ATE486949T1 - Verfahren zur herstellung von n- acetylneuraminsäure - Google Patents
Verfahren zur herstellung von n- acetylneuraminsäureInfo
- Publication number
- ATE486949T1 ATE486949T1 AT00118139T AT00118139T ATE486949T1 AT E486949 T1 ATE486949 T1 AT E486949T1 AT 00118139 T AT00118139 T AT 00118139T AT 00118139 T AT00118139 T AT 00118139T AT E486949 T1 ATE486949 T1 AT E486949T1
- Authority
- AT
- Austria
- Prior art keywords
- acid
- culture
- producing
- aqueous medium
- acetylneuraminic
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 abstract 6
- DTBNBXWJWCWCIK-UHFFFAOYSA-N phosphoenolpyruvic acid Chemical compound OC(=O)C(=C)OP(O)(O)=O DTBNBXWJWCWCIK-UHFFFAOYSA-N 0.000 abstract 6
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 abstract 4
- SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 abstract 3
- 239000012736 aqueous medium Substances 0.000 abstract 3
- 244000005700 microbiome Species 0.000 abstract 3
- 229940107700 pyruvic acid Drugs 0.000 abstract 3
- 102000003960 Ligases Human genes 0.000 abstract 1
- 108090000364 Ligases Proteins 0.000 abstract 1
- OVRNDRQMDRJTHS-OZRXBMAMSA-N N-acetyl-beta-D-mannosamine Chemical compound CC(=O)N[C@@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-OZRXBMAMSA-N 0.000 abstract 1
- 102000048245 N-acetylneuraminate lyases Human genes 0.000 abstract 1
- 108700023220 N-acetylneuraminate lyases Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
Landscapes
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24267099 | 1999-08-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE486949T1 true ATE486949T1 (de) | 2010-11-15 |
Family
ID=17092499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00118139T ATE486949T1 (de) | 1999-08-30 | 2000-08-29 | Verfahren zur herstellung von n- acetylneuraminsäure |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6846656B1 (https=) |
| EP (1) | EP1081230B1 (https=) |
| JP (1) | JP3946423B2 (https=) |
| KR (1) | KR100819398B1 (https=) |
| CN (1) | CN1172003C (https=) |
| AT (1) | ATE486949T1 (https=) |
| CA (1) | CA2317118C (https=) |
| DE (1) | DE60045176D1 (https=) |
| ES (1) | ES2352669T3 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7329514B2 (en) * | 2002-02-28 | 2008-02-12 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing n-acetylneuraminic acid |
| WO2004009830A1 (ja) * | 2002-07-18 | 2004-01-29 | Yamasa Corporation | Cmp-n-アセチルノイラミン酸の製造法 |
| CA2868618C (en) * | 2002-10-16 | 2017-05-23 | Gen-Probe Incorporated | Compositions and methods for detecting west nile virus |
| US7927840B2 (en) | 2006-09-11 | 2011-04-19 | Gen Probe Incorporated | Method for detecting West Nile Virus nucleic acids in the 3′ non-coding region |
| JP2006271372A (ja) * | 2005-03-01 | 2006-10-12 | Yamasa Shoyu Co Ltd | 糖鎖の製造法 |
| CN102586319A (zh) * | 2006-02-09 | 2012-07-18 | 麦迪卡格公司 | 唾液酸在植物中的合成 |
| JP5079272B2 (ja) * | 2006-06-30 | 2012-11-21 | 協和発酵バイオ株式会社 | シチジン‐５´‐一リン酸‐ｎ‐アセチルノイラミン酸およびｎ‐アセチルノイラミン酸含有糖質の製造法 |
| AT510299B1 (de) * | 2010-12-22 | 2012-03-15 | Univ Wien Tech | Verfahren und mittel zur herstellung von n-acetylneuraminsäure (neunac) |
| GB201106095D0 (en) * | 2011-04-11 | 2011-05-25 | Glycom As | N-Substituted mannosamine derivatives, process for their preparation and use thereof |
| KR101525230B1 (ko) | 2013-05-31 | 2015-06-01 | 주식회사 진켐 | 시알산 유도체의 제조방법 |
| WO2015037698A1 (ja) * | 2013-09-12 | 2015-03-19 | 協和発酵バイオ株式会社 | Ｎ－アセチルノイラミン酸及びｎ－アセチルノイラミン酸含有糖質の製造法 |
| CN104725439A (zh) * | 2014-12-25 | 2015-06-24 | 常熟市联创化学有限公司 | N-氘代乙酰神经氨酸的合成方法 |
| CN105559087A (zh) * | 2015-12-16 | 2016-05-11 | 开平牵牛生化制药有限公司 | 一种含燕窝酸的益生菌产品及其制备方法 |
| CN106520864A (zh) * | 2016-09-28 | 2017-03-22 | 南京农业大学 | 一种酶法合成唾液酸类似物的方法及其应用 |
| EP3473644A1 (en) | 2017-10-17 | 2019-04-24 | Jennewein Biotechnologie GmbH | Fermentative production of n-acetylneuraminic acid |
| EP3486326A1 (en) | 2017-11-21 | 2019-05-22 | Jennewein Biotechnologie GmbH | Method for the purification of n-acetylneuraminic acid from a fermentation broth |
| CN108330095B (zh) * | 2018-03-01 | 2020-12-29 | 江南大学 | 一种积累n-乙酰神经氨酸的重组谷氨酸棒杆菌及其应用 |
| CN111411066B (zh) * | 2020-03-30 | 2022-08-23 | 江南大学 | 一种双途径复合产神经氨酸枯草芽孢杆菌及构建方法 |
| CN113337495B (zh) * | 2021-06-03 | 2022-10-11 | 江南大学 | 一种提高唾液酸产量的方法与应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3937891A1 (de) | 1989-11-15 | 1991-05-16 | Forschungszentrum Juelich Gmbh | Enzymatisches verfahren zur herstellung von n-acetylneuraminsaeure |
| JP3131655B2 (ja) | 1992-02-03 | 2001-02-05 | マルキン忠勇株式会社 | Ｎ−アセチルノイラミン酸の製造法 |
| JP3151982B2 (ja) | 1992-12-28 | 2001-04-03 | 東レ株式会社 | ホスホエノールピルビン酸の製造方法 |
| GB9311873D0 (en) | 1993-06-09 | 1993-07-28 | Glaxo Group Ltd | Process |
| JP3944866B2 (ja) | 1996-06-18 | 2007-07-18 | マルキンバイオ株式会社 | Ｎ−アセチルノイラミン酸シンターゼ、及びこれを用いるｎ−アセチルノイラミン酸の製造方法 |
-
2000
- 2000-08-25 US US09/645,321 patent/US6846656B1/en not_active Expired - Lifetime
- 2000-08-28 JP JP2000257221A patent/JP3946423B2/ja not_active Expired - Lifetime
- 2000-08-29 DE DE60045176T patent/DE60045176D1/de not_active Expired - Lifetime
- 2000-08-29 ES ES00118139T patent/ES2352669T3/es not_active Expired - Lifetime
- 2000-08-29 EP EP00118139A patent/EP1081230B1/en not_active Expired - Lifetime
- 2000-08-29 AT AT00118139T patent/ATE486949T1/de not_active IP Right Cessation
- 2000-08-30 CN CNB001264052A patent/CN1172003C/zh not_active Expired - Lifetime
- 2000-08-30 KR KR1020000050828A patent/KR100819398B1/ko not_active Expired - Lifetime
- 2000-08-30 CA CA2317118A patent/CA2317118C/en not_active Expired - Lifetime
-
2003
- 2003-01-09 US US10/338,872 patent/US7579175B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1081230A3 (en) | 2002-06-05 |
| CA2317118C (en) | 2010-03-16 |
| JP3946423B2 (ja) | 2007-07-18 |
| CN1172003C (zh) | 2004-10-20 |
| US6846656B1 (en) | 2005-01-25 |
| DE60045176D1 (de) | 2010-12-16 |
| KR20010050270A (ko) | 2001-06-15 |
| CA2317118A1 (en) | 2001-02-28 |
| EP1081230B1 (en) | 2010-11-03 |
| US20030109007A1 (en) | 2003-06-12 |
| KR100819398B1 (ko) | 2008-04-04 |
| EP1081230A2 (en) | 2001-03-07 |
| CN1286308A (zh) | 2001-03-07 |
| JP2001136982A (ja) | 2001-05-22 |
| US7579175B2 (en) | 2009-08-25 |
| ES2352669T3 (es) | 2011-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |