JP2001504936A - マイクロ製造される拡散ベースの化学センサ - Google Patents
マイクロ製造される拡散ベースの化学センサInfo
- Publication number
- JP2001504936A JP2001504936A JP53711297A JP53711297A JP2001504936A JP 2001504936 A JP2001504936 A JP 2001504936A JP 53711297 A JP53711297 A JP 53711297A JP 53711297 A JP53711297 A JP 53711297A JP 2001504936 A JP2001504936 A JP 2001504936A
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.サンプルストリーム中の分析物粒子の存在を検出するチャネルセルシステム であって、 a)層流チャネルと、 b)該層流チャネルに、それぞれ(1)インジケータストリームと、(2)該 サンプルストリームとを案内する、該層流チャネルと流体連通している少なくと も2つの入口手段であって、 c)該層流チャネルが該ストリームの層流を可能にするに十分小さい深さと、 該分析物の粒子が該インジケータストリーム中に拡散して該サンプルストリーム 中の相対的に大きな粒子を実質的に排除することを可能にするに十分な長さとを 有し、それにより検出領域を形成する、入口手段と、 d)該ストリームを該層流チャネルから出るように案内して単一の混合ストリ ームを形成する出口手段と、 を含む、チャネルセルシステム。 2.前記分析物粒子との接触の結果、前記インジケータストリーム中に担持され たインジケータ物質内の変化を検出する蛍光検出器をさらに含む、請求項1に記 載のシステム。 3.試料ストリームを前記層流チャネルの長さに沿って、連続的間隔で前記イン ジケータストリームから出るように案内する手段と、該試料ストリームの各々中 の該インジケータストリームからシグナルを測定する手段とを含み、それにより 前記サンプルストリーム中の前記分析物の濃度が決定され得る、請求項1に記載 のシステム。 4.前記層流チャネルと流体連通しているV溝チャネルをさらに含む、請求項1 に記載のチャネルセルシステム。 5.前記層流チャネルと流体連通しているシースフローモジュールをさらに含む 、請求項1に記載のチャネルセルシステム。 6.前記インジケータストリームがレポータービーズを含む、請求項1に記載の チャネルセルシステム。 7.前記層流チャネルが回旋する、請求項1に記載のチャネルセルシステム。 8.分析物検出領域を含む、請求項1に記載のチャネルセルシステム。 9.前記層流チャネルと流体連通しており、それにより溶解した粒子と溶解して いない粒子との両方を検出する、少なくとも1つの分岐フローチャネルをさらに 含む、請求項1に記載のチャネルセルシステム。 10.前記サンプルストリーム中の前記分析物粒子の存在を伝達により検出する 、基板内に形成された、請求項1に記載のチャネルセルシステムであって、 (a)前記入口手段と前記出口手段との間の分析物検出領域と、 (b)該基板の両側にシールされた光学的に透明な板と、 を含み、 (c)該分析物検出領域が、該基板の幅方向を横切る空間において、該透明板 間に存在する、システム。 11.請求項1に記載のシステムを用いて、サンプルストリーム中の分析物粒子 の存在を検出する方法であって、 a)該サンプルストリームを層流チャネルに案内する工程と、 b)インジケータストリームを該層流チャネルに案内し、該サンプルストリー ムと該インジケータストリームとが該チャネル内において隣接する層流ストリー ム中で流れるようにする工程と、 c)該分析物粒子が該インジケータストリーム中に拡散することを可能にする 工程と、 d)該インジケータストリーム中の該分析物粒子の存在を検出する工程と、 を含む、方法。 12.前記インジケータストリームが、前記分析物粒子に接触したときに、検出 可能な特性の変化により該分析物粒子の存在を示すインジケータ物質を含み、前 記検出工程が該インジケータ物質の特性の変化を検出することを含む、請求項1 1に記載の方法。 13.請求項8に記載のチャネルセルを用いて反応のための動力学的速度定数を 決定する方法であって、 (a)前記サンプルストリームと前記インジケータストリームとを、入口を有 する前記層流チャネルに案内する工程と、 (b)前記分析物粒子が該インジケータストリーム中に拡散することを可能に して、分析物検出領域を形成する工程と、 (c)該入口から公知の距離において、該インジケータストリーム中の該分析 物の存在を検出する工程と、 を含む、方法。
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US08/625,808 US5716852A (en) | 1996-03-29 | 1996-03-29 | Microfabricated diffusion-based chemical sensor |
PCT/US1997/005245 WO1997039338A1 (en) | 1996-03-29 | 1997-03-31 | Microfabricated diffusion-based chemical sensor |
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US (2) | US5716852A (ja) |
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Also Published As
Publication number | Publication date |
---|---|
US5716852A (en) | 1998-02-10 |
DE69724943D1 (de) | 2003-10-23 |
EP0890094A4 (en) | 1999-10-06 |
JP2007292773A (ja) | 2007-11-08 |
WO1997039338A1 (en) | 1997-10-23 |
EP0890094A1 (en) | 1999-01-13 |
US5972710A (en) | 1999-10-26 |
DE69724943T2 (de) | 2004-07-15 |
EP0890094B1 (en) | 2003-09-17 |
AU3877797A (en) | 1997-11-07 |
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