CN1146411C - 1,3-丙二醇衍生物的新用途 - Google Patents

1,3-丙二醇衍生物的新用途 Download PDF

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Publication number
CN1146411C
CN1146411C CNB971998582A CN97199858A CN1146411C CN 1146411 C CN1146411 C CN 1146411C CN B971998582 A CNB971998582 A CN B971998582A CN 97199858 A CN97199858 A CN 97199858A CN 1146411 C CN1146411 C CN 1146411C
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CN
China
Prior art keywords
formula
compound
pharmaceutically acceptable
recipient
rejection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB971998582A
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English (en)
Chinese (zh)
Other versions
CN1237906A (zh
Inventor
S
S·科藤斯
R·P·霍夫
R·温格
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Novartis AG
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Novartis AG
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Filing date
Publication date
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Publication of CN1237906A publication Critical patent/CN1237906A/zh
Application granted granted Critical
Publication of CN1146411C publication Critical patent/CN1146411C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/131—Amines acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/133—Amines having hydroxy groups, e.g. sphingosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Light Receiving Elements (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CNB971998582A 1996-11-19 1997-11-17 1,3-丙二醇衍生物的新用途 Expired - Fee Related CN1146411C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9624038.7A GB9624038D0 (en) 1996-11-19 1996-11-19 Organic compounds
GB9624038.7 1996-11-19

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB2004100059961A Division CN1293876C (zh) 1996-11-19 1997-11-17 1，3－丙二醇衍生物的新用途

Publications (2)

Publication Number Publication Date
CN1237906A CN1237906A (zh) 1999-12-08
CN1146411C true CN1146411C (zh) 2004-04-21

Family

ID=10803173

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB971998582A Expired - Fee Related CN1146411C (zh) 1996-11-19 1997-11-17 1,3-丙二醇衍生物的新用途
CNB2004100059961A Expired - Fee Related CN1293876C (zh) 1996-11-19 1997-11-17 1，3－丙二醇衍生物的新用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB2004100059961A Expired - Fee Related CN1293876C (zh) 1996-11-19 1997-11-17 1，3－丙二醇衍生物的新用途

Country Status (24)

Country Link
US (3) US6274629B1 (https=)
EP (2) EP0941082B1 (https=)
JP (2) JP4004070B2 (https=)
CN (2) CN1146411C (https=)
AT (2) ATE275947T1 (https=)
AU (1) AU728420B2 (https=)
BR (1) BR9713105A (https=)
CA (1) CA2270952C (https=)
CZ (1) CZ174999A3 (https=)
DE (2) DE69730727T2 (https=)
DK (1) DK1312359T3 (https=)
ES (2) ES2227726T3 (https=)
GB (1) GB9624038D0 (https=)
HU (1) HUP0000343A3 (https=)
ID (1) ID21568A (https=)
IL (1) IL129824A (https=)
NO (1) NO992259D0 (https=)
NZ (1) NZ335629A (https=)
PL (1) PL190348B1 (https=)
PT (2) PT941082E (https=)
RU (1) RU2217136C2 (https=)
SI (1) SI1312359T1 (https=)
SK (1) SK284806B6 (https=)
WO (1) WO1998022100A2 (https=)

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DK1129066T3 (da) 1998-11-11 2005-03-29 Novartis Ag Fremstilling af 2-amino-2-[2-(C2-20alkylphenyl)ethyl]propan-1,3-dioler
CN1411373A (zh) * 1999-12-16 2003-04-16 特瓦制药工业有限公司 制备来氟米特的新方法和新晶形的来氟米特
EP1315735A4 (en) 2000-08-31 2005-04-06 Merck & Co Inc Phosphate derivatives as immunoregulatory compounds
JP4318921B2 (ja) * 2001-02-22 2009-08-26 ノバルティス アクチエンゲゼルシャフト 移植片の機能発現遅延の処置のための医薬の製造のためのリンパ球ホーミング促進剤の使用
US6995139B2 (en) * 2001-04-20 2006-02-07 Debiopharm S.A. Cyclic undecapeptide pro-drugs and uses thereof
BR0209319A (pt) * 2001-06-08 2004-07-20 Novartis Ag Tratamento ou profilaxia de rejeição de enxerto de célula produtora de insulina
GB0117921D0 (en) * 2001-07-23 2001-09-12 Novartis Ag Organic compounds
US20040136972A1 (en) * 2001-09-07 2004-07-15 Yeda Research And Development Co. Ltd. Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues
US7780993B2 (en) * 2001-09-07 2010-08-24 Yeda Research And Development Co. Ltd. Therapeutic transplantation using developing, human or porcine, renal or hepatic, grafts
GB0125443D0 (en) * 2001-10-23 2001-12-12 Novartis Ag Organic Compounds
DK1471054T3 (da) 2002-01-11 2009-11-09 Daiichi Sankyo Co Ltd Aminoalkohol-derivat eller phosphonsyre-derivat og medicinsk sammensætning, der indeholder disse
GB0217777D0 (en) * 2002-07-31 2002-09-11 Novartis Ag Organic compounds
IL165425A0 (en) * 2004-11-28 2006-01-15 Yeda Res & Dev Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues
PE20130200A1 (es) 2003-04-08 2013-03-09 Novartis Ag Composicion farmaceutica que contiene un agonista del receptor s1p y un alcohol de azucar
US7524887B2 (en) 2003-06-06 2009-04-28 Sanofi-Aventis Deutschland Gmbh 2-amino-1,3-propanediol compounds for the treatment of acute pain
EP1484057A1 (en) * 2003-06-06 2004-12-08 Aventis Pharma Deutschland GmbH Use of 2-amino-1-3-propanediol derivatives for the manufacture of a medicament for the treatment of various types of pain
PL1643983T3 (pl) * 2003-06-24 2010-10-29 Univ Connecticut Sposoby hamowania przepuszczalności naczyń krwionośnych i apoptozy
US7074659B2 (en) * 2003-11-13 2006-07-11 Volterra Semiconductor Corporation Method of fabricating a lateral double-diffused MOSFET (LDMOS) transistor
NZ549162A (en) 2004-02-24 2009-12-24 Sankyo Co Amino-pyrrol alcohol compounds
PL1773307T3 (pl) * 2004-07-30 2015-03-31 Novartis Ag Preparaty 2-amino-1,3-propanodioli i ich analogów
BRPI0619894B8 (pt) * 2005-12-15 2021-05-25 Mitsubishi Tanabe Pharma Corp composto de amina e composição farmacêutica
AR085749A1 (es) 2011-04-01 2013-10-23 Novartis Ag Formulaciones
RU2496486C1 (ru) 2012-07-11 2013-10-27 Александр Васильевич Иващенко Фармацевтическая композиция с улучшенной сыпучестью, лекарственное средство, способ получения и применение
US9815772B2 (en) * 2013-03-05 2017-11-14 Biocon Limited Process for the preparation of 2-amino-1,3-propane diol compounds and salts thereof
US20180250235A1 (en) 2015-09-18 2018-09-06 Sanovel Ilac Sanayi Ve Ticaret A.S. Fingolimod capsule composition
CN115477590B (zh) * 2021-05-31 2023-12-12 上海云晟研新生物科技有限公司 芬戈莫德药用盐、制备方法、含其的药物组合物及应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904679A (en) * 1972-05-23 1975-09-09 Upjohn Co 15-Methyl and 15-ethyl prostaglandin F{HD 2{331 {0 {B analogs
ES2196002T3 (es) * 1991-07-25 2003-12-16 Idec Pharma Corp Anticuerpos recombinantes para terapia humana.
US6136310A (en) * 1991-07-25 2000-10-24 Idec Pharmaceuticals Corporation Recombinant anti-CD4 antibodies for human therapy
US5747034A (en) * 1992-07-09 1998-05-05 Chiron Corporation Methods and materials for the induction of T cell anergy
GB9221220D0 (en) * 1992-10-09 1992-11-25 Sandoz Ag Organic componds
DE69321823T2 (de) * 1992-10-21 1999-06-02 Taito Co., Ltd., Tokio/Tokyo 2-amino-1, 3- propandiolverbindung und immunosuppressium
WO1997024112A1 (en) * 1995-12-28 1997-07-10 Yoshitomi Pharmaceutical Industries, Ltd. External preparation
JP2002241272A (ja) * 1996-07-18 2002-08-28 Mitsubishi Pharma Corp 医薬処方組成物
US6476004B1 (en) * 1996-07-18 2002-11-05 Mitsubishi Pharma Corporation Pharmaceutical composition
KR20000075745A (ko) * 1997-02-27 2000-12-26 가마후라 아키오 의약 조성물

Also Published As

Publication number Publication date
ES2227726T3 (es) 2005-04-01
US20030069315A1 (en) 2003-04-10
EP1312359A3 (en) 2004-01-02
PL333463A1 (en) 1999-12-20
DE69738033T2 (de) 2008-04-30
SK65999A3 (en) 1999-12-10
SI1312359T1 (sl) 2008-08-31
CN1237906A (zh) 1999-12-08
HUP0000343A3 (en) 2001-06-28
PT1312359E (pt) 2007-11-09
RU2217136C2 (ru) 2003-11-27
GB9624038D0 (en) 1997-01-08
EP1312359B1 (en) 2007-08-15
ES2289041T3 (es) 2008-02-01
CN1293876C (zh) 2007-01-10
AU5483198A (en) 1998-06-10
ATE369846T1 (de) 2007-09-15
DK1312359T3 (da) 2007-10-08
JP2001503780A (ja) 2001-03-21
WO1998022100A2 (en) 1998-05-28
BR9713105A (pt) 2000-04-11
EP1312359A2 (en) 2003-05-21
HUP0000343A2 (hu) 2000-12-28
ID21568A (id) 1999-06-24
HK1022639A1 (en) 2000-08-18
PT941082E (pt) 2004-12-31
US6274629B1 (en) 2001-08-14
WO1998022100A3 (en) 1998-06-25
IL129824A (en) 2003-07-31
JP4004070B2 (ja) 2007-11-07
SK284806B6 (sk) 2005-11-03
JP2004256554A (ja) 2004-09-16
DE69730727D1 (de) 2004-10-21
CA2270952C (en) 2007-09-18
NO992259L (no) 1999-05-10
CZ174999A3 (cs) 1999-08-11
ATE275947T1 (de) 2004-10-15
CA2270952A1 (en) 1998-05-28
EP0941082B1 (en) 2004-09-15
DE69738033D1 (de) 2007-09-27
DE69730727T2 (de) 2005-09-22
NO992259D0 (no) 1999-05-10
EP0941082A2 (en) 1999-09-15
PL190348B1 (pl) 2005-11-30
IL129824A0 (en) 2000-02-29
CN1515253A (zh) 2004-07-28
US6486209B2 (en) 2002-11-26
AU728420B2 (en) 2001-01-11
US20010056124A1 (en) 2001-12-27
NZ335629A (en) 2001-09-28

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Legal Events

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C06 Publication
PB01 Publication
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20040421

Termination date: 20091217