JP2000512144A - 抗菌活性を有する6,7―ジヒドロキシ―8―メチル―4―オキソ―4h―1―ベンゾピラン―5―カルボン酸 - Google Patents
抗菌活性を有する6,7―ジヒドロキシ―8―メチル―4―オキソ―4h―1―ベンゾピラン―5―カルボン酸Info
- Publication number
- JP2000512144A JP2000512144A JP10501152A JP50115298A JP2000512144A JP 2000512144 A JP2000512144 A JP 2000512144A JP 10501152 A JP10501152 A JP 10501152A JP 50115298 A JP50115298 A JP 50115298A JP 2000512144 A JP2000512144 A JP 2000512144A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- pharmaceutically acceptable
- oxo
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.式(I): [式中、Rは、水素原子またはアセチル基である。] で示される化合物、又はその医薬的に許容される塩。 2.6,7−ジヒドロキシ−8−メチル−4−オキソ−4H−1−ベンゾピラン −5−カルボン酸又はその医薬的に許容される塩である請求項1に記載の化合物 。 3.6,7−ジアセチルオキシ−8−メチル−4−オキソ−4H−1−ベンゾフ ラン−5−カルボン酸又はその医薬的に許容される塩である請求項1に記載の化 合物。 4.式I(R=H)の化合物を調製するための発酵方法であって、DSMZの収 集番号10611と同定されるStreptomyces種の菌株、または該化 合物を産生す ることができるその変異体または突然変異体の存在下において、炭素、窒素、お よび無機塩の同化源を含有する宋養液体培地中で好気性条件下に行われる発酵を 含んで成る方法。 5.発酵が、23℃〜31℃の範囲の温度において、96〜200時間行われる 請求項4に記載の、式I(R=H)の化合物を調製するための発酵方法。 6.該化合物を精製し、および/またはその医薬的に許容される塩を調製する工 程を含んで成る請求項4または5に記載の、式I(R=H)の化合物を調製する ための発酵方法。 7.請求項1〜3に記載の1つまたはそれ以上の化合物を、医薬的に許容される 賦形剤と共に含有する治療組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96MI001174A IT1283115B1 (it) | 1996-06-07 | 1996-06-07 | Acido 6,7-didrossi-8-metil-4-oxo-1-benzopiran carbossilico con attivita' antibatterica. |
IT96A001174 | 1996-06-07 | ||
PCT/EP1997/002899 WO1997047616A1 (en) | 1996-06-07 | 1997-06-04 | 6,7-dihydroxy-8-methyl-4-oxo-4h-1-benzopyran-5-carboxylic acid with antibacterial activity |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2000512144A true JP2000512144A (ja) | 2000-09-19 |
Family
ID=11374399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10501152A Ceased JP2000512144A (ja) | 1996-06-07 | 1997-06-04 | 抗菌活性を有する6,7―ジヒドロキシ―8―メチル―4―オキソ―4h―1―ベンゾピラン―5―カルボン酸 |
Country Status (5)
Country | Link |
---|---|
JP (1) | JP2000512144A (ja) |
DE (2) | DE19781792T1 (ja) |
GB (1) | GB2328945B (ja) |
IT (1) | IT1283115B1 (ja) |
WO (1) | WO1997047616A1 (ja) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE769146A (fr) * | 1970-07-01 | 1971-11-03 | Takeda Chemical Industries Ltd | Derives d'acides chromone-carboxylique |
JPS59122486A (ja) * | 1982-12-28 | 1984-07-14 | Eisai Co Ltd | 2−メチルクロモン誘導体およびその製造方法 |
-
1996
- 1996-06-07 IT IT96MI001174A patent/IT1283115B1/it active IP Right Grant
-
1997
- 1997-06-04 WO PCT/EP1997/002899 patent/WO1997047616A1/en active Application Filing
- 1997-06-04 JP JP10501152A patent/JP2000512144A/ja not_active Ceased
- 1997-06-04 DE DE19781792T patent/DE19781792T1/de active Pending
- 1997-06-04 GB GB9825857A patent/GB2328945B/en not_active Expired - Lifetime
- 1997-06-04 DE DE19781792A patent/DE19781792B4/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ITMI961174A0 (it) | 1996-06-07 |
IT1283115B1 (it) | 1998-04-07 |
ITMI961174A1 (it) | 1997-12-07 |
GB9825857D0 (en) | 1999-01-20 |
DE19781792T1 (de) | 1999-05-27 |
DE19781792B4 (de) | 2006-06-08 |
WO1997047616A1 (en) | 1997-12-18 |
GB2328945A (en) | 1999-03-10 |
GB2328945B (en) | 2000-01-12 |
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Legal Events
Date | Code | Title | Description |
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A313 | Final decision of rejection without a dissenting response from the applicant |
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