JP2001136982A5 - - Google Patents

Info

Publication number

JP2001136982A5

JP2001136982A5 JP2000257221A JP2000257221A JP2001136982A5 JP 2001136982 A5 JP2001136982 A5 JP 2001136982A5 JP 2000257221 A JP2000257221 A JP 2000257221A JP 2000257221 A JP2000257221 A JP 2000257221A JP 2001136982 A5 JP2001136982 A5 JP 2001136982A5

Authority

JP

Japan

Prior art keywords

microorganism

culture

acetylneuraminic acid

corynebacterium

genus

Prior art date

2000-08-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 244000005700 microbiome Species 0.000 claims description 26
• SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims description 11
• 238000000034 method Methods 0.000 claims description 9
• 241000186216 Corynebacterium Species 0.000 claims description 6
• SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 claims description 6
• 102000003960 Ligases Human genes 0.000 claims description 5
• 108090000364 Ligases Proteins 0.000 claims description 5
• LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims description 5
• 239000012736 aqueous medium Substances 0.000 claims description 5
• 229930029653 phosphoenolpyruvate Natural products 0.000 claims description 5
• DTBNBXWJWCWCIK-UHFFFAOYSA-N phosphoenolpyruvic acid Chemical compound OC(=O)C(=C)OP(O)(O)=O DTBNBXWJWCWCIK-UHFFFAOYSA-N 0.000 claims description 5
• 102000048245 N-acetylneuraminate lyases Human genes 0.000 claims description 4
• 108700023220 N-acetylneuraminate lyases Proteins 0.000 claims description 4
• OVRNDRQMDRJTHS-OZRXBMAMSA-N N-acetyl-beta-D-mannosamine Chemical compound CC(=O)N[C@@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-OZRXBMAMSA-N 0.000 claims description 3
• 238000004519 manufacturing process Methods 0.000 claims description 3
• 241000186145 Corynebacterium ammoniagenes Species 0.000 claims description 2
• 241000186226 Corynebacterium glutamicum Species 0.000 claims description 2
• 239000002609 medium Substances 0.000 claims description 2
• 108020004414 DNA Proteins 0.000 claims 8
• OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims 6
• OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims 6
• MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims 6
• 229950006780 n-acetylglucosamine Drugs 0.000 claims 6
• 241000588722 Escherichia Species 0.000 claims 5
• 241000235070 Saccharomyces Species 0.000 claims 2
• ZUQUTHURQVDNKF-WZPXOXCRSA-N 1-[(3S,4R,5S,6R)-3-amino-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]ethanone Chemical compound C(C)(=O)C1(O)[C@@H](N)[C@@H](O)[C@H](O)[C@H](O1)CO ZUQUTHURQVDNKF-WZPXOXCRSA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 241001517047 Corynebacterium acetoacidophilum Species 0.000 claims 1
• 241000588724 Escherichia coli Species 0.000 claims 1
• 125000003047 N-acetyl group Chemical group 0.000 claims 1
• 241000588653 Neisseria Species 0.000 claims 1
• 108020004511 Recombinant DNA Proteins 0.000 claims 1
• 241000194017 Streptococcus Species 0.000 claims 1
• 241000192584 Synechocystis Species 0.000 claims 1
• 125000003275 alpha amino acid group Chemical group 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 108010084853 neuraminic acid aldolase Proteins 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
• DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 2
• 230000015572 biosynthetic process Effects 0.000 description 1