JP2000516589A5 - - Google Patents
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- Publication number
- JP2000516589A5 JP2000516589A5 JP1998508453A JP50845398A JP2000516589A5 JP 2000516589 A5 JP2000516589 A5 JP 2000516589A5 JP 1998508453 A JP1998508453 A JP 1998508453A JP 50845398 A JP50845398 A JP 50845398A JP 2000516589 A5 JP2000516589 A5 JP 2000516589A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2207996P | 1996-07-29 | 1996-07-29 | |
| US60/022,079 | 1996-07-29 | ||
| PCT/EP1997/003889 WO1998004552A1 (en) | 1996-07-29 | 1997-07-19 | Substituted bisindolylmaleimides for the inhibition of cell proliferation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000516589A JP2000516589A (ja) | 2000-12-12 |
| JP2000516589A5 true JP2000516589A5 (enExample) | 2005-03-10 |
Family
ID=21807711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10508453A Ceased JP2000516589A (ja) | 1996-07-29 | 1997-07-19 | 細胞増殖阻害のための置換ビスインドリルマレイミド |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US5856517A (enExample) |
| EP (1) | EP0915872B1 (enExample) |
| JP (1) | JP2000516589A (enExample) |
| KR (1) | KR20000029637A (enExample) |
| CN (2) | CN1151149C (enExample) |
| AR (1) | AR008267A1 (enExample) |
| AT (1) | ATE240318T1 (enExample) |
| AU (1) | AU739742B2 (enExample) |
| BR (1) | BR9711605A (enExample) |
| CA (1) | CA2262092A1 (enExample) |
| CO (1) | CO4900055A1 (enExample) |
| CY (1) | CY2483B1 (enExample) |
| DE (1) | DE69722003T2 (enExample) |
| DK (1) | DK0915872T3 (enExample) |
| ES (1) | ES2198001T3 (enExample) |
| HR (1) | HRP970414A2 (enExample) |
| MA (1) | MA24287A1 (enExample) |
| PE (1) | PE91698A1 (enExample) |
| PT (1) | PT915872E (enExample) |
| SA (1) | SA97180473A (enExample) |
| TR (1) | TR199900157T2 (enExample) |
| WO (1) | WO1998004552A1 (enExample) |
| ZA (1) | ZA976492B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20000585B1 (en) * | 1998-03-17 | 2009-02-28 | F. Hoffmann - La Roche Ag | Substituted bisindolymaleimides for the inhibition of cell proliferation |
| US6743785B2 (en) * | 1999-12-16 | 2004-06-01 | Eli Lilly And Company | Agents and methods for the treatment of proliferative diseases |
| US6313143B1 (en) * | 1999-12-16 | 2001-11-06 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| US6867198B2 (en) | 1999-12-16 | 2005-03-15 | Eli Lilly And Company | Agents and methods for the treatment of proliferative diseases |
| DE60010934T2 (de) * | 1999-12-16 | 2005-05-19 | Eli Lilly And Co., Indianapolis | Medikamente geeignet zur Behandlung von proliferativen Erkrankungen |
| US6281356B1 (en) | 1999-12-22 | 2001-08-28 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| TWI335221B (en) * | 2001-09-27 | 2011-01-01 | Alcon Inc | Inhibtors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma |
| US20030139373A1 (en) * | 2001-11-20 | 2003-07-24 | Breimer Lars Holger | Method for cancer therapy |
| AR040083A1 (es) * | 2002-05-22 | 2005-03-16 | Smithkline Beecham Corp | Compuesto bis-(monoetanolamina) del acido 3'-[(2z)-[1-(3,4-dimetilfenil) -1,5-dihidro-3-metil-5-oxo-4h-pirazol-4-iliden] hidrazino] -2'-hidroxi-[1,1'-bifenil]-3-carboxilico, procedimiento para prepararlo, composicion farmaceutica que lo comprende, procedimiento para preparar dicha composicion farmac |
| US7012100B1 (en) | 2002-06-04 | 2006-03-14 | Avolix Pharmaceuticals, Inc. | Cell migration inhibiting compositions and methods and compositions for treating cancer |
| DK1846406T5 (da) | 2005-02-09 | 2011-10-31 | Arqule Inc | Maleimidderivater, farmaceutiske sammensætninger og fremgangsmåder til behandling af cancer |
| MX2009006533A (es) * | 2006-12-19 | 2009-06-26 | Novartis Ag | Derivados de indolil-maleimida como inhibidores de cinasa. |
| JP5490688B2 (ja) | 2007-06-22 | 2014-05-14 | アークル インコーポレイテッド | 癌の治療のためのインドリルピロリジン |
| CA2690799C (en) | 2007-06-22 | 2015-06-16 | Arqule, Inc. | Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer |
| CN101801937A (zh) | 2007-06-22 | 2010-08-11 | 艾科尔公司 | 喹唑啉酮化合物及其使用方法 |
| JP2009035537A (ja) * | 2007-07-10 | 2009-02-19 | Nippon Synthetic Chem Ind Co Ltd:The | Ｎ−置換アニリン誘導体及び１−置換インドール誘導体の製造方法 |
| FR2927075A1 (fr) * | 2008-02-04 | 2009-08-07 | Centre Nat Rech Scient | Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes |
| GB201111427D0 (en) * | 2011-07-05 | 2011-08-17 | Amakem Nv | Novel bisindolylmaleimides, pan-pkc inhibitors |
| CA2939219C (en) | 2014-02-11 | 2023-02-28 | Mitokinin Llc | Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease |
| EP3741375A1 (en) | 2014-07-17 | 2020-11-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for treating neuromuscular junction-related diseases |
| WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
| KR20200019228A (ko) * | 2017-06-21 | 2020-02-21 | 미토키닌, 인크. | 신경퇴행성 및 미토콘드리아 질환의 치료를 위한 조성물 및 이를 사용하는 방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK75289A3 (en) * | 1988-02-10 | 1998-05-06 | Hoffmann La Roche | Substituted pyrroles, their use for producing a drug, and the drug on their base |
| IL94274A0 (en) * | 1989-05-05 | 1991-03-10 | Goedecke Ag | Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same |
| US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| DE4005969A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| JPH0539289A (ja) * | 1991-02-15 | 1993-02-19 | Masahiro Irie | 無水マレイン酸誘導体およびその製造方法 |
| AU3761393A (en) * | 1992-03-20 | 1993-10-21 | Wellcome Foundation Limited, The | Indole derivatives with antiviral activity |
| DE4217964A1 (de) * | 1992-05-30 | 1993-12-02 | Goedecke Ag | Indolocarbazol-Imide und deren Verwendung |
-
1997
- 1997-07-15 PE PE1997000630A patent/PE91698A1/es not_active Application Discontinuation
- 1997-07-19 DK DK97934498T patent/DK0915872T3/da active
- 1997-07-19 CA CA002262092A patent/CA2262092A1/en not_active Abandoned
- 1997-07-19 CN CNB971967768A patent/CN1151149C/zh not_active Expired - Fee Related
- 1997-07-19 AT AT97934498T patent/ATE240318T1/de not_active IP Right Cessation
- 1997-07-19 PT PT97934498T patent/PT915872E/pt unknown
- 1997-07-19 TR TR1999/00157T patent/TR199900157T2/xx unknown
- 1997-07-19 WO PCT/EP1997/003889 patent/WO1998004552A1/en not_active Ceased
- 1997-07-19 JP JP10508453A patent/JP2000516589A/ja not_active Ceased
- 1997-07-19 KR KR1019997000706A patent/KR20000029637A/ko not_active Abandoned
- 1997-07-19 AU AU37690/97A patent/AU739742B2/en not_active Ceased
- 1997-07-19 CN CNA031275400A patent/CN1495182A/zh active Pending
- 1997-07-19 DE DE69722003T patent/DE69722003T2/de not_active Expired - Fee Related
- 1997-07-19 BR BR9711605A patent/BR9711605A/pt not_active Application Discontinuation
- 1997-07-19 ES ES97934498T patent/ES2198001T3/es not_active Expired - Lifetime
- 1997-07-19 EP EP97934498A patent/EP0915872B1/en not_active Expired - Lifetime
- 1997-07-22 ZA ZA9706492A patent/ZA976492B/xx unknown
- 1997-07-22 AR ARP970103309A patent/AR008267A1/es not_active Application Discontinuation
- 1997-07-24 US US08/899,852 patent/US5856517A/en not_active Expired - Fee Related
- 1997-07-25 CO CO97042581A patent/CO4900055A1/es unknown
- 1997-07-25 HR HR60/022,079A patent/HRP970414A2/hr not_active Application Discontinuation
- 1997-07-29 MA MA24744A patent/MA24287A1/fr unknown
- 1997-10-06 SA SA97180473A patent/SA97180473A/ar unknown
-
1998
- 1998-10-05 US US09/166,766 patent/US6030994A/en not_active Expired - Fee Related
-
2004
- 2004-11-15 CY CY0400081A patent/CY2483B1/xx unknown