JP4870571B2 - サンプルの流れの位置決め法及び該方法を用いた分析システム - Google Patents
サンプルの流れの位置決め法及び該方法を用いた分析システム Download PDFInfo
- Publication number
- JP4870571B2 JP4870571B2 JP2006543771A JP2006543771A JP4870571B2 JP 4870571 B2 JP4870571 B2 JP 4870571B2 JP 2006543771 A JP2006543771 A JP 2006543771A JP 2006543771 A JP2006543771 A JP 2006543771A JP 4870571 B2 JP4870571 B2 JP 4870571B2
- Authority
- JP
- Japan
- Prior art keywords
- flow
- fluid
- interface
- sample
- induction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/274—Calibration, base line adjustment, drift correction
- G01N21/276—Calibration, base line adjustment, drift correction with alternation of sample and standard in optical path
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
- G01N2021/058—Flat flow cell
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
Landscapes
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Mathematical Physics (AREA)
- Theoretical Computer Science (AREA)
- Engineering & Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Optical Measuring Cells (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Description
a)第一の誘導流体の層流とそれに隣接する第一の誘導流体とは異なる第二の誘導流体の層流とを、それら2種類の流体の流れが互いに検出可能な界面を伴って一緒に上記表面の上を流れるように用意する工程、
b)上記2種類の誘導流体の間の界面を検出する工程、
c)必要に応じて、上記2種類の誘導流体の相対流速を調節することによって上記界面の横方向位置を所望の位置に調節する工程、及び
d)上記2種類の誘導流体の間にサンプル流体の流れが挟まれるように、第一の誘導流体の層流と第二の誘導流体の層流の間にサンプル流体の層流を導入する工程
を含む方法を提供する。
フローセル内の表面上のサンプル流体の層流を位置決めする方法であって、該方法は、以下
A.較正手順であって、以下の工程:
a)第一の誘導流体の層流とそれに隣接する第一の誘導流体とは異なる第二の誘導流体の層流とを、それら2種類の流体の流れが互いに検出可能な界面を伴って一緒に上記表面の上を流れるように用意する工程、
b)上記2種類の誘導流体の間の界面を検出する工程、
c)必要に応じて、上記2種類の誘導流体の相対流速を調節することによって上記界面の横方向位置を所望の位置に調節する工程、
d)上記界面の位置に対応する流れ関連設定を保存する工程、及び
e)上記界面の2以上の異なる規定位置についての流れ関連設定を得るために、必要に応じて、工程c)及び工程d)を繰り返す工程
を含む手順と、
B.サンプル導入手順であって、以下の工程:
f)上記界面が規定位置にある状態で2種類の誘導流体(好ましくは、手順Aにおいて使用される第一の誘導流体及び第二の誘導流体)の層流を得るために、較正流れ関連設定を上記2種類の誘導流体に適用する工程、
g)上記サンプル流体の流れが上記誘導流体の間に挟まれるように、上記2種類の誘導流体の層流の間に上記サンプル流体の層流を導入する工程;及び
h)必要に応じて、上記界面が異なる規定位置にある状態で少なくとも1回工程f)及び工程g)を繰り返す工程
を含む手順と
を含む。
Claims (9)
- フローセル内の表面でサンプル流体の層流を位置決めする方法であって、当該方法が、
a)第一の誘導流体の層流とそれに隣接する第一の誘導流体とは異なる第二の誘導流体の層流とを、それら2種類の流体の流れが互いに検出可能な界面を伴って一緒に上記表面の上を流れるように用意する工程と、
b)上記2種類の誘導流体の間の界面を検出する工程と、
c)上記2種類の誘導流体の相対流速を調節することによって上記界面の横方向位置を所望の位置に調節する工程と、
d)上記2種類の誘導流体の間にサンプル流体の流れが挟まれるように、第一の誘導流体の層流と第二の誘導流体の層流の間にサンプル流体の層流を導入する工程と
を含む、方法。 - サンプル流体の流れの幅を、それぞれの誘導流体との界面の位置を検出し、サンプル流体の相対流速の調節によって界面を横方向に変位させることによって制御する、請求項1記載の方法。
- 前記サンプル流体の流れを導入する際に、前記フローセルを流れる合計流速を一定に保つ、請求項1又は請求項2記載の方法。
- 前記2種類の誘導流体が異なる屈折率を有し、前記界面の位置が屈折率の変化によって検出される、請求項1乃至請求項3のいずれか1項記載の方法。
- 前記界面の位置がエバネセント波ベースのセンシングによって検出される、請求項4記載の方法。
- 前記フローセルがΨ型である、請求項1乃至請求項5のいずれか1項記載の方法。
- 前記工程c)の後に、前記界面の位置に対応する流れ関連設定を保存する、請求項1乃至請求項6のいずれか1項記載の方法。
- 前記界面の2以上の異なる規定位置について、較正流れ関連設定を得るため工程b)〜工程c)を少なくとも1回繰り返す、請求項7記載の方法。
- 前記工程d)を行う前に、界面が所望の規定位置にある層流を得るために第一の誘導流体及び第二の誘導流体に対する較正流れ関連設定を適用し、異なる規定位置の界面で工程d)を少なくとも1回繰り返す、請求項8記載の方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52895003P | 2003-12-10 | 2003-12-10 | |
SE0303319-8 | 2003-12-10 | ||
SE0303319A SE0303319D0 (sv) | 2003-12-10 | 2003-12-10 | Sample flow positioning method and analytical system using the method |
US60/528,950 | 2003-12-10 | ||
PCT/SE2004/001825 WO2005057186A1 (en) | 2003-12-10 | 2004-12-08 | Sample flow positioning method and analytical system using the method |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2007514161A JP2007514161A (ja) | 2007-05-31 |
JP2007514161A5 JP2007514161A5 (ja) | 2011-05-26 |
JP4870571B2 true JP4870571B2 (ja) | 2012-02-08 |
Family
ID=34680754
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006543771A Expired - Fee Related JP4870571B2 (ja) | 2003-12-10 | 2004-12-08 | サンプルの流れの位置決め法及び該方法を用いた分析システム |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1692488B1 (ja) |
JP (1) | JP4870571B2 (ja) |
AT (1) | ATE517329T1 (ja) |
AU (1) | AU2004297498B2 (ja) |
WO (1) | WO2005057186A1 (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012102663A1 (en) * | 2011-01-24 | 2012-08-02 | Ge Healthcare Bio-Sciences Ab | Method of coupling binding agents to a substrate surface |
WO2015089092A1 (en) * | 2013-12-10 | 2015-06-18 | Illumina, Inc. | Biosensors for biological or chemical analysis and methods of manufacturing the same |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001504936A (ja) * | 1996-03-29 | 2001-04-10 | ユニバーシティ オブ ワシントン | マイクロ製造される拡散ベースの化学センサ |
JP2002509248A (ja) * | 1998-01-20 | 2002-03-26 | バイアコア アーベー | 感知面における層流のための方法および装置 |
JP2002539918A (ja) * | 1999-03-24 | 2002-11-26 | トルサナ バイオセンサー アクティーゼルスカブ | 固体表面上の空間的に向けられた相互作用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63262565A (ja) * | 1987-04-20 | 1988-10-28 | Hitachi Ltd | フロ−セル |
-
2004
- 2004-12-08 AU AU2004297498A patent/AU2004297498B2/en not_active Ceased
- 2004-12-08 WO PCT/SE2004/001825 patent/WO2005057186A1/en active Application Filing
- 2004-12-08 EP EP04801730A patent/EP1692488B1/en active Active
- 2004-12-08 JP JP2006543771A patent/JP4870571B2/ja not_active Expired - Fee Related
- 2004-12-08 AT AT04801730T patent/ATE517329T1/de not_active IP Right Cessation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001504936A (ja) * | 1996-03-29 | 2001-04-10 | ユニバーシティ オブ ワシントン | マイクロ製造される拡散ベースの化学センサ |
JP2002509248A (ja) * | 1998-01-20 | 2002-03-26 | バイアコア アーベー | 感知面における層流のための方法および装置 |
JP2002539918A (ja) * | 1999-03-24 | 2002-11-26 | トルサナ バイオセンサー アクティーゼルスカブ | 固体表面上の空間的に向けられた相互作用 |
Also Published As
Publication number | Publication date |
---|---|
AU2004297498A1 (en) | 2005-06-23 |
AU2004297498B2 (en) | 2009-10-01 |
ATE517329T1 (de) | 2011-08-15 |
EP1692488A1 (en) | 2006-08-23 |
JP2007514161A (ja) | 2007-05-31 |
EP1692488B1 (en) | 2011-07-20 |
WO2005057186A1 (en) | 2005-06-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US9316636B2 (en) | Method and system for determination of molecular interaction parameters | |
US9958438B2 (en) | Multi-channel flowcell | |
EP1631824B1 (en) | Method and system for determination of molecular interaction parameters | |
US11796536B2 (en) | Method for determining analyte-ligand binding on a sensor surface | |
US10545090B2 (en) | Method and system for more reliable determination of interaction parameters for low affinity analytes | |
US7219528B2 (en) | Sample flow positioning method and analytical system using the method | |
CN107110842B (zh) | 确定溶剂校正曲线的方法 | |
US10151694B2 (en) | Method and system for sensor response curve evaluation | |
JP4870571B2 (ja) | サンプルの流れの位置決め法及び該方法を用いた分析システム | |
JP2007514161A5 (ja) | ||
EP3161454B1 (en) | Normalization of mass transport properties on optical sensor surfaces |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20070823 |
|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20070906 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20071206 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A712 Effective date: 20080618 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100831 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20101130 |
|
RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20101130 |
|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20101130 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20101224 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20101207 |
|
A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20110228 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110324 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110407 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20111018 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20111117 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20141125 Year of fee payment: 3 |
|
LAPS | Cancellation because of no payment of annual fees |