GB2328945A - 6,7-Dihydroxy-8-Methyl-4-Oxo-4H-1-Benzopyran-5-Carboxylic Acid with antibacterial activity - Google Patents

6,7-Dihydroxy-8-Methyl-4-Oxo-4H-1-Benzopyran-5-Carboxylic Acid with antibacterial activity

Info

Publication number
GB2328945A
GB2328945A GB9825857A GB9825857A GB2328945A GB 2328945 A GB2328945 A GB 2328945A GB 9825857 A GB9825857 A GB 9825857A GB 9825857 A GB9825857 A GB 9825857A GB 2328945 A GB2328945 A GB 2328945A
Authority
GB
United Kingdom
Prior art keywords
antibacterial activity
benzopyran
dihydroxy
oxo
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9825857A
Other versions
GB9825857D0 (en
GB2328945B (en
Inventor
Lorena Luisa Fedeli
Guiliano Franchi
Inventi Augusto Solari
Luca Piacenza
Giovanni Rivola
Rosaria Rossi
Luisa Garofano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MINI RICERCA SCIENT TECNOLOG
Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST)
Original Assignee
MINI RICERCA SCIENT TECNOLOG
Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MINI RICERCA SCIENT TECNOLOG, Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST) filed Critical MINI RICERCA SCIENT TECNOLOG
Publication of GB9825857D0 publication Critical patent/GB9825857D0/en
Publication of GB2328945A publication Critical patent/GB2328945A/en
Application granted granted Critical
Publication of GB2328945B publication Critical patent/GB2328945B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

There are provided compounds of formula (I) wherein R is a hydrogen atom or an acetyl group, and their pharmaceutically acceptable salt, having antibacterial activity. The compound of formula (I) of the invention wherein R is hydrogen is prepared by fermentation of the micro-organism Streptomyces sp. identified in our data bank by the number 17040 and registered on 20.3.1996 with the DMSZ under the number 10611. The compound of formula (I) (R = -COCH3) is obtained by acetylation with acetic anhydride, in pyridine, of the compound (I) (R = H).
GB9825857A 1996-06-07 1997-06-04 6,7-Dihydroxy-8-Methyl-4-Oxo-4H-1-Benzopyran-5-Carboxylic Acid with antibacterial activity Expired - Lifetime GB2328945B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI001174A IT1283115B1 (en) 1996-06-07 1996-06-07 6,7-DIDROXY-8-METHYL-4-OXO-1-BENZOPYRANE CARBOXYL ACID WITH ANTIBACTERIAL ACTIVITY.
PCT/EP1997/002899 WO1997047616A1 (en) 1996-06-07 1997-06-04 6,7-dihydroxy-8-methyl-4-oxo-4h-1-benzopyran-5-carboxylic acid with antibacterial activity

Publications (3)

Publication Number Publication Date
GB9825857D0 GB9825857D0 (en) 1999-01-20
GB2328945A true GB2328945A (en) 1999-03-10
GB2328945B GB2328945B (en) 2000-01-12

Family

ID=11374399

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9825857A Expired - Lifetime GB2328945B (en) 1996-06-07 1997-06-04 6,7-Dihydroxy-8-Methyl-4-Oxo-4H-1-Benzopyran-5-Carboxylic Acid with antibacterial activity

Country Status (5)

Country Link
JP (1) JP2000512144A (en)
DE (2) DE19781792T1 (en)
GB (1) GB2328945B (en)
IT (1) IT1283115B1 (en)
WO (1) WO1997047616A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2132260A1 (en) * 1970-07-01 1972-02-03 Takeda Chemical Industries Ltd Chromonic acid derivatives and process for their preparation
EP0114899A1 (en) * 1982-12-28 1984-08-08 Eisai Co., Ltd. 2-Methylchromone derivatives and their preparation process

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2132260A1 (en) * 1970-07-01 1972-02-03 Takeda Chemical Industries Ltd Chromonic acid derivatives and process for their preparation
EP0114899A1 (en) * 1982-12-28 1984-08-08 Eisai Co., Ltd. 2-Methylchromone derivatives and their preparation process

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, abstr no 88:117779u & Agric. Biol. Chem., 1978, Vol. 42(1), pages 159-165 *
Chemical Abstracts, abstr no 99:209832m & Agric. Biol. Chem., 1983, Vol. 47(9), pages 2029-2033 *

Also Published As

Publication number Publication date
IT1283115B1 (en) 1998-04-07
JP2000512144A (en) 2000-09-19
WO1997047616A1 (en) 1997-12-18
ITMI961174A0 (en) 1996-06-07
GB9825857D0 (en) 1999-01-20
DE19781792B4 (en) 2006-06-08
GB2328945B (en) 2000-01-12
DE19781792T1 (en) 1999-05-27
ITMI961174A1 (en) 1997-12-07

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Expiry date: 20170603