ATE361364T1 - Antikörper gegen die ed-b domäne von fibronektin, ihre herstellung und verwendungen - Google Patents
Antikörper gegen die ed-b domäne von fibronektin, ihre herstellung und verwendungenInfo
- Publication number
- ATE361364T1 ATE361364T1 AT97923243T AT97923243T ATE361364T1 AT E361364 T1 ATE361364 T1 AT E361364T1 AT 97923243 T AT97923243 T AT 97923243T AT 97923243 T AT97923243 T AT 97923243T AT E361364 T1 ATE361364 T1 AT E361364T1
- Authority
- AT
- Austria
- Prior art keywords
- fibronectin
- production
- domain
- antibodies
- specific
- Prior art date
Links
- 102000016359 Fibronectins Human genes 0.000 title abstract 3
- 108010067306 Fibronectins Proteins 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000027455 binding Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000009870 specific binding Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9610967A GB9610967D0 (en) | 1996-05-24 | 1996-05-24 | Specific binding members,materials and methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE361364T1 true ATE361364T1 (de) | 2007-05-15 |
Family
ID=10794298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97923243T ATE361364T1 (de) | 1996-05-24 | 1997-05-23 | Antikörper gegen die ed-b domäne von fibronektin, ihre herstellung und verwendungen |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US7273924B1 (enExample) |
| EP (1) | EP0906426B1 (enExample) |
| JP (2) | JP4750912B2 (enExample) |
| KR (2) | KR100741452B1 (enExample) |
| CN (1) | CN100447159C (enExample) |
| AT (1) | ATE361364T1 (enExample) |
| AU (1) | AU729081B2 (enExample) |
| BG (1) | BG65138B1 (enExample) |
| BR (1) | BR9709350B1 (enExample) |
| CA (1) | CA2256308C (enExample) |
| CZ (1) | CZ295531B6 (enExample) |
| DE (1) | DE69737683T2 (enExample) |
| DK (1) | DK0906426T3 (enExample) |
| EA (1) | EA004329B1 (enExample) |
| ES (1) | ES2286831T3 (enExample) |
| GB (1) | GB9610967D0 (enExample) |
| HU (1) | HUP0200546A2 (enExample) |
| IL (2) | IL127216A0 (enExample) |
| IS (1) | IS2508B (enExample) |
| NO (1) | NO324904B1 (enExample) |
| NZ (1) | NZ333083A (enExample) |
| PL (1) | PL188557B1 (enExample) |
| PT (1) | PT906426E (enExample) |
| SI (1) | SI0906426T1 (enExample) |
| SK (1) | SK285916B6 (enExample) |
| TR (1) | TR199802416T2 (enExample) |
| UA (1) | UA74129C2 (enExample) |
| WO (1) | WO1997045544A1 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
| GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
| US6685943B1 (en) | 1997-01-21 | 2004-02-03 | The Texas A&M University System | Fibronectin binding protein compositions and methods of use |
| US7244826B1 (en) * | 1998-04-24 | 2007-07-17 | The Regents Of The University Of California | Internalizing ERB2 antibodies |
| US20030176663A1 (en) * | 1998-05-11 | 2003-09-18 | Eidgenossische Technische Hochscule | Specific binding molecules for scintigraphy |
| US20030045681A1 (en) * | 1998-05-11 | 2003-03-06 | Anthony J. Zelano | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| TWI259837B (en) * | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| WO2001062800A1 (en) * | 2000-02-24 | 2001-08-30 | Eidgenössische Technische Hochschule Zürich | Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis |
| JP4917232B2 (ja) * | 2000-02-24 | 2012-04-18 | フィロジェン ソチエタ ペル アツィオニ | 病理学的病変における脈管形成の処理のための組成物及び方法 |
| US7094750B2 (en) | 2000-05-09 | 2006-08-22 | Greenville Hospital System | Therapeutic pore-forming peptides |
| AU2001281824A1 (en) * | 2000-06-15 | 2001-12-24 | Patrizia Castellani | Methods for quantitative determination of b-fibronectin in biological fluids and tissues |
| HRP20030263A2 (en) * | 2000-09-07 | 2005-10-31 | Schering Aktiengesellschaft | RECEPTOR IN THE ED<SUB>b</SUB>-FIBRONECTIN-DOMAIN |
| IT1317108B1 (it) * | 2000-12-06 | 2003-05-26 | Philogen Srl | Processo per la selezione di frammenti anticorporali anti-angiogenesi,frammenti anticorpali anti-angiogenesi cosi' ottenuti e loro uso. |
| US7456146B2 (en) * | 2001-05-09 | 2008-11-25 | Ghc Research Development Corporation | Lytic peptide prodrugs |
| BR0306715A (pt) | 2002-01-03 | 2004-12-28 | Schering Ag | Métodos para diagnóstico e tratamento de tumores |
| RU2347787C2 (ru) * | 2002-03-11 | 2009-02-27 | Филоджен С.П.А. | Избирательный направленный перенос в сосудистую сеть опухоли с использованием молекул антител |
| SI2269656T1 (sl) | 2002-07-15 | 2014-11-28 | Board Of Regents, The University Of Texas System | Izbrana protitelesa, ki se veĹľejo na aminofosfolipide, in njihova uporaba v zdravljanju raka |
| CA2518371A1 (en) | 2003-03-14 | 2004-09-30 | Wyeth | Antibodies against human il-21 receptor and uses therefor |
| DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| AU2005203962C1 (en) | 2004-01-05 | 2012-11-08 | Antisoma Research Limited | Interleukin-12 targeted to oncofoetal fibronectin |
| ATE534750T1 (de) | 2004-07-30 | 2011-12-15 | Adeza Biomedical Corp | Onkofetales fibronektin als zervixkarzinom-marker |
| US7785591B2 (en) * | 2004-10-14 | 2010-08-31 | Morphosys Ag | Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies |
| EP1803814A1 (en) | 2005-12-27 | 2007-07-04 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Method of improving the antibody selection capacity in phage-display library |
| EP1925664A1 (en) | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Artificial binding proteins based on a modified alpha helical region of ubiquitin |
| US8253725B2 (en) * | 2007-12-28 | 2012-08-28 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Method and system for generating surface models of geometric structures |
| ES2382058T3 (es) | 2008-01-17 | 2012-06-04 | Philogen S.P.A. | Combinación de una proteína de fusión de un anticuerpo dirigido contra el EDB de la fibronectina-IL-2, y una molécula de unión a los linfocitos B, progenitores de los linfocitos B y/o sus homólogos cancerosos |
| EP2100621A1 (en) | 2008-03-10 | 2009-09-16 | mivenion GmbH | Polyether polyol dendron conjugates with effector molecules for biological targeting |
| EP2116555A1 (en) | 2008-05-08 | 2009-11-11 | Bayer Schering Pharma Aktiengesellschaft | Use of a radioactively labelled molecule specifically binding to ED-B fibronectin in a method of treatment of Hodgkin lymphoma |
| IT1392027B1 (it) * | 2008-12-12 | 2012-02-09 | Castellani | Anticorpo monoclonale e suo uso per la identificazione della isoforma oncofetale della fibronettina (b-fn) a scopo diagnostico o terapeutico. |
| BR112012014417B1 (pt) | 2009-12-14 | 2021-11-09 | Scil Proteins Gmbh | Proteínas ubiquitinas modificadas tendo uma atividade de ligação específica para o extradomínio b de fibronectina |
| WO2011110490A1 (en) | 2010-03-09 | 2011-09-15 | Bayer Pharma Aktiengesellschaft | Process for the production of radioactively labelled scfv antibody fragments, kits and compositions |
| WO2012171541A1 (en) | 2011-06-15 | 2012-12-20 | Scil Proteins Gmbh | Human fusion proteins comprising interferons and hetero-dimeric modified ubiquitin proteins |
| JP6146821B2 (ja) | 2011-06-15 | 2017-06-14 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | 修飾ユビキチンに基づく二量体型結合タンパク質 |
| EP2861616A1 (en) | 2012-06-13 | 2015-04-22 | Scil Proteins GmbH | Human fusion proteins comprising single chain tnfalpha and targeting domains |
| WO2014094799A1 (en) | 2012-12-19 | 2014-06-26 | Scil-Proteins-Gmbh | Ubiquitin moieties as a means for prolonging serum half-life |
| WO2014194784A1 (zh) * | 2013-06-06 | 2014-12-11 | 合肥立方制药股份有限公司 | 人源抗纤连蛋白ed-b结构域的抗体及其用途 |
| WO2016124702A1 (en) | 2015-02-06 | 2016-08-11 | Scil Proteins Gmbh | Novel egfr binding proteins |
| PL3322721T4 (pl) | 2015-07-16 | 2022-06-06 | Navigo Proteins Gmbh | Nowe białka wiążące immunoglobulinę i ich zastosowanie w oczyszczaniu na bazie powinowactwa |
| WO2017013136A1 (en) | 2015-07-20 | 2017-01-26 | Scil Proteins Gmbh | Novel binding proteins based on di-ubiquitin muteins and methods for generation |
| WO2017084017A1 (zh) * | 2015-11-16 | 2017-05-26 | 合肥立方制药股份有限公司 | Ed-b蛋白在诊断组织增生中的应用 |
| US11813336B2 (en) | 2016-05-04 | 2023-11-14 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
| CA3030208A1 (en) | 2016-08-11 | 2018-02-15 | Navigo Proteins Gmbh | Novel alkaline stable immunoglobulin binding proteins |
| EP4617283A2 (en) | 2016-10-17 | 2025-09-17 | Pfizer Inc. | Anti-edb antibodies and antibody-drug conjugates |
| US11390666B2 (en) | 2017-06-07 | 2022-07-19 | Philogen S.P.A. | Vascular endothelial growth factor/anti-fibronectin antibody fusion proteins |
| CN111148759B (zh) * | 2017-09-30 | 2023-09-19 | 合肥立方制药股份有限公司 | 结合至纤维连接蛋白b结构域的蛋白 |
| WO2019091918A1 (en) | 2017-11-07 | 2019-05-16 | Navigo Proteins Gmbh | Fusion proteins with specificity for ed-b and long serum half-life for diagnosis or treatment of cancer |
| EP3660039A1 (en) | 2018-11-30 | 2020-06-03 | Philogen S.p.A. | Il2 immunoconjugates |
| WO2020070150A1 (en) | 2018-10-02 | 2020-04-09 | Philogen S.P.A | Il2 immunoconjugates |
| JP2022544760A (ja) | 2019-08-15 | 2022-10-21 | ヤンセン バイオテツク，インコーポレーテツド | 改善された単鎖可変断片のための材料及び方法 |
| WO2021116337A1 (en) | 2019-12-11 | 2021-06-17 | Cilag Gmbh International | Multispecific binding molecules comprising ltbr and edb binding domains and uses thereof |
| CN111234016B (zh) * | 2020-02-23 | 2021-09-07 | 北京康普美特创新医药科技有限责任公司 | 一种抗补体c5分子的全人源单克隆抗体及应用 |
| CN111171149B (zh) * | 2020-02-23 | 2021-09-07 | 北京康普美特创新医药科技有限责任公司 | 一种抗补体c5分子的人源化单链抗体及其应用 |
| KR102614063B1 (ko) | 2020-12-24 | 2023-12-19 | 대화제약 주식회사 | 엑스트라도메인 b 피브로넥틴에 특이적으로 결합하는 신규한 항체 |
| CN118510535A (zh) | 2022-01-04 | 2024-08-16 | 菲洛根股份公司 | 包含il-12的免疫细胞因子与激酶抑制剂的组合 |
| US20250262307A1 (en) | 2022-08-01 | 2025-08-21 | Philochem Ag | Conjugates of psma-binding moieties with cytotoxic agents |
| WO2024052333A1 (en) | 2022-09-06 | 2024-03-14 | Philochem Ag | Multivalent fibroblast activation protein ligands for targeted delivery applications |
| WO2025061801A1 (en) | 2023-09-19 | 2025-03-27 | Philochem Ag | Therapeutic combination of an anti-edb fibronectin domain antibody il2 or il12 fusion protein and a lutetium-177 radioconjugate |
| WO2025221736A2 (en) | 2024-04-15 | 2025-10-23 | Janssen Biotech, Inc. | Ltbr binding molecules and uses thereof |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| EP0460709B1 (en) | 1985-01-28 | 1997-05-21 | Xoma Corporation | AraB promoters and method of producing polypeptides, including cecropins, by microbiological techniques |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4894326A (en) | 1986-04-09 | 1990-01-16 | Fred Hutchinson Cancer Research Center | Monoclonal antibody defining oncofetal structure of fibronectin |
| US5243029A (en) * | 1986-04-09 | 1993-09-07 | Fred Hutchinson Cancer Research Center | Oncofetal structure of fibronectin |
| CA1341235C (en) | 1987-07-24 | 2001-05-22 | Randy R. Robinson | Modular assembly of antibody genes, antibodies prepared thereby and use |
| EP0311434A3 (en) * | 1987-10-09 | 1990-05-09 | The De La Rue Company Plc | Integrated circuit card |
| EP0396612B1 (en) | 1988-01-11 | 1996-07-24 | Xoma Corporation | Novel plasmid vector with pectate lyase signal sequence |
| IT1217724B (it) * | 1988-05-26 | 1990-03-30 | Ist Naz Ric Sul Cancro | Anticorpo monoclonale specifico per una sequenza di fibronettina espressa in cellule trasformate ibridoma secernente tale anticorpo e impiego dell'anticorpo monoclonale per la diagnosi di tumori |
| US5177015A (en) | 1988-08-12 | 1993-01-05 | Fred Hutchinson Cancer Research Centre | Onco-developmentally regulated α-N-acetylgalactosaminyltransferase |
| US5843156A (en) | 1988-08-24 | 1998-12-01 | Endoluminal Therapeutics, Inc. | Local polymeric gel cellular therapy |
| JPH0276598A (ja) * | 1988-09-14 | 1990-03-15 | Fujita Gakuen | 抗ｅｄ−ｂ抗体 |
| JPH04169195A (ja) * | 1990-10-31 | 1992-06-17 | Fujita Gakuen | 抗ｅｄ―ｂモノクローナル抗体 |
| AU3178993A (en) | 1991-11-25 | 1993-06-28 | Enzon, Inc. | Multivalent antigen-binding proteins |
| US5629291A (en) | 1992-01-31 | 1997-05-13 | La Jolla Cancer Research Foundation | Methods of modulating fibronectin extracellular matrix assembly |
| US5877289A (en) | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
| US6093399A (en) | 1992-03-05 | 2000-07-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the specific coagulation of vasculature |
| US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
| US6004555A (en) | 1992-03-05 | 1999-12-21 | Board Of Regents, The University Of Texas System | Methods for the specific coagulation of vasculature |
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US6036955A (en) | 1992-03-05 | 2000-03-14 | The Scripps Research Institute | Kits and methods for the specific coagulation of vasculature |
| US5976535A (en) | 1992-06-09 | 1999-11-02 | Neorx Corporation | Pretargeting protocols for the enhanced localization of cytotoxins to target sites and cytotoxic combinations useful therefore |
| US5561114A (en) | 1992-09-25 | 1996-10-01 | Otsuka Pharmaceutical Factory Inc. | Adsorbent for cellular fibronectin, a method for fractional purification of fibronectin and a method of hemocatharisis |
| US5491130A (en) | 1992-11-10 | 1996-02-13 | The United States Of America As Represented By The Department Of Health And Human Services | Peptide inhibitors of fibronectin and related collagen-binding proteins |
| JP3720353B2 (ja) | 1992-12-04 | 2005-11-24 | メディカル リサーチ カウンシル | 多価および多重特異性の結合タンパク質、それらの製造および使用 |
| US6015897A (en) | 1993-12-07 | 2000-01-18 | Neorx Corporation | Biotinamido-n-methylglycyl-seryl-o-succinamido-benzyl dota |
| US5523229A (en) | 1994-03-22 | 1996-06-04 | Trustees Of The University Of Pennsylvania | Antibodies specific for oncofetal fibronectin |
| DE4417865A1 (de) | 1994-05-20 | 1995-11-23 | Behringwerke Ag | Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie |
| ITFI940095A1 (it) | 1994-05-23 | 1995-11-23 | Molteni & C | Coniugati fotodinamici aventi proprieta' biocide |
| US5648485A (en) | 1994-10-26 | 1997-07-15 | University Of British Columbia | β, β-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins |
| WO1996023816A1 (en) | 1995-02-01 | 1996-08-08 | British Technology Group Limited | Radiolabelled proteins |
| WO1997002479A2 (en) | 1995-06-30 | 1997-01-23 | Yale University | Human monoclonal anti-tumor antibodies |
| US5808146A (en) | 1995-11-09 | 1998-09-15 | Emory University | Amino acid analogs for tumor imaging |
| GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
| US5913884A (en) | 1996-09-19 | 1999-06-22 | The General Hospital Corporation | Inhibition of fibrosis by photodynamic therapy |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| US6394952B1 (en) | 1998-02-03 | 2002-05-28 | Adeza Biomedical Corporation | Point of care diagnostic systems |
| US6267722B1 (en) | 1998-02-03 | 2001-07-31 | Adeza Biomedical Corporation | Point of care diagnostic systems |
| TWI259837B (en) | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| WO2001062800A1 (en) | 2000-02-24 | 2001-08-30 | Eidgenössische Technische Hochschule Zürich | Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis |
| JP4917232B2 (ja) | 2000-02-24 | 2012-04-18 | フィロジェン ソチエタ ペル アツィオニ | 病理学的病変における脈管形成の処理のための組成物及び方法 |
| BR0306715A (pt) | 2002-01-03 | 2004-12-28 | Schering Ag | Métodos para diagnóstico e tratamento de tumores |
| JP4169195B2 (ja) * | 2003-06-24 | 2008-10-22 | 株式会社河合楽器製作所 | 電子楽音発生装置の記録制御装置 |
-
1996
- 1996-05-24 GB GB9610967A patent/GB9610967D0/en active Pending
-
1997
- 1997-05-23 IL IL12721697A patent/IL127216A0/xx active IP Right Grant
- 1997-05-23 SK SK1612-98A patent/SK285916B6/sk not_active IP Right Cessation
- 1997-05-23 TR TR1998/02416T patent/TR199802416T2/xx unknown
- 1997-05-23 NZ NZ33308397A patent/NZ333083A/xx not_active IP Right Cessation
- 1997-05-23 WO PCT/GB1997/001412 patent/WO1997045544A1/en not_active Ceased
- 1997-05-23 KR KR1020067006008A patent/KR100741452B1/ko not_active Expired - Lifetime
- 1997-05-23 CZ CZ19983815A patent/CZ295531B6/cs not_active IP Right Cessation
- 1997-05-23 BR BRPI9709350-5A patent/BR9709350B1/pt not_active IP Right Cessation
- 1997-05-23 CA CA 2256308 patent/CA2256308C/en not_active Expired - Lifetime
- 1997-05-23 PL PL97330075A patent/PL188557B1/pl not_active IP Right Cessation
- 1997-05-23 EP EP19970923243 patent/EP0906426B1/en not_active Expired - Lifetime
- 1997-05-23 US US09/194,356 patent/US7273924B1/en not_active Expired - Fee Related
- 1997-05-23 ES ES97923243T patent/ES2286831T3/es not_active Expired - Lifetime
- 1997-05-23 HU HU0200546A patent/HUP0200546A2/hu unknown
- 1997-05-23 SI SI9730765T patent/SI0906426T1/sl unknown
- 1997-05-23 UA UA98126836A patent/UA74129C2/uk unknown
- 1997-05-23 CN CNB971949026A patent/CN100447159C/zh not_active Expired - Lifetime
- 1997-05-23 DK DK97923243T patent/DK0906426T3/da active
- 1997-05-23 PT PT97923243T patent/PT906426E/pt unknown
- 1997-05-23 JP JP54182897A patent/JP4750912B2/ja not_active Expired - Lifetime
- 1997-05-23 AU AU29101/97A patent/AU729081B2/en not_active Expired
- 1997-05-23 AT AT97923243T patent/ATE361364T1/de active
- 1997-05-23 EA EA199801043A patent/EA004329B1/ru not_active IP Right Cessation
- 1997-05-23 DE DE1997637683 patent/DE69737683T2/de not_active Expired - Lifetime
- 1997-05-23 KR KR10-2005-7000518A patent/KR20050010081A/ko not_active Ceased
-
1998
- 1998-10-29 IS IS4883A patent/IS2508B/is unknown
- 1998-11-23 IL IL127216A patent/IL127216A/en not_active IP Right Cessation
- 1998-11-23 NO NO19985459A patent/NO324904B1/no not_active IP Right Cessation
- 1998-11-24 BG BG102950A patent/BG65138B1/bg unknown
-
2007
- 2007-08-21 US US11/842,774 patent/US8703143B2/en not_active Expired - Fee Related
-
2008
- 2008-08-07 JP JP2008204682A patent/JP2009050261A/ja active Pending
-
2013
- 2013-10-04 US US14/046,224 patent/US9096670B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE361364T1 (de) | Antikörper gegen die ed-b domäne von fibronektin, ihre herstellung und verwendungen | |
| FR2724182B1 (fr) | Obtention d'un anticorps monoclonal recombinant a partir d'un anticorps monoclonal humain anti-rhesus d, sa production en cellules d'insecte, et ses utilisations | |
| ATE377027T1 (de) | Tetravalente antikörperkonstrukte | |
| CY1112101T1 (el) | Νευροτροφικοι παραγοντες | |
| AU5055593A (en) | Antibodies specific for HIV | |
| DE69433406D1 (de) | Antikörper gegen cd40 | |
| ES2177632T3 (es) | Purificacion de anticuerpos. | |
| CY1105836T1 (el) | 12, 13-τροποποιημενα παραγωγα εποθιλονης | |
| DE69939820D1 (de) | Internalisierende erbb2 antikörper | |
| BR9808491A (pt) | Compostos calcilìticos | |
| FI964845L (fi) | CD44v6:n vastaiset monoklonaaliset vasta-aineet | |
| DE60017019D1 (de) | Antikörper gegen Spaltprodukte von Vimentin | |
| PT840620E (pt) | Antagonistas de il-8 para o tratamento de asma | |
| EA200200974A1 (ru) | Моноклональные антитела к рецептору лпнп человека, их получение и применение | |
| DE69728897D1 (de) | Saeugetierchemokine | |
| DE50114321D1 (de) | REZEPTOR DER EDb-FIBRONEKTIN-DOMÄNE (II) | |
| DE59605545D1 (de) | Alkoholhaltige instant-getränkemischung, ihre herstellung und verwendung | |
| DE69838645D1 (de) | Epitope der gp120 v1/v" domäne von hiv-1 geeignet zur herstellung neutralisierender antikörper | |
| DE60042273D1 (de) | Antitumorantikörper, proteine und deren verwendung | |
| DE69434087D1 (de) | ENTEROTOXINE VON SHIGELLA FLEXNERI 2a | |
| DE59611293D1 (de) | Protein mit dnase-aktivität | |
| EA200000705A1 (ru) | Промежуточные соединения и способ синтеза 17-замещенных 16.бета.-арилокси 4-азастероидов | |
| TW288020B (en) | Monoclonal antibodies specific to methamphetamine, hybridoma producing the antibodies, kits containing the antibodies and uses thereof | |
| EA199800028A1 (ru) | Винилсульфоксиды и способы их синтеза | |
| HUP0003029A2 (hu) | Ankrod specifikus monoklonális antitestek, antitestfragmentumok, keverékeik és alkalmazásuk |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0906426 Country of ref document: EP |