |
EP2768982A4 (en) | 2011-10-21 | 2015-06-03 | Adaptive Biotechnologies Corp | QUANTIFICATION OF ADAPTIVE IMMUNOCELL GENOMES IN A COMPLEX MIX OF CELLS |
EP2788509B1 (en) | 2011-12-09 | 2018-07-11 | Adaptive Biotechnologies Corporation | Diagnosis of lymphoid malignancies and minimal residual disease detection |
US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
WO2013110007A1 (en) * | 2012-01-18 | 2013-07-25 | The Trustees Of Columbia University In The City Of New York | USE OF FATOSTATIN FOR TREATING CANCER HAVING A p53 MUTATION |
WO2013109981A1 (en) | 2012-01-20 | 2013-07-25 | Sequenom, Inc. | Diagnostic processes that factor experimental conditions |
JP6116586B2 (ja) * | 2012-01-20 | 2017-04-19 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 固形ガンを患う患者の生存期間の予後診断のための方法 |
US9238836B2 (en) | 2012-03-30 | 2016-01-19 | Pacific Biosciences Of California, Inc. | Methods and compositions for sequencing modified nucleic acids |
ES2930180T3 (es) | 2012-03-02 | 2022-12-07 | Sequenom Inc | Métodos para enriquecer ácido nucleico canceroso a partir de una muestra biológica |
EP2823060B1 (en) | 2012-03-05 | 2018-02-14 | Adaptive Biotechnologies Corporation | Determining paired immune receptor chains from frequency matched subunits |
US20150072349A1 (en) * | 2012-03-16 | 2015-03-12 | University Health Network | Cancer Biomarkers and Methods of Use |
EP2831279B1 (en) | 2012-03-26 | 2023-05-03 | The Johns Hopkins University | Rapid aneuploidy detection |
WO2013166444A2 (en) | 2012-05-04 | 2013-11-07 | Boreal Genomics Corp. | Biomarker analysis using scodaphoresis |
DK2831276T3 (da) | 2012-05-08 | 2016-08-01 | Adaptive Biotechnologies Corp | Sammensætninger og fremgangsmåde til at måle og kalibrere amplifikations-bias i multipleks-PCR-reaktioner |
CN107315088A (zh) * | 2012-05-10 | 2017-11-03 | 尤特罗皮克斯制药股份有限公司 | 对癌症的代理功能性诊断测试 |
US10504613B2 (en) | 2012-12-20 | 2019-12-10 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US10289800B2 (en) | 2012-05-21 | 2019-05-14 | Ariosa Diagnostics, Inc. | Processes for calculating phased fetal genomic sequences |
SG11201407901PA (en) | 2012-05-21 | 2015-01-29 | Fluidigm Corp | Single-particle analysis of particle populations |
US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
WO2013192423A2 (en) | 2012-06-20 | 2013-12-27 | Eutropics Pharmaceuticals, Inc. | Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives |
US10497461B2 (en) | 2012-06-22 | 2019-12-03 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
EP2872648B1 (en) | 2012-07-13 | 2019-09-04 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
FR2993668B1 (fr) * | 2012-07-17 | 2015-07-03 | Cisbio Bioassays | Methode theranostique basee sur la detection de dimeres her2-her2 |
CA2878280A1 (en) | 2012-07-19 | 2014-01-23 | Ariosa Diagnostics, Inc. | Multiplexed sequential ligation-based detection of genetic variants |
ES2749118T3 (es) | 2012-10-01 | 2020-03-19 | Adaptive Biotechnologies Corp | Evaluación de la inmunocompetencia por la diversidad de los receptores de inmunidad adaptativa y caracterización de la clonalidad |
EP2904534B1 (en) | 2012-10-04 | 2021-12-15 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US10482994B2 (en) | 2012-10-04 | 2019-11-19 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
KR20150064211A (ko) * | 2012-10-12 | 2015-06-10 | 고쿠리츠다이가쿠호징 히로사키다이가쿠 | 전립선암과 전립선 비대를 식별하기 위한 방법 및 키트 |
WO2015160439A2 (en) | 2014-04-17 | 2015-10-22 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
EP2912466B1 (en) * | 2012-10-26 | 2018-08-29 | Institut Gustave Roussy | Methods for predicting the sensitivity of a subject to immunotherapy |
US20160038503A1 (en) | 2012-11-21 | 2016-02-11 | David Richard | Methods and compositions useful for treating diseases involving bcl-2 family proteins with isoquinoline and quinoline derivatives |
MX366911B (es) * | 2012-11-28 | 2019-07-30 | Nektar Therapeutics | Método para evaluar y predecir la eficacia del tratamiento del cáncer de mama con un inhibidor de topoisomerasa i de acción prolongada. |
EP2759602A1 (en) | 2013-01-25 | 2014-07-30 | Charité - Universitätsmedizin Berlin | Non-invasive prenatal genetic diagnostic methods |
US20130309666A1 (en) | 2013-01-25 | 2013-11-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US20140222512A1 (en) * | 2013-02-01 | 2014-08-07 | Goodsnitch, Inc. | Receiving, tracking and analyzing business intelligence data |
CA2900529A1 (en) * | 2013-02-08 | 2014-08-14 | Institute For Myeloma & Bone Cancer Research | Improved diagnostic, prognostic, and monitoring methods for multiple myeloma, chronic lymphocytic leukemia, and b-cell non-hodgkin lymphoma |
US11585814B2 (en) | 2013-03-09 | 2023-02-21 | Immunis.Ai, Inc. | Methods of detecting prostate cancer |
US10494675B2 (en) | 2013-03-09 | 2019-12-03 | Cell Mdx, Llc | Methods of detecting cancer |
US11060145B2 (en) | 2013-03-13 | 2021-07-13 | Sequenom, Inc. | Methods and compositions for identifying presence or absence of hypermethylation or hypomethylation locus |
CN105121660B (zh) | 2013-03-15 | 2018-09-28 | 香港中文大学 | 确定多胎妊娠的胎儿基因组 |
WO2014144822A2 (en) | 2013-03-15 | 2014-09-18 | Immumetrix, Inc. | Methods and compositions for tagging and analyzing samples |
US9340835B2 (en) | 2013-03-15 | 2016-05-17 | Boreal Genomics Corp. | Method for separating homoduplexed and heteroduplexed nucleic acids |
GB201304810D0 (en) | 2013-03-15 | 2013-05-01 | Isis Innovation | Assay |
WO2014165596A1 (en) | 2013-04-03 | 2014-10-09 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
TWI522367B (zh) * | 2013-04-12 | 2016-02-21 | Univ Chang Gung | Urine biomarkers are used to predict bladder and kidney cancer |
EP2986326B1 (en) * | 2013-04-15 | 2018-09-05 | Cedars-Sinai Medical Center | Methods for detecting cancer metastasis |
WO2014180910A1 (en) | 2013-05-09 | 2014-11-13 | Roche Diagnostics Gmbh | Method of determining the fraction of fetal dna in maternal blood using hla markers |
US20140343982A1 (en) * | 2013-05-14 | 2014-11-20 | Landmark Graphics Corporation | Methods and systems related to workflow mentoring |
CN107095872A (zh) * | 2013-05-16 | 2017-08-29 | 国立大学法人京都大学 | 用于确定癌症预后的方法 |
US9725494B2 (en) * | 2013-05-17 | 2017-08-08 | United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Soluble CD27 (sCD27) and the use thereof |
WO2014190286A2 (en) | 2013-05-24 | 2014-11-27 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
WO2014194289A1 (en) * | 2013-05-31 | 2014-12-04 | Nektar Therapeutics | Method for predicting and evaluating responsiveness to cancer treatment with dna-damaging chemotherapeutic agents |
DK3011051T3 (en) | 2013-06-21 | 2019-04-23 | Sequenom Inc | Method for non-invasive evaluation of genetic variations |
US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
FR3008096B1 (fr) * | 2013-07-03 | 2015-08-14 | Gregory Raux | Kit et methode de detection in vitro du rhesus d |
ES2938048T3 (es) | 2013-07-24 | 2023-04-04 | Streck Llc | Composiciones y procedimientos para estabilizar las células tumorales circulantes |
US10732182B2 (en) | 2013-08-01 | 2020-08-04 | Eutropics Pharmaceuticals, Inc. | Method for predicting cancer sensitivity |
US10577655B2 (en) | 2013-09-27 | 2020-03-03 | Natera, Inc. | Cell free DNA diagnostic testing standards |
WO2015048535A1 (en) | 2013-09-27 | 2015-04-02 | Natera, Inc. | Prenatal diagnostic resting standards |
US10262755B2 (en) | 2014-04-21 | 2019-04-16 | Natera, Inc. | Detecting cancer mutations and aneuploidy in chromosomal segments |
ES2968644T3 (es) | 2013-10-04 | 2024-05-13 | Sequenom Inc | Métodos y procedimientos para la evaluación no invasiva de variaciones genéticas |
JP6680680B2 (ja) | 2013-10-07 | 2020-04-15 | セクエノム, インコーポレイテッド | 染色体変化の非侵襲性評価のための方法およびプロセス |
JP6538044B2 (ja) | 2013-10-30 | 2019-07-03 | ユートロピクス ファーマシューティカルズ, インコーポレイテッド | 化学療法感受性および化学毒性を判定する方法 |
CN105829589B (zh) | 2013-11-07 | 2021-02-02 | 小利兰·斯坦福大学理事会 | 用于分析人体微生物组及其组分的无细胞核酸 |
EP2876442A1 (en) * | 2013-11-22 | 2015-05-27 | Institut de Cancérologie de l'Ouest | Olfactomedin-4, neudesin and desmoplakin as biomarkers of breast cancer |
US20160304968A1 (en) * | 2013-12-02 | 2016-10-20 | Oncomed Pharmaceuticals, Inc. | Identification of Predictive Biomarkers Associated With WNT Pathway Inhibitors |
WO2015134787A2 (en) | 2014-03-05 | 2015-09-11 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
EP3736344A1 (en) | 2014-03-13 | 2020-11-11 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
EP3957749A1 (en) | 2014-04-21 | 2022-02-23 | Natera, Inc. | Detecting tumour specific mutations in biopsies with whole exome sequencing and in cell-free samples |
US10133996B2 (en) * | 2014-04-22 | 2018-11-20 | International Business Machines Corporation | Object lifecycle analysis tool |
EP3175000B1 (en) | 2014-07-30 | 2020-07-29 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
EP3693742B1 (en) | 2014-09-11 | 2022-04-06 | Harry Stylli | Methods of detecting prostate cancer |
CA2966201A1 (en) | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
US10793915B2 (en) | 2015-01-12 | 2020-10-06 | Eutropics Pharmaceuticals, Inc. | Context dependent diagnostics test for guiding cancer treatment |
US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
US11168351B2 (en) | 2015-03-05 | 2021-11-09 | Streck, Inc. | Stabilization of nucleic acids in urine |
RU2717829C2 (ru) | 2015-04-20 | 2020-03-26 | Толеро Фармасьютикалз, Инк. | Прогнозирование ответа на альвоцидиб с помощью анализа профиля митохондрий |
WO2016183106A1 (en) | 2015-05-11 | 2016-11-17 | Natera, Inc. | Methods and compositions for determining ploidy |
TR201911032T4 (tr) | 2015-05-18 | 2019-08-21 | Tolero Pharmaceuticals Inc | Artırılmış biyoyararlanıma sahip alvocıdıb ön ilaçları. |
US11130986B2 (en) | 2015-05-20 | 2021-09-28 | Quantum-Si Incorporated | Method for isolating target nucleic acid using heteroduplex binding proteins |
EP3298166B1 (en) | 2015-05-22 | 2020-02-12 | Nipd Genetics Public Company Limited | Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing |
DE102015111329B4 (de) | 2015-07-13 | 2017-02-02 | Bernd-Peter Ernst | Verfahren zum Bestimmen einer relativen Häufigkeit von verschiedenen Genen oder Chromosomen eines Genoms in einer Probe |
JP7083497B2 (ja) | 2015-08-03 | 2022-06-13 | スミトモ ファーマ オンコロジー, インコーポレイテッド | がんの処置のための併用療法 |
US10323280B2 (en) | 2015-10-16 | 2019-06-18 | Inguran, Llc | Methods of genomic evaluation in livestock |
US11377687B2 (en) | 2015-10-16 | 2022-07-05 | Inguran, Llc | Methods of genomic evaluation in livestock |
US20170145475A1 (en) | 2015-11-20 | 2017-05-25 | Streck, Inc. | Single spin process for blood plasma separation and plasma composition including preservative |
WO2017123741A1 (en) | 2016-01-12 | 2017-07-20 | Institute For Myeloma & Bone Cancer Research | Improved methods for monitoring immune status of a subject |
US11708574B2 (en) | 2016-06-10 | 2023-07-25 | Myriad Women's Health, Inc. | Nucleic acid sequencing adapters and uses thereof |
WO2018002147A1 (en) | 2016-06-30 | 2018-01-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Detection of borealin mutations for diagnosing thyroid dysgenesis |
EP3491560A1 (en) | 2016-07-27 | 2019-06-05 | Sequenom, Inc. | Genetic copy number alteration classifications |
WO2018022991A1 (en) | 2016-07-29 | 2018-02-01 | Streck, Inc. | Suspension composition for hematology analysis control |
CA3037366A1 (en) | 2016-09-29 | 2018-04-05 | Myriad Women's Health, Inc. | Noninvasive prenatal screening using dynamic iterative depth optimization |
US11485996B2 (en) | 2016-10-04 | 2022-11-01 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
US11274349B2 (en) | 2016-11-08 | 2022-03-15 | Cedars-Sinai Medical Center | Methods for diagnosing cancer |
US11279694B2 (en) | 2016-11-18 | 2022-03-22 | Sumitomo Dainippon Pharma Oncology, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
CA3047557A1 (en) | 2016-12-19 | 2018-06-28 | Tolero Pharmaceuticals, Inc. | Profiling peptides and methods for sensitivity profiling |
GB2559319B (en) | 2016-12-23 | 2019-01-16 | Cs Genetics Ltd | Reagents and methods for the analysis of linked nucleic acids |
WO2018140521A1 (en) | 2017-01-24 | 2018-08-02 | Sequenom, Inc. | Methods and processes for assessment of genetic variations |
EP3585889A1 (en) | 2017-02-21 | 2020-01-01 | Natera, Inc. | Compositions, methods, and kits for isolating nucleic acids |
CA3057589A1 (en) | 2017-03-24 | 2018-09-27 | Counsyl, Inc. | Copy number variant caller |
WO2018231944A1 (en) | 2017-06-13 | 2018-12-20 | Berenson James R | Diagnostic, prognostic, and monitoring methods for solid tumor cancers |
SK862017A3 (sk) | 2017-08-24 | 2020-05-04 | Grendar Marian Doc Mgr Phd | Spôsob použitia fetálnej frakcie a chromozómovej reprezentácie pri určovaní aneuploidného stavu v neinvazívnom prenatálnom testovaní |
WO2019055579A1 (en) | 2017-09-12 | 2019-03-21 | Tolero Pharmaceuticals, Inc. | TREATMENT REGIME FOR CANCERS THAT ARE INSENSITIVE TO BCL-2 INHIBITORS USING THE MCL-1 ALVOCIDIB INHIBITOR |
CA3080117A1 (en) | 2017-10-27 | 2019-05-02 | Juno Diagnostics, Inc. | Devices, systems and methods for ultra-low volume liquid biopsy |
WO2019229113A1 (en) | 2018-05-30 | 2019-12-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Detection of tubb1 mutations for diagnosing thyroid dysgenesis |
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US11525159B2 (en) | 2018-07-03 | 2022-12-13 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
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GB201909325D0 (en) | 2019-06-28 | 2019-08-14 | Cs Genetics Ltd | Reagents and methods for analysis for microparticles |
GB202010970D0 (en) | 2020-07-16 | 2020-09-02 | Immunovia Ab | Methods, arrays and uses thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991008304A1 (en) * | 1989-11-24 | 1991-06-13 | Isis Innovation Limited | Prenatal genetic determination |
WO1995006137A1 (en) * | 1993-08-27 | 1995-03-02 | Australian Red Cross Society | Detection of genes |
CH686982A5 (fr) | 1993-12-16 | 1996-08-15 | Maurice Stroun | Méthode pour le diagnostic de cancers. |
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JP2015142588A (ja) * | 2007-07-23 | 2015-08-06 | ザ チャイニーズ ユニバーシティー オブ ホンコン | ゲノム配列決定を使用する胎児染色体異数性の診断 |
JP2017148073A (ja) * | 2007-07-23 | 2017-08-31 | ザ チャイニーズ ユニバーシティー オブ ホンコン | ゲノム配列決定を使用する胎児染色体異数性の診断 |
JP2019000113A (ja) * | 2007-07-23 | 2019-01-10 | ザ チャイニーズ ユニバーシティー オブ ホンコン | ゲノム配列決定を使用する胎児染色体異数性の診断 |
JP2020115887A (ja) * | 2007-07-23 | 2020-08-06 | ザ チャイニーズ ユニバーシティー オブ ホンコン | ゲノム配列決定を使用する胎児染色体異数性の診断 |
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JP2014507134A (ja) * | 2011-01-05 | 2014-03-27 | ザ・チャイニーズ・ユニバーシティー・オブ・ホンコン | 胎児の性染色体遺伝子型の非侵襲的出生前同定 |
US10152568B2 (en) | 2011-01-05 | 2018-12-11 | The Chinese University Of Hong Kong | Noninvasive prenatal genotyping of fetal sex chromosomes |
KR101256206B1 (ko) * | 2012-03-02 | 2013-04-19 | 의료법인 제일의료재단 | 태아의 성별 결정을 위한 분석방법 및 장치 |
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EP0994963B1 (en) | 2003-05-14 |
ES2198700T3 (es) | 2004-02-01 |
DK0994963T4 (da) | 2012-07-02 |
CA2282793A1 (en) | 1998-09-11 |
PT994963E (pt) | 2003-08-29 |
AU6507498A (en) | 1998-09-22 |
US6258540B1 (en) | 2001-07-10 |
JP4245666B2 (ja) | 2009-03-25 |
DK0994963T3 (da) | 2003-09-15 |
GB9704444D0 (en) | 1997-04-23 |
DE69814639T3 (de) | 2012-09-13 |
WO1998039474A1 (en) | 1998-09-11 |
EP0994963A1 (en) | 2000-04-26 |
AU727919B2 (en) | 2001-01-04 |
CA2282793C (en) | 2010-10-12 |
ES2198700T5 (es) | 2012-07-31 |
DE69814639D1 (de) | 2003-06-18 |
HK1026720A1 (en) | 2000-12-22 |
DE69814639T2 (de) | 2004-03-25 |
EP0994963B2 (en) | 2012-06-06 |
ATE240409T1 (de) | 2003-05-15 |
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