JP2001503780A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2001503780A5 JP2001503780A5 JP1998523200A JP52320098A JP2001503780A5 JP 2001503780 A5 JP2001503780 A5 JP 2001503780A5 JP 1998523200 A JP1998523200 A JP 1998523200A JP 52320098 A JP52320098 A JP 52320098A JP 2001503780 A5 JP2001503780 A5 JP 2001503780A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- recipients
- hydrochloride
- graft
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940126062 Compound A Drugs 0.000 description 4
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000000203 mixture Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical group N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- KKGQTZUTZRNORY-UHFFFAOYSA-N fingolimod Chemical compound CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 KKGQTZUTZRNORY-UHFFFAOYSA-N 0.000 description 1
- SWZTYAVBMYWFGS-UHFFFAOYSA-N fingolimod hydrochloride Chemical compound Cl.CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 SWZTYAVBMYWFGS-UHFFFAOYSA-N 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9624038.7 | 1996-11-19 | ||
| GBGB9624038.7A GB9624038D0 (en) | 1996-11-19 | 1996-11-19 | Organic compounds |
| PCT/EP1997/006408 WO1998022100A2 (en) | 1996-11-19 | 1997-11-17 | New use for 1,3-propanediol derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004152002A Division JP2004256554A (ja) | 1996-11-19 | 2004-05-21 | １，３−プロパンジオール誘導体の新しい用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001503780A JP2001503780A (ja) | 2001-03-21 |
| JP2001503780A5 true JP2001503780A5 (https=) | 2007-08-30 |
| JP4004070B2 JP4004070B2 (ja) | 2007-11-07 |
Family
ID=10803173
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52320098A Expired - Fee Related JP4004070B2 (ja) | 1996-11-19 | 1997-11-17 | １，３―プロパンジオール誘導体の新しい用途 |
| JP2004152002A Pending JP2004256554A (ja) | 1996-11-19 | 2004-05-21 | １，３−プロパンジオール誘導体の新しい用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004152002A Pending JP2004256554A (ja) | 1996-11-19 | 2004-05-21 | １，３−プロパンジオール誘導体の新しい用途 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US6274629B1 (https=) |
| EP (2) | EP0941082B1 (https=) |
| JP (2) | JP4004070B2 (https=) |
| CN (2) | CN1293876C (https=) |
| AT (2) | ATE369846T1 (https=) |
| AU (1) | AU728420B2 (https=) |
| BR (1) | BR9713105A (https=) |
| CA (1) | CA2270952C (https=) |
| CZ (1) | CZ174999A3 (https=) |
| DE (2) | DE69738033T2 (https=) |
| DK (1) | DK1312359T3 (https=) |
| ES (2) | ES2227726T3 (https=) |
| GB (1) | GB9624038D0 (https=) |
| HU (1) | HUP0000343A3 (https=) |
| ID (1) | ID21568A (https=) |
| IL (1) | IL129824A (https=) |
| NO (1) | NO992259L (https=) |
| NZ (1) | NZ335629A (https=) |
| PL (1) | PL190348B1 (https=) |
| PT (2) | PT1312359E (https=) |
| RU (1) | RU2217136C2 (https=) |
| SI (1) | SI1312359T1 (https=) |
| SK (1) | SK284806B6 (https=) |
| WO (1) | WO1998022100A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1457478B1 (en) | 1998-11-11 | 2017-07-19 | Novartis AG | Production of 2-amino-2-[2-(4-alkyl-phenyl)ethyl]propane-1,3-diols |
| CN1411373A (zh) * | 1999-12-16 | 2003-04-16 | 特瓦制药工业有限公司 | 制备来氟米特的新方法和新晶形的来氟米特 |
| WO2002018395A1 (en) | 2000-08-31 | 2002-03-07 | Merck & Co., Inc. | Phosphate derivatives as immunoregulatory agents |
| ES2267993T3 (es) * | 2001-02-22 | 2007-03-16 | Novartis Ag | Uso de agentes de migracion acelerada de linfocitos para la fabricacion de un medicamento para el tratamiento de la funcion retardada del injerto. |
| CN1507451A (zh) * | 2001-04-20 | 2004-06-23 | �±Ȱ·�ķ�ɷ�����˾ | 可用作前体药物的修饰环孢菌素及其应用 |
| ES2322442T3 (es) * | 2001-06-08 | 2009-06-22 | Novartis Ag | Tratamiento o profilaxis del rechazo de injertos de celulas productoras de insulina. |
| GB0117921D0 (en) * | 2001-07-23 | 2001-09-12 | Novartis Ag | Organic compounds |
| US7780993B2 (en) * | 2001-09-07 | 2010-08-24 | Yeda Research And Development Co. Ltd. | Therapeutic transplantation using developing, human or porcine, renal or hepatic, grafts |
| US20040136972A1 (en) * | 2001-09-07 | 2004-07-15 | Yeda Research And Development Co. Ltd. | Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues |
| GB0125443D0 (en) | 2001-10-23 | 2001-12-12 | Novartis Ag | Organic Compounds |
| BR0306811A (pt) | 2002-01-11 | 2004-10-26 | Sankyo Co | Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero |
| GB0217777D0 (en) * | 2002-07-31 | 2002-09-11 | Novartis Ag | Organic compounds |
| IL165425A0 (en) * | 2004-11-28 | 2006-01-15 | Yeda Res & Dev | Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues |
| CA2521325C (en) | 2003-04-08 | 2010-09-14 | Novartis Ag | Solid pharmaceutical compositions comprising a s1p receptor agonist and a sugar alcohol |
| EP1484057A1 (en) * | 2003-06-06 | 2004-12-08 | Aventis Pharma Deutschland GmbH | Use of 2-amino-1-3-propanediol derivatives for the manufacture of a medicament for the treatment of various types of pain |
| US7524887B2 (en) | 2003-06-06 | 2009-04-28 | Sanofi-Aventis Deutschland Gmbh | 2-amino-1,3-propanediol compounds for the treatment of acute pain |
| EP1643983B1 (en) * | 2003-06-24 | 2010-05-05 | The University of Connecticut | Methods of inhibiting vascular permeability and apoptosis |
| US7074659B2 (en) * | 2003-11-13 | 2006-07-11 | Volterra Semiconductor Corporation | Method of fabricating a lateral double-diffused MOSFET (LDMOS) transistor |
| JP2005272453A (ja) | 2004-02-24 | 2005-10-06 | Sankyo Co Ltd | アミノアルコール化合物 |
| MX2007001236A (es) * | 2004-07-30 | 2007-03-23 | Novartis Ag | Formulaciones de compuestos de 2-amino-1, 3-propanodiol. |
| KR101346527B1 (ko) * | 2005-12-15 | 2013-12-31 | 미쓰비시 타나베 파마 코퍼레이션 | 아민 화합물 및 그 의약 용도 |
| AR085749A1 (es) | 2011-04-01 | 2013-10-23 | Novartis Ag | Formulaciones |
| RU2496486C1 (ru) | 2012-07-11 | 2013-10-27 | Александр Васильевич Иващенко | Фармацевтическая композиция с улучшенной сыпучестью, лекарственное средство, способ получения и применение |
| US9815772B2 (en) * | 2013-03-05 | 2017-11-14 | Biocon Limited | Process for the preparation of 2-amino-1,3-propane diol compounds and salts thereof |
| US20180250235A1 (en) | 2015-09-18 | 2018-09-06 | Sanovel Ilac Sanayi Ve Ticaret A.S. | Fingolimod capsule composition |
| JP2024521882A (ja) * | 2021-05-31 | 2024-06-04 | 上海雲晟研新生物科技有限公司 | フィンゴリモド薬用塩、製造方法、それを含む医薬組成物及び使用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3904679A (en) * | 1972-05-23 | 1975-09-09 | Upjohn Co | 15-Methyl and 15-ethyl prostaglandin F{HD 2{331 {0 {B analogs |
| US6136310A (en) * | 1991-07-25 | 2000-10-24 | Idec Pharmaceuticals Corporation | Recombinant anti-CD4 antibodies for human therapy |
| CA2114015C (en) * | 1991-07-25 | 2002-12-10 | Roland A. Newman | Recombinant antibodies for human therapy |
| US5747034A (en) * | 1992-07-09 | 1998-05-05 | Chiron Corporation | Methods and materials for the induction of T cell anergy |
| GB9221220D0 (en) * | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| US5604229A (en) * | 1992-10-21 | 1997-02-18 | Yoshitomi Pharmaceutical Industries, Ltd. | 2-amino-1,3-propanediol compound and immunosuppressant |
| ES2230571T3 (es) | 1995-12-28 | 2005-05-01 | Mitsubishi Pharma Corporation | `composicion farmaceutica destinada para la administracion topica que comprende el 2-amino-2-(2-(4-octilfenil)etil) propan-1,3-diol para el tratamiento de las enfermedades causadas por una alteracion inmunitaria. |
| JP2002241272A (ja) * | 1996-07-18 | 2002-08-28 | Mitsubishi Pharma Corp | 医薬処方組成物 |
| US6476004B1 (en) * | 1996-07-18 | 2002-11-05 | Mitsubishi Pharma Corporation | Pharmaceutical composition |
| DE69840169D1 (de) * | 1997-02-27 | 2008-12-11 | Novartis Ag | Arzneimittel zubereitung enthaltend 2-amino-2-ä2-(4-octylphenyl)ethylüpropane-1,3-diol, ein lecithin und ein saccharid |
-
1996
- 1996-11-19 GB GBGB9624038.7A patent/GB9624038D0/en active Pending
-
1997
- 1997-11-17 CA CA002270952A patent/CA2270952C/en not_active Expired - Fee Related
- 1997-11-17 SK SK659-99A patent/SK284806B6/sk unknown
- 1997-11-17 PL PL97333463A patent/PL190348B1/pl not_active IP Right Cessation
- 1997-11-17 BR BR9713105-9A patent/BR9713105A/pt not_active Application Discontinuation
- 1997-11-17 ID IDW990370A patent/ID21568A/id unknown
- 1997-11-17 EP EP97951219A patent/EP0941082B1/en not_active Expired - Lifetime
- 1997-11-17 RU RU99112577/14A patent/RU2217136C2/ru not_active IP Right Cessation
- 1997-11-17 CN CNB2004100059961A patent/CN1293876C/zh not_active Expired - Fee Related
- 1997-11-17 DK DK02025422T patent/DK1312359T3/da active
- 1997-11-17 AT AT02025422T patent/ATE369846T1/de not_active IP Right Cessation
- 1997-11-17 SI SI9730772T patent/SI1312359T1/sl unknown
- 1997-11-17 US US09/308,098 patent/US6274629B1/en not_active Expired - Lifetime
- 1997-11-17 AU AU54831/98A patent/AU728420B2/en not_active Ceased
- 1997-11-17 ES ES97951219T patent/ES2227726T3/es not_active Expired - Lifetime
- 1997-11-17 HU HU0000343A patent/HUP0000343A3/hu unknown
- 1997-11-17 WO PCT/EP1997/006408 patent/WO1998022100A2/en not_active Ceased
- 1997-11-17 CZ CZ991749A patent/CZ174999A3/cs unknown
- 1997-11-17 JP JP52320098A patent/JP4004070B2/ja not_active Expired - Fee Related
- 1997-11-17 EP EP02025422A patent/EP1312359B1/en not_active Expired - Lifetime
- 1997-11-17 DE DE69738033T patent/DE69738033T2/de not_active Expired - Fee Related
- 1997-11-17 ES ES02025422T patent/ES2289041T3/es not_active Expired - Lifetime
- 1997-11-17 DE DE69730727T patent/DE69730727T2/de not_active Expired - Fee Related
- 1997-11-17 IL IL12982497A patent/IL129824A/xx not_active IP Right Cessation
- 1997-11-17 PT PT02025422T patent/PT1312359E/pt unknown
- 1997-11-17 NZ NZ335629A patent/NZ335629A/en unknown
- 1997-11-17 PT PT97951219T patent/PT941082E/pt unknown
- 1997-11-17 AT AT97951219T patent/ATE275947T1/de not_active IP Right Cessation
- 1997-11-17 CN CNB971998582A patent/CN1146411C/zh not_active Expired - Fee Related
-
1999
- 1999-05-10 NO NO992259A patent/NO992259L/no unknown
-
2001
- 2001-07-03 US US09/898,143 patent/US6486209B2/en not_active Expired - Fee Related
-
2002
- 2002-09-30 US US10/261,536 patent/US20030069315A1/en not_active Abandoned
-
2004
- 2004-05-21 JP JP2004152002A patent/JP2004256554A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2001503780A5 (https=) | ||
| LU90956I2 (fr) | Metvix principe actif méthylaminolevulinique sous forme d'un selde préférence l'hyhrochlorure méthylaminolevulinique | |
| AU684059B2 (en) | Application of riluzole in the treatment of Parkinson's disease and Parkinsonian syndromes | |
| GEP20043324B (en) | Purine Derivatives | |
| YU13695A (sh) | Upotreba 2-fenil-3-aroilbenzotiofena i njihove farmaceutske formulacije | |
| JP2002531505A5 (https=) | ||
| YU17700A (sh) | Oralne kompozicije levosimendana | |
| JP2002510633A5 (https=) | ||
| GEP20043383B (en) | Cell Adhesion-Inhibiting Antiinflammatory and Immune-Suppressive Compounds | |
| JP2002519425A5 (https=) | ||
| BR9914631A (pt) | Composição imunológica oral indutora de tolerância para prevenção e/ou tratamento de enfermidades e método para prevenção e/ou tratamento de enfermidades | |
| RU2002100058A (ru) | Кристаллические производные 1-метилкарбапенема | |
| CA2321547A1 (en) | Indole derivatives and medicinal compositions containing the same | |
| JP2002522501A5 (https=) | ||
| CA2389032A1 (en) | Preventive or therapeutic agents for inflammatory diseases of intestine | |
| WO1999033450A3 (en) | Pharmaceutical composition containing sibutramine and orlistat | |
| IL128851A (en) | Pharmaceutical composition for lowering the uric acid level in the human body | |
| CA2320878A1 (fr) | Microgranules de sulfate de morphine, procede de fabrication et preparations pharmaceutiques | |
| CA2438509A1 (en) | Use of cyclohexenone derivatives for the manufacture of a medicament in the treatment of dysuria | |
| WO2000056315A8 (en) | Treatment of pain | |
| CA2217513A1 (en) | Pharmaceutical agents for the treatment of alzheimer's disease | |
| WO2001026641A3 (en) | Morpholinol derivatives for the treatment of obesity | |
| IE38655L (en) | Pharmaceutical compositions | |
| KR970061248A (ko) | 알츠하이머병 치료용 1, 1, 2-트리페닐부트-1-엔 유도체 | |
| CA2298493A1 (en) | Aminoethylphenoxyacetic acid derivatives and drugs for pain remission and calculi removal promotion in urinary lithiasis |