GB9610967D0 - Specific binding members,materials and methods - Google Patents
Specific binding members,materials and methodsInfo
- Publication number
- GB9610967D0 GB9610967D0 GB9610967A GB9610967A GB9610967D0 GB 9610967 D0 GB9610967 D0 GB 9610967D0 GB 9610967 A GB9610967 A GB 9610967A GB 9610967 A GB9610967 A GB 9610967A GB 9610967 D0 GB9610967 D0 GB 9610967D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- methods
- materials
- specific binding
- binding members
- specific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000009870 specific binding Effects 0.000 title abstract 2
- 102000016359 Fibronectins Human genes 0.000 abstract 2
- 108010067306 Fibronectins Proteins 0.000 abstract 2
- 230000027455 binding Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (34)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9610967A GB9610967D0 (en) | 1996-05-24 | 1996-05-24 | Specific binding members,materials and methods |
| HK99105868.0A HK1020990B (en) | 1996-05-24 | 1997-05-23 | Antibodies to the ed-b domain of fibronectin, their construction and uses |
| HU0200546A HUP0200546A2 (en) | 1996-05-24 | 1997-05-23 | Antibodies to the ed-b domain of fibronectin, their construction and uses |
| JP54182897A JP4750912B2 (ja) | 1996-05-24 | 1997-05-23 | フィブロネクチンのed―bドメインに対する抗体、それらの構造及び用途 |
| PL97330075A PL188557B1 (pl) | 1996-05-24 | 1997-05-23 | Sposób wytwarzania swoiście wiążącego się czynnika, swoiście wiążący się czynnik, kwas nukleinowy ifag |
| SI9730765T SI0906426T1 (sl) | 1996-05-24 | 1997-05-23 | Protitelesa proti ED-B domeni fibronektina, njihova konstrukcija in njihove uporabe |
| EA199801043A EA004329B1 (ru) | 1996-05-24 | 1997-05-23 | Антитела против домена ed-b фибронектина, их конструирование и использование |
| EP19970923243 EP0906426B1 (en) | 1996-05-24 | 1997-05-23 | Antibodies to the ed-b domain of fibronectin, their construction and uses |
| CA 2256308 CA2256308C (en) | 1996-05-24 | 1997-05-23 | Antibodies to the ed-b domain of fibronectin, their construction and uses |
| US09/194,356 US7273924B1 (en) | 1996-05-24 | 1997-05-23 | Antibodies to the ED-B domain of fibronectin, their construction and uses |
| KR1020067006008A KR100741452B1 (ko) | 1996-05-24 | 1997-05-23 | 피브로넥틴 ed-b 도메인에 대한 항체, 그 제조방법 및용도 |
| PT97923243T PT906426E (pt) | 1996-05-24 | 1997-05-23 | Anticorpos para o domínio ed-b de fibronectina, sua construção e utilizações |
| BRPI9709350-5A BR9709350B1 (pt) | 1996-05-24 | 1997-05-23 | anticorpo recombinante ou fragmento de anticorpo recombinante, composiÇço farmacÊutica, Ácido nuclÈico, bacteriàfago, cÉlula hospedeira bacteriana ou de levedura, uso de anticorpo ou fragmento de anticorpo recombinante, processo para a produÇço do mesmo, e, kit diagnàstico. |
| CNB971949026A CN100447159C (zh) | 1996-05-24 | 1997-05-23 | 结合纤连蛋白ed-b结构域的抗体及其构建和应用 |
| AU29101/97A AU729081B2 (en) | 1996-05-24 | 1997-05-23 | Antibodies to the ED-B domain of fibronectin, their construction and uses |
| DK97923243T DK0906426T3 (da) | 1996-05-24 | 1997-05-23 | Antistoffer mod ED-B-domænet af fibronektin, deres konstruktion og anvendelser |
| ES97923243T ES2286831T3 (es) | 1996-05-24 | 1997-05-23 | Anticuerpos para el dominio ed-b de fibronectina, la construccion de estos y sus usos. |
| TR1998/02416T TR199802416T2 (xx) | 1996-05-24 | 1997-05-23 | Fibronektinin ED-B b�lgesi i�in antikorlar, yap�lar� ve kullan�mlar�. |
| NZ33308397A NZ333083A (en) | 1996-05-24 | 1997-05-23 | Antibodies to the ED-B domain of fibronectin (FN), their construction and uses |
| UA98126836A UA74129C2 (uk) | 1996-05-24 | 1997-05-23 | Виділене антитіло або фрагмент антитіла, що є специфічним до онкоембріонального домену ed-b фібронектину (fn) та таким, що безпосередньо з ним зв'язується |
| IL12721697A IL127216A0 (en) | 1996-05-24 | 1997-05-23 | Antibodies to the ed-b domain of fibronectin their construction and uses |
| DE1997637683 DE69737683T2 (de) | 1996-05-24 | 1997-05-23 | Antikörper gegen die ed-b domäne von fibronektin, ihre herstellung und verwendungen |
| PCT/GB1997/001412 WO1997045544A1 (en) | 1996-05-24 | 1997-05-23 | Antibodies to the ed-b domain of fibronectin, their construction and uses |
| AT97923243T ATE361364T1 (de) | 1996-05-24 | 1997-05-23 | Antikörper gegen die ed-b domäne von fibronektin, ihre herstellung und verwendungen |
| SK1612-98A SK285916B6 (sk) | 1996-05-24 | 1997-05-23 | Protilátky proti ED-B doméne fibronektínu, ich konštrukcia a použitie |
| CZ19983815A CZ295531B6 (cs) | 1996-05-24 | 1997-05-23 | Izolovaná protilátka, způsob její výroby a použití |
| KR10-2005-7000518A KR20050010081A (ko) | 1996-05-24 | 1997-05-23 | 피브로넥틴 ed-b 도메인에 대한 항체, 그 제조방법 및용도 |
| IS4883A IS2508B (is) | 1996-05-24 | 1998-10-29 | Mótefni gegn ED-B hneppinu í fíbrónektíni, smíði þeirra og notkanir |
| NO19985459A NO324904B1 (no) | 1996-05-24 | 1998-11-23 | Antistoff eller antistoffragment rettet mot ED-B domenenet til fibronektin, farmasoytisk sammensetning, nukleinsyre, fag, vertcelle, fremgangsmate for fremstilling, ulike anvendelser samt diagnostisk kit |
| IL127216A IL127216A (en) | 1996-05-24 | 1998-11-23 | Antibody-specific antibody or fragment - Fibronectin B – ED embryos, process for their preparation and use |
| BG102950A BG65138B1 (bg) | 1996-05-24 | 1998-11-24 | Антитела за ed-b домен на фибронектин, техният строеж и използвания |
| US11/842,774 US8703143B2 (en) | 1996-05-24 | 2007-08-21 | Antibodies of the ED-B domain of fibronectin, their construction and uses |
| JP2008204682A JP2009050261A (ja) | 1996-05-24 | 2008-08-07 | フィブロネクチンのed―bドメインに対する抗体、それらの構造及び用途 |
| US14/046,224 US9096670B2 (en) | 1996-05-24 | 2013-10-04 | Antibodies of the ED-B domain of fibronectin, their construction and uses |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9610967A GB9610967D0 (en) | 1996-05-24 | 1996-05-24 | Specific binding members,materials and methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB9610967D0 true GB9610967D0 (en) | 1996-07-31 |
Family
ID=10794298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9610967A Pending GB9610967D0 (en) | 1996-05-24 | 1996-05-24 | Specific binding members,materials and methods |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US7273924B1 (enExample) |
| EP (1) | EP0906426B1 (enExample) |
| JP (2) | JP4750912B2 (enExample) |
| KR (2) | KR100741452B1 (enExample) |
| CN (1) | CN100447159C (enExample) |
| AT (1) | ATE361364T1 (enExample) |
| AU (1) | AU729081B2 (enExample) |
| BG (1) | BG65138B1 (enExample) |
| BR (1) | BR9709350B1 (enExample) |
| CA (1) | CA2256308C (enExample) |
| CZ (1) | CZ295531B6 (enExample) |
| DE (1) | DE69737683T2 (enExample) |
| DK (1) | DK0906426T3 (enExample) |
| EA (1) | EA004329B1 (enExample) |
| ES (1) | ES2286831T3 (enExample) |
| GB (1) | GB9610967D0 (enExample) |
| HU (1) | HUP0200546A2 (enExample) |
| IL (2) | IL127216A0 (enExample) |
| IS (1) | IS2508B (enExample) |
| NO (1) | NO324904B1 (enExample) |
| NZ (1) | NZ333083A (enExample) |
| PL (1) | PL188557B1 (enExample) |
| PT (1) | PT906426E (enExample) |
| SI (1) | SI0906426T1 (enExample) |
| SK (1) | SK285916B6 (enExample) |
| TR (1) | TR199802416T2 (enExample) |
| UA (1) | UA74129C2 (enExample) |
| WO (1) | WO1997045544A1 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
| US6685943B1 (en) | 1997-01-21 | 2004-02-03 | The Texas A&M University System | Fibronectin binding protein compositions and methods of use |
| US7244826B1 (en) | 1998-04-24 | 2007-07-17 | The Regents Of The University Of California | Internalizing ERB2 antibodies |
| US20030176663A1 (en) * | 1998-05-11 | 2003-09-18 | Eidgenossische Technische Hochscule | Specific binding molecules for scintigraphy |
| TWI259837B (en) * | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| US20030045681A1 (en) * | 1998-05-11 | 2003-03-06 | Anthony J. Zelano | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| EP1259548A1 (en) * | 2000-02-24 | 2002-11-27 | Eidgenössische Technische Hochschule Zürich | Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis |
| CA2399866C (en) * | 2000-02-24 | 2011-05-10 | Philogen S.R.L. | Compositions and methods for treatment of angiogenesis in pathological lesions |
| EP1282642B1 (en) | 2000-05-09 | 2006-09-06 | Greenville Hospital System | Therapeutic pore-forming peptides |
| AU2001281824A1 (en) * | 2000-06-15 | 2001-12-24 | Patrizia Castellani | Methods for quantitative determination of b-fibronectin in biological fluids and tissues |
| AU1218202A (en) * | 2000-09-07 | 2002-03-22 | Schering Ag | Receptor in the ED<sub>b</sub> fibronectin domain |
| IT1317108B1 (it) * | 2000-12-06 | 2003-05-26 | Philogen Srl | Processo per la selezione di frammenti anticorporali anti-angiogenesi,frammenti anticorpali anti-angiogenesi cosi' ottenuti e loro uso. |
| US7456146B2 (en) * | 2001-05-09 | 2008-11-25 | Ghc Research Development Corporation | Lytic peptide prodrugs |
| MXPA04006517A (es) | 2002-01-03 | 2005-03-31 | Schering Ag | Conjugados que comprenden un anticuerpo especifico para el dominio ed-b de fibronectina y sus usos para la deteccion y tratamiento de tumores. |
| SI1483297T1 (sl) * | 2002-03-11 | 2010-04-30 | Philogen Spa | Protitelesa, izvedena iz anti ED-B L19, in ki ciljajo vaskulaturo tumorja |
| KR20110025885A (ko) | 2002-07-15 | 2011-03-11 | 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 | 포스파티딜에탄올아민에 결합하는 펩타이드, 및 바이러스 감염을 치료하는데 있어서 이의 용도 |
| JP4914209B2 (ja) | 2003-03-14 | 2012-04-11 | ワイス | ヒトil−21受容体に対する抗体および該抗体の使用 |
| DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| US8420087B2 (en) | 2004-01-05 | 2013-04-16 | Antisoma Research Limited | Interleukin-12 targeted to oncofoetal fibronectin |
| AU2005280528B2 (en) | 2004-07-30 | 2010-12-23 | Adeza Biomedical Corporation | Oncofetal fibronectin as a marker for disease and other conditions and methods for detection of oncofetal fibronectin |
| US7785591B2 (en) | 2004-10-14 | 2010-08-31 | Morphosys Ag | Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies |
| EP1803814A1 (en) | 2005-12-27 | 2007-07-04 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Method of improving the antibody selection capacity in phage-display library |
| EP1925664A1 (en) | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Artificial binding proteins based on a modified alpha helical region of ubiquitin |
| US8253725B2 (en) * | 2007-12-28 | 2012-08-28 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Method and system for generating surface models of geometric structures |
| EP2085095B1 (en) * | 2008-01-17 | 2012-03-07 | Philogen S.p.A. | Combination of an anti-EDb fibronectin antibody-IL-2 fusion protein, and a molecule binding to B cells, B cell progenitors and/or their cancerous counterpart |
| EP2100621A1 (en) | 2008-03-10 | 2009-09-16 | mivenion GmbH | Polyether polyol dendron conjugates with effector molecules for biological targeting |
| EP2116555A1 (en) | 2008-05-08 | 2009-11-11 | Bayer Schering Pharma Aktiengesellschaft | Use of a radioactively labelled molecule specifically binding to ED-B fibronectin in a method of treatment of Hodgkin lymphoma |
| IT1392027B1 (it) * | 2008-12-12 | 2012-02-09 | Castellani | Anticorpo monoclonale e suo uso per la identificazione della isoforma oncofetale della fibronettina (b-fn) a scopo diagnostico o terapeutico. |
| BR112012014194A2 (pt) | 2009-12-14 | 2017-01-10 | Scil Proteins Gmbh | um método para identificar proteínas ubiquitinas modificadas hetero-multiméricas com capacidade de ligação a ligandos |
| WO2011110490A1 (en) | 2010-03-09 | 2011-09-15 | Bayer Pharma Aktiengesellschaft | Process for the production of radioactively labelled scfv antibody fragments, kits and compositions |
| WO2012171541A1 (en) | 2011-06-15 | 2012-12-20 | Scil Proteins Gmbh | Human fusion proteins comprising interferons and hetero-dimeric modified ubiquitin proteins |
| EP2721152B1 (en) | 2011-06-15 | 2019-03-27 | Navigo Proteins GmbH | Dimeric binding proteins based on modified ubiquitins |
| US20150183846A1 (en) | 2012-06-13 | 2015-07-02 | Scil Proteins Gmbh | Human fusion proteins comprising single chain tnfalpha and targeting domains |
| WO2014094799A1 (en) | 2012-12-19 | 2014-06-26 | Scil-Proteins-Gmbh | Ubiquitin moieties as a means for prolonging serum half-life |
| WO2014194784A1 (zh) * | 2013-06-06 | 2014-12-11 | 合肥立方制药股份有限公司 | 人源抗纤连蛋白ed-b结构域的抗体及其用途 |
| JP6738340B2 (ja) | 2015-02-06 | 2020-08-12 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングNavigo Proteins GmbH | 新規なegfr結合タンパク質 |
| ES2916101T3 (es) | 2015-07-16 | 2022-06-28 | Navigo Proteins Gmbh | Nuevas proteínas de unión a inmunoglobulina y su uso en la purificación por afinidad |
| JP2018520675A (ja) | 2015-07-20 | 2018-08-02 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングNavigo Proteins GmbH | ジユビキチン変異タンパク質をベースとした新規結合タンパク質及びその生成方法 |
| CN108291915B (zh) * | 2015-11-16 | 2021-01-05 | 合肥立方制药股份有限公司 | Ed-b蛋白在诊断组织增生中的应用 |
| JP2019526526A (ja) | 2016-05-04 | 2019-09-19 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングNavigo Proteins GmbH | ペプチドリンカーを含む化学的部分の部位特異的カップリングのための標的化合物 |
| DK3497117T5 (da) | 2016-08-11 | 2024-09-02 | Navigo Proteins Gmbh | Nye alkalisk stabile immunglobulin-bindende proteiner |
| JP7039577B2 (ja) | 2016-10-17 | 2022-03-22 | ファイザー・インク | 抗edb抗体および抗体-薬物コンジュゲート |
| CA3065153C (en) | 2017-06-07 | 2023-09-05 | Philogen S.P.A. | Vascular endothelial growth factor/anti-fibronectin antibody fusion proteins |
| US11192943B2 (en) | 2017-09-30 | 2021-12-07 | Hefei Lifeon Pharmaceutical Co., Ltd. | Protein binding to fibronectin B domain |
| EP3706804B1 (en) | 2017-11-07 | 2022-02-23 | Navigo Proteins GmbH | Fusion proteins with specificity for ed-b and long serum half-life for diagnosis or treatment of cancer |
| WO2020070150A1 (en) | 2018-10-02 | 2020-04-09 | Philogen S.P.A | Il2 immunoconjugates |
| EP3660039A1 (en) | 2018-11-30 | 2020-06-03 | Philogen S.p.A. | Il2 immunoconjugates |
| PH12022550348A1 (en) | 2019-08-15 | 2022-12-12 | Janssen Biotech Inc | Materials and methods for improved single chain variable fragments |
| US20210188990A1 (en) | 2019-12-11 | 2021-06-24 | Cilag Gmbh International | Multispecific binding molecules comprising ltbr and edb binding domains and uses thereof |
| CN111171149B (zh) * | 2020-02-23 | 2021-09-07 | 北京康普美特创新医药科技有限责任公司 | 一种抗补体c5分子的人源化单链抗体及其应用 |
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| KR102614063B1 (ko) | 2020-12-24 | 2023-12-19 | 대화제약 주식회사 | 엑스트라도메인 b 피브로넥틴에 특이적으로 결합하는 신규한 항체 |
| CA3242326A1 (en) | 2022-01-04 | 2023-07-13 | Cipo | Combination of an immunocytokine comprising il-12 and a kinase inhibitor |
| US20250262307A1 (en) | 2022-08-01 | 2025-08-21 | Philochem Ag | Conjugates of psma-binding moieties with cytotoxic agents |
| WO2024052333A1 (en) | 2022-09-06 | 2024-03-14 | Philochem Ag | Multivalent fibroblast activation protein ligands for targeted delivery applications |
| WO2025061801A1 (en) | 2023-09-19 | 2025-03-27 | Philochem Ag | Therapeutic combination of an anti-edb fibronectin domain antibody il2 or il12 fusion protein and a lutetium-177 radioconjugate |
| WO2025221736A2 (en) | 2024-04-15 | 2025-10-23 | Janssen Biotech, Inc. | Ltbr binding molecules and uses thereof |
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