JP2001501968A - 局所薬剤デリバリのためのゲル調合物 - Google Patents
局所薬剤デリバリのためのゲル調合物Info
- Publication number
- JP2001501968A JP2001501968A JP10525740A JP52574098A JP2001501968A JP 2001501968 A JP2001501968 A JP 2001501968A JP 10525740 A JP10525740 A JP 10525740A JP 52574098 A JP52574098 A JP 52574098A JP 2001501968 A JP2001501968 A JP 2001501968A
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- weight
- amount
- present
- imidazo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 93
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims abstract description 66
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 37
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- RXNTZIJLOZMJTM-UHFFFAOYSA-N 2-(2h-quinolin-1-yl)ethanol Chemical compound C1=CC=C2N(CCO)CC=CC2=C1 RXNTZIJLOZMJTM-UHFFFAOYSA-N 0.000 claims description 7
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- UZFMOKQJFYMBGY-UHFFFAOYSA-N 4-hydroxy-TEMPO Chemical compound CC1(C)CC(O)CC(C)(C)N1[O] UZFMOKQJFYMBGY-UHFFFAOYSA-N 0.000 claims 2
- 229910052710 silicon Inorganic materials 0.000 claims 2
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- HKIWBOKRKRFJNV-UHFFFAOYSA-N 2-imidazo[4,5-c]quinolin-1-ylethanol Chemical compound C1=CC=CC2=C3N(CCO)C=NC3=CN=C21 HKIWBOKRKRFJNV-UHFFFAOYSA-N 0.000 claims 1
- WGNUNYPERJMVRM-UHFFFAOYSA-N 3-pyridylacetic acid Chemical compound OC(=O)CC1=CC=CN=C1 WGNUNYPERJMVRM-UHFFFAOYSA-N 0.000 claims 1
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- 208000025009 anogenital human papillomavirus infection Diseases 0.000 description 3
- 201000004201 anogenital venereal wart Diseases 0.000 description 3
- 238000004166 bioassay Methods 0.000 description 3
- 238000012385 systemic delivery Methods 0.000 description 3
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 241000710188 Encephalomyocarditis virus Species 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
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- 229940042129 topical gel Drugs 0.000 description 2
- 239000012049 topical pharmaceutical composition Substances 0.000 description 2
- HQBUPOAKJGJGCD-UHFFFAOYSA-N 3h-imidazo[4,5-c]quinolin-4-amine Chemical compound NC1=NC2=CC=CC=C2C2=C1N=CN2 HQBUPOAKJGJGCD-UHFFFAOYSA-N 0.000 description 1
- 229910002012 Aerosil® Inorganic materials 0.000 description 1
- 229910002016 Aerosil® 200 Inorganic materials 0.000 description 1
- 239000004254 Ammonium phosphate Substances 0.000 description 1
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- 206010052428 Wound Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
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- 239000012190 activator Substances 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 229910000148 ammonium phosphate Inorganic materials 0.000 description 1
- 235000019289 ammonium phosphates Nutrition 0.000 description 1
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- 210000004748 cultured cell Anatomy 0.000 description 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
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- 238000010438 heat treatment Methods 0.000 description 1
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 229940100601 interleukin-6 Drugs 0.000 description 1
- 229940096397 interleukin-8 Drugs 0.000 description 1
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
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- 238000005259 measurement Methods 0.000 description 1
- PQLXHQMOHUQAKB-UHFFFAOYSA-N miltefosine Chemical compound CCCCCCCCCCCCCCCCOP([O-])(=O)OCC[N+](C)(C)C PQLXHQMOHUQAKB-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
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- 239000008250 pharmaceutical cream Substances 0.000 description 1
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- OJTDGPLHRSZIAV-UHFFFAOYSA-N propane-1,2-diol Chemical compound CC(O)CO.CC(O)CO OJTDGPLHRSZIAV-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 治療的に効果的な量の薬剤、コロイド状二酸化ケイ素、プロピレングリ コール、およびトリアセチンを含む調合物である薬剤の局所投与のためのゲル調 合物。 2. コロイド状二酸化ケイ素が、調合物の総重量を基準にして約7〜約12重 量%の量で存在する請求項1に記載のゲル調合物。 3. プロピレングリコールが、調合物の総重量を基準にして、約1〜約30重 量%の量で存在する請求項1に記載のゲル調合物。 4. プロピレングリコールが、調合物の総重量を基準にして約5〜約25重量 %の量で存在する請求項1に記載のゲル調合物。 5. トリアセチンが、調合物の総重量を基準にして約58〜約92重量%の量で 存在する請求項1に記載のゲル調合物。 6. 治療的に効果的な量の4-アミノ-2-エトキシメチル-α,α-ジメチル-1H- イミダゾ[4,5-c]キノリン-1-エタノールと、 コロイド状二酸化ケイ素と、 トリアセチンとを含む調合物である、 4-アミノ-2-エトキシメチル-α,α-ジメチル-1H-イミダゾ[4,5-c]キノリン-1-エ タノールの局所投与のためのゲル調合物。 7. プロピレングリコールをさらに含む請求項6に記載のゲル調合物。 8. 4-アミノ-2-エトキシメチル-α,α-ジメチル-1H-イミダゾ[4,5-c]キノ リン-1-エタノールが、調合物の総重量を基準にして約0.001〜約0.6重量%の量 で存在する請求項6に記載のゲル調合物 9. 4-アミノ-2-エトキシメチル-α,α-ジメチル-1H-イミダゾ[4,5.c]キノ リン-1-エタノールが、調合物の総重量を基準にして約0.01〜約0.5重量%の量で 存在する請求項6に記載のゲル調合物。 10. 4-アミノ-2-エトキシメチル-α,α-ジメチル-1H-イミダゾ[4,5-c]キノ リン-1-エタノールが、ゲル調合物中に溶解されている請求項6に記載のゲル調 合物。 11. コロイド状二酸化ケイ素が、調合物の総重量を基準にして約7〜約12重 量%の量で存在する請求項6に記載のゲル調合物。 12. コロイド状二酸化ケイ素が、調合物の総重量を基準にして約8〜約10重 量%の量で存在する請求項6に記載のゲル調合物。 13. トリアセチンが、調合物の総重量を基準にして約88〜約93重量%の量で 存在する請求項6に記載のゲル調合物。 14. トリアセチンが、調合物の総重量を基準にして約58〜約92重量%の量で 存在する請求項7に記載のゲル調合物。 15. (a) 治療的に効果的な量の4-アミノ-2-エトキシメチル-α,α-ジメ チル-1H-イミダゾ[4,5-c]キノリン-1-エタノールと、 (b) 調合物の総重量を基準にして、約7〜約12重量%の量で存在する コロイド状二酸化ケイ素と、 (c) 調合物の総重量を基準にして、約1〜約30重量%の量で存在する プロピレングリコールと、 (d) 調合物の総重量を基準にして、約58〜約92重量%の量で存在す るトリアセチンとを含む調合物である、 4-アミノ-2-エトキシメチル-α,α-ジメチル-1H-イミダゾ[4,5-c]キノリン-1-エ タノールの局所投与のためのゲル調合物。 16. プロピレングリコールが、調合物の総重量を基準にして約5〜約25重量 %の量で存在する請求項15に記載のゲル調合物。 17. 4-アミノ-2-エトキシメチル-α,α-ジメチル-1H-イミダゾ[4,5-c]キノ リン-1-エタノールが、調合物の総重量を基準にして約0.001〜約0.6重量%の量 で存在する請求項15に記載のゲル調合物。 18. 約0.05〜約0.3重量%の4-アミノ-2-エトキシメチル-α,α-ジメチル-1H -イミダゾ[4,5-c]キノリン-1-エタノール、約8〜約10重量%のコロイド状二酸化 ケイ素、および約90〜約92重量%のトリアセチンを含む請求項15に記載のゲル調 合物。 19. 約0.05〜約0.3重量%の4-アミノ-2-エトキシメチル-α,α-ジメチル-1H -イミダゾ[4,5.c]キノリン-1-エタノール、約8〜約10重量%のコロイド状二酸化 ケイ素、約15〜約25重量%のプロピレングリコール、および約65〜約77重量%の トリアセチンを含む請求項15に記載のゲル調合物。 20. ほ乳類の皮膚または粘膜に、4-アミノ-2-エトキシメチル-α,α-ジメチ ル-1H-イミダゾ[4,5-c]キノリン-1-エタノールを含む、サイトカイン誘導に効果 的な量のゲル調合物をつけるステップを含む、ほ乳類の皮膚または粘膜に局在性 にサイトカインを誘導する方法。 21. ほ乳類の皮膚または粘膜に、4-アミノ-2-エトキシメチル-α,α-ジメチ ル-1H-イミダゾ[4,5-c]キノリン-1-エタノールを含む、インターフェロン誘導に 効果的な量のゲル調合物をつけるステップを含む、ほ乳類の皮膚または粘膜に局 在性にインターフェロンを誘導する方法。 22. ほ乳類の皮膚または粘膜に、4-アミノ-2-エトキシメチル-α,α-ジメチ ル-1H-イミダゾ[4,5-c]キノリン-1-エタノールを含む、腫瘍壊死因子誘導に効果 的な量のゲル調合物をつけるステップを含む、ほ乳類の皮膚または粘膜に局在性 に腫瘍壊死因子を誘導する方法。 23. ゲル調合物が皮膚および/または粘膜上の病変に適用される請求項20に 記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US08/759,992 US5939090A (en) | 1996-12-03 | 1996-12-03 | Gel formulations for topical drug delivery |
US08/759,992 | 1996-12-03 | ||
PCT/US1997/021995 WO1998024436A2 (en) | 1996-12-03 | 1997-12-01 | Gel formulations for topical drug delivery |
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JP2001501968A true JP2001501968A (ja) | 2001-02-13 |
JP4615633B2 JP4615633B2 (ja) | 2011-01-19 |
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JP52574098A Expired - Fee Related JP4615633B2 (ja) | 1996-12-03 | 1997-12-01 | 局所薬剤デリバリのためのゲル調合物 |
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US (2) | US5939090A (ja) |
EP (1) | EP0942724B1 (ja) |
JP (1) | JP4615633B2 (ja) |
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1996
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KR20000069233A (ko) | 2000-11-25 |
PT942724E (pt) | 2003-12-31 |
HU229599B1 (hu) | 2014-02-28 |
AU5368698A (en) | 1998-06-29 |
US5939090A (en) | 1999-08-17 |
US6365166B2 (en) | 2002-04-02 |
EP0942724A2 (en) | 1999-09-22 |
BR9713677A (pt) | 2000-03-28 |
ATE245422T1 (de) | 2003-08-15 |
IL130065A (en) | 2004-06-20 |
ES2200206T3 (es) | 2004-03-01 |
KR100503716B1 (ko) | 2005-07-26 |
HUP0000568A2 (hu) | 2000-10-28 |
WO1998024436A3 (en) | 1998-08-06 |
EP0942724B1 (en) | 2003-07-23 |
DE69723721T2 (de) | 2004-04-15 |
CZ195599A3 (cs) | 1999-09-15 |
CA2273094C (en) | 2005-08-16 |
NZ335821A (en) | 2001-04-27 |
BR9713677B1 (pt) | 2009-05-05 |
WO1998024436A2 (en) | 1998-06-11 |
DK0942724T3 (da) | 2003-11-17 |
CZ301713B6 (cs) | 2010-06-02 |
JP4615633B2 (ja) | 2011-01-19 |
AU723897B2 (en) | 2000-09-07 |
NO992638D0 (no) | 1999-06-01 |
DE69723721D1 (de) | 2003-08-28 |
IL130065A0 (en) | 2000-02-29 |
US20020015715A1 (en) | 2002-02-07 |
NO992638L (no) | 1999-07-16 |
CA2273094A1 (en) | 1998-06-11 |
HUP0000568A3 (en) | 2001-01-29 |
NO325684B1 (no) | 2008-07-07 |
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