JP2000511416A5 - - Google Patents
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- Publication number
- JP2000511416A5 JP2000511416A5 JP1997541828A JP54182897A JP2000511416A5 JP 2000511416 A5 JP2000511416 A5 JP 2000511416A5 JP 1997541828 A JP1997541828 A JP 1997541828A JP 54182897 A JP54182897 A JP 54182897A JP 2000511416 A5 JP2000511416 A5 JP 2000511416A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9610967A GB9610967D0 (en) | 1996-05-24 | 1996-05-24 | Specific binding members,materials and methods |
| GB9610967.3 | 1996-05-24 | ||
| PCT/GB1997/001412 WO1997045544A1 (en) | 1996-05-24 | 1997-05-23 | Antibodies to the ed-b domain of fibronectin, their construction and uses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008204682A Division JP2009050261A (ja) | 1996-05-24 | 2008-08-07 | フィブロネクチンのｅｄ―ｂドメインに対する抗体、それらの構造及び用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2000511416A JP2000511416A (ja) | 2000-09-05 |
| JP2000511416A5 true JP2000511416A5 (enExample) | 2005-02-10 |
| JP4750912B2 JP4750912B2 (ja) | 2011-08-17 |
Family
ID=10794298
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54182897A Expired - Lifetime JP4750912B2 (ja) | 1996-05-24 | 1997-05-23 | フィブロネクチンのｅｄ―ｂドメインに対する抗体、それらの構造及び用途 |
| JP2008204682A Pending JP2009050261A (ja) | 1996-05-24 | 2008-08-07 | フィブロネクチンのｅｄ―ｂドメインに対する抗体、それらの構造及び用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008204682A Pending JP2009050261A (ja) | 1996-05-24 | 2008-08-07 | フィブロネクチンのｅｄ―ｂドメインに対する抗体、それらの構造及び用途 |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US7273924B1 (enExample) |
| EP (1) | EP0906426B1 (enExample) |
| JP (2) | JP4750912B2 (enExample) |
| KR (2) | KR100741452B1 (enExample) |
| CN (1) | CN100447159C (enExample) |
| AT (1) | ATE361364T1 (enExample) |
| AU (1) | AU729081B2 (enExample) |
| BG (1) | BG65138B1 (enExample) |
| BR (1) | BR9709350B1 (enExample) |
| CA (1) | CA2256308C (enExample) |
| CZ (1) | CZ295531B6 (enExample) |
| DE (1) | DE69737683T2 (enExample) |
| DK (1) | DK0906426T3 (enExample) |
| EA (1) | EA004329B1 (enExample) |
| ES (1) | ES2286831T3 (enExample) |
| GB (1) | GB9610967D0 (enExample) |
| HU (1) | HUP0200546A2 (enExample) |
| IL (2) | IL127216A0 (enExample) |
| IS (1) | IS2508B (enExample) |
| NO (1) | NO324904B1 (enExample) |
| NZ (1) | NZ333083A (enExample) |
| PL (1) | PL188557B1 (enExample) |
| PT (1) | PT906426E (enExample) |
| SI (1) | SI0906426T1 (enExample) |
| SK (1) | SK285916B6 (enExample) |
| TR (1) | TR199802416T2 (enExample) |
| UA (1) | UA74129C2 (enExample) |
| WO (1) | WO1997045544A1 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
| GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
| US6685943B1 (en) | 1997-01-21 | 2004-02-03 | The Texas A&M University System | Fibronectin binding protein compositions and methods of use |
| US7244826B1 (en) | 1998-04-24 | 2007-07-17 | The Regents Of The University Of California | Internalizing ERB2 antibodies |
| US20030045681A1 (en) * | 1998-05-11 | 2003-03-06 | Anthony J. Zelano | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| US20030176663A1 (en) * | 1998-05-11 | 2003-09-18 | Eidgenossische Technische Hochscule | Specific binding molecules for scintigraphy |
| TWI259837B (en) * | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| ATE333900T1 (de) | 2000-02-24 | 2006-08-15 | Philogen Spa | Zusamensetzungen und verfahren zur behandlung von angiogenese in pathologischen schädigungen |
| AU4243201A (en) * | 2000-02-24 | 2001-09-03 | Eidgenoess Tech Hochschule | Antibody specific for the ed-b domain of fibronectin, conjugates comprising saidantibody, and their use for the detection and treatment of angiogenesis |
| US7094750B2 (en) | 2000-05-09 | 2006-08-22 | Greenville Hospital System | Therapeutic pore-forming peptides |
| WO2001096599A2 (en) * | 2000-06-15 | 2001-12-20 | Philogen S.R.L. | Methods for quantitative determination of b-fibronectin in biological fluids and tissues |
| AU1218202A (en) * | 2000-09-07 | 2002-03-22 | Schering Ag | Receptor in the ED<sub>b</sub> fibronectin domain |
| IT1317108B1 (it) * | 2000-12-06 | 2003-05-26 | Philogen Srl | Processo per la selezione di frammenti anticorporali anti-angiogenesi,frammenti anticorpali anti-angiogenesi cosi' ottenuti e loro uso. |
| US7456146B2 (en) * | 2001-05-09 | 2008-11-25 | Ghc Research Development Corporation | Lytic peptide prodrugs |
| RU2352582C2 (ru) | 2002-01-03 | 2009-04-20 | Шеринг Акциенгезельшафт | Конъюгаты, содержащие антитело, специфическое для ed-в-домена фибронектина, и их применение для обнаружения и лечения опухолей |
| KR100983385B1 (ko) * | 2002-03-11 | 2010-09-20 | 바이엘 쉐링 파마 악티엔게젤샤프트 | 항체 분자를 이용한 종양 맥관구조의 선택적 표적화 |
| CN101653603B (zh) | 2002-07-15 | 2014-07-09 | 得克萨斯大学体系董事会 | 磷脂酰乙醇胺结合肽缀合物及其治疗病毒感染的用途 |
| MXPA05009556A (es) | 2003-03-14 | 2005-11-16 | Wyeth Corp | Anticuerpos contra receptor de il-21 humano y sus usos. |
| DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| CA2552590A1 (en) | 2004-01-05 | 2005-07-21 | Emd Lexigen Research Center Corp. | Interleukin-12 targeted to oncofoetal fibronectin |
| NZ582466A (en) | 2004-07-30 | 2011-09-30 | Adeza Biomedical Corp | Oncofetal fibronectin as a marker for disease and other conditions and methods for detection of oncofetal fibronectin |
| US7785591B2 (en) * | 2004-10-14 | 2010-08-31 | Morphosys Ag | Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies |
| EP1803814A1 (en) * | 2005-12-27 | 2007-07-04 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Method of improving the antibody selection capacity in phage-display library |
| EP1925664A1 (en) | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Artificial binding proteins based on a modified alpha helical region of ubiquitin |
| US8253725B2 (en) * | 2007-12-28 | 2012-08-28 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Method and system for generating surface models of geometric structures |
| ES2382058T3 (es) * | 2008-01-17 | 2012-06-04 | Philogen S.P.A. | Combinación de una proteína de fusión de un anticuerpo dirigido contra el EDB de la fibronectina-IL-2, y una molécula de unión a los linfocitos B, progenitores de los linfocitos B y/o sus homólogos cancerosos |
| EP2100621A1 (en) | 2008-03-10 | 2009-09-16 | mivenion GmbH | Polyether polyol dendron conjugates with effector molecules for biological targeting |
| EP2116555A1 (en) | 2008-05-08 | 2009-11-11 | Bayer Schering Pharma Aktiengesellschaft | Use of a radioactively labelled molecule specifically binding to ED-B fibronectin in a method of treatment of Hodgkin lymphoma |
| IT1392027B1 (it) * | 2008-12-12 | 2012-02-09 | Castellani | Anticorpo monoclonale e suo uso per la identificazione della isoforma oncofetale della fibronettina (b-fn) a scopo diagnostico o terapeutico. |
| US8921304B2 (en) | 2009-12-14 | 2014-12-30 | Scil Proteins Gmbh | Modified ubiquitin proteins having a specific binding activity for the extradomain B of fibronectin |
| WO2011110490A1 (en) | 2010-03-09 | 2011-09-15 | Bayer Pharma Aktiengesellschaft | Process for the production of radioactively labelled scfv antibody fragments, kits and compositions |
| DK2721152T3 (da) | 2011-06-15 | 2019-07-01 | Navigo Proteins Gmbh | Dimere bindingsproteiner baseret på modificerede ubiquitiner |
| WO2012171541A1 (en) | 2011-06-15 | 2012-12-20 | Scil Proteins Gmbh | Human fusion proteins comprising interferons and hetero-dimeric modified ubiquitin proteins |
| US20150183846A1 (en) | 2012-06-13 | 2015-07-02 | Scil Proteins Gmbh | Human fusion proteins comprising single chain tnfalpha and targeting domains |
| WO2014094799A1 (en) | 2012-12-19 | 2014-06-26 | Scil-Proteins-Gmbh | Ubiquitin moieties as a means for prolonging serum half-life |
| CN104395342B (zh) * | 2013-06-06 | 2017-07-04 | 合肥立方制药股份有限公司 | 人源抗纤连蛋白ed‑b结构域的抗体及其用途 |
| WO2016124702A1 (en) | 2015-02-06 | 2016-08-11 | Scil Proteins Gmbh | Novel egfr binding proteins |
| JP6856938B2 (ja) | 2015-07-16 | 2021-04-14 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | 新規な免疫グロブリン結合タンパク質およびアフィニティ精製におけるそれらの使用 |
| US10584152B2 (en) | 2015-07-20 | 2020-03-10 | Navigo Proteins Gmbh | Binding proteins based on di-ubiquitin muteins and methods for generation |
| WO2017084017A1 (zh) * | 2015-11-16 | 2017-05-26 | 合肥立方制药股份有限公司 | Ed-b蛋白在诊断组织增生中的应用 |
| CA3022751A1 (en) | 2016-05-04 | 2017-11-09 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
| EP3497117B1 (en) | 2016-08-11 | 2024-01-24 | Navigo Proteins GmbH | Novel alkaline stable immunoglobulin-binding proteins |
| RU2758632C2 (ru) | 2016-10-17 | 2021-11-01 | Пфайзер Инк. | Антитела против edb и конъюгаты антитело-лекарственное средство |
| EP3634999A1 (en) | 2017-06-07 | 2020-04-15 | Philogen S.p.A. | Vascular endothelial growth factor/anti-fibronectin antibody fusion proteins |
| WO2019062877A1 (zh) * | 2017-09-30 | 2019-04-04 | 合肥立方制药股份有限公司 | 结合至纤维连接蛋白b结构域的蛋白 |
| EP3706804B1 (en) | 2017-11-07 | 2022-02-23 | Navigo Proteins GmbH | Fusion proteins with specificity for ed-b and long serum half-life for diagnosis or treatment of cancer |
| WO2020070150A1 (en) | 2018-10-02 | 2020-04-09 | Philogen S.P.A | Il2 immunoconjugates |
| EP3660039A1 (en) | 2018-11-30 | 2020-06-03 | Philogen S.p.A. | Il2 immunoconjugates |
| US12509493B2 (en) | 2018-12-18 | 2025-12-30 | Navigo Proteins Gmbh | FOLR1 specific binding proteins for cancer diagnosis and treatment |
| TW202120537A (zh) | 2019-08-15 | 2021-06-01 | 美商健生生物科技公司 | 用於經改善的單鏈可變片段之材料及方法 |
| CN115087670B (zh) | 2019-12-11 | 2025-10-28 | 西拉格国际有限责任公司 | 包含ltbr和edb结合结构域的多特异性结合分子及其用途 |
| CN111234016B (zh) * | 2020-02-23 | 2021-09-07 | 北京康普美特创新医药科技有限责任公司 | 一种抗补体c5分子的全人源单克隆抗体及应用 |
| CN111171149B (zh) * | 2020-02-23 | 2021-09-07 | 北京康普美特创新医药科技有限责任公司 | 一种抗补体c5分子的人源化单链抗体及其应用 |
| KR102614063B1 (ko) | 2020-12-24 | 2023-12-19 | 대화제약 주식회사 | 엑스트라도메인 b 피브로넥틴에 특이적으로 결합하는 신규한 항체 |
| WO2023131611A1 (en) | 2022-01-04 | 2023-07-13 | Philogen S.P.A. | Combination of an immunocytokine comprising il-12 and a kinase inhibitor |
| EP4565277A1 (en) | 2022-08-01 | 2025-06-11 | Philochem AG | Conjugates of psma-binding moieties with cytotoxic agents |
| EP4584256A1 (en) | 2022-09-06 | 2025-07-16 | Philochem AG | Multivalent fibroblast activation protein ligands for targeted delivery applications |
| WO2025061801A1 (en) | 2023-09-19 | 2025-03-27 | Philochem Ag | Therapeutic combination of an anti-edb fibronectin domain antibody il2 or il12 fusion protein and a lutetium-177 radioconjugate |
| WO2025221728A2 (en) | 2024-04-15 | 2025-10-23 | Janssen Biotech, Inc. | Ltbr binding molecules and uses thereof |
| WO2026003203A1 (en) | 2024-06-27 | 2026-01-02 | Philogen S.P.A. | Combination of an immunocytokine comprising targeted il2 and a jak inhibitor |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| DE3650625T2 (de) | 1985-01-28 | 1997-10-02 | Xoma Corp | AraB-Promoter und Verfahren zur Herstellung von Polypeptiden einschliesslich Cecropinen mittels mikrobiologischer Verfahren |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4894326A (en) | 1986-04-09 | 1990-01-16 | Fred Hutchinson Cancer Research Center | Monoclonal antibody defining oncofetal structure of fibronectin |
| US5243029A (en) * | 1986-04-09 | 1993-09-07 | Fred Hutchinson Cancer Research Center | Oncofetal structure of fibronectin |
| CA1341235C (en) | 1987-07-24 | 2001-05-22 | Randy R. Robinson | Modular assembly of antibody genes, antibodies prepared thereby and use |
| JPH02598A (ja) * | 1987-10-09 | 1990-01-05 | De La Rue Co Plc:The | 集積回路カード |
| EP0396612B1 (en) | 1988-01-11 | 1996-07-24 | Xoma Corporation | Novel plasmid vector with pectate lyase signal sequence |
| IT1217724B (it) * | 1988-05-26 | 1990-03-30 | Ist Naz Ric Sul Cancro | Anticorpo monoclonale specifico per una sequenza di fibronettina espressa in cellule trasformate ibridoma secernente tale anticorpo e impiego dell'anticorpo monoclonale per la diagnosi di tumori |
| US5177015A (en) | 1988-08-12 | 1993-01-05 | Fred Hutchinson Cancer Research Centre | Onco-developmentally regulated α-N-acetylgalactosaminyltransferase |
| US5843156A (en) | 1988-08-24 | 1998-12-01 | Endoluminal Therapeutics, Inc. | Local polymeric gel cellular therapy |
| JPH0276598A (ja) * | 1988-09-14 | 1990-03-15 | Fujita Gakuen | 抗ｅｄ−ｂ抗体 |
| JPH04169195A (ja) * | 1990-10-31 | 1992-06-17 | Fujita Gakuen | 抗ｅｄ―ｂモノクローナル抗体 |
| ATE297465T1 (de) | 1991-11-25 | 2005-06-15 | Enzon Inc | Verfahren zur herstellung von multivalenten antigenbindenden proteinen |
| US5629291A (en) | 1992-01-31 | 1997-05-13 | La Jolla Cancer Research Foundation | Methods of modulating fibronectin extracellular matrix assembly |
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
| US6093399A (en) | 1992-03-05 | 2000-07-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the specific coagulation of vasculature |
| US5877289A (en) | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
| US6004555A (en) | 1992-03-05 | 1999-12-21 | Board Of Regents, The University Of Texas System | Methods for the specific coagulation of vasculature |
| US6036955A (en) | 1992-03-05 | 2000-03-14 | The Scripps Research Institute | Kits and methods for the specific coagulation of vasculature |
| US5976535A (en) | 1992-06-09 | 1999-11-02 | Neorx Corporation | Pretargeting protocols for the enhanced localization of cytotoxins to target sites and cytotoxic combinations useful therefore |
| CA2123699C (en) | 1992-09-25 | 1999-12-07 | Takashi Komai | An adsorbent for cellular fibronectin, a method for fractional purification of fibronectin and a method of hemocatharisis |
| US5491130A (en) | 1992-11-10 | 1996-02-13 | The United States Of America As Represented By The Department Of Health And Human Services | Peptide inhibitors of fibronectin and related collagen-binding proteins |
| DE69329974T2 (de) | 1992-12-04 | 2001-07-19 | Medical Research Council, London | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| US6015897A (en) | 1993-12-07 | 2000-01-18 | Neorx Corporation | Biotinamido-n-methylglycyl-seryl-o-succinamido-benzyl dota |
| US5523229A (en) | 1994-03-22 | 1996-06-04 | Trustees Of The University Of Pennsylvania | Antibodies specific for oncofetal fibronectin |
| DE4417865A1 (de) | 1994-05-20 | 1995-11-23 | Behringwerke Ag | Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie |
| ITFI940095A1 (it) | 1994-05-23 | 1995-11-23 | Molteni & C | Coniugati fotodinamici aventi proprieta' biocide |
| US5648485A (en) | 1994-10-26 | 1997-07-15 | University Of British Columbia | β, β-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins |
| WO1996023816A1 (en) | 1995-02-01 | 1996-08-08 | British Technology Group Limited | Radiolabelled proteins |
| US6140470A (en) | 1995-06-30 | 2000-10-31 | Yale University | Human monoclonal anti-tumor antibodies |
| US5808146A (en) | 1995-11-09 | 1998-09-15 | Emory University | Amino acid analogs for tumor imaging |
| GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
| US5913884A (en) | 1996-09-19 | 1999-06-22 | The General Hospital Corporation | Inhibition of fibrosis by photodynamic therapy |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| US6394952B1 (en) | 1998-02-03 | 2002-05-28 | Adeza Biomedical Corporation | Point of care diagnostic systems |
| US6267722B1 (en) | 1998-02-03 | 2001-07-31 | Adeza Biomedical Corporation | Point of care diagnostic systems |
| TWI259837B (en) | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| ATE333900T1 (de) | 2000-02-24 | 2006-08-15 | Philogen Spa | Zusamensetzungen und verfahren zur behandlung von angiogenese in pathologischen schädigungen |
| AU4243201A (en) | 2000-02-24 | 2001-09-03 | Eidgenoess Tech Hochschule | Antibody specific for the ed-b domain of fibronectin, conjugates comprising saidantibody, and their use for the detection and treatment of angiogenesis |
| RU2352582C2 (ru) | 2002-01-03 | 2009-04-20 | Шеринг Акциенгезельшафт | Конъюгаты, содержащие антитело, специфическое для ed-в-домена фибронектина, и их применение для обнаружения и лечения опухолей |
| JP4169195B2 (ja) * | 2003-06-24 | 2008-10-22 | 株式会社河合楽器製作所 | 電子楽音発生装置の記録制御装置 |
-
1996
- 1996-05-24 GB GB9610967A patent/GB9610967D0/en active Pending
-
1997
- 1997-05-23 CZ CZ19983815A patent/CZ295531B6/cs not_active IP Right Cessation
- 1997-05-23 AT AT97923243T patent/ATE361364T1/de active
- 1997-05-23 NZ NZ33308397A patent/NZ333083A/xx not_active IP Right Cessation
- 1997-05-23 TR TR1998/02416T patent/TR199802416T2/xx unknown
- 1997-05-23 AU AU29101/97A patent/AU729081B2/en not_active Expired
- 1997-05-23 PT PT97923243T patent/PT906426E/pt unknown
- 1997-05-23 SI SI9730765T patent/SI0906426T1/sl unknown
- 1997-05-23 BR BRPI9709350-5A patent/BR9709350B1/pt not_active IP Right Cessation
- 1997-05-23 DK DK97923243T patent/DK0906426T3/da active
- 1997-05-23 DE DE1997637683 patent/DE69737683T2/de not_active Expired - Lifetime
- 1997-05-23 EA EA199801043A patent/EA004329B1/ru not_active IP Right Cessation
- 1997-05-23 KR KR1020067006008A patent/KR100741452B1/ko not_active Expired - Lifetime
- 1997-05-23 CN CNB971949026A patent/CN100447159C/zh not_active Expired - Lifetime
- 1997-05-23 JP JP54182897A patent/JP4750912B2/ja not_active Expired - Lifetime
- 1997-05-23 ES ES97923243T patent/ES2286831T3/es not_active Expired - Lifetime
- 1997-05-23 UA UA98126836A patent/UA74129C2/uk unknown
- 1997-05-23 CA CA 2256308 patent/CA2256308C/en not_active Expired - Lifetime
- 1997-05-23 WO PCT/GB1997/001412 patent/WO1997045544A1/en not_active Ceased
- 1997-05-23 PL PL97330075A patent/PL188557B1/pl not_active IP Right Cessation
- 1997-05-23 EP EP19970923243 patent/EP0906426B1/en not_active Expired - Lifetime
- 1997-05-23 IL IL12721697A patent/IL127216A0/xx active IP Right Grant
- 1997-05-23 HU HU0200546A patent/HUP0200546A2/hu unknown
- 1997-05-23 KR KR10-2005-7000518A patent/KR20050010081A/ko not_active Ceased
- 1997-05-23 SK SK1612-98A patent/SK285916B6/sk not_active IP Right Cessation
- 1997-05-23 US US09/194,356 patent/US7273924B1/en not_active Expired - Fee Related
-
1998
- 1998-10-29 IS IS4883A patent/IS2508B/is unknown
- 1998-11-23 NO NO19985459A patent/NO324904B1/no not_active IP Right Cessation
- 1998-11-23 IL IL127216A patent/IL127216A/en not_active IP Right Cessation
- 1998-11-24 BG BG102950A patent/BG65138B1/bg unknown
-
2007
- 2007-08-21 US US11/842,774 patent/US8703143B2/en not_active Expired - Fee Related
-
2008
- 2008-08-07 JP JP2008204682A patent/JP2009050261A/ja active Pending
-
2013
- 2013-10-04 US US14/046,224 patent/US9096670B2/en not_active Expired - Fee Related