JP2000508668A - ポリオール組成物 - Google Patents
ポリオール組成物Info
- Publication number
- JP2000508668A JP2000508668A JP9537673A JP53767397A JP2000508668A JP 2000508668 A JP2000508668 A JP 2000508668A JP 9537673 A JP9537673 A JP 9537673A JP 53767397 A JP53767397 A JP 53767397A JP 2000508668 A JP2000508668 A JP 2000508668A
- Authority
- JP
- Japan
- Prior art keywords
- mannitol
- polyols
- composition
- sorbitol
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/16—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by suspending the powder material in a gas, e.g. in fluidised beds or as a falling curtain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C31/18—Polyhydroxylic acyclic alcohols
- C07C31/26—Hexahydroxylic alcohols
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Polyurethanes Or Polyureas (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Pulleys (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.本質的に少なくとも二つのポリオールおよび適宜結合剤からなる組成物であ って、共噴霧乾燥または共流動層造粒によって得られ、80重量%よりも多い 含量で少なくとも一つの非吸湿性ポリオールを有する、前記組成物。 2.非吸湿性ポリオールがマンニトール、ラクチトール、イソマルチトール、キ シリトールおよびエリスリトールからなるグループから選択されることを特徴 とする、請求項1に記載の組成物。 3.少なくとも二つのポリオールを水に溶かし、得られる水溶液を気流中120 −300°Cの温度で噴霧することによって得られる、請求項1または2に記 載の組成物。 4.少なくとも二つのポリオールを水に溶かし、得られる混合物を気流中40− 150°Cの温度で渦回転することによって得られる、請求項1−3のいずれ かに記載の組成物。 5.マンニトールおよびソルビトール、マンニトールおよびラクチトール、また はマンニトール、ソルビトールおよびラクチトールおよび他のポリオール、特 にマンニトール、ソルビトールおよびラクチトールがポリオールとして使用さ れることを特徴とする、請求項1−3のいずれかに記載の組成物。 6.ソルビトール/ラクチトールに対するマンニトールの割合が80:20から 99:1の範囲、特に90:10から98:2の範囲であることを特徴とする 、請求項5に記載の組成物。 7.マンニトール:ソルビトール:ラクチトール比が、90:1:9または90 :9:1から98:1:1の範囲であることを特徴とする、請求項のひとつに 記載の組成物。 8.水含量が1重量%より少ないことを特徴とする、請求項1〜7のいずれかに 記載の組成物。 9.0.05−5重量%の結合剤を含むことを特徴とする、請求項1〜8のいず れかに記載の組成物。 10.結晶構造においてフィラメントを有することを特徴とする、請求項1〜9 のいずれかに記載の組成物。 11.請求項1−10のいずれかに記載の組成物を含む錠剤または圧縮品。 12.少なくとも一つの医薬活性化合物を含む、請求項11に記載の錠剤。 13.本質的に少なくとも二つのポリオールおよび適宜少なくとも一つの結合剤 からなる組成物を製造する方法であって、以下の工程、 a)少なくとも二つのポリオールの水溶液を製造することであって、該溶液は 全ポリオール含量に対して80重量%よりも多い1又は2以上の非吸湿性ポ リオールを含み、 b1)得られる溶液を気流中120−300°Cの温度で噴霧し、水を蒸発さ せるか、または b2)得られる溶液を気流中40−150°Cの温度で渦回転し、水を蒸発さ せることを含む、前記方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19615418A DE19615418A1 (de) | 1996-04-22 | 1996-04-22 | Polyol-Zusammensetzung |
DE19615418.9 | 1996-04-22 | ||
PCT/EP1997/001787 WO1997039739A2 (de) | 1996-04-22 | 1997-04-10 | Polyol-zusammensetzung |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2000508668A true JP2000508668A (ja) | 2000-07-11 |
JP2000508668A5 JP2000508668A5 (ja) | 2004-12-09 |
JP4343272B2 JP4343272B2 (ja) | 2009-10-14 |
Family
ID=7791693
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53767397A Expired - Lifetime JP4343272B2 (ja) | 1996-04-22 | 1997-04-10 | ポリオール組成物 |
Country Status (17)
Country | Link |
---|---|
US (1) | US6165511A (ja) |
EP (1) | EP0896528B1 (ja) |
JP (1) | JP4343272B2 (ja) |
CN (1) | CN1147290C (ja) |
AT (1) | ATE210971T1 (ja) |
CA (1) | CA2252609C (ja) |
CZ (1) | CZ291589B6 (ja) |
DE (2) | DE19615418A1 (ja) |
DK (1) | DK0896528T3 (ja) |
ES (1) | ES2169385T3 (ja) |
HK (1) | HK1019202A1 (ja) |
ID (1) | ID17384A (ja) |
MY (1) | MY116890A (ja) |
PT (1) | PT896528E (ja) |
RU (1) | RU2184535C2 (ja) |
TW (1) | TWI237567B (ja) |
WO (1) | WO1997039739A2 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004285052A (ja) * | 2003-03-06 | 2004-10-14 | Lion Corp | 化粧料組成物 |
JP2012519729A (ja) * | 2009-03-09 | 2012-08-30 | エスピーアイ ファーマ,インコーポレイテッド | 高度に圧密可能かつ耐久性のある直接圧縮賦形剤および賦形剤系 |
JP2012532169A (ja) * | 2009-07-10 | 2012-12-13 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 錠剤を製造するための組成物およびその調製方法 |
JP2012532168A (ja) * | 2009-07-10 | 2012-12-13 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 水分含量の低い打錠補助剤およびその調製方法 |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0000279A3 (en) | 1996-11-15 | 2002-07-29 | Merck Patent Gmbh | Method for producing shaped and unshaped polyol masses |
US20030203036A1 (en) | 2000-03-17 | 2003-10-30 | Gordon Marc S. | Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients |
GB9716432D0 (en) * | 1997-08-05 | 1997-10-08 | Cerestar Holding Bv | Tableting of erythritol |
FI107732B (fi) * | 1998-03-18 | 2001-09-28 | Xyrofin Oy | Laktitolin kiteyttäminen, kiteinen laktitolituote ja sen käyttö |
DE19943491B4 (de) * | 1999-09-10 | 2010-04-01 | Südzucker AG Mannheim/Ochsenfurt | Verbesserte Komprimate |
US6872414B1 (en) | 1999-09-20 | 2005-03-29 | Xyrofin Oy | Anhydrous lactitol crystals, a product containing the same and a process for the preparation thereof as well as use thereof |
US7575761B2 (en) | 2000-06-30 | 2009-08-18 | Novartis Pharma Ag | Spray drying process control of drying kinetics |
US20030188679A1 (en) * | 2000-08-25 | 2003-10-09 | Eugen Schwarz | Powdered mannitol and mannitol-containing compositions |
US20040014680A1 (en) * | 2000-10-16 | 2004-01-22 | Hiroaki Nakagami | Medicinal compositions quickly disintegrating in the oral cavity and process for producing the same |
DE60227691D1 (de) | 2001-11-01 | 2008-08-28 | Nektar Therapeutics | Sprühtrocknungsverfahren |
CA2363528A1 (en) * | 2001-11-19 | 2003-05-19 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Immediate release tablet containing naproxen sodium |
EP1481211B1 (en) * | 2001-11-29 | 2009-04-22 | J. Rettenmaier & Söhne GmbH + Co. KG | Process for co-spray drying liquid herbal extracts with dry silicified mcc |
DE10161402A1 (de) † | 2001-12-13 | 2003-06-18 | Merck Patent Gmbh | Verfahren zur Herstellung von direkt tablettierbarem beta-Mannit |
US7118765B2 (en) | 2001-12-17 | 2006-10-10 | Spi Pharma, Inc. | Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms |
FI20021312A (fi) * | 2002-07-03 | 2004-01-04 | Danisco Sweeteners Oy | Polyolikoostumusten kiteyttäminen, kiteinen polyolikoostumustuote ja sen käyttö |
DE10240778A1 (de) * | 2002-08-30 | 2004-03-11 | Merck Patent Gmbh | Verfahren zur Herstellung von direkt tablettierbarem a-Mannit |
WO2004095942A2 (de) * | 2003-04-30 | 2004-11-11 | Ipc Prozess Center Gmbh & Co. | Coffein enthaltende tablette |
KR20060015316A (ko) * | 2003-05-28 | 2006-02-16 | 넥타르 테라퓨틱스 | 아미노산 및/또는 인지질로 부분 또는 완전 코팅된수불용성 활성제 미립자의 제조를 위한 알코올성 수용액의분무 건조법 |
BRPI0709909A2 (pt) * | 2006-03-31 | 2011-07-26 | Rubicon Res Private Ltd | tabletes de desintegraÇço oral |
US20100092564A1 (en) * | 2006-12-21 | 2010-04-15 | Jae Han Park | Composition of and Method for Preparing Orally Disintegrating Tablets |
DE102008014237A1 (de) * | 2008-03-14 | 2009-09-17 | J. Rettenmaier & Söhne Gmbh + Co. Kg | Direktverpressbares Tablettierhilfsmittel |
WO2009152921A1 (de) * | 2008-06-20 | 2009-12-23 | Merck Patent Gmbh | Direkt verpressbare polyolkombination |
CN102088959B (zh) * | 2008-06-20 | 2016-05-25 | 默克专利股份有限公司 | 可直接压缩的且快速崩解的片剂基质 |
EP2228175B1 (de) | 2009-03-12 | 2013-06-19 | Ferton Holding SA | Verwendung eines Pulvers oder Pulvergemisches zur Herstellung eines Mittels zur Pulverstrahlreinigung von Zahnoberflächen |
PT2238974E (pt) * | 2009-04-09 | 2013-07-09 | E Pharma Trento Spa | Granulado para a formulação de comprimidos orodispersíveis |
US20110027444A1 (en) * | 2009-07-28 | 2011-02-03 | Heartland Sweeteners, LLC | No-calorie sweetener compositions |
US20110027446A1 (en) * | 2009-07-28 | 2011-02-03 | Heartland Sweeteners, LLC | No-calorie sweetener compositions |
US20110027445A1 (en) * | 2009-07-28 | 2011-02-03 | Heartland Sweeteners, LLC | No-calorie sweetener compositions |
MX2012001893A (es) | 2009-08-18 | 2012-03-16 | Cargill Inc | Tableteado de eritritol e isomaltosa. |
EP2384742A1 (en) | 2010-05-03 | 2011-11-09 | The Jordanian Pharmaceutical Manufacturing Co. | Pharmaceutical excipient, method for its preparation and use thereof |
WO2012031720A1 (en) | 2010-09-07 | 2012-03-15 | Cargill, Incorporated | Solidified sugar alcohol mixture |
JP2014501226A (ja) * | 2010-12-17 | 2014-01-20 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 直接圧縮可能なδ−マンニトールの調製方法 |
CN103415284B (zh) * | 2011-03-09 | 2016-12-07 | 巴斯夫欧洲公司 | 用于制备快速崩解的片剂的药物配制物 |
CN104095184B (zh) * | 2014-07-15 | 2016-03-30 | 浙江华康药业股份有限公司 | 一种粒状复合糖醇及其制备方法 |
EP3206671A4 (en) | 2014-10-16 | 2018-06-13 | Cargill, Incorporated | Process for preparing a directly compressible erythritol&uses thereof |
CN104447898B (zh) * | 2014-11-06 | 2017-03-29 | 山东绿健生物技术有限公司 | 一种固体乳糖醇及其制备方法与应用 |
EP4183389A1 (en) | 2021-11-18 | 2023-05-24 | KRKA, d.d., Novo mesto | Pharmaceutical composition comprising apremilast |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3245170A1 (de) * | 1982-12-07 | 1984-06-07 | Merck Patent Gmbh, 6100 Darmstadt | Verbesserter sorbit, verfahren zur herstellung und verwendung |
ATE128959T1 (de) * | 1989-01-24 | 1995-10-15 | Spi Polyols Inc | Kryoschützende kristalline sorbitolkügelchen. |
FR2670398B1 (fr) * | 1990-12-14 | 1995-02-17 | Roquette Freres | Composition pulverulente directement compressible et procede d'obtention. |
US5158789A (en) * | 1991-08-09 | 1992-10-27 | Ici Americas Inc. | Melt cocrystallized sorbitol/xylitol compositions |
US5876754A (en) * | 1992-01-17 | 1999-03-02 | Alfatec-Pharma Gmbh | Solid bodies containing active substances and a structure consisting of hydrophilic macromolecules, plus a method of producing such bodies |
FR2710637B1 (fr) * | 1993-09-28 | 1995-12-08 | Roquette Freres | Mannitol pulvérulent de friabilité modérée et son procédé de préparation. |
-
1996
- 1996-04-22 DE DE19615418A patent/DE19615418A1/de not_active Withdrawn
-
1997
- 1997-04-10 WO PCT/EP1997/001787 patent/WO1997039739A2/de not_active Application Discontinuation
- 1997-04-10 PT PT97920646T patent/PT896528E/pt unknown
- 1997-04-10 CA CA002252609A patent/CA2252609C/en not_active Expired - Lifetime
- 1997-04-10 CN CNB97194024XA patent/CN1147290C/zh not_active Expired - Lifetime
- 1997-04-10 RU RU98121204/14A patent/RU2184535C2/ru active
- 1997-04-10 CZ CZ19983385A patent/CZ291589B6/cs not_active IP Right Cessation
- 1997-04-10 ID IDP971194A patent/ID17384A/id unknown
- 1997-04-10 JP JP53767397A patent/JP4343272B2/ja not_active Expired - Lifetime
- 1997-04-10 DK DK97920646T patent/DK0896528T3/da active
- 1997-04-10 DE DE59705894T patent/DE59705894D1/de not_active Revoked
- 1997-04-10 ES ES97920646T patent/ES2169385T3/es not_active Expired - Lifetime
- 1997-04-10 AT AT97920646T patent/ATE210971T1/de not_active IP Right Cessation
- 1997-04-10 US US09/171,536 patent/US6165511A/en not_active Expired - Lifetime
- 1997-04-10 EP EP97920646A patent/EP0896528B1/de not_active Revoked
- 1997-04-17 MY MYPI97001672A patent/MY116890A/en unknown
- 1997-04-18 TW TW086105071A patent/TWI237567B/zh not_active IP Right Cessation
-
1999
- 1999-10-04 HK HK99104290A patent/HK1019202A1/xx not_active IP Right Cessation
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004285052A (ja) * | 2003-03-06 | 2004-10-14 | Lion Corp | 化粧料組成物 |
JP2012519729A (ja) * | 2009-03-09 | 2012-08-30 | エスピーアイ ファーマ,インコーポレイテッド | 高度に圧密可能かつ耐久性のある直接圧縮賦形剤および賦形剤系 |
JP2016041692A (ja) * | 2009-03-09 | 2016-03-31 | エスピーアイ ファーマ,インコーポレイテッド | 高度に圧密可能かつ耐久性のある直接圧縮賦形剤および賦形剤系 |
JP2012532169A (ja) * | 2009-07-10 | 2012-12-13 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 錠剤を製造するための組成物およびその調製方法 |
JP2012532168A (ja) * | 2009-07-10 | 2012-12-13 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 水分含量の低い打錠補助剤およびその調製方法 |
JP2015108027A (ja) * | 2009-07-10 | 2015-06-11 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 錠剤を製造するための組成物およびその調製方法 |
JP2015110660A (ja) * | 2009-07-10 | 2015-06-18 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 水分含量の低い打錠補助剤およびその調製方法 |
Also Published As
Publication number | Publication date |
---|---|
RU2184535C2 (ru) | 2002-07-10 |
DE59705894D1 (de) | 2002-01-31 |
ATE210971T1 (de) | 2002-01-15 |
CZ291589B6 (cs) | 2003-04-16 |
ES2169385T3 (es) | 2002-07-01 |
MY116890A (en) | 2004-04-30 |
WO1997039739A2 (de) | 1997-10-30 |
HK1019202A1 (en) | 2000-01-28 |
TWI237567B (en) | 2005-08-11 |
CN1216466A (zh) | 1999-05-12 |
EP0896528A2 (de) | 1999-02-17 |
PT896528E (pt) | 2002-06-28 |
US6165511A (en) | 2000-12-26 |
ID17384A (id) | 1997-12-24 |
WO1997039739A3 (de) | 1997-11-27 |
CA2252609C (en) | 2007-01-30 |
CN1147290C (zh) | 2004-04-28 |
EP0896528B1 (de) | 2001-12-19 |
DE19615418A1 (de) | 1997-10-23 |
DK0896528T3 (da) | 2002-04-08 |
JP4343272B2 (ja) | 2009-10-14 |
CA2252609A1 (en) | 1997-10-30 |
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